EP1214101A4 - Method for detecting and killing epithelial cancer cells - Google Patents

Method for detecting and killing epithelial cancer cells

Info

Publication number
EP1214101A4
EP1214101A4 EP01916271A EP01916271A EP1214101A4 EP 1214101 A4 EP1214101 A4 EP 1214101A4 EP 01916271 A EP01916271 A EP 01916271A EP 01916271 A EP01916271 A EP 01916271A EP 1214101 A4 EP1214101 A4 EP 1214101A4
Authority
EP
European Patent Office
Prior art keywords
detecting
cancer cells
epithelial cancer
killing
killing epithelial
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
EP01916271A
Other languages
German (de)
French (fr)
Other versions
EP1214101A1 (en
Inventor
Samuel D Bernal
Douglas D Burkett
Ralph E Green
Seth D Rose
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Zila Inc
Original Assignee
Zila Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zila Inc filed Critical Zila Inc
Publication of EP1214101A1 publication Critical patent/EP1214101A1/en
Publication of EP1214101A4 publication Critical patent/EP1214101A4/en
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/30—Staining; Impregnating ; Fixation; Dehydration; Multistep processes for preparing samples of tissue, cell or nucleic acid material and the like for analysis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/006—Biological staining of tissues in vivo, e.g. methylene blue or toluidine blue O administered in the buccal area to detect epithelial cancer cells, dyes used for delineating tissues during surgery
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Physics & Mathematics (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
EP01916271A 2000-02-28 2001-02-27 Method for detecting and killing epithelial cancer cells Ceased EP1214101A4 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
PCT/US2000/005387 WO2001064110A1 (en) 2000-02-28 2000-02-28 Method for detecting and killing epithelial cancer cells
WOPCT/US00/05387 2000-02-28
PCT/US2001/006318 WO2001064255A1 (en) 2000-02-28 2001-02-27 Method for detecting and killing epithelial cancer cells

Publications (2)

Publication Number Publication Date
EP1214101A1 EP1214101A1 (en) 2002-06-19
EP1214101A4 true EP1214101A4 (en) 2005-04-13

Family

ID=21741108

Family Applications (1)

Application Number Title Priority Date Filing Date
EP01916271A Ceased EP1214101A4 (en) 2000-02-28 2001-02-27 Method for detecting and killing epithelial cancer cells

Country Status (14)

Country Link
EP (1) EP1214101A4 (en)
JP (1) JP2003525044A (en)
KR (2) KR20080080681A (en)
CN (1) CN100544770C (en)
AU (2) AU2000237154A1 (en)
BR (1) BR0104747A (en)
CA (1) CA2370741A1 (en)
CZ (1) CZ20013861A3 (en)
IL (1) IL146141A0 (en)
MX (1) MXPA01010886A (en)
NO (1) NO20015242L (en)
NZ (1) NZ515202A (en)
RU (1) RU2226404C2 (en)
WO (2) WO2001064110A1 (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001064110A1 (en) * 2000-02-28 2001-09-07 Zila, Inc. Method for detecting and killing epithelial cancer cells
BR0013636A (en) * 2000-06-30 2005-01-11 Zila Inc Use of a rhodamine composition for identification and delineation of cancerous epithelial tissue
IL149330A0 (en) * 2000-09-26 2002-11-10 Zila Inc Method for early prediction of the onset of invasive cancer
CA2457407A1 (en) * 2001-12-14 2003-07-17 Zila, Inc. Light-directed molecular analysis for cancer prognosis and diagnosis
US6929817B2 (en) 2002-05-14 2005-08-16 National Starch & Chemical Investment Holding Corporation Slowly digestible starch product
US6890571B2 (en) 2002-05-14 2005-05-10 National Starch And Chemical Investment Holding Corporation Slowly digestible starch product
US7081261B2 (en) * 2002-05-14 2006-07-25 National Starch And Chemical Investment Holding Corporation Resistant starch prepared by isoamylase debranching of low amylose starch
JP2005535605A (en) * 2002-06-04 2005-11-24 ジラ バイオテクノロジー・インク Toluidine blue O drug and its in vivo staining of dysplastic tissue and its use in chemotherapy treatment
CA2583427A1 (en) * 2004-09-30 2006-04-20 Zila Biotechnology, Inc. Light-directed method for detecting and aiding further evaluation of abnormal mucosal tissue
EP1835929B8 (en) 2005-01-06 2016-07-27 Novo Nordisk A/S Anti-kir combination treatments and methods
CN105510321A (en) * 2011-12-29 2016-04-20 闫文广 Detection agent composition for epithelial tissue tumor cells and preparing method thereof

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4321251A (en) * 1979-12-19 1982-03-23 The United States Of America As Represented By The Department Of Health And Human Services Detection of malignant lesions of the oral cavity utilizing toluidine blue rinse
US5882627A (en) * 1996-01-16 1999-03-16 Zila Pharmaceuticals, Inc. Methods and compositions for in-vivo detection of oral cancers precancerous conditions
WO2000037107A2 (en) * 1998-12-23 2000-06-29 G.D. Searle & Co. Use of cyclooxygenase-2 inhibitor, a matrix metallaproteinase inhibitor, an antineoplastic agent and optionally radiation as a combination treatment of neoplasia
US6086852A (en) * 1997-11-13 2000-07-11 Zila, Inc. In vivo stain composition, process of manufacture, and methods of use to identify dysplastic tissue
WO2001064110A1 (en) * 2000-02-28 2001-09-07 Zila, Inc. Method for detecting and killing epithelial cancer cells
WO2002007693A1 (en) * 2000-07-20 2002-01-31 Zila, Inc. Improved diagnostic method for detecting dysplastic epithelial tissue
WO2002026266A1 (en) * 2000-09-26 2002-04-04 Zila, Inc. Method for early prediction of the onset of invasive cancer

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5194373A (en) * 1985-06-06 1993-03-16 Thomas Jefferson University Method of determining endothelial cell coverage of a prosthetic surface
US4816395A (en) * 1985-12-19 1989-03-28 Peralta Cancer Research Institute Method for predicting chemosensitivity of anti-cancer drugs
DE69229471T2 (en) * 1991-10-31 1999-11-25 Zila Inc BIOLOGICAL DYE COMPOSITION, PROCESS FOR ITS PRODUCTION AND USE FOR MARKING THE OUTLINE OF EPITHELIC CARSINOMAS

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4321251A (en) * 1979-12-19 1982-03-23 The United States Of America As Represented By The Department Of Health And Human Services Detection of malignant lesions of the oral cavity utilizing toluidine blue rinse
US5882627A (en) * 1996-01-16 1999-03-16 Zila Pharmaceuticals, Inc. Methods and compositions for in-vivo detection of oral cancers precancerous conditions
US6086852A (en) * 1997-11-13 2000-07-11 Zila, Inc. In vivo stain composition, process of manufacture, and methods of use to identify dysplastic tissue
WO2000037107A2 (en) * 1998-12-23 2000-06-29 G.D. Searle & Co. Use of cyclooxygenase-2 inhibitor, a matrix metallaproteinase inhibitor, an antineoplastic agent and optionally radiation as a combination treatment of neoplasia
WO2001064110A1 (en) * 2000-02-28 2001-09-07 Zila, Inc. Method for detecting and killing epithelial cancer cells
WO2002007693A1 (en) * 2000-07-20 2002-01-31 Zila, Inc. Improved diagnostic method for detecting dysplastic epithelial tissue
WO2002026266A1 (en) * 2000-09-26 2002-04-04 Zila, Inc. Method for early prediction of the onset of invasive cancer

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
CHEN L B ET AL: "STUDIES OF MITOCHONDRIA IN CARCINOMA CELLS WITH RHODAMINE 123", WEINSTEIN, I. B. AND H. J. VOGEL (ED.). P AND S BIOMEDICAL SCIENCES SYMPOSIA: GENES AND PROTEINS IN ONCOGENESIS; JUNE 4-6, 1982. XXI+403P. ACADEMIC PRESS, INC.: NEW YORK, N.Y., USA; LONDON, ENGLAND. ILLUS, 1983, pages P369 - 387, XP008043059, ISSN: 0-12-742420-2 *
GABRIELLI D. ET AL: "Binding, Aggregation and Photochemical Properties of Methylene Blue in Mitochondrial Suspensions", PHOTCHEMISTRY AND PHOTOBIOLOGY, vol. 79, no. 3, 2004, pages 227 - 232 *
LILEY D.T.J. ET AL: "Localization of Nonintercalative DNA Binding Antitumour Drug in Mitochondria: Relationship to Multidrug Resistance", EUROPEAN JOURNAL OF CLINICAL ONCOLOGY, vol. 25, no. 9, 1989, pages 1287 - 1293, ISSN: 0277-5379 *
See also references of WO0164255A1 *
SUN X. ET AL: "Anticarcinoma Activity of a Novel Drug, 3-Ethyl-3'-methyl-thiatelluracarbocyanine Idiode (Te), a Tellurium-containing Cyanine Targeted at Mitochondria", CLINICAL CANCER RESEARCH, vol. 2, August 1996 (1996-08-01), United States, pages 1335 - 1340, ISSN: 1078-0432 *

Also Published As

Publication number Publication date
AU2000237154A1 (en) 2001-09-12
JP2003525044A (en) 2003-08-26
KR100907122B1 (en) 2009-07-09
NZ515202A (en) 2003-05-30
WO2001064255A1 (en) 2001-09-07
CZ20013861A3 (en) 2002-08-14
WO2001064110A1 (en) 2001-09-07
CA2370741A1 (en) 2001-09-07
CN1365288A (en) 2002-08-21
KR20080080681A (en) 2008-09-04
NO20015242D0 (en) 2001-10-26
AU785489B2 (en) 2007-11-15
RU2226404C2 (en) 2004-04-10
BR0104747A (en) 2002-09-17
IL146141A0 (en) 2002-07-25
KR20020000222A (en) 2002-01-05
NO20015242L (en) 2001-11-29
CN100544770C (en) 2009-09-30
EP1214101A1 (en) 2002-06-19
MXPA01010886A (en) 2002-05-06
AU4331601A (en) 2001-09-12

Similar Documents

Publication Publication Date Title
AU2001267065A1 (en) Method and system for detecting fraud
GB2371810B (en) Electrochemical processing
EP1156324A4 (en) Sample discriminating method
GB0008303D0 (en) Measurement system and method
EP1224964A4 (en) Method and device for processing pfc
AU2001251237A1 (en) Area measurement device and method
AU2553801A (en) Sir measuring device and sir measuring method
EP1209484A4 (en) Method and device for distance detection
AU2001281633A1 (en) Detection method
IL146141A0 (en) Method for detecting and killing epithelial cancer cells
AU8323801A (en) Method and system for detecting hidden edges
AUPR050700A0 (en) Detection method
AUPQ667800A0 (en) Detection method
HK1048599A1 (en) Cancer cell implantation inhibitors
AU2000229243A1 (en) Electromagnetic detection apparatus
AU2001285172A1 (en) Enhanced electro-deposition device and method
GB0020363D0 (en) Detector asssemblies and methods
HUP0400066A2 (en) Method and means for detecting gluten-induced diseases
AU7039401A (en) Currency receiving device and method
AU2001236295A1 (en) Method and system for detection
EP1258730A4 (en) Method for detecting substance
AUPQ677300A0 (en) Detection method
EP1182815A4 (en) Matched filter and method for determining correlation
AU2000236747A1 (en) Shape determining method and device
GB0030076D0 (en) Analysis method

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 20020225

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR

AX Request for extension of the european patent

Free format text: RO

A4 Supplementary search report drawn up and despatched

Effective date: 20050228

RIC1 Information provided on ipc code assigned before grant

Ipc: 7A 61K 49/00 A

Ipc: 7A 61B 10/00 B

Ipc: 7A 61K 31/54 B

Ipc: 7A 61P 35/00 B

17Q First examination report despatched

Effective date: 20060601

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION HAS BEEN REFUSED

18R Application refused

Effective date: 20091013