EP1211502A3 - A self-calibrating isotopic gas analyzer - Google Patents

A self-calibrating isotopic gas analyzer Download PDF

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Publication number
EP1211502A3
EP1211502A3 EP02004740A EP02004740A EP1211502A3 EP 1211502 A3 EP1211502 A3 EP 1211502A3 EP 02004740 A EP02004740 A EP 02004740A EP 02004740 A EP02004740 A EP 02004740A EP 1211502 A3 EP1211502 A3 EP 1211502A3
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EP
European Patent Office
Prior art keywords
isotopic
gas analyzer
calibrating
self
isotopic gas
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP02004740A
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German (de)
French (fr)
Other versions
EP1211502A2 (en
Inventor
Ilan Ben-Oren
Lewis Colman
Ephraim Carlebach
Boaz Giron
Gershon Levitsky
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Oridion BreathID Ltd
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Oridion BreathID Ltd
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Publication date
Application filed by Oridion BreathID Ltd filed Critical Oridion BreathID Ltd
Publication of EP1211502A2 publication Critical patent/EP1211502A2/en
Publication of EP1211502A3 publication Critical patent/EP1211502A3/en
Withdrawn legal-status Critical Current

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/497—Physical analysis of biological material of gaseous biological material, e.g. breath
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/08—Detecting, measuring or recording devices for evaluating the respiratory organs
    • A61B5/083—Measuring rate of metabolism by using breath test, e.g. measuring rate of oxygen consumption
    • A61B5/0836—Measuring rate of CO2 production
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/08—Detecting, measuring or recording devices for evaluating the respiratory organs
    • A61B5/097—Devices for facilitating collection of breath or for directing breath into or through measuring devices
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
    • G01N21/31—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
    • G01N21/35—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light
    • G01N21/3504—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light for analysing gases, e.g. multi-gas analysis
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/0004—Gaseous mixtures, e.g. polluted air
    • G01N33/0006—Calibrating gas analysers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2560/00—Constructional details of operational features of apparatus; Accessories for medical measuring apparatus
    • A61B2560/02—Operational features
    • A61B2560/0242—Operational features adapted to measure environmental factors, e.g. temperature, pollution
    • A61B2560/0247—Operational features adapted to measure environmental factors, e.g. temperature, pollution for compensation or correction of the measured physiological value
    • A61B2560/0252—Operational features adapted to measure environmental factors, e.g. temperature, pollution for compensation or correction of the measured physiological value using ambient temperature
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2560/00—Constructional details of operational features of apparatus; Accessories for medical measuring apparatus
    • A61B2560/02—Operational features
    • A61B2560/0242—Operational features adapted to measure environmental factors, e.g. temperature, pollution
    • A61B2560/0247—Operational features adapted to measure environmental factors, e.g. temperature, pollution for compensation or correction of the measured physiological value
    • A61B2560/0257—Operational features adapted to measure environmental factors, e.g. temperature, pollution for compensation or correction of the measured physiological value using atmospheric pressure
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2201/00—Features of devices classified in G01N21/00
    • G01N2201/06—Illumination; Optics
    • G01N2201/063—Illuminating optical parts
    • G01N2201/0631—Homogeneising elements

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Pathology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Food Science & Technology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Physiology (AREA)
  • Pulmonology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Surgery (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Combustion & Propulsion (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Lock And Its Accessories (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Optical Measuring Cells (AREA)
  • Analysing Materials By The Use Of Radiation (AREA)

Abstract

A method of self-calibrating an isotopic gas analyzer, comprising the steps of:
  • generating from a single gas sample having at least two isotopic components, at least two secondary samples having different concentrations of at least one of said isotopic components;
  • measuring by means of said isotopic gas analyzer, isotopic ratios of said at least two isotopic components in said at least two secondary samples; and
  • adjusting the calibration of said gas analyzer to correct significant differences found between said isotopic ratios.
    • Figure 00000001
    EP02004740A 1997-09-17 1998-09-17 A self-calibrating isotopic gas analyzer Withdrawn EP1211502A3 (en)

    Applications Claiming Priority (3)

    Application Number Priority Date Filing Date Title
    IL121793A IL121793A (en) 1997-09-17 1997-09-17 Isotopic gas analyzer
    IL12179397 1997-09-17
    EP98945516A EP1012573B1 (en) 1997-09-17 1998-09-17 Isotopic gas analyzer

    Related Parent Applications (1)

    Application Number Title Priority Date Filing Date
    EP98945516A Division EP1012573B1 (en) 1997-09-17 1998-09-17 Isotopic gas analyzer

    Publications (2)

    Publication Number Publication Date
    EP1211502A2 EP1211502A2 (en) 2002-06-05
    EP1211502A3 true EP1211502A3 (en) 2004-03-03

    Family

    ID=11070650

    Family Applications (3)

    Application Number Title Priority Date Filing Date
    EP02004740A Withdrawn EP1211502A3 (en) 1997-09-17 1998-09-17 A self-calibrating isotopic gas analyzer
    EP02004741A Withdrawn EP1217355A3 (en) 1997-09-17 1998-09-17 A gas sample chamber system
    EP98945516A Expired - Lifetime EP1012573B1 (en) 1997-09-17 1998-09-17 Isotopic gas analyzer

    Family Applications After (2)

    Application Number Title Priority Date Filing Date
    EP02004741A Withdrawn EP1217355A3 (en) 1997-09-17 1998-09-17 A gas sample chamber system
    EP98945516A Expired - Lifetime EP1012573B1 (en) 1997-09-17 1998-09-17 Isotopic gas analyzer

    Country Status (8)

    Country Link
    US (1) US7063667B1 (en)
    EP (3) EP1211502A3 (en)
    JP (1) JP2001516875A (en)
    AT (1) ATE288075T1 (en)
    AU (1) AU9279498A (en)
    DE (1) DE69828799T2 (en)
    IL (1) IL121793A (en)
    WO (1) WO1999014576A2 (en)

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    US6486474B1 (en) * 1999-08-13 2002-11-26 Regents Of The University Of Minnesota Infrared spectrometer for the measurement of isotopic ratios
    DE19962588A1 (en) * 1999-12-23 2001-07-05 Abb Patent Gmbh Method and device for calibrating a measuring device
    EP1282814A2 (en) * 2000-04-04 2003-02-12 Oridion Medical Ltd. Breath test apparatus and methods
    DE10062126A1 (en) * 2000-12-13 2002-06-20 Inficon Gmbh Process for the detection of a gas with the aid of an infrared gas analyzer and a gas analyzer suitable for carrying out these processes
    IL148468A (en) 2002-03-03 2012-12-31 Exalenz Bioscience Ltd Breath collection system
    US7338444B2 (en) * 2002-06-28 2008-03-04 Oridion Breathid Ltd Management of gastro-intestinal disorders
    WO2005006988A1 (en) 2003-06-19 2005-01-27 Everest Biomedical Instruments Breath end-tidal gas monitor
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    Also Published As

    Publication number Publication date
    IL121793A0 (en) 1998-02-22
    EP1012573A2 (en) 2000-06-28
    DE69828799D1 (en) 2005-03-03
    JP2001516875A (en) 2001-10-02
    WO1999014576A2 (en) 1999-03-25
    ATE288075T1 (en) 2005-02-15
    EP1012573B1 (en) 2005-01-26
    EP1211502A2 (en) 2002-06-05
    IL121793A (en) 2008-06-05
    WO1999014576A3 (en) 1999-08-19
    AU9279498A (en) 1999-04-05
    DE69828799T2 (en) 2006-01-05
    EP1217355A2 (en) 2002-06-26
    US7063667B1 (en) 2006-06-20
    EP1217355A3 (en) 2005-04-06

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