EP1218041A1 - Systeme d'insertion multi-canaux pour administration simultanee d'elements biologiquement actifs a plusieurs sites organiques - Google Patents

Systeme d'insertion multi-canaux pour administration simultanee d'elements biologiquement actifs a plusieurs sites organiques

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Publication number
EP1218041A1
EP1218041A1 EP00947360A EP00947360A EP1218041A1 EP 1218041 A1 EP1218041 A1 EP 1218041A1 EP 00947360 A EP00947360 A EP 00947360A EP 00947360 A EP00947360 A EP 00947360A EP 1218041 A1 EP1218041 A1 EP 1218041A1
Authority
EP
European Patent Office
Prior art keywords
channeled
insertion system
channels
longitudinally extending
set forth
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP00947360A
Other languages
German (de)
English (en)
Inventor
Hoi Sang U
James Peter Amis
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of California
MacroPore Inc
Original Assignee
University of California
MacroPore Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of California, MacroPore Inc filed Critical University of California
Publication of EP1218041A1 publication Critical patent/EP1218041A1/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/34—Trocars; Puncturing needles
    • A61B17/3468—Trocars; Puncturing needles for implanting or removing devices, e.g. prostheses, implants, seeds, wires
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/34—Trocars; Puncturing needles
    • A61B17/3417—Details of tips or shafts, e.g. grooves, expandable, bendable; Multiple coaxial sliding cannulas, e.g. for dilating
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/00234—Surgical instruments, devices or methods, e.g. tourniquets for minimally invasive surgery
    • A61B2017/00238—Type of minimally invasive operation
    • A61B2017/00274—Prostate operation, e.g. prostatectomy, turp, bhp treatment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/22—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for
    • A61B2017/22072—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for with an instrument channel, e.g. for replacing one instrument by the other
    • A61B2017/22074—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for with an instrument channel, e.g. for replacing one instrument by the other the instrument being only slidable in a channel, e.g. advancing optical fibre through a channel
    • A61B2017/22077—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for with an instrument channel, e.g. for replacing one instrument by the other the instrument being only slidable in a channel, e.g. advancing optical fibre through a channel with a part piercing the tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/34—Trocars; Puncturing needles
    • A61B17/3417—Details of tips or shafts, e.g. grooves, expandable, bendable; Multiple coaxial sliding cannulas, e.g. for dilating
    • A61B17/3421—Cannulas
    • A61B2017/3445—Cannulas used as instrument channel for multiple instruments
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00315—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for treatment of particular body parts
    • A61B2018/00547—Prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/0021—Catheters; Hollow probes characterised by the form of the tubing
    • A61M25/0023—Catheters; Hollow probes characterised by the form of the tubing by the form of the lumen, e.g. cross-section, variable diameter
    • A61M25/0026—Multi-lumen catheters with stationary elements
    • A61M2025/0034—Multi-lumen catheters with stationary elements characterized by elements which are assembled, connected or fused, e.g. splittable tubes, outer sheaths creating lumina or separate cores
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/0021—Catheters; Hollow probes characterised by the form of the tubing
    • A61M25/0023—Catheters; Hollow probes characterised by the form of the tubing by the form of the lumen, e.g. cross-section, variable diameter
    • A61M25/0026—Multi-lumen catheters with stationary elements
    • A61M2025/0036—Multi-lumen catheters with stationary elements with more than four lumina
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/0021—Catheters; Hollow probes characterised by the form of the tubing
    • A61M25/0023—Catheters; Hollow probes characterised by the form of the tubing by the form of the lumen, e.g. cross-section, variable diameter
    • A61M25/0026—Multi-lumen catheters with stationary elements
    • A61M2025/004—Multi-lumen catheters with stationary elements characterized by lumina being arranged circumferentially
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/0067—Catheters; Hollow probes characterised by the distal end, e.g. tips
    • A61M25/0082—Catheter tip comprising a tool
    • A61M2025/0096—Catheter tip comprising a tool being laterally outward extensions or tools, e.g. hooks or fibres

Definitions

  • the present invention relates generally to surgical devices and, more particularly, to catheters and needles for insertion into organs.
  • Needles have existed in the prior art for facilitating insertion of catheters into fluid spaces such as the blood stream or the subarachnoid space.
  • Each catheter so introduced followed the direction of the axis of the needle through which the catheter was inserted, and thus the catheter was targeted to a region aligned with and distal of the needle.
  • the multi-channeled insertion system of the present invention enables numerous points of interest within an organ to be marked, diagnosed and treated through only a single incision into the organ.
  • the multi-channeled insertion system of the present invention includes a number of channels for facilitating the insertion of various devices therethrough.
  • the multi-channeled insertion system is initially inserted into an organ and, subsequently, two or more needles are inserted into the organ through the channels of the multi-channeled insertion system. At least one of the two or more needles will typically diverge from an axis of the multi-channeled insertion system as the needle is further inserted into the organ.
  • the multi-channeled insertion system thus facilitates the introduction of various delivery and/or visualization devices to different areas within a region of interest, through a single insertion of the multi-channeled insertion system.
  • the locations of the various delivery and/or visualization devices can be verified anatomically using magnetic resonance (MR) scanning, and can further be defined physiologically using one or more data recorders incorporated into the inserted devices.
  • MR magnetic resonance
  • the multi-channeled insertion system is first introduced into proximity of a region of interest. This step can be performed through the use of stereotaxy as in the case of the brain or the use of MR guidance. The precise location of the multi-channeled insertion system can then be verified with MR scanning and, subsequently, the relationships between the device and the region of interest determined. Multiple smaller tubular structures, e.g., needles, catheters, electrodes, assay devices, or endoscopes, can be directed to desired regions of interest through specifically designed channels of the multi-channeled insertion system.
  • the channels are specifically designed to have the smaller tubular structures exit at predetermined angles, to thereby direct the smaller tubular structures to various components or sub-regions of the region of interest.
  • the locations of the smaller tubular components can then be verified using MR scanning.
  • the smaller tubular components can comprise electrodes for monitoring and recording parameters relating to different brain regions.
  • Biologically active elements such as cells, genetic elements, proteins or other biologically active elements, to be delivered to each region can be inoculated through the lumens of the smaller tubular components of the multi-channeled insertion system.
  • Figure 1 is a longitudinal cross-sectional view of the multi-channeled insertion system of the present invention
  • Figure 2 is an axial cross-sectional view of the multi-channeled insertion system, taken along the line 2-2 of Figure 1 ;
  • Figure 3 is a side-elevation view of the multi-channeled insertion system of the present invention.
  • Figure 4 is an end view of the multi-channeled insertion system of the present invention.
  • Figure 5 is a side-elevation view of the support structure of the multi- channeled insertion system in accordance with the present invention
  • Figure 6 is an end view of the support structure, taken along line 6-6 of
  • Figure 7 illustrates a multi-channeled insertion system, inserted through an aperture in a skull and having two needles extending therefrom into close proximity of a target
  • Figure 8 illustrates a multi-channeled insertion system, inserted through an aperture in a skull and having five needles extending therefrom into close proximity of a target
  • Figure 9 illustrates another multi-channeled insertion system, inserted through an aperture in a skull and having at least one needle formed of a memory material
  • Figure 10 illustrates a multi-channeled insertion system having alignment structures on at least one of the channels thereof;
  • Figure 11 illustrates a multi-channeled insertion system having a central delivery needle and a single side delivery needle for application about an axis of the multi-channeled insertion system
  • Figure 12 illustrates two target sites disposed within the cranium of a patient at coordinates determined by stereotaxic procedures
  • Figure 13 illustrates two needles extending from a multi-channeled insertion system to the two target sites in accordance with the present invention.
  • the multi-channeled insertion system of the present invention is adapted for insertion into body cavities and tissue, such as an organ. Organs can include the brain, liver, kidneys, prostate, etc.
  • the multi-channeled insertion system preferably comprises: (1 ) a non-scatterable metal, such as titanium, (2) a plastic, or (3) other alloy metals that will not scatter a Magnetic Resonance Imaging
  • the multi-channeled insertion system may be constructed of scatterable materials.
  • FIG. 1 A longitudinal cross-sectional view of the multi-channeled insertion system 10 is shown in Figure 1.
  • An axial cross-sectional view, taken along the line 2-2 of Figure 1 is shown in Figure 2.
  • the multi-channeled insertion system 10 comprises a tubular structure 12, a channel support structure 14 holding or forming a central channel 16, and a plurality of additional channels 18. In the illustrated embodiment, the spaces between the channels 18 and the channel support structure 14 are operated as pressure release channels.
  • Figure 3 is a side-elevation side-elevation view of the multi-channeled insertion system 10
  • Figure 4 is an end view of the multi-channeled insertion system 10.
  • Figure 5 is a side-elevation side-elevation view of the support structure 14, and
  • Figure 6 is an end view of the support structure 14.
  • Each of the channels 18 preferably is configured to accommodate a delivery needle 20 or other object therethrough.
  • the delivery needle 20 preferably comprises titanium, but may be formed of a plastic or other alloy metals or materials that will not scatter or otherwise interfere with an MRI or other viewing beam.
  • the multi-channeled insertion system 10 can be used to precisely target a specific area with only a single incision, for example.
  • the single insertion of the multi-channeled insertion system 10 into the organ can reduce a possibility of hemorrhaging.
  • the specific area can be targeted with up to 4 delivery needles, in the illustrated embodiment. In modified embodiments, the target area can be targeted with up to 6 or 8, or more, delivery needles.
  • the target in this case the brain, is located and identified through stereotaxic procedures incorporating CAT, MRI, or other scanning protocols.
  • a benefit of forming the multi-channeled insertion system 10 of non-scatterable material is the ability of viewing the multi-channeled insertion system 10 in real time after insertion into the patient.
  • the brain is then plotted 3-dimensionally, relative to a halo device secured to the scull of the patient.
  • halo device are intended to refer to any device for holding the skull for imaging. Such devices will typically operate by identifying a non-visible target, such as the brain, through interpolation of three axes, for example.
  • the target site within the brain is triangulated with needles.
  • the multi-channeled insertion system of the present invention is preferably formed of a non-scatterable material to facilitate the collection of MRI data, for example, subsequent to the slight movement of the target (brain).
  • the multi-channeled insertion system 10 of the present invention can be moved closer to the target site, based upon image data (such as MRI) collected subsequent to the insertion of the multi-channeled insertion system 10.
  • an endoscope housed within the central channel 16 provides real-time visual information for accurate placement of the multi- channeled insertion system 10 and subsequent placement of the delivery needles.
  • post-insertion MRI data can be collected, due to the fact that the multi-channeled insertion system 10 is formed of non-scatterable material.
  • the halo is also formed of non-scatterable metal.
  • the delivery needles are inserted through the channels and near to or into the tissue of the target in order to reach targeted site locations on or within the target. As shown in Figure 1 , a delivery needle 21 is output at an angle 22 from a distal end 24 of a channel 18 of the multi-channeled insertion system 10.
  • the angle 22, which is measured relative to an axis 27 of the multi-channeled insertion system 10, can be calculated by the surgeon or other user, to ensure that the ultimate destination of the delivery needle 21 coincides with the targeted site location to be marked or treated.
  • Treatment can include, for example, chemotherapy injections, application of electrical stimulus, or injection of cellular structure such as fetal stem cells, proteins, genetic materials.
  • the same or similar procedures can be implemented for the other channels 18 of the multi-channeled insertion system 10.
  • the exit angle 22 is measured from the axis 27 in a direction radially outwardly from the axis 27.
  • they may also be configured to have different measured directions.
  • the exit angle 22 may be measured in a direction perpendicular to a plane containing both the illustrated direction and angle and the axis 27.
  • the delivery needle shown in Figure 1 would extend at an angle out of the paper, instead of extending at an angle toward the top of Figure 1.
  • the distal end 24 of the channel 18 ( Figure 1 ) is preferably shaped or curved to transition the inserted delivery needle 21 from alignment with the axis 27 to the exit angle.
  • the user determines the number, nature and coordinates of targeted site locations to be marked or treated and, further, determines a configuration and implementation of the multi-channeled insertion system 10 that can be used to achieve the placement of the delivery needles 21 at the required locations.
  • the determined solution will often be one of many possible solutions, and may be a function of, inter alia, the equipment on-hand, the trauma to be incurred by the patient and the available time and subsequent procedures to be conducted.
  • Figure 12 illustrates two target sites T1 and T2 to be treated. Using conventional means, the surgeon determines that the first target site T1 is located a distance D1 below the cranium surface and a distance D2 to the left.
  • the second target site T2 is determined to be located a distance D1 below the cranium surface and a distance D3 to the right , or 180 degrees, from T1.
  • the surgeon obtains a multi- channeled insertion system 110 having two channels, each exiting at 45 degrees from the longitudinal axis of the multi-channeled insertion system 110.
  • the two channels are configured to have components of travel that are 180 degrees away from each other (i.e., as shown in Figure 13, one channel points left toward the first target site T1 and the other channel points right toward the second target site T2).
  • the surgeon advances the multi- channeled insertion system 110 a depth D4 below the surface of the cranium 35 to a point 112 above and between the two target sites T1 and T2.
  • a first needle 114 is then advanced through the first channel to the D4 depth below the cranium 35, and advanced an additional distance D5 at an angle of 45 degrees from the axis of the multi-channeled insertion system 110 toward the target site T1.
  • a second needle 116 is advanced through the second channel to the D4 depth below the cranium 35; and then advanced an additional distance D6 at an angle of 45 degrees from the axis of the multi-channeled insertion system 110 toward the target site T2.
  • D1 , D2 and D3 are 8 cm, 1 cm and 1 cm, respectively
  • D4, D5 and D6 will be 7 cm, 1.4 cm, and 1.4 cm, respectively, in the illustrated example.
  • many other solutions are possible for achieving a single insertion through the aperture 33 and a subsequent branching to the target sites T1 and T2.
  • the multi-channeled insertion system 110 can be advanced to a depth of 8 cm and the two needles 114, 116 branched left and right 1 cm each to the target sites T1 and T2.
  • the multi- channeled insertion system 110 it may be preferred to insert the multi- channeled insertion system 110 to a depth less than 7 cm, and to branch the two needles toward the two target sites T1 and T2 at the appropriate distances and angles accordingly. In yet another embodiment, it may be preferred to insert the multi-channeled insertion system 110 closer to the target site T1 than the target site T2, and to branch the second needle 116 a greater distance toward the second target site T2 than the first needle 114 is advanced toward the first target site T1.
  • Various factors may influence the solution to reaching the targets T1 and T2, such as types of tissues, the density of vessels in the various tissues surrounding the targets T1 and T2, the equipment on hand, the surgical procedures to be implemented.
  • the multi-channeled insertion system 110 and the needles 114, 116 comprise non- scatterable materials to enable an imaging scan for verification that the needles 114, 116 are properly placed in the correct proximities to the two target sites T1 and T2.
  • a multi-channeled insertion system may be prefabricated having the illustrated four (or five) channels, with at least one of the channels having a different exit angle.
  • a user may have a selection of different multi-channeled insertion systems 10 on hand, and may select, from the inventory of multi- channeled insertion systems 10, a multi-channeled insertion system 10 that will provide the proper solution.
  • a computer program or other procedure may be implemented to assist the user in selecting the proper procedure.
  • the computer program may have the user input information including the desired target site locations and the inventory of multi-channeled insertion systems 10 on hand.
  • the configuration of the multi-channeled insertion system 10 can be generated on- site, in a matter of minutes or hours.
  • the specifications may include information pertaining to the number of channels; from 1 to 10 channels, for example, the placement of an endoscope, if any; and the exit angles and directions of the channel or channels, for example .
  • a computer program or other procedure may be implemented to assist the user in selecting the proper custom configuration and preferred implementation of the multi-channeled insertion system 10.
  • the computer program may have the user input information including the desired target site locations, the trauma to be incurred by the patient and the available time and subsequent procedures to be conducted.
  • the computer program would then generate, in accordance with one embodiment, both specifications for the fabrication of a multi-channeled insertion system 10 and detailed instructions for using the fabricated multi-channeled insertion systems 10 in a procedure to target the desired target site locations.
  • Figure 7 illustrates a multi-channeled insertion system 10, inserted through an aperture 33 in a skull 35 and into close proximity of a target 38.
  • a central delivery needle 41 extends from the central channel 16 ( Figure 2), and a side delivery needle 43 extends from one of the additional channels 18.
  • the multi- channeled insertion system 10 is illustrated inserted a predetermined distance from the target 38, with the central delivery needle 41 and the side delivery needle 43 extending predetermined distances at predetermined angles to the axis 27 ( Figure 1 ) of the multi-channeled insertion system 10.
  • the central delivery needle 41 and the side delivery needle 43 are advanced from the distal end of the multi-channeled insertion system 10 to locations 45, 47 on or close to the target 38 for marking and/or delivery procedures.
  • the central delivery needle 41 is shown having an angle of zero, relative to the axis 27 of the multi-channeled insertion system 10. In modified embodiments, however, the central delivery needle 41 can form an angle other than zero with the axis 27 of the multi-channeled insertion system 10. In other modified embodiments, a viewing device such as an endoscope may be placed within the central channel 16 or, alternatively, within the additional channel 18 which in the illustrated embodiment would otherwise have housed the side delivery needle 43. Subsequently, the central delivery needle 41 and the side delivery needle 43 can be advanced further into the target 38 for additional marking and/or delivery functions. For example, the central delivery needle 41 and the side delivery needle 43 can be advanced to the phantom locations 49 and 51 and, subsequently, advanced to the phantom locations 53 and 55.
  • a viewing device such as an endoscope
  • Figure 8 illustrates a multi-channeled insertion system 10, inserted through an aperture 33 in a skull 35 and into close proximity of a target 74.
  • a central delivery needle 60 extends from the central channel 16 ( Figure 2), and a plurality of side delivery needles 63, 65, 69 and 71 extend from a corresponding plurality of channels of the multi-channeled insertion system 10.
  • the central delivery needle 60 and the plurality of side delivery needles 63, 65, 69 and 71 extend predetermined distances at predetermined angles to a plurality of locations on or close to the target 74 for marking and/or delivery procedures.
  • the central delivery needle 60 is shown having an angle of zero, relative to the axis 27 of the multi-channeled insertion system 10.
  • the central delivery needle 60 can form an angle other than zero with the axis 27 of the multi-channeled insertion system 10.
  • a viewing device such as an endoscope may be placed within the central channel 16 or, alternatively, within one or more of the channels housing the side delivery needles 63, 65, 69 and 71.
  • one or more of the delivery needles can be formed of a memory material or memory metal, such as a Nitenol material comprising Nickel Titanium alloy.
  • the memory metal is preferably formed of a non-scatterable material.
  • the side delivery needle 71 of Figure 8 is shown comprising a memory metal, which in the instant application is formed to curve in a proximal direction.
  • Figure 9 illustrates a multi-channeled insertion system 10 positioned near a target 89.
  • the side delivery needle 91 comprises a memory metal, which in the instant application is advanced to mark or treat a first location 93 of the target 89.
  • the side delivery needle 91 may later be advanced to a second location 95 of the target 89. Subsequently, the side delivery needle 91 may be retracted and advanced between the first location 93 and the second location 95 on the target 89.
  • the side delivery needle 91 may be moved through the target 89 between two or more locations.
  • Any one or more of the other delivery needles 60, 63, 65 and 69 may be formed of memory metals, as well.
  • any given delivery needle may be formed to bend in a proximal, distal, or any other direction.
  • one or more ribs 111 and/or one or more slots 113 may be formed on one or more of the channels 16 and/or 18, with complementary slots and/or ribs being formed on the endoscope or delivery needles, for preventing rotation of the endoscope or delivery needles.
  • the formation of the ribs and/or slots can be especially beneficial when the delivery needles comprise memory metals.
  • the channel 18 comprises a slot 111 for accommodating a rib of a delivery needle, and further comprises a rib 113 for accommodating a slot of the delivery needle.
  • the delivery needle is configured to abut directly and be held by the support structure 14 and the tubular structure 12.
  • a slot may be formed, for example, on the support structure 14 for directly accommodating a rib of a delivery needle.
  • a rib may be formed, for example, on the tubular structure 12 for directly accommodating a slot of a delivery needle.
  • Combinations of ribs and slots may be used. Only a single slot or rib, or a combination thereof, may be placed only on the tubular structure 12 and/or the support structure 14.
  • the tubular structure 12 or the support structure 14 may be advantageously formed to be slightly thicker and/or the delivery needle may be advantageously formed to be slightly thicker.
  • one or more of the channels 18 can be removed from and reinserted into the multi-channeled insertion system 10, either in vitro or in vivo, regardless of whether slots or ribs are formed on the removable channels.
  • Figure 11 shows a multi-channeled insertion system 10 having a central delivery needle 60 and a single side delivery needle 101. After the location 104 is marked or treated, the side delivery needle 101 is retracted, and the multi- channeled insertion system 10 is rotated about its axis in the direction of the arrow A1. The side delivery needle 101 is extended for marking or treating of a second location 106 of the target.
  • the central needle 60 helps to stabilize the side delivery needle 101 as it is rotated.
  • This procedure may be repeated for various angular positions and various lengths of the side delivery needle 101.
  • an endoscope is used instead of the central needle 60.
  • a plurality of side needles are controlled similarly to the side delivery needle 101.
  • the tubular structure 12 ( Figure 2) comprise titanium or other non-scattering metal, in order to provide sufficient rigidity to the multi-channeled insertion system 10.
  • the internal star shaped structure 14 may be formed of plastic when the tubular structure 12 is formed of a non-scattering metal.
  • the tubular structure 12 is formed of plastic and the internal star shaped structure 14 is formed of a non- scatterable metal. Both the internal star shaped structure 14 and the tubular structure 12 can be formed of a non-scatterable metal for maximum rigidity, or both the internal star shaped structure 14 and the tubular structure 12 can be formed of plastic for maximum flexibility.
  • Chemical markers may be placed on or formed into parts of the multi-channeled insertion system 10 for enhancing visibility of the parts to imaging operations, such as MRI.
  • the multi-channeled insertion system 10 and/or one or more of the channels 16, 18 may be shaped to have cross sections other than circular, such as rectangular, and may be formed of other materials such as stainless steel that will scatter an MRI beam.
  • the delivery needles may be shaped to have cross sections other than circular, such as rectangular, and may be formed of other materials such as stainless steel.
  • the diameter of the tubular structure 12 is preferably 2 to 3 mm
  • the diameter of the central channel 18 is preferably about .5 mm
  • the diameter of the central channel 16 is preferably about .5 mm.
  • Fluids may be aspirated through one or more of the channels (or devices inserted within the channels), and/or a tissue collection devices or microelectrodes can be inserted through one or more of the channels, for performing various assays and the assay information recorded.
  • the region or regions of interest may be characterized physiologically, diagnosed, treated, and monitored.
  • the multi-channeled insertion system 10 may thus be left in an organ on a prolonged basis or permanently for the administration of drugs and/or the measurement of parameters of the organ.

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  • Health & Medical Sciences (AREA)
  • Surgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pathology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Abstract

L'invention concerne un système (10) d'insertion multi-canaux qui comprend une structure (12) longitudinale présentant une extrémité proximale, une extrémité distale et un axe s'étendant entre l'extrémité proximale et l'extrémité distale. Ledit système comprend en outre plusieurs canaux (18), chacun commençant à et s'étendant distalement à partir d'un port d'entrée et se terminant à un port de sortie, placé distalement du port d'entrée. Chaque canal est construit de façon à prendre en compte une structure tubulaire le traversant, lesdites structures tubulaires sortant des ports de sortie selon des angles différents les unes par rapport aux autres.
EP00947360A 1999-07-14 2000-07-14 Systeme d'insertion multi-canaux pour administration simultanee d'elements biologiquement actifs a plusieurs sites organiques Withdrawn EP1218041A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US14378999P 1999-07-14 1999-07-14
US143789P 1999-07-14
PCT/US2000/019219 WO2001005450A1 (fr) 1999-07-14 2000-07-14 Systeme d'insertion multi-canaux pour administration simultanee d'elements biologiquement actifs a plusieurs sites organiques

Publications (1)

Publication Number Publication Date
EP1218041A1 true EP1218041A1 (fr) 2002-07-03

Family

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Application Number Title Priority Date Filing Date
EP00947360A Withdrawn EP1218041A1 (fr) 1999-07-14 2000-07-14 Systeme d'insertion multi-canaux pour administration simultanee d'elements biologiquement actifs a plusieurs sites organiques

Country Status (3)

Country Link
EP (1) EP1218041A1 (fr)
AU (1) AU6098500A (fr)
WO (1) WO2001005450A1 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11298506B2 (en) 2018-09-17 2022-04-12 Stryker Corporation Intra-ventricular infusion and evacuation catheter for treatment of intracerebral hemorrhage (ICH)
US20200085453A1 (en) * 2018-09-17 2020-03-19 Stryker Corporation Intra-ventricular infusion and evacuation catheter for treatment of intracerebral hemorrhage (ich)

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3327585A1 (de) * 1982-08-06 1984-02-09 John Martin Oxford Evans Chirurgisches instrument fuer die epidurale und spinale anaesthesie
US5209741A (en) * 1991-07-08 1993-05-11 Endomedix Corporation Surgical access device having variable post-insertion cross-sectional geometry
GB9307572D0 (en) * 1993-04-13 1993-06-02 Gould Derek A Transintimal recanalisation device

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See references of WO0105450A1 *

Also Published As

Publication number Publication date
AU6098500A (en) 2001-02-05
WO2001005450A1 (fr) 2001-01-25

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