EP1218486A4 - Improvement of clavulanic acid production - Google Patents
Improvement of clavulanic acid productionInfo
- Publication number
- EP1218486A4 EP1218486A4 EP20000970455 EP00970455A EP1218486A4 EP 1218486 A4 EP1218486 A4 EP 1218486A4 EP 20000970455 EP20000970455 EP 20000970455 EP 00970455 A EP00970455 A EP 00970455A EP 1218486 A4 EP1218486 A4 EP 1218486A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- improvement
- acid production
- clavulanic acid
- clavulanic
- production
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
- C12N15/76—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for Actinomyces; for Streptomyces
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
- C12P17/188—Heterocyclic compound containing in the condensed system at least one hetero ring having nitrogen atoms and oxygen atoms as the only ring heteroatoms
Landscapes
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Physics & Mathematics (AREA)
- General Chemical & Material Sciences (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Plant Pathology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Enzymes And Modification Thereof (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US15421399P | 1999-09-16 | 1999-09-16 | |
US154213P | 1999-09-16 | ||
PCT/US2000/025186 WO2001019959A1 (en) | 1999-09-16 | 2000-09-15 | Improvement of clavulanic acid production |
Publications (2)
Publication Number | Publication Date |
---|---|
EP1218486A1 EP1218486A1 (en) | 2002-07-03 |
EP1218486A4 true EP1218486A4 (en) | 2002-11-04 |
Family
ID=22550464
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP20000970455 Withdrawn EP1218486A4 (en) | 1999-09-16 | 2000-09-15 | Improvement of clavulanic acid production |
Country Status (4)
Country | Link |
---|---|
EP (1) | EP1218486A4 (en) |
AU (1) | AU7983400A (en) |
HK (1) | HK1047957A1 (en) |
WO (1) | WO2001019959A1 (en) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN100355895C (en) * | 2004-12-17 | 2007-12-19 | 天津科技大学 | Plasmid with bar streptomycete Lat gene loss, derivative and constructing method thereof |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0349121A2 (en) * | 1988-06-02 | 1990-01-03 | Beecham Group Plc | Method for producing clavulanic acid |
CA2108113A1 (en) * | 1993-10-08 | 1995-04-09 | Susan E. Jensen | Dna sequence encoding enzymes of clavulanic acid biosynthesis |
WO1998033896A2 (en) * | 1997-02-04 | 1998-08-06 | Smithkline Beecham Plc | Microorganisms with increased production of clavulanic acid |
ES2131001A1 (en) * | 1997-06-16 | 1999-07-01 | Antibioticos Sau | Process for increasing the production of clavulanic acid by the expression of biosynthetic regulator genes from Streptomyces clavuligerus |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0673432B1 (en) * | 1992-12-02 | 1999-03-24 | Smithkline Beecham Plc | Process for preparing clavulanic acid |
-
2000
- 2000-09-15 AU AU79834/00A patent/AU7983400A/en not_active Abandoned
- 2000-09-15 EP EP20000970455 patent/EP1218486A4/en not_active Withdrawn
- 2000-09-15 WO PCT/US2000/025186 patent/WO2001019959A1/en not_active Application Discontinuation
-
2002
- 2002-12-31 HK HK02109461.9A patent/HK1047957A1/en unknown
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0349121A2 (en) * | 1988-06-02 | 1990-01-03 | Beecham Group Plc | Method for producing clavulanic acid |
CA2108113A1 (en) * | 1993-10-08 | 1995-04-09 | Susan E. Jensen | Dna sequence encoding enzymes of clavulanic acid biosynthesis |
WO1998033896A2 (en) * | 1997-02-04 | 1998-08-06 | Smithkline Beecham Plc | Microorganisms with increased production of clavulanic acid |
ES2131001A1 (en) * | 1997-06-16 | 1999-07-01 | Antibioticos Sau | Process for increasing the production of clavulanic acid by the expression of biosynthetic regulator genes from Streptomyces clavuligerus |
Non-Patent Citations (10)
Title |
---|
IVES PAUL R ET AL: "Manipulation of the physiology of clavulanic acid production in Streptomyces clavuligerus.", MICROBIOLOGY (READING), vol. 143, no. 11, November 1997 (1997-11-01), pages 3573 - 3579, XP002216540, ISSN: 1350-0872 * |
JENSEN S E ET AL: "BIOSYNTHESIS AND MOLECULAR GENETICS OF CLAVULANIC ACID", ANTONIE VAN LEEUWENHOEK, DORDRECHT, NL, vol. 75, 1999, pages 125 - 133, XP000937780 * |
JENSEN SUSAN E ET AL: "Enzymes catalyzing the early steps of clavulanic acid biosynthesis are encoded by two sets of paralogous genes in Streptomyces clavuligerus.", ANTIMICROBIAL AGENTS AND CHEMOTHERAPY., vol. 44, no. 3, March 2000 (2000-03-01), pages 720 - 726, XP002216539, ISSN: 0066-4804 * |
MCNAUGHTON H J ET AL: "BETA-LACTAM SYNTHETASE: IMPLICATIONS FOR BETA-LACTAMASE EVOLUTION", CHEMICAL COMMUNICATIONS, ROYAL SOCIETY OF CHEMISTRY, GB, vol. 21, 1998, pages 2325 - 2326, XP002900777, ISSN: 1359-7345 * |
PEREZ-REDONDO ROSARIO ET AL: "Deletion of the pyc gene blocks clavulanic acid biosynthesis except in glycerol-containing medium: Evidence for two different genes in formation of the C3 unit.", JOURNAL OF BACTERIOLOGY, vol. 181, no. 22, November 1999 (1999-11-01), pages 6922 - 6928, XP002216538, ISSN: 0021-9193 * |
PITLIK, J.; TOWNSEND, C. A.: "The fate of [2,3,3-2H3, 1,2-13C2]-D, L-glycerate in clavulanic acid biosynthesis", CHEMICAL COMMUNICATIONS, vol. 2, 1997, pages 225 - 226, XP001107210 * |
ROMERO J ET AL: "utilization of ornithine and arginine as specific precursors of clavulanic acid by S. clavuligerus", APPLIED AND ENVIRONMENTAL MICROBIOLOGY, WASHINGTON,DC, US, vol. 52, no. 4, 1 October 1986 (1986-10-01), pages 892 - 897, XP002083075, ISSN: 0099-2240 * |
See also references of WO0119959A1 * |
TOWNSEND C A ET AL: "BIOSYNTHESIS OF CLAVULANIC-ACID ORIGIN OF THE 3-CARBON UNIT", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 107, no. 4, 1985, pages 1066 - 1068, XP001106978, ISSN: 0002-7863 * |
TOWNSEND C A ET AL: "BIOSYNTHESIS OF CLAVULANIC-ACID ORIGIN OF THE 5 CARBON UNIT", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 107, no. 4, 1985, pages 1065 - 1066, XP001117431, ISSN: 0002-7863 * |
Also Published As
Publication number | Publication date |
---|---|
AU7983400A (en) | 2001-04-17 |
HK1047957A1 (en) | 2003-03-14 |
EP1218486A1 (en) | 2002-07-03 |
WO2001019959A1 (en) | 2001-03-22 |
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Legal Events
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