EP1278769A2 - Tuberkulose antigene und verfahren zu ihrer anwendung - Google Patents

Tuberkulose antigene und verfahren zu ihrer anwendung

Info

Publication number
EP1278769A2
EP1278769A2 EP01923542A EP01923542A EP1278769A2 EP 1278769 A2 EP1278769 A2 EP 1278769A2 EP 01923542 A EP01923542 A EP 01923542A EP 01923542 A EP01923542 A EP 01923542A EP 1278769 A2 EP1278769 A2 EP 1278769A2
Authority
EP
European Patent Office
Prior art keywords
polypeptide
acid sequence
nucleic acid
amino acid
immunogenic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP01923542A
Other languages
English (en)
French (fr)
Inventor
Else Marie Agger
Peter Andersen
Li Mei Meng Okkels
Karin Weldingh
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Statens Serum Institut SSI
Original Assignee
Statens Serum Institut SSI
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Statens Serum Institut SSI filed Critical Statens Serum Institut SSI
Publication of EP1278769A2 publication Critical patent/EP1278769A2/de
Withdrawn legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/35Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Mycobacteriaceae (F)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/51Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/52Bacterial cells; Fungal cells; Protozoal cells
    • A61K2039/523Bacterial cells; Fungal cells; Protozoal cells expressing foreign proteins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/51Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/53DNA (RNA) vaccination
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
EP01923542A 2000-04-19 2001-04-19 Tuberkulose antigene und verfahren zu ihrer anwendung Withdrawn EP1278769A2 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
DK200000666 2000-04-19
DKPA200000666 2000-04-19
DK200100283 2001-02-21
DKPA200100283 2001-02-21
PCT/DK2001/000276 WO2001079274A2 (en) 2000-04-19 2001-04-19 Tuberculosis antigens and methods of use thereof

Publications (1)

Publication Number Publication Date
EP1278769A2 true EP1278769A2 (de) 2003-01-29

Family

ID=26068815

Family Applications (1)

Application Number Title Priority Date Filing Date
EP01923542A Withdrawn EP1278769A2 (de) 2000-04-19 2001-04-19 Tuberkulose antigene und verfahren zu ihrer anwendung

Country Status (4)

Country Link
EP (1) EP1278769A2 (de)
AU (1) AU2001250294A1 (de)
CA (1) CA2405247A1 (de)
WO (1) WO2001079274A2 (de)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4820489B2 (ja) 1999-05-04 2011-11-24 ユニバーシティー、オブ、メディシン、アンド、デンティストリー、オブ、ニュージャージー ヒト型結核菌により発現され且つbcgによって発現されないタンパク質、ならびに診断薬およびワクチンとしてのそれらの使用
WO2004006952A2 (en) 2002-07-13 2004-01-22 Statens Serum Institut Therapeutic tuberculosis vaccines
DE10251747A1 (de) * 2002-11-05 2004-05-19 Tuhh-Technologie-Gmbh Gentechnisch veränderte Penicillinamidase und Verfahren zu ihrer Herstellung
WO2004099771A1 (en) * 2003-05-08 2004-11-18 Statens Serum Institut A new specific epitope based immunological diagnosis of tuberculosis
WO2005061534A2 (en) * 2003-12-23 2005-07-07 Statens Serum Institut Improved tuberculosis vaccines
ITRM20040091A1 (it) 2004-02-19 2004-05-19 Istituto Naz Per Le Malattie Test immunologico rapido per la diagnosi ed il monitoraggio dell'infezione tubercolare.
GB0406271D0 (en) * 2004-03-19 2004-04-21 Isis Innovation Diagnostic test
SG159554A1 (en) 2004-11-16 2010-03-30 Crucell Holland Bv Multivalent vaccines comprising recombinant viral vectors
JP5219808B2 (ja) 2005-06-23 2013-06-26 ステイテンス・セラム・インスティテュート 改良された結核ワクチン
CA2616766A1 (en) 2005-07-26 2007-02-01 University Of Medicine And Dentistry Of New Jersey Antibody profiles characteristic of tuberculosis state
GB0618127D0 (en) * 2006-09-14 2006-10-25 Isis Innovation Biomarker
US9650639B2 (en) 2008-05-19 2017-05-16 Advaxis, Inc. Dual delivery system for heterologous antigens
US9017660B2 (en) 2009-11-11 2015-04-28 Advaxis, Inc. Compositions and methods for prevention of escape mutation in the treatment of Her2/neu over-expressing tumors
EP2288379A4 (de) 2008-05-19 2012-08-08 Advaxis Doppeltes freisetzungssystem für heterologe antigene
US20100015171A1 (en) 2008-07-15 2010-01-21 Statens Serum Institute Vaccines comprising tb 10.4
WO2010121618A1 (en) 2009-04-24 2010-10-28 Statens Serum Institut A tuberculosis tb vaccine to prevent reactivation
US10016617B2 (en) 2009-11-11 2018-07-10 The Trustees Of The University Of Pennsylvania Combination immuno therapy and radiotherapy for the treatment of Her-2-positive cancers
CN102713629B (zh) 2009-11-20 2016-02-24 俄勒冈健康科学大学 用于检测结核分枝杆菌感染的方法
JP5981436B2 (ja) 2010-10-01 2016-08-31 ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルバニア 寄生的に感染している対象におけるワクチン不応答性を反転させるためのリステリアワクチンベクターの使用
CA2829960A1 (en) 2011-03-11 2012-09-20 John Rothman Listeria-based adjuvants
BR112014022662A2 (pt) 2012-03-12 2017-10-03 Advaxis Inc Inibição da função de célula supressora seguindo tratamento de vacina de listeria
WO2018111536A1 (en) 2016-12-14 2018-06-21 Becton, Dickinson And Company Methods and compositions for obtaining a tuberculosis assessment in a subject
CN108267589B (zh) * 2016-12-30 2020-10-23 首都医科大学附属北京胸科医院 结核分枝杆菌蛋白在制备诊断结核潜伏感染者和/或活动性肺结核产品中的用途
GB2621127A (en) * 2022-07-29 2024-02-07 Univ Johannesburg Witwatersrand Vaccine constructs comprising tuberculosis antigens

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1449922T3 (da) * 1997-04-02 2007-12-03 Statens Seruminstitut Nukleinsyrefragmenter og polypeptidfragmenter afledt af M. tuberculosis
US6555653B2 (en) * 1997-05-20 2003-04-29 Corixa Corporation Compounds for diagnosis of tuberculosis and methods for their use
US6613881B1 (en) * 1997-05-20 2003-09-02 Corixa Corporation Compounds for immunotherapy and diagnosis of tuberculosis and methods of their use
AU750173B2 (en) * 1997-11-10 2002-07-11 Statens Serum Institut Nucleic acid fragments and polypeptide fragments derived from M. tuberculosis
US7595383B1 (en) * 1999-05-04 2009-09-29 University Of Medicine And Dentistry Of New Jersey Secreted proteins of Mycobacterium tuberculosis and their use as vaccines and diagnostic reagents
JP4820489B2 (ja) * 1999-05-04 2011-11-24 ユニバーシティー、オブ、メディシン、アンド、デンティストリー、オブ、ニュージャージー ヒト型結核菌により発現され且つbcgによって発現されないタンパク質、ならびに診断薬およびワクチンとしてのそれらの使用

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See references of WO0179274A2 *

Also Published As

Publication number Publication date
WO2001079274A2 (en) 2001-10-25
AU2001250294A1 (en) 2001-10-30
WO2001079274A8 (en) 2004-04-29
CA2405247A1 (en) 2001-10-25
WO2001079274B1 (en) 2002-08-08
WO2001079274A3 (en) 2002-07-11

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Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

AK Designated contracting states

Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR

AX Request for extension of the european patent

Extension state: AL LT LV MK RO SI

17P Request for examination filed

Effective date: 20030113

17Q First examination report despatched

Effective date: 20040715

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 20051101