EP1274432A4 - Compositions containing itraconazole with improved bioavailability and narrow intra- and inter-individual variation of its absorption - Google Patents

Compositions containing itraconazole with improved bioavailability and narrow intra- and inter-individual variation of its absorption

Info

Publication number
EP1274432A4
EP1274432A4 EP99962555A EP99962555A EP1274432A4 EP 1274432 A4 EP1274432 A4 EP 1274432A4 EP 99962555 A EP99962555 A EP 99962555A EP 99962555 A EP99962555 A EP 99962555A EP 1274432 A4 EP1274432 A4 EP 1274432A4
Authority
EP
European Patent Office
Prior art keywords
inter
absorption
compositions containing
improved bioavailability
individual variation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP99962555A
Other languages
German (de)
French (fr)
Other versions
EP1274432A1 (en
Inventor
Jong-Won Kwon
Jung-Hun Kim
Hun-Sik Wang
Sun-Woo Jang
Woong-Tak Bae
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Dong A Pharmaceutical Co Ltd
Original Assignee
Dong A Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dong A Pharmaceutical Co Ltd filed Critical Dong A Pharmaceutical Co Ltd
Publication of EP1274432A1 publication Critical patent/EP1274432A1/en
Publication of EP1274432A4 publication Critical patent/EP1274432A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1611—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats

Landscapes

  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
EP99962555A 1999-12-08 1999-12-31 Compositions containing itraconazole with improved bioavailability and narrow intra- and inter-individual variation of its absorption Withdrawn EP1274432A4 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
KR9955802 1999-12-08
KR1019990055802A KR100694667B1 (en) 1999-12-08 1999-12-08 Antifungal compositions containing itraconazole with both improved bioavailability and narrow intra- and inter-individual variation of its absorption
PCT/KR1999/000854 WO2001041765A1 (en) 1999-12-08 1999-12-31 Compositions containing itraconazole with improved bioavailability and narrow intra- and inter-individual variation of its absorption

Publications (2)

Publication Number Publication Date
EP1274432A1 EP1274432A1 (en) 2003-01-15
EP1274432A4 true EP1274432A4 (en) 2004-11-10

Family

ID=19624262

Family Applications (1)

Application Number Title Priority Date Filing Date
EP99962555A Withdrawn EP1274432A4 (en) 1999-12-08 1999-12-31 Compositions containing itraconazole with improved bioavailability and narrow intra- and inter-individual variation of its absorption

Country Status (7)

Country Link
EP (1) EP1274432A4 (en)
JP (1) JP2003516354A (en)
KR (1) KR100694667B1 (en)
CN (1) CN1398184A (en)
AU (1) AU1896400A (en)
CA (1) CA2393737A1 (en)
WO (1) WO2001041765A1 (en)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20010097244A (en) * 2000-04-21 2001-11-08 유충식 Pharmaceutical composition containing itraconazole with gastric ph-independently improved solubility and preparation method thereof
KR100432949B1 (en) * 2000-06-13 2004-05-31 코오롱제약주식회사 Itraconazole composition of the powders and granules type, its pharmaceutical preparation and method
KR100438485B1 (en) * 2001-08-13 2004-07-09 한국디디에스제약 주식회사 Pharmaceutical compositions containing of azole antifungal drugs
KR100425755B1 (en) * 2001-08-27 2004-04-03 주식회사 원진신약 Compositions containing itraconazole and their preparation methods
KR100441745B1 (en) * 2001-11-30 2004-07-27 환인제약 주식회사 Composition of itraconazole for oral administration and process for preparing thereof
JP2005523262A (en) 2002-02-01 2005-08-04 ファイザー・プロダクツ・インク Pharmaceutical compositions of amorphous dispersions of drugs and lipophilic microphase-forming substances
US6682759B2 (en) * 2002-02-01 2004-01-27 Depomed, Inc. Manufacture of oral dosage forms delivering both immediate-release and sustained-release drugs
KR100557680B1 (en) * 2002-11-23 2006-03-07 한국유나이티드제약 주식회사 Pellet preparations and methods for improved solubility of itraconazole
DK1438961T4 (en) † 2003-01-14 2014-11-17 Acino Pharma Ag Bioequivalent composition of itraconazole dispersed in a hydrophilic polymer
EP1438960B2 (en) † 2003-01-14 2012-12-19 Acino Pharma AG Compostion of itraconazole dispersed in a hydrophilic polymer having enhanced bioavailability
HU227142B1 (en) * 2003-07-02 2010-08-30 Egis Gyogyszergyar Nyilvanosan Capsule of improved release containing fluconazole
BRPI0413277A (en) 2003-08-04 2006-10-10 Pfizer Prod Inc pharmaceutical compositions of amorphous drug adsorbates and lipophilic microphase forming materials
US20050058670A1 (en) * 2003-09-09 2005-03-17 Jong-Soo Woo Oral itraconazole composition which is not affected by ingested food and process for preparing same
CN1285590C (en) * 2004-02-23 2006-11-22 上海医药工业研究院 Itraconazole hydrochloride, oral solid combination and preparation method
US7507823B2 (en) 2004-05-06 2009-03-24 Bristol-Myers Squibb Company Process of making aripiprazole particles
KR100555794B1 (en) * 2005-03-17 2006-03-03 삼천당제약주식회사 Composition comprising itraconazole for oral administration
RS20080439A (en) * 2006-03-27 2009-05-06 Panacea Biotec Ltd., Sustained release pharmaceutical composition on the basis of a release system comprising an acid-soluble polymer and a ph-dependent polymer
GB0613925D0 (en) * 2006-07-13 2006-08-23 Unilever Plc Improvements relating to nanodispersions
GB0814953D0 (en) * 2008-08-18 2008-09-24 Unilever Plc Improvements relating to nanodisperse compositions
JP2012527491A (en) * 2009-05-27 2012-11-08 サムヤン バイオファーマシューティカルズ コーポレイション Slightly soluble drug-containing microspheres with improved bioavailability and method for producing the same
CN102309488A (en) * 2010-07-02 2012-01-11 北京京卫燕康药物研究所有限公司 Itraconazole medicinal composition and preparation method thereof
JP6730315B2 (en) * 2015-01-20 2020-07-29 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングＭｅｒｃｋ Ｐａｔｅｎｔ Ｇｅｓｅｌｌｓｃｈａｆｔ ｍｉｔ ｂｅｓｃｈｒａｅｎｋｔｅｒ Ｈａｆｔｕｎｇ Solid dispersion of compounds using polyvinyl alcohol as carrier polymer

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000030616A1 (en) * 1998-11-20 2000-06-02 Rtp Pharma Inc. Dispersible phospholipid stabilized microparticles

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PH30929A (en) * 1992-09-03 1997-12-23 Janssen Pharmaceutica Nv Beads having a core coated with an antifungal and a polymer.
JP2000514059A (en) * 1996-06-28 2000-10-24 シェーリング コーポレイション Oral composition containing a triazole antifungal compound
FR2758461A1 (en) * 1997-01-17 1998-07-24 Pharma Pass PHARMACEUTICAL COMPOSITION HAVING HIGH BIOAVAILABILITY AND PROCESS FOR PREPARING THE SAME
KR19990001564A (en) * 1997-06-16 1999-01-15 유충식 Azole antifungal agents with improved solubility and preparations containing them
KR19990055802A (en) * 1997-12-27 1999-07-15 김영환 Semiconductor device manufacturing method
KR100288890B1 (en) * 1997-12-31 2001-05-02 최현식 Itraconazole oral formulation and production thereof
DE69808670T2 (en) * 1997-12-31 2003-07-03 Choongwae Pharma Corp., Seoul/Soul PRODUCTION METHOD AND COMPOSITION OF AN ORAL PREPARATION OF ITRACONAZOLE

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000030616A1 (en) * 1998-11-20 2000-06-02 Rtp Pharma Inc. Dispersible phospholipid stabilized microparticles

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of WO0141765A1 *

Also Published As

Publication number Publication date
CN1398184A (en) 2003-02-19
KR20010054823A (en) 2001-07-02
WO2001041765A1 (en) 2001-06-14
AU1896400A (en) 2001-06-18
EP1274432A1 (en) 2003-01-15
CA2393737A1 (en) 2001-06-14
JP2003516354A (en) 2003-05-13
KR100694667B1 (en) 2007-03-14

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