EP1245238A3 - Exotoxin ligand - Google Patents

Exotoxin ligand Download PDF

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Publication number
EP1245238A3
EP1245238A3 EP02004217A EP02004217A EP1245238A3 EP 1245238 A3 EP1245238 A3 EP 1245238A3 EP 02004217 A EP02004217 A EP 02004217A EP 02004217 A EP02004217 A EP 02004217A EP 1245238 A3 EP1245238 A3 EP 1245238A3
Authority
EP
European Patent Office
Prior art keywords
adsorbent
ligands
bacterial toxins
ligand
fluid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP02004217A
Other languages
German (de)
French (fr)
Other versions
EP1245238A2 (en
EP1245238B1 (en
Inventor
Hans E. Dr. Maschke
Veit Dr. Otto
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fresenius Medical Care Deutschland GmbH
Original Assignee
Fresenius Hemocare GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fresenius Hemocare GmbH filed Critical Fresenius Hemocare GmbH
Publication of EP1245238A2 publication Critical patent/EP1245238A2/en
Publication of EP1245238A3 publication Critical patent/EP1245238A3/en
Application granted granted Critical
Publication of EP1245238B1 publication Critical patent/EP1245238B1/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
    • B01J20/3231—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the coating or impregnating layer
    • B01J20/3242—Layers with a functional group, e.g. an affinity material, a ligand, a reactant or a complexing group
    • B01J20/3268—Macromolecular compounds
    • B01J20/3272—Polymers obtained by reactions otherwise than involving only carbon to carbon unsaturated bonds
    • B01J20/3274—Proteins, nucleic acids, polysaccharides, antibodies or antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/58—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. poly[meth]acrylate, polyacrylamide, polystyrene, polyvinylpyrrolidone, polyvinylalcohol or polystyrene sulfonic acid resin
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
    • B01J20/3202—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the carrier, support or substrate used for impregnation or coating
    • B01J20/3206—Organic carriers, supports or substrates
    • B01J20/3208—Polymeric carriers, supports or substrates
    • B01J20/321—Polymeric carriers, supports or substrates consisting of a polymer obtained by reactions involving only carbon to carbon unsaturated bonds
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
    • B01J20/3231—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the coating or impregnating layer
    • B01J20/3242—Layers with a functional group, e.g. an affinity material, a ligand, a reactant or a complexing group
    • B01J20/3244—Non-macromolecular compounds
    • B01J20/3246—Non-macromolecular compounds having a well defined chemical structure
    • B01J20/3248—Non-macromolecular compounds having a well defined chemical structure the functional group or the linking, spacer or anchoring group as a whole comprising at least one type of heteroatom selected from a nitrogen, oxygen or sulfur, these atoms not being part of the carrier as such

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Analytical Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • External Artificial Organs (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

A ligand (I) for bacterial toxins which is capable of selective interaction with the beta -folded-hinge- alpha helix structure of super-antigens is new. Independent claims are also included for: (1) An adsorbent comprising one or more of the ligands covalently bonded to a matrix; (2) Method for the removal of bacterial toxins from a fluid comprising preparing an adsorbent and contacting the adsorbent with the fluid; (3) An adsorber for reducing the concentration of bacterial toxins in blood or blood plasma comprising a receptacle containing the adsorbent; (4) A pharmaceutical preparation containing the ligands optionally together with carrier(s) and/or diluent(s); and (5) A diagnostic kit containing the ligands.
EP02004217A 2001-03-30 2002-02-25 Exotoxin ligand Expired - Lifetime EP1245238B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10116042A DE10116042A1 (en) 2001-03-30 2001-03-30 Exotoxin ligand
DE10116042 2001-03-30

Publications (3)

Publication Number Publication Date
EP1245238A2 EP1245238A2 (en) 2002-10-02
EP1245238A3 true EP1245238A3 (en) 2003-03-12
EP1245238B1 EP1245238B1 (en) 2007-09-19

Family

ID=7679856

Family Applications (1)

Application Number Title Priority Date Filing Date
EP02004217A Expired - Lifetime EP1245238B1 (en) 2001-03-30 2002-02-25 Exotoxin ligand

Country Status (6)

Country Link
US (1) US20020177573A1 (en)
EP (1) EP1245238B1 (en)
JP (1) JP2003012694A (en)
AT (1) ATE373490T1 (en)
DE (2) DE10116042A1 (en)
ES (1) ES2292652T3 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004072095A2 (en) * 2003-02-12 2004-08-26 Yissum Research Development Company Of The Hebrew University Of Jerusalem Cyclized peptides as exotoxin antagonists
JP5670336B2 (en) 2008-10-02 2015-02-18 ユニヴァーシティ オヴ ピッツバーグ オヴ ザ コモンウェルス システム オヴ ハイアー エデュケーション Administration of polymer adsorbents for the treatment of systemic inflammation
CN114602237B (en) * 2022-03-10 2023-11-28 华兰生物工程股份有限公司 Method for removing endotoxin from human plasma or human plasma derivative raw material

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1989001335A1 (en) * 1987-08-14 1989-02-23 Kanegafuchi Chemical Industry Co., Ltd. Biospecific polymers
EP0424698A1 (en) * 1989-10-03 1991-05-02 Fresenius AG Adsorbent for removing biomacromolecules, particularly LDL and endotoxines, from whole blood in extracorporeal circuit
WO1994025483A1 (en) * 1993-05-03 1994-11-10 The University Of British Columbia Immunotherapeutic peptides derived from toxic shock syndrome toxin-1, antibodies thereto, their uses in pharmaceutical compositions and diagnosis
WO1998029444A1 (en) * 1996-12-30 1998-07-09 Yissum Research Development Company Of The Hebrew University Of Jerusalem Broad spectrum pyrogenic exotoxins antagonists and vaccines
DE19705366A1 (en) * 1997-02-12 1998-08-13 Fresenius Ag Device for cleaning protein-containing solutions, method for producing a carrier material for the device and use of the device
EP0993834A1 (en) * 1997-04-21 2000-04-19 Kaneka Corporation Adsorbents for toxic shock syndrome toxin-1, method for eliminating the toxin by adsorption, adsorbers packed with the adsorbents, and use of the adsorbents
EP1191034A1 (en) * 2000-09-26 2002-03-27 Kaneka Corporation Enterotoxin absorbent, method of adsorptive removal, and adsorption apparatus

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6075119A (en) * 1997-04-07 2000-06-13 The Rockefeller University Peptides useful for reducing symptoms of toxic shock syndrome

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1989001335A1 (en) * 1987-08-14 1989-02-23 Kanegafuchi Chemical Industry Co., Ltd. Biospecific polymers
EP0424698A1 (en) * 1989-10-03 1991-05-02 Fresenius AG Adsorbent for removing biomacromolecules, particularly LDL and endotoxines, from whole blood in extracorporeal circuit
WO1994025483A1 (en) * 1993-05-03 1994-11-10 The University Of British Columbia Immunotherapeutic peptides derived from toxic shock syndrome toxin-1, antibodies thereto, their uses in pharmaceutical compositions and diagnosis
WO1998029444A1 (en) * 1996-12-30 1998-07-09 Yissum Research Development Company Of The Hebrew University Of Jerusalem Broad spectrum pyrogenic exotoxins antagonists and vaccines
DE19705366A1 (en) * 1997-02-12 1998-08-13 Fresenius Ag Device for cleaning protein-containing solutions, method for producing a carrier material for the device and use of the device
EP0993834A1 (en) * 1997-04-21 2000-04-19 Kaneka Corporation Adsorbents for toxic shock syndrome toxin-1, method for eliminating the toxin by adsorption, adsorbers packed with the adsorbents, and use of the adsorbents
EP1191034A1 (en) * 2000-09-26 2002-03-27 Kaneka Corporation Enterotoxin absorbent, method of adsorptive removal, and adsorption apparatus

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
JETT M ET AL: "IDENTIFICATION OF STAPHYLOCOCCAL ENTEROTOXIN B SEQUENCES IMPORTANT FOR INDUCTION OF LYMPHOCYTE PROLIFERATION BY USING SYNTHETIC PEPTIDE FRAGMENTS OF THE TOXIN", INFECTION AND IMMUNITY, AMERICAN SOCIETY FOR MICROBIOLOGY. WASHINGTON, US, vol. 62, no. 8, 1 August 1994 (1994-08-01), pages 3408 - 3415, XP002062764, ISSN: 0019-9567 *

Also Published As

Publication number Publication date
JP2003012694A (en) 2003-01-15
DE50210908D1 (en) 2007-10-31
EP1245238A2 (en) 2002-10-02
ATE373490T1 (en) 2007-10-15
EP1245238B1 (en) 2007-09-19
ES2292652T3 (en) 2008-03-16
US20020177573A1 (en) 2002-11-28
DE10116042A1 (en) 2002-10-24

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