EP1211240A4 - Biscyclopropanecarboxylic acid amide compounds and medicinal use thereof - Google Patents
Biscyclopropanecarboxylic acid amide compounds and medicinal use thereofInfo
- Publication number
- EP1211240A4 EP1211240A4 EP00956838A EP00956838A EP1211240A4 EP 1211240 A4 EP1211240 A4 EP 1211240A4 EP 00956838 A EP00956838 A EP 00956838A EP 00956838 A EP00956838 A EP 00956838A EP 1211240 A4 EP1211240 A4 EP 1211240A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- represent
- inhibitors
- biscyclopropanecarboxylic
- acid amide
- amide compounds
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/57—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings
- C07C233/60—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/57—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings
- C07C233/62—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/16—Sulfones; Sulfoxides having sulfone or sulfoxide groups and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C317/22—Sulfones; Sulfoxides having sulfone or sulfoxide groups and singly-bound oxygen atoms bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Oncology (AREA)
- Transplantation (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Biscyclopropanecarboxylic acid amide compounds represented by general formula (I) and NF-kappa B activation inhibitors, inflammatory cytokine production inhibitors, matrix metalloprotease production inhibitors, inflammatory cell adhesion factor expression inhibitors and antiinflammatory agents, antirheumatic agents, immunosuppressors, cancer metastasis inhibitors or antiviral agents containing the above compounds as the active ingredient: (I) wherein R1 to R4 represent each methyl, etc.; R5 and R6 represent each hydrogen, etc.; andUS0023405sent a group represented by one of general formulae (II) to (V): wherein B1 to B10 represent each an aromatic ring or an aromatic heterocycle; and -X1- to -X6- represent each an interatomic bond, etc.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP24748399 | 1999-09-01 | ||
JP24748399 | 1999-09-01 | ||
PCT/JP2000/005914 WO2001016091A1 (en) | 1999-09-01 | 2000-08-31 | Biscyclopropanecarboxylic acid amide compounds and medicinal use thereof |
Publications (2)
Publication Number | Publication Date |
---|---|
EP1211240A1 EP1211240A1 (en) | 2002-06-05 |
EP1211240A4 true EP1211240A4 (en) | 2003-02-12 |
Family
ID=17164143
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP00956838A Withdrawn EP1211240A4 (en) | 1999-09-01 | 2000-08-31 | Biscyclopropanecarboxylic acid amide compounds and medicinal use thereof |
Country Status (4)
Country | Link |
---|---|
US (1) | US6563002B2 (en) |
EP (1) | EP1211240A4 (en) |
AU (1) | AU6866700A (en) |
WO (1) | WO2001016091A1 (en) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20020064147A (en) | 1999-07-01 | 2002-08-07 | 아지노모토 가부시키가이샤 | Heterocyclic compounds and medicinal use thereof |
WO2002036547A1 (en) * | 2000-11-01 | 2002-05-10 | Ajinomoto Co.,Inc. | Cyclopropanecarboxylic acid amide compounds and medicinal use thereof |
JP2004269356A (en) * | 2000-12-27 | 2004-09-30 | Ajinomoto Co Inc | Adhesion preventing agent for wound part |
ATE457716T1 (en) | 2002-12-30 | 2010-03-15 | Angiotech Int Ag | RELEASE OF ACTIVE INGREDIENTS FROM QUICK-GELLING POLYMER COMPOSITION |
EP1613269B1 (en) | 2003-04-04 | 2015-02-25 | Incyte Corporation | Compositions, methods and kits relating to her-2 cleavage |
US7327068B2 (en) | 2005-02-02 | 2008-02-05 | Bae Systems Information And Electronic Systems Integration Inc. | Sensors and related devices and methods |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4975459A (en) * | 1989-12-13 | 1990-12-04 | Rohm And Haas Company | Microbicidal and plant growth regulating compounds |
CA2332989A1 (en) * | 1998-05-22 | 1999-12-02 | Avanir Pharmaceuticals | Benzimidazole derivatives as modulators of ige |
RU2001106631A (en) * | 1998-09-11 | 2004-03-20 | Адзиномото Ко., Инк. (Jp) | DERIVATIVES OF BENZENE AND THEIR PHARMACEUTICAL USE |
JP2000169479A (en) * | 1998-12-09 | 2000-06-20 | Kyowa Hakko Kogyo Co Ltd | Nf-kappa b activation inhibitor |
-
2000
- 2000-08-31 AU AU68667/00A patent/AU6866700A/en not_active Abandoned
- 2000-08-31 EP EP00956838A patent/EP1211240A4/en not_active Withdrawn
- 2000-08-31 WO PCT/JP2000/005914 patent/WO2001016091A1/en not_active Application Discontinuation
-
2002
- 2002-03-01 US US10/085,073 patent/US6563002B2/en not_active Expired - Fee Related
Non-Patent Citations (1)
Title |
---|
No further relevant documents disclosed * |
Also Published As
Publication number | Publication date |
---|---|
US6563002B2 (en) | 2003-05-13 |
US20020161053A1 (en) | 2002-10-31 |
WO2001016091A1 (en) | 2001-03-08 |
AU6866700A (en) | 2001-03-26 |
EP1211240A1 (en) | 2002-06-05 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
17P | Request for examination filed |
Effective date: 20020318 |
|
AK | Designated contracting states |
Kind code of ref document: A1 Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE |
|
AX | Request for extension of the european patent |
Free format text: AL;LT;LV;MK;RO;SI |
|
A4 | Supplementary search report drawn up and despatched |
Effective date: 20021230 |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION HAS BEEN WITHDRAWN |
|
18W | Application withdrawn |
Effective date: 20030303 |