EP1218486A4 - Improvement of clavulanic acid production - Google Patents

Improvement of clavulanic acid production

Info

Publication number
EP1218486A4
EP1218486A4 EP20000970455 EP00970455A EP1218486A4 EP 1218486 A4 EP1218486 A4 EP 1218486A4 EP 20000970455 EP20000970455 EP 20000970455 EP 00970455 A EP00970455 A EP 00970455A EP 1218486 A4 EP1218486 A4 EP 1218486A4
Authority
EP
European Patent Office
Prior art keywords
improvement
acid production
clavulanic acid
clavulanic
production
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP20000970455
Other languages
German (de)
French (fr)
Other versions
EP1218486A1 (en
Inventor
Craig A Townsend
Rongfeng Li
Nusrat Khaleeli
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Johns Hopkins University
Original Assignee
Johns Hopkins University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Johns Hopkins University filed Critical Johns Hopkins University
Publication of EP1218486A1 publication Critical patent/EP1218486A1/en
Publication of EP1218486A4 publication Critical patent/EP1218486A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
    • C12N15/76—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for Actinomyces; for Streptomyces
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/188—Heterocyclic compound containing in the condensed system at least one hetero ring having nitrogen atoms and oxygen atoms as the only ring heteroatoms

Landscapes

  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Plant Pathology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
EP20000970455 1999-09-16 2000-09-15 Improvement of clavulanic acid production Withdrawn EP1218486A4 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US15421399P 1999-09-16 1999-09-16
US154213P 1999-09-16
PCT/US2000/025186 WO2001019959A1 (en) 1999-09-16 2000-09-15 Improvement of clavulanic acid production

Publications (2)

Publication Number Publication Date
EP1218486A1 EP1218486A1 (en) 2002-07-03
EP1218486A4 true EP1218486A4 (en) 2002-11-04

Family

ID=22550464

Family Applications (1)

Application Number Title Priority Date Filing Date
EP20000970455 Withdrawn EP1218486A4 (en) 1999-09-16 2000-09-15 Improvement of clavulanic acid production

Country Status (4)

Country Link
EP (1) EP1218486A4 (en)
AU (1) AU7983400A (en)
HK (1) HK1047957A1 (en)
WO (1) WO2001019959A1 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN100355895C (en) * 2004-12-17 2007-12-19 天津科技大学 Plasmid with bar streptomycete Lat gene loss, derivative and constructing method thereof

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0349121A2 (en) * 1988-06-02 1990-01-03 Beecham Group Plc Method for producing clavulanic acid
CA2108113A1 (en) * 1993-10-08 1995-04-09 Susan E. Jensen Dna sequence encoding enzymes of clavulanic acid biosynthesis
WO1998033896A2 (en) * 1997-02-04 1998-08-06 Smithkline Beecham Plc Microorganisms with increased production of clavulanic acid
ES2131001A1 (en) * 1997-06-16 1999-07-01 Antibioticos Sau Process for increasing the production of clavulanic acid by the expression of biosynthetic regulator genes from Streptomyces clavuligerus

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0673432B1 (en) * 1992-12-02 1999-03-24 Smithkline Beecham Plc Process for preparing clavulanic acid

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0349121A2 (en) * 1988-06-02 1990-01-03 Beecham Group Plc Method for producing clavulanic acid
CA2108113A1 (en) * 1993-10-08 1995-04-09 Susan E. Jensen Dna sequence encoding enzymes of clavulanic acid biosynthesis
WO1998033896A2 (en) * 1997-02-04 1998-08-06 Smithkline Beecham Plc Microorganisms with increased production of clavulanic acid
ES2131001A1 (en) * 1997-06-16 1999-07-01 Antibioticos Sau Process for increasing the production of clavulanic acid by the expression of biosynthetic regulator genes from Streptomyces clavuligerus

Non-Patent Citations (10)

* Cited by examiner, † Cited by third party
Title
IVES PAUL R ET AL: "Manipulation of the physiology of clavulanic acid production in Streptomyces clavuligerus.", MICROBIOLOGY (READING), vol. 143, no. 11, November 1997 (1997-11-01), pages 3573 - 3579, XP002216540, ISSN: 1350-0872 *
JENSEN S E ET AL: "BIOSYNTHESIS AND MOLECULAR GENETICS OF CLAVULANIC ACID", ANTONIE VAN LEEUWENHOEK, DORDRECHT, NL, vol. 75, 1999, pages 125 - 133, XP000937780 *
JENSEN SUSAN E ET AL: "Enzymes catalyzing the early steps of clavulanic acid biosynthesis are encoded by two sets of paralogous genes in Streptomyces clavuligerus.", ANTIMICROBIAL AGENTS AND CHEMOTHERAPY., vol. 44, no. 3, March 2000 (2000-03-01), pages 720 - 726, XP002216539, ISSN: 0066-4804 *
MCNAUGHTON H J ET AL: "BETA-LACTAM SYNTHETASE: IMPLICATIONS FOR BETA-LACTAMASE EVOLUTION", CHEMICAL COMMUNICATIONS, ROYAL SOCIETY OF CHEMISTRY, GB, vol. 21, 1998, pages 2325 - 2326, XP002900777, ISSN: 1359-7345 *
PEREZ-REDONDO ROSARIO ET AL: "Deletion of the pyc gene blocks clavulanic acid biosynthesis except in glycerol-containing medium: Evidence for two different genes in formation of the C3 unit.", JOURNAL OF BACTERIOLOGY, vol. 181, no. 22, November 1999 (1999-11-01), pages 6922 - 6928, XP002216538, ISSN: 0021-9193 *
PITLIK, J.; TOWNSEND, C. A.: "The fate of [2,3,3-2H3, 1,2-13C2]-D, L-glycerate in clavulanic acid biosynthesis", CHEMICAL COMMUNICATIONS, vol. 2, 1997, pages 225 - 226, XP001107210 *
ROMERO J ET AL: "utilization of ornithine and arginine as specific precursors of clavulanic acid by S. clavuligerus", APPLIED AND ENVIRONMENTAL MICROBIOLOGY, WASHINGTON,DC, US, vol. 52, no. 4, 1 October 1986 (1986-10-01), pages 892 - 897, XP002083075, ISSN: 0099-2240 *
See also references of WO0119959A1 *
TOWNSEND C A ET AL: "BIOSYNTHESIS OF CLAVULANIC-ACID ORIGIN OF THE 3-CARBON UNIT", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 107, no. 4, 1985, pages 1066 - 1068, XP001106978, ISSN: 0002-7863 *
TOWNSEND C A ET AL: "BIOSYNTHESIS OF CLAVULANIC-ACID ORIGIN OF THE 5 CARBON UNIT", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 107, no. 4, 1985, pages 1065 - 1066, XP001117431, ISSN: 0002-7863 *

Also Published As

Publication number Publication date
AU7983400A (en) 2001-04-17
HK1047957A1 (en) 2003-03-14
EP1218486A1 (en) 2002-07-03
WO2001019959A1 (en) 2001-03-22

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