EP1221853A4 - Oligodendrocyte cell cultures and methods for their preparation and use - Google Patents

Oligodendrocyte cell cultures and methods for their preparation and use

Info

Publication number
EP1221853A4
EP1221853A4 EP00986805A EP00986805A EP1221853A4 EP 1221853 A4 EP1221853 A4 EP 1221853A4 EP 00986805 A EP00986805 A EP 00986805A EP 00986805 A EP00986805 A EP 00986805A EP 1221853 A4 EP1221853 A4 EP 1221853A4
Authority
EP
European Patent Office
Prior art keywords
preparation
methods
cell cultures
oligodendrocyte cell
oligodendrocyte
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP00986805A
Other languages
German (de)
French (fr)
Other versions
EP1221853A1 (en
Inventor
John W Mcdonald
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Washington
Washington University in St Louis WUSTL
Original Assignee
University of Washington
Washington University in St Louis WUSTL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Washington, Washington University in St Louis WUSTL filed Critical University of Washington
Publication of EP1221853A1 publication Critical patent/EP1221853A1/en
Publication of EP1221853A4 publication Critical patent/EP1221853A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0618—Cells of the nervous system
    • C12N5/0622—Glial cells, e.g. astrocytes, oligodendrocytes; Schwann cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/115—Basic fibroblast growth factor (bFGF, FGF-2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/13—Nerve growth factor [NGF]; Brain-derived neurotrophic factor [BDNF]; Cilliary neurotrophic factor [CNTF]; Glial-derived neurotrophic factor [GDNF]; Neurotrophins [NT]; Neuregulins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/135—Platelet-derived growth factor [PDGF]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/30—Hormones
    • C12N2501/38—Hormones with nuclear receptors
    • C12N2501/385—Hormones with nuclear receptors of the family of the retinoic acid recptor, e.g. RAR, RXR; Peroxisome proliferator-activated receptor [PPAR]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2502/00—Coculture with; Conditioned medium produced by
    • C12N2502/08—Coculture with; Conditioned medium produced by cells of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/02—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from embryonic cells
EP00986805A 1999-10-22 2000-10-21 Oligodendrocyte cell cultures and methods for their preparation and use Withdrawn EP1221853A4 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US16112599P 1999-10-22 1999-10-22
US161125P 1999-10-22
PCT/US2000/041367 WO2001028342A1 (en) 1999-10-22 2000-10-21 Oligodendrocyte cell cultures and methods for their preparation and use

Publications (2)

Publication Number Publication Date
EP1221853A1 EP1221853A1 (en) 2002-07-17
EP1221853A4 true EP1221853A4 (en) 2004-08-25

Family

ID=22579930

Family Applications (1)

Application Number Title Priority Date Filing Date
EP00986805A Withdrawn EP1221853A4 (en) 1999-10-22 2000-10-21 Oligodendrocyte cell cultures and methods for their preparation and use

Country Status (5)

Country Link
EP (1) EP1221853A4 (en)
JP (1) JP2003511090A (en)
AU (1) AU2297901A (en)
CA (1) CA2388736A1 (en)
WO (1) WO2001028342A1 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050101014A1 (en) 2002-07-11 2005-05-12 Keirstead Hans S. Oligodendrocytes derived from human embryonic stem cells for remyelination and treatment of spinal cord injury
US7285415B2 (en) * 2002-07-11 2007-10-23 The Regents Of The University Of California Oligodendrocytes derived from human embryonic stem cells for remyelination and treatment of spinal cord injury
CN101939362A (en) 2008-01-30 2011-01-05 杰龙公司 Synthetic surfaces for culturing stem cell derived oligodendrocyte progenitor cells
US9177967B2 (en) 2013-12-24 2015-11-03 Intel Corporation Heterogeneous semiconductor material integration techniques
AU2017240591B2 (en) * 2016-03-30 2023-08-24 Asterias Biotherapeutics, Inc. Oligodendrocyte progenitor cell compositions
KR20210121112A (en) 2019-01-23 2021-10-07 아스테리아스 바이오세라퓨틱스, 인크. Dorsal-derived oligodendrocyte progenitor cells from human pluripotent stem cells

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5618531A (en) * 1990-10-19 1997-04-08 New York University Method for increasing the viability of cells which are administered to the brain or spinal cord

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
BAIN, G. ET AL: "Embryonic stem cells express neuronal propertiesin vitro", DEVELOPMENTAL BIOLOGY, vol. 168, 1995, pages 342 - 357 *
LIU S ET AL: "Differentiation, enrichment and purification of oligodendrocytes from cultured embryonic stem cells", SOCIETY FOR NEUROSCIENCE ABSTRACTS, vol. 25, no. 1-2, 1999, & 29TH ANNUAL MEETING OF THE SOCIETY FOR NEUROSCIENCE.; MIAMI BEACH, FLORIDA, USA; OCTOBER 23-28, 1999, pages 2039, XP002285564, ISSN: 0190-5295 *
OKABE S ET AL: "Development of neuronal precursor cells and functional postmitotic neurons from embryonic stem cells in vitro.", MECHANISMS OF DEVELOPMENT. SEP 1996, vol. 59, no. 1, September 1996 (1996-09-01), pages 89 - 102, XP002285562, ISSN: 0925-4773 *
See also references of WO0128342A1 *
STEWART T J ET AL: "Embryonic stem cell derived oligodendrocytes are capable of myelinating many neuronal axons in culture", SOCIETY FOR NEUROSCIENCE ABSTRACTS, vol. 25, no. 1-2, 1999, & 29TH ANNUAL MEETING OF THE SOCIETY FOR NEUROSCIENCE.; MIAMI BEACH, FLORIDA, USA; OCTOBER 23-28, 1999, pages 749, XP002285565, ISSN: 0190-5295 *
STRÜBING C ET AL: "Differentiation of pluripotent embryonic stem cells into the neuronal lineage in vitro gives rise to mature inhibitory and excitatory neurons.", MECHANISMS OF DEVELOPMENT. OCT 1995, vol. 53, no. 2, October 1995 (1995-10-01), pages 275 - 287, XP002285563, ISSN: 0925-4773 *

Also Published As

Publication number Publication date
WO2001028342A1 (en) 2001-04-26
CA2388736A1 (en) 2001-04-26
JP2003511090A (en) 2003-03-25
AU2297901A (en) 2001-04-30
EP1221853A1 (en) 2002-07-17

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