EP1208101A4 - Vitronectin receptor antagonists useful for the treatment of strokes - Google Patents

Vitronectin receptor antagonists useful for the treatment of strokes

Info

Publication number
EP1208101A4
EP1208101A4 EP00952558A EP00952558A EP1208101A4 EP 1208101 A4 EP1208101 A4 EP 1208101A4 EP 00952558 A EP00952558 A EP 00952558A EP 00952558 A EP00952558 A EP 00952558A EP 1208101 A4 EP1208101 A4 EP 1208101A4
Authority
EP
European Patent Office
Prior art keywords
strokes
treatment
receptor antagonists
vitronectin receptor
antagonists useful
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP00952558A
Other languages
German (de)
French (fr)
Other versions
EP1208101A1 (en
Inventor
Frank C Barone
Tian-Li Yue
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SmithKline Beecham Corp
Original Assignee
SmithKline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SmithKline Beecham Corp filed Critical SmithKline Beecham Corp
Publication of EP1208101A1 publication Critical patent/EP1208101A1/en
Publication of EP1208101A4 publication Critical patent/EP1208101A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
EP00952558A 1999-08-06 2000-08-04 Vitronectin receptor antagonists useful for the treatment of strokes Withdrawn EP1208101A4 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US14756799P 1999-08-06 1999-08-06
US147567P 1999-08-06
PCT/US2000/021433 WO2001010867A1 (en) 1999-08-06 2000-08-04 Vitronectin receptor antagonists useful for the treatment of strokes

Publications (2)

Publication Number Publication Date
EP1208101A1 EP1208101A1 (en) 2002-05-29
EP1208101A4 true EP1208101A4 (en) 2003-03-19

Family

ID=22522092

Family Applications (1)

Application Number Title Priority Date Filing Date
EP00952558A Withdrawn EP1208101A4 (en) 1999-08-06 2000-08-04 Vitronectin receptor antagonists useful for the treatment of strokes

Country Status (4)

Country Link
EP (1) EP1208101A4 (en)
JP (1) JP2003506452A (en)
AU (1) AU6523200A (en)
WO (1) WO2001010867A1 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1352641A (en) 1999-09-29 2002-06-05 奥索-麦克尼尔药品公司 Isonipecotamides for the treatment of integrin mediated disorders
WO2002081467A1 (en) 2001-04-09 2002-10-17 Ortho-Mcneil Pharmaceutical, Inc. Quinazoline and quinazoline-like compounds for the treatment of integrin-mediated disorders
KR20100054884A (en) 2001-10-22 2010-05-25 더 스크립스 리서치 인스티튜트 Antibody targeting compounds
US8518927B2 (en) 2009-02-10 2013-08-27 The Scripps Research Institute Chemically programmed vaccination

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996006087A1 (en) * 1994-08-22 1996-02-29 Smithkline Beecham Corporation Bicyclic compounds
WO1997001540A1 (en) * 1995-06-29 1997-01-16 Smithkline Beecham Corporation Integrin receptor antagonists
WO1997024119A1 (en) * 1995-12-29 1997-07-10 Smithkline Beecham Corporation Vitronectin receptor antagonists
WO1998014192A1 (en) * 1996-10-02 1998-04-09 Smithkline Beecham Corporation Vitronectin receptor antagonists
WO1999006049A1 (en) * 1997-08-04 1999-02-11 Smithkline Beecham Corporation Integrin receptor antagonists
WO1999011626A1 (en) * 1997-09-04 1999-03-11 Smithkline Beecham Corporation Integrin receptor antagonists

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996006087A1 (en) * 1994-08-22 1996-02-29 Smithkline Beecham Corporation Bicyclic compounds
WO1997001540A1 (en) * 1995-06-29 1997-01-16 Smithkline Beecham Corporation Integrin receptor antagonists
WO1997024119A1 (en) * 1995-12-29 1997-07-10 Smithkline Beecham Corporation Vitronectin receptor antagonists
WO1998014192A1 (en) * 1996-10-02 1998-04-09 Smithkline Beecham Corporation Vitronectin receptor antagonists
WO1999006049A1 (en) * 1997-08-04 1999-02-11 Smithkline Beecham Corporation Integrin receptor antagonists
WO1999011626A1 (en) * 1997-09-04 1999-03-11 Smithkline Beecham Corporation Integrin receptor antagonists

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
ELLISON J A ET AL: "OSTEOPONTIN AND ITS INTEGRIN RECEPTOR ALPHAVBETA3 ARE UPREGULATED DURING FORMATION OF THE GLIAL SCAR AFTER FOCAL STROKE", STROKE, AMERICAN HEART ASSOCIATION, DALLAS TX, US, vol. 29, no. 8, August 1998 (1998-08-01), pages 1698 - 1706, XP001029459, ISSN: 0039-2499 *
See also references of WO0110867A1 *

Also Published As

Publication number Publication date
JP2003506452A (en) 2003-02-18
WO2001010867A1 (en) 2001-02-15
AU6523200A (en) 2001-03-05
EP1208101A1 (en) 2002-05-29

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Legal Events

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PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

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Effective date: 20030130

RIC1 Information provided on ipc code assigned before grant

Ipc: 7C 07D 487/00 A

Ipc: 7C 07D 417/12 B

Ipc: 7C 07D 413/12 B

Ipc: 7A 61K 31/47 B

Ipc: 7C 07D 401/12 B

Ipc: 7A 61P 9/00 B

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Effective date: 20030416