EP1208377A4 - Melanocortin metallopeptide constructs, combinatorial libraries and applications - Google Patents

Melanocortin metallopeptide constructs, combinatorial libraries and applications

Info

Publication number
EP1208377A4
EP1208377A4 EP00944681A EP00944681A EP1208377A4 EP 1208377 A4 EP1208377 A4 EP 1208377A4 EP 00944681 A EP00944681 A EP 00944681A EP 00944681 A EP00944681 A EP 00944681A EP 1208377 A4 EP1208377 A4 EP 1208377A4
Authority
EP
European Patent Office
Prior art keywords
applications
combinatorial libraries
melanocortin
constructs
metallopeptide constructs
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP00944681A
Other languages
German (de)
French (fr)
Other versions
EP1208377A1 (en
Inventor
Shubh D Sharma
Yi-Qun Shi
Wei Yang
Hui-Zhi Cai
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Palatin Technologies Inc
Original Assignee
Palatin Technologies Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Palatin Technologies Inc filed Critical Palatin Technologies Inc
Publication of EP1208377A1 publication Critical patent/EP1208377A1/en
Publication of EP1208377A4 publication Critical patent/EP1208377A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1016—Tetrapeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/16—Emollients or protectives, e.g. against radiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
    • C07K1/047—Simultaneous synthesis of different peptide species; Peptide libraries
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/655—Somatostatins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/665—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans derived from pro-opiomelanocortin, pro-enkephalin or pro-dynorphin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
    • C07K5/1008—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1019—Tetrapeptides with the first amino acid being basic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1024—Tetrapeptides with the first amino acid being heterocyclic
EP00944681A 1999-08-12 2000-06-15 Melanocortin metallopeptide constructs, combinatorial libraries and applications Withdrawn EP1208377A4 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US14899499P 1999-08-12 1999-08-12
US148994P 1999-08-12
PCT/US2000/016396 WO2001013112A1 (en) 1999-08-12 2000-06-15 Melanocortin metallopeptide constructs, combinatorial libraries and applications

Publications (2)

Publication Number Publication Date
EP1208377A1 EP1208377A1 (en) 2002-05-29
EP1208377A4 true EP1208377A4 (en) 2005-04-20

Family

ID=22528350

Family Applications (1)

Application Number Title Priority Date Filing Date
EP00944681A Withdrawn EP1208377A4 (en) 1999-08-12 2000-06-15 Melanocortin metallopeptide constructs, combinatorial libraries and applications

Country Status (5)

Country Link
EP (1) EP1208377A4 (en)
JP (1) JP2004519410A (en)
AU (1) AU5874200A (en)
CA (1) CA2379647A1 (en)
WO (1) WO2001013112A1 (en)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002064091A2 (en) 2001-02-13 2002-08-22 Palatin Technologies, Inc. Melanocortin metallopeptides for treatment of sexual dysfunction
US7235625B2 (en) 1999-06-29 2007-06-26 Palatin Technologies, Inc. Multiple agent therapy for sexual dysfunction
AU2844901A (en) * 1999-12-30 2001-07-16 7Tm Pharma A method of identifying ligands of biological target molecules
US7351690B2 (en) * 2000-12-19 2008-04-01 Palatin Technologies, Inc. Knockout identification of target-specific sites in peptides
ATE385811T1 (en) * 2000-12-19 2008-03-15 Palatin Technologies Inc IDENTIFICATION OF TARGETED FOLDING SITES IN PEPTIDES AND PROTEINS
EP1441750A4 (en) * 2001-07-11 2006-10-18 Palatin Technologies Inc Linear and cyclic melanocortin receptor-specific peptides
AU2002331064B2 (en) * 2001-08-10 2007-08-23 Palatin Technologies, Inc. Peptidomimetics of biologically active metallopeptides
WO2003055477A1 (en) * 2001-12-21 2003-07-10 7Tm Pharma A/S Method for the treatment of mc receptor related disorders with a chelate and/or a chelator
US7323462B2 (en) 2002-12-10 2008-01-29 Pfizer Inc. Morpholine dopamine agonists
WO2006094725A1 (en) * 2005-03-10 2006-09-14 Bayer Schering Pharma Aktiengesellschaft Chelators for radioactively labeled conjugates comprising a stabilizing sidechain
EP1700608A1 (en) * 2005-03-10 2006-09-13 Schering AG Chelators for radioactively labeled conjugates comprising a stabilizing sidechain
US7754691B1 (en) 2005-07-07 2010-07-13 Palatin Technologies, Inc. Linear melanocortin receptor-specific peptides for cachexia
WO2013067309A1 (en) 2011-11-04 2013-05-10 Xion Pharmaceutical Corporation Methods and compositions for oral administration of melanocortin receptor agonist compounds
EP3003540B1 (en) 2013-06-03 2019-03-20 Basf Se Improved membranes

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999010016A1 (en) * 1997-08-21 1999-03-04 Resolution Pharmaceuticals Inc. Combinatorial library
WO2000036136A1 (en) * 1998-12-14 2000-06-22 Palatin Technologies, Inc. Metallopeptide combinatorial libraries and applications

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5443816A (en) * 1990-08-08 1995-08-22 Rhomed Incorporated Peptide-metal ion pharmaceutical preparation and method
DK0486622T3 (en) * 1989-08-09 1999-07-19 Rhomed Inc Direct radiolabelling of antibodies and other proteins with technetium or rhenium
US5200504A (en) * 1990-10-02 1993-04-06 The Scripps Research Institute Metallopeptides having stabilized secondary structures
US6027711A (en) * 1995-06-07 2000-02-22 Rhomed Incorporated Structurally determined metallo-constructs and applications
US5891418A (en) * 1995-06-07 1999-04-06 Rhomed Incorporated Peptide-metal ion pharmaceutical constructs and applications

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999010016A1 (en) * 1997-08-21 1999-03-04 Resolution Pharmaceuticals Inc. Combinatorial library
WO2000036136A1 (en) * 1998-12-14 2000-06-22 Palatin Technologies, Inc. Metallopeptide combinatorial libraries and applications

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 9, 17 May 1999 (1999-05-17), GB OXFORD, pages 1469 - 1474, XP004164914 *
See also references of WO0113112A1 *

Also Published As

Publication number Publication date
JP2004519410A (en) 2004-07-02
CA2379647A1 (en) 2001-02-22
EP1208377A1 (en) 2002-05-29
AU5874200A (en) 2001-03-13
WO2001013112A1 (en) 2001-02-22

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Inventor name: CAI, HUI-ZHI

Inventor name: SHARMA, SHUBH, D.

Inventor name: YANG, WEI

Inventor name: SHI, YI-QUN

A4 Supplementary search report drawn up and despatched

Effective date: 20050304

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