EP1205196A1 - A prefilled telescoping multiple chamber ampoule device - Google Patents
A prefilled telescoping multiple chamber ampoule device Download PDFInfo
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- EP1205196A1 EP1205196A1 EP01126274A EP01126274A EP1205196A1 EP 1205196 A1 EP1205196 A1 EP 1205196A1 EP 01126274 A EP01126274 A EP 01126274A EP 01126274 A EP01126274 A EP 01126274A EP 1205196 A1 EP1205196 A1 EP 1205196A1
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- European Patent Office
- Prior art keywords
- piston
- pistons
- prefilled
- container
- telescoping
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/19—Syringes having more than one chamber, e.g. including a manifold coupling two parallelly aligned syringes through separate channels to a common discharge assembly
Definitions
- Another object of the invention is to provide a prefilled telescoping multiple chamber ampoule device which offers the possibility of adapting it to various application purposes without changing the basic design.
- the nozzle applicator 180 Prior to activation of the prefilled ampoule device 100 the nozzle applicator 180 has to be attached to the forward end of the piston unit 150, unless done before, for example, prior to enclosing the components 132 and 134 within the container 110 by inserting the rearward ends of the pistons of the piston unit 150.
- the prefilled ampoule device 100 can be telescopically moved into an open release position by manually applying an axial compression force to the axially opposite parts of the device, i.e. the container 110 and the nozzle applicator 180. Accordingly, the nozzle applicator 180 and the container 110 have also the functions of manipulating parts.
- the reservoir defined in the chamber 412 contains a first flowable component 432
- the reservoir defined in the chamber 414 contains a second flowable component 434.
- the peripheral sealing lips 420 are fluid-tightly pressed into circumferential contact with the outer walls of the pistons 452 and 454 at a location above the rearward end of each piston and below the transverse inlet opening 462 of the passage 460.
- the function of the sealing lips 420 is comparable to the function of the sealing lips 120, 220, and 320 in the first, second and third embodiment.
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- Health & Medical Sciences (AREA)
- Vascular Medicine (AREA)
- Engineering & Computer Science (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Package Specialized In Special Use (AREA)
- Containers And Packaging Bodies Having A Special Means To Remove Contents (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
Abstract
Description
- The invention relates to prefilled telescoping multiple chamber ampoule devices separately storing at least two different flowable components. More particularly, the invention relates to prefilled telescoping multiple chamber ampoule devices for dispensing at least two different flowable components which are separately stored in the device. The dispensed components are allowed to intermix with one another after being released and prior to application, or they are kept separately after being released for successive application. The range of application comprises the fields of medicine, chemistry, bio genetics, cosmetics and other fields where it is necessary to store the different components of a multi-component product separately from one another and just mix them with one another immediately prior to application or apply them successively. Furthermore, in these fields of application it is frequently necessary or at least desirable to store the individual components in an air-tight or fluid-tight manner.
- International PCT application having the publication number WO 99/17833, published on April 15, 1999, discloses a fibrin sealant cartridge assembly for applying a solution of fibrinogen and a solution of thrombin. The cartridge assembly comprises a container unit having a first and a second container arranged parallel to one another, a piston unit comprising a first and a second piston matingly cooperating with the first and the second container, respectively. Each container stores one of the two solutions. Each piston has a passageway axially extending within the piston through the entire piston. Hence, each passageway has an axial inlet opening which is always in fluid communication with the associated container. Furthermore, each passageway has an axial outlet opening which is in fluid communication with a nozzle attached to the piston. Telescopic movement of the container unit towards the piston unit decreases the volumetric capacity of the containers forcing the solutions therein to flow into the passageways and be dispensed from the nozzles onto an application site. A trip applicator may be attached to the two nozzles for dispensing the two solutions in close proximity to one another. The trip applicator allows a user to spread and/or mix the protein solutions on the application site after they have been dispensed through the outlet openings of the trip applicator. By arranging the outlet openings of the trip applicator very close to each other the solutions intermix before being tripped onto the application site.
- In the fibrin sealant cartridge assembly described above, there is a possibility of contaminating the solutions stored in the container as the passageways axially extending through the entire pistons are in continuous fluid communication with the containers. Furthermore, the piston unit consists of several parts including a sealing ring being attached to the outer wall of each piston.
- It is an object of the present invention to provide a prefilled telescoping multiple chamber ampoule device which prevents contamination of individual components contained in the device during transportation and storage, and which has a simple construction, can be assembled in an easy manner and manufactured at low expense for allowing the device to be disposed of after use.
- Another object of the invention is to provide a prefilled telescoping multiple chamber ampoule device which avoids an unintentional release or dispense of the components stored in the device.
- Another object of the invention is to provide a prefilled telescoping multiple chamber ampoule device which offers the possibility of adapting it to various application purposes without changing the basic design.
- Another object of the invention is to provide a novel piston unit for use in a prefilled telescoping multiple chamber ampoule device.
- These and other objects are accomplished by providing a novel prefilled telescoping multiple chamber ampoule device separately storing at least two different flowable components. The ampoule device comprises a container having at least two axially extending chambers which are arranged in parallel to one another. Each chamber has a closed rearward end and an open forward end. An integrally formed circumferential sealing means projects inwardly from the inner wall of each chamber. In addition, the ampoule device comprises a piston unit having at least two pistons. A transversely extending mount integrally adjoins the forward ends of the pistons. Each piston has a passage which axially extends within the interior of the piston. The passage has an axial outlet opening at a forward end of the piston and a transverse inlet opening near a rearward end of the piston. Each piston is aligned with one of said chambers and, with its rearward end ahead, is inserted into the open forward end of the chamber and matingly arranged therein for coaxial telescoping movement of the container and the piston unit towards one another from a closed storage position into an open release position. In the closed storage position the rearward end of each piston is spaced a distance from the rearward end of the respective chamber so as to define therein a reservoir containing one of the flowable components. Furthermore, in the closed storage position the circumferential sealing means is sealingly pressed into circumferential contact with the outer wall of the piston at a location so as to prevent fluid communication between the reservoir and the transverse inlet opening of the passage of the piston. Thereby, release of the component from the reservoir into the transverse inlet opening of the passage is prevented in the closed storage position. After initial and during telescoping movement into the open release position, the rearward ends of the pistons are moved towards the rearward ends of the chambers whereby the sealing means expose the transverse inlet openings of passages of the pistons to the reservoirs. Thereby, the components stored in the reservoirs are released through the outlet openings of the passages of the pistons as the volumes of the reservoirs are reduced. Furthermore, after initial telescoping movement the sealing means come into sealing contact with the outer walls of the pistons at a location between the transverse inlet openings and the forward ends of the pistons. Thereby, escape of the components from the reservoirs to the open forward ends of the chambers is prevented.
- Preferably, the circumferential sealing means is a sealing lip which, in the closed storage position, is in sealing contact with the outer wall of the piston at a location between the rearward end and the transverse inlet opening of the piston. Optionally, an additional sealing lip is provided which is axially spaced from the first mentioned sealing lip in forward direction. The additional sealing lip assists frictional holding in the closed storage position and guidance during telescoping movement.
- In order to provide a multi component dispensing system featuring mixing of the released components, in a preferred embodiment of the invention, the piston unit has a collection and mixing compartment integrally formed on top of the forward ends of the pistons. The collection and mixing compartment is in fluid communication with each one of the outlet openings of the passages of the pistons for simultaneously receiving each one of the released components during telescoping movement.
- In order to provide a multi component dispensing system featuring separate and successive application of the released components, in a preferred embodiment of the invention, the piston unit has at least two separate compartments integrally formed on top of the forward ends of the pistons. The compartments extend in axial direction and are arranged in parallel to one another. Each compartment is in fluid communication with only one of the outlet openings of the longitudinal passages of the pistons for separately receiving only one of the released components during telescoping movement. The compartments have open forward ends which may be provided with a common or, alternatively, individual closure means. The closure means may be provided with applicator means.
- A novel piston unit for use in a prefilled telescoping multiple chamber ampoule device comprising a container having at least two axially extending chambers arranged in parallel to one another, comprises at least two pistons having forward ends which are integrally connected with one another. Each piston has a passage which axially extends within the interior of the piston. Each piston is aligned with one of the chambers and matingly arranged therein for coaxial telescoping movement of the container and the piston unit towards one another. According to an aspect of the invention, the piston unit has a collection and mixing compartment integrally formed on top of the integrally connected forward ends of the pistons. The compartment is in fluid communication with each one of the outlet openings of the passages of the pistons for simultaneously receiving components released from the container during telescoping movement. According to another aspect of the invention, the piston unit has at least two separate compartments integrally formed on top of the forward ends of the pistons. The compartments extend in axial direction and are arranged in parallel to one another. Each compartment is in fluid communication with only one of the outlet openings of the longitudinal passages of the pistons for separately receiving only one of the released components during telescoping movement.
- Alternatively, each compartment is in fluid communication with two outlet openings of the longitudinal passages of the piston. Another alternative is that one compartment of the at least two compartments is in fluid communication with two or even more outlet openings of the longitudinal passages and another compartment is in fluid communication with a different number of outlet openings, for example, only one outlet opening.
- The compartments have open forward ends which may be provided with a common or, alternatively, individual closure means. The closure means may be provided with applicator means.
- According to a further development of the invention, the one or more of the compartments formed on top of the pistons may also be prefilled with a component.
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- Fig. 1 is a longitudinal sectional view of a first embodiment of a prefilled telescoping multiple chamber ampoule device of the present invention showing the device in a closed storage position;
- Fig. 2 is a transverse sectional view of the first embodiment along line II-II in Fig. 1;
- Fig. 3 is another transverse sectional view of the first embodiment along line III-III in Fig. 1;
- Fig. 4 is a longitudinal sectional view of a forward portion of the first embodiment utilizing another type of applicator and showing the device after release of the components;
- Fig. 5 is a longitudinal sectional view of a second embodiment of a prefilled telescoping multiple chamber ampoule device of the present invention showing the device in a closed storage position;
- Fig. 6 is a longitudinal sectional view of the second embodiment showing the device in an open release position together with an applicator;
- Fig. 7 is a longitudinal sectional view of a third embodiment of a prefilled telescoping multiple chamber ampoule device of the present invention showing the device in a closed storage position;
- Fig. 8 is a longitudinal sectional view of the third embodiment showing the device in an open release position;
- Fig. 9 is a longitudinal sectional view of a forward portion of the third embodiment showing the device after release of the components together with another type of applicator;
- Fig. 10 is a longitudinal sectional view of a forward portion of the third embodiment showing a similar type of applicator prior to release of the components;
- Fig. 11 is a longitudinal sectional view of the third embodiment showing the device after release of the components together with a further type of applicator;
- Fig. 12 is a longitudinal sectional view of a fourth embodiment of a prefilled telescoping multiple chamber ampoule device of the present invention showing the device in a closed storage position;
- Fig. 13 is a top plan view of a piston unit of the fourth embodiment;
- Fig. 14 is a top plan view of a container of the fourth embodiment;
- Fig. 15 is a transverse sectional view of the piston unit of the fourth embodiment along line XV-XV in Fig. 12;
- Fig. 16 is a bottom plan view of the container of the fourth embodiment;
- Fig. 17 is a top plan view of a piston unit of a fifth embodiment; and
- Fig. 18 is a top plan view of a container of the fifth embodiment.
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- Referring to Fig. 1 to 3, a prefilled telescoping multiple
chamber ampoule device 100 according to a first embodiment of the present invention comprises acontainer 110 and apiston unit 150. - The
container 110 includes two separatecylindrical chambers chambers container 110 and are arranged in parallel to one another. The rearward ends of thechambers bottom wall 116 of thecontainer 110. The forward ends of thecontainers chambers outer wall 118 of thecontainer 110 and separated from one another by apartition 119. Each one of thechambers lip 120 projecting radially inwardly from the inner wall of each chamber between the rearwardbottom wall 116 and the forward open end of the chambers. - In a preferred embodiment, the
portion 119 may be reduced to a rather narrow connecting strip. Alternatively, each one of thechambers - The
piston unit 150 consists of two cylindrical plungers orpistons pistons plate 158. Each one of thepistons longitudinal passage 160 which axially extends within the interior of the piston. Thepassage 160 has an axial outlet opening 164 to the exterior of thepiston unit 150 at the forward end of the piston. Furthermore, thepassage 160 has a transverse inlet opening 162 from the exterior of thepiston unit 150 near the rearward end of the piston. Thepiston unit 150 and thecontainer 110 are designed in such a manner that thepistons chambers container 110 and thepiston unit 150 towards one another. - Depending on the application, an applicator such as a
nozzle applicator 180 may be provided. Thenozzle applicator 180 consists of aforward portion 181 and arearward portion 185. Theforward portion 181 has a tapered tubular shape and surrounds anoutlet channel 182 having a relatively small transverse cross-sectional area. Therearward portion 185 defines an inside space 186 which has an open rearward end and a larger transverse cross-sectional area, the dimensions of which match with the outer dimensions of the transverse cross-sectional are of the forward end of thepiston unit 150. In other words, the forward end of thepiston unit 150 can be inserted into the inside space 186 of therearward portion 185 in a fluid-tight manner. Thenozzle applicator 180 has asloping shoulder 183 between theforward portion 181 and therearward portion 185. Thesloping shoulder 183 defines on its inside a flat,truncated compartment 184 adjoining the inside space 186 and theoutput channel 182. Preferably, astatic mixer 188 is inserted in theoutlet channel 182 which has an increasingly smaller diameter from its rearward end to its forward outlet end. - Fig. 1 shows the prefilled telescoping multiple
chamber ampoule device 100 in a closed storage position. In the closed storage position the rearward ends of thepistons chambers 132 and 134 so that the rearward end of each piston is spaced a distance from the bottom of each one of thechambers chamber 112 contains a first flowable component 132, and the reservoir defined in thechamber 114 contains a secondflowable component 134. In the closed storage position the peripheral sealinglips 120 are fluid-tightly pressed into circumferential contact with the outer walls of thepistons passage 160 within each piston so as to prevent release of thecomponents 132 and 134 from the reservoirs into thetransverse inlet openings 162 and to frictionally hold thepiston unit 150 in place within thecontainer 110 during storage and transportation. - The
nozzle applicator 180 may be provided separately from the prefilled subassembly of thedevice 100 which consists only of two basic parts, i.e. thecontainer 110 and thepiston unit 150. However, preferably, thenozzle applicator 180 is already attached to thepiston unit 150 in the closed storage position, as shown in Fig. 1. - Prior to activation of the
prefilled ampoule device 100 thenozzle applicator 180 has to be attached to the forward end of thepiston unit 150, unless done before, for example, prior to enclosing thecomponents 132 and 134 within thecontainer 110 by inserting the rearward ends of the pistons of thepiston unit 150. Starting from the closed storage position shown in Fig. 1, theprefilled ampoule device 100 can be telescopically moved into an open release position by manually applying an axial compression force to the axially opposite parts of the device, i.e. thecontainer 110 and thenozzle applicator 180. Accordingly, thenozzle applicator 180 and thecontainer 110 have also the functions of manipulating parts. More specifically, thesloping shoulder 183 offers an engaging surface for one or two fingers of one hand and thebottom wall 116 of thecontainer 110 offers an engaging surface for another finger of the same hand to telescopically move thepiston unit 150 and thecontainer 110 towards one another into the open release position. - At the start of telescoping movement the
transverse openings 162 ride over the sealinglips 120 and positive pressure is created within the reservoirs of thechambers components 132 and 134. Accordingly, thecomponents 132 and 134 enter into thetransverse inlet openings 162 and are pressed in forward direction through thelongitudinal channels 160 of thepistons mixing compartment 184 and from there through theoutlet channel 182 to the outside of the device. In thecompartment 184 and theoutlet channel 182 the two components are intermixed before being sprayed out of the outlet opening of theoutlet channel 182. Preferably, the intermixing of the two components is enhanced by means of astatic mixer 188 provided within theoutlet channel 182. - During axial telescoping movement from the closed storage position, shown in Fig. 1, to the open release position the sealing
lips 120 are fluid-tightly pressed into circumferential sliding contact with the outer walls of thepistons transverse openings 162 and the forward end of thepiston unit 150 so as to prevent escape of thecomponents 132 and 134 from the reservoirs within thechambers container 110. - In this context, according to the invention, the
container 110 is molded from an elastomeric material or any other appropriate material having elastic characteristics, while thepiston unit 150 can be molded from a similar material or a relatively rigid plastic material. In a preferred embodiment bothparts parts container 110 in its entirety is more elastic than thepiston unit 150. Thepiston unit 150 can even be rigid, whereas thecontainer 110 should have a certain degree of elasticity to allow both the sealing engagement between the sealinglips 120 and the outer walls of thepistons parts parts pistons lips 120 and as large or almost as large as the inner diameters of thechambers cylindrical chambers lips 120 which are continuously in sealing contact with the outer walls of thepistons chambers lips 120 such that the sealinglips 120 are expanded to the outer diameters of thepistons lips 120 may be deformed. Of course, the overall design is such that during the axial telescoping movement there are adequate radial spaces or clearances between the inner walls of thechambers pistons pistons flowable components 132 and 134 contained in the reservoirs of thechambers transverse inlet openings 162. These considerations apply to each one of the embodiments disclosed herein. - During telescoping movement and dispense of the mixture from the outlet opening of the output channel 182 a relatively high pressure may built up within the flat conically shaped mixing
chamber 184. In order to avoid that the forward end of thepiston unit 150 inserted into the inside space 186 of the spray ornozzle applicator 180 will be pushed out of the rearward end of theapplicator 180 adequate connecting means should be provided between theapplicator 180 and thepiston unit 150, such as press fit, snap on and similar fastening means, well known in the art. In some applications it may be sufficient to provide the inner wall of therearward portion 185 or the outer wall of the forward end of thepiston unit 150 with an integrally formed frictional and sealing lip transversely extending inwardly or outwardly, respectively. - Furthermore, integrally formed
gripping means 187 may be provided on theapplicator 180 for the purpose of better handling during telescoping movement. - Other alternative means for improving the manual manipulation of the device for telescoping movement are well known in the art, for example, in the form of transverse protrusions extending from the
container 150 or theapplicator 180. - In this context, according to the invention, the
applicator 180 is molded from an elastomeric material or any other appropriate material having elastic characteristics. - With reference to Fig. 4, it should be noted that a variety of applicators may be used in replacement of the spray or
nozzle applicator 180. For example, Fig. 4 discloses adropper applicator 190 the rearward end of which has been attached to the forward end of thepiston unit 150. Thedropper applicator 190 provides a relativelylarge mixing compartment 194 for receiving amixture 136 consisting of the entire volumes of the twocomponents 132 and 134 after the prefilled ampoule device has been fully moved in the open release position in which the rearward ends of thepistons bottom wall 116 of thecontainer 110. - Referring to Fig. 5 and 6, a prefilled telescoping multiple
chamber ampoule device 200 according to a second embodiment of the present invention comprises acontainer 210 and apiston unit 250. Preferably, a closure means may be provided such as aremovable cap 270. - The
container 210 has a construction similar to that of thecontainer 110 and includes two separatecylindrical chambers bottom wall 216, anouter wall 218 having a rearward portion which surrounds thechambers partition 219 separating thechambers lip 220 projecting radially inwardly from the inner wall of each chamber. - The
container 210 is modified with respect to thecontainer 110 insofar as theouter wall 218 has a forward portion that extends in the forward direction beyond the forward ends of thecylindrical chambers partition 219. In addition, thecontainer 210 is provided with a further integrally formedannular sealing lip 222 projecting radially inwardly from the inner wall of each chamber. The annular peripheral sealinglip 222 is spaced by a short distance in the forward direction from the sealinglip 220, as it can be seen from Fig. 5 and 6. - The
piston unit 250 has a construction that is more or less identical to the construction of thepiston unit 150 and consists of two plungers orpistons plate 258, a longitudinal channel 260 within each piston having a transverse inlet opening 262 and anaxial outlet opening 264. - Fig. 5 shows the prefilled
telescoping ampoule device 200 in the closed shipping or storage position. As it can be seen, the forward portion of theouter wall 218 of thecontainer 210 defines an inner space for entirely receiving thepiston unit 250 in the closed storage position. Accordingly, a closure means or cover such as thecap 270 can be provided on top of the forward end of thecontainer 210. - In the closed storage position, shown in Fig. 5, the rearward ends of the
pistons chambers flowable substance 232 and a secondflowable substance 234. In the closed storage position, the sealinglips pistons lips 222 are optional. They may improve the sealing function and the frictional function maintaining thepiston unit 250 in the closed storage position during transportation and storage. The optional provision of a further sealing lip such as sealinglip 222 applies to each one of the embodiments disclosed herein. - For activation of the
prefilled ampoule device 200 and telescopical movement of thepiston 250 and thecontainer 210 towards one another, thecap 270 is removed and pressure is applied upon the forward face of thepiston unit 250 by means of a tool, such as an immerging or dippingapplicator 272, while thecontainer 250 is held in hand or standing on a base, such as a table. Alternatively, a rod like extension (not shown) is integrally formed on top of the forward end of thepiston unit 150 axially extending in the forward direction for manually activating the ampoule device. The rod like extension may protrude through an opening of thecap 270 to the outside of the device. - Fig. 6 shows the
prefilled ampoule device 200 in the fully open release position in which the twosubstances piston unit 250 and the inner surface of the forward portion of theouter wall 218 of thecontainer 210. Accordingly, the mixing compartment contains amixture 236 of the two dispensedcomponents mixture 236 can be applied by means of the dippingapplicator 272 which can be immerged into themixture 236 via the open forward end of thecontainer 210. - Referring to Fig. 7 and 8, a prefilled telescoping multiple
chamber ampoule device 300 according to a third embodiment of the present invention comprises acontainer 310 and apiston unit 350 and may be provided with a closure means or cover such as acap 370. - The construction of the
container 310 essentially corresponds to the construction of thecontainer 110. Accordingly, thecontainer 310 includes two separatecylindrical chambers bottom wall 316, a surroundingouter wall 318, apartition 319 and an annular peripheral sealinglip 320 projecting radiadly inwardly from the inner wall of each chamber. - The
piston unit 350 has a construction that corresponds essentially to that of thepiston unit 150. Accordingly, thepiston unit 350 consists of twopistons plate 358 connecting the forward ends of the pistons together, alongitudinal channel 360 extending within each piston and having atransverse inlet opening 362 and anaxial outlet opening 364. In addition to thepiston units piston unit 350 has an integrally formedmixing compartment 366 on top of the forward ends of thepistons mixing compartment 366 is peripherally surrounded by anouter wall 355 axially extending in forward direction from the forward ends of thepistons plate 358 defines the bottom of themixing compartment 366 and theoutlet openings 364 of thelongitudinal channels 360 are in fluid communication with themixing compartment 366. Themixing compartment 366 has an open forward end. Fig. 7 shows the prefilledtelescoping ampoule device 300 in the closed storage position in which a firstflowable component 332 and a secondflowable component 334 are contained and enclosed in the reservoirs of thechambers chamber 366 may be provided with a removable closure means or cover such as thecap 370. - Fig. 8 shows the prefilled
telescoping ampoule device 300 in the fully open release position after telescoping movement. In the fully open release position the twocomponents longitudinal channels 360 into themixing compartment 366 which now contains amixture 336 of the two releasedcomponents cap 370 themixture 336 can be applied by an applicator such as theapplicator 272 shown in Fig. 6. - Fig. 9 shows a modified closure means in form of a
cap 380 having a throughhole 382. The throughhole 382 allows the insertion of a separately providedapplicator tool 384 for immersion into themixture 336. - Fig. 10 shows another modified closure means in form of a
cap 385. Anapplicator tool 389 extends through the cap into themixing compartment 366. Theapplicator tool 389 is fluid-tightly connected to thecap 385 by amembrane 387 or the like. For activating the prefilledtelescoping ampoule device 300 and starting telescoping movement, theapplicator tool 389 is rotated in order to rupture themembrane 387. Theapplicator tool 389 is now free to be pushed deeper into themixing compartment 366 until it comes into contact with the forward end face of theplate 358 or thepistons piston unit 350 into thecontainer 310 for axial telescoping movement. Thereby thecomponents longitudinal channels 360 into themixing compartment 366. - Alternatively, for telescoping movement manual pressure is applied to the
cap 385 andcontainer 310. Thereafter, theapplicator tool 389 is freed from themembrane 387 and thecap 385. - As shown in Fig. 11, other applicator means such as a
dropper applicator 390 may be attached to the open forward end of themixing compartment 366 in order to dispense themixture 336 in form of single droplets as it can be seen for example in Fig. 4. - Referring to Fig. 12 to 16, a prefilled telescoping multiple
chamber ampoule device 400 according to a fourth embodiment of the present invention comprises an integrally formed container 410 and an integrally formedpiston unit 450. - The container 410 includes two separate
cylindrical chambers chambers container 450. The rearward ends of the tubular portions are closed bybottom walls like portion 419 supporting the tubular portions and leaving thechambers like portion 419 has an essentially oval cross-sectional area. Referring to Fig. 12, 13, and 16, the tubular portions defining thechambers - The plate-
like portion 419 transversely extends beyond the outer walls of the tubular portions. The peripheral side wall of the plate-like portion 419 is integrally connected to anouter wall 418 of thecontainer 450. A forward portion of theouter wall 418 axially extends from the plate-like portion 419 in forward direction. Referring to Fig. 12 and 13, the forward portion of theouter wall 418 surrounds a space which has an open forward end and an essentially oval cross-sectional area. - A rearward portion of the
outer wall 418 axially extends from the plate-like portion 418 in the rearward direction. The rearward portion of theouter wall 418 surrounds the tubular portions and is spaced therefrom in transverse direction. The rearward end of theouter wall 418 and thebottom walls - Referring to Fig. 12, each one of the
chambers lip 420 projecting radially inwardly from the inner wall of each chamber at a location spaced by a distance from the plate-like portion 419. Optionally, each one of thechambers lip 422 projecting radially inwardly from the inner wall of each chamber at a location between the sealinglip 420 and the plate-like portion 419. - The
piston unit 450 consists of two cylindrical plungers orpistons pistons plate 458. Each one of thepistons longitudinal passage 460 which axially extends within the interior of the piston. Thepassage 460 has an axial outlet opening 464 at the forward end of the piston. Furthermore, thepassage 460 has a transverse inlet opening 462 near the rearward end of the piston. - The
piston unit 450 has an integrally formed collecting andmixing compartment 466 on top of the forward ends of thepistons compartment 466 is peripherally surrounded by anouter wall 455 axially extending in forward direction from the forward surface of theplate 458. The connectingplate 458 defines the bottom of themixing compartment 466 and transversely extends beyond the outer walls of thepistons outlet openings 464 of the longitudinal passages orchannels 460 are in fluid communication with thecompartment 466. Referring to Fig. 13, theouter wall 455 of thecompartment 466 has an essentially oval outer contour in the transverse direction corresponding to the inner contour of the forward portion of theouter wall 418 of the container 410. - The
piston unit 450 and the container 410 are designed in such a manner that thepistons chambers piston unit 450 towards one another. Fig. 12 shows the prefilled telescoping multiplechamber ampoule device 400 in a closed storage position. In the closed storage position the rearward ends of thepistons chambers bottom wall chambers chamber 412 contains a firstflowable component 432, and the reservoir defined in thechamber 414 contains a secondflowable component 434. In the closed storage position the peripheral sealinglips 420 are fluid-tightly pressed into circumferential contact with the outer walls of thepistons passage 460. The function of the sealinglips 420 is comparable to the function of the sealinglips - The optionally provided sealing
lips 422 have a function comparable to that of the sealinglips 222 in the second embodiment. Preferably, the sealinglips 422 are spaced a distance from the rearward surface of the plate-like portion 419. - Furthermore, in the closed storage position the rearward end of the
outer wall 455 slightly extends into the space defined by the forward portion of theouter wall 418 of the container 410 for better guiding thepiston unit 450 within the container 410 during telescoping movement. - Fig. 12 to 16 show only the two basic integrally formed parts of the
prefilled ampoule device 400, i.e. the container 410 and thepiston unit 450. With reference to Figure 5 to 11, thecompartment 466 of thepiston unit 450 may be utilized together with different closure and applicator means. For example, closure means such as 270, 370 or 380 may be provided, preferably, in combination with separate applicators such as 272 and 384. Closure means such as 385 may be provided with a built-inapplicator 389. A built-on dropper such as 390 may be provided. In this connection, the dropper may have different forms for example a conical form ending in a dropper tip on its forward end. After telescoping movement from the closed storage position into the open release position the mixture of the two components is contained in thecompartment 466 and may be dispensed via the dropper tip by pressing the dropper which is manufactured from a correspondingly flexible or elastic plastic material. - According to an alternative embodiment of the invention, instead of a common collecting and
mixing compartment piston unit components compartment - Referring to Fig. 17 and 18, a fifth embodiment of the present invention comprises an integrally formed
container 510 and an integrally formedpiston unit 550. - The
container 510 substantially corresponds to container 410, however, includes fourcylindrical chambers like portion 519. Thepiston unit 550 substantially corresponds to thepiston unit 450, however, has four cylindrical plungers orpistons piston unit 550 has two integrally formedcompartments outer wall 555 and acommon partition 557. In case of need, asecond partition 559 or even a third partition (not shown) may be provided in order to have more than two compartments. Providing these partitions allows to arrange one or more of theoutlet openings 564 of the longitudinal passages of the pistons in common or in separate compartments. In this manner, the user can apply a mixture of two or even more components and/or selectively apply one or more components without being mixed with another component. - The device according to the invention may be used as unidose dispenser for two or more components. Standard materials for manufacturing the device according to the invention are low density polyethylenes, high density polyethylenes and polypropylenes. However, other flexible or elastic materials or elastomers may be used. This holds particularly true for the container. The piston unit may alternatively be manufactured from a rigid material, for example, a metal.
- According to the invention it is contemplated to provide prefilled telescoping multiple chamber ampoule devices which are different from the embodiments disclosed herein but operate in substantially the same manner. Therefore, it is understood that various modifications may be made to the embodiments disclosed herein. For example, three or more chambers may be provided containing either the same or different flowable media. The chambers of the container and the compartments of the piston unit may have different diameters and cross-sectional shapes. Additional annular peripheral sealing lips may be integrally formed on the inner walls of the chambers. Instead of a rather narrow sealing lip, there may be integrally provided a broader sealing ring axially extending across the transverse inlet opening of the piston in the closed storage position. While specific applicator and closure means have been described, other discharging applicators such as hollow needles, spray heads, microbrushes, brushes and the like as well as other covers such as plugs, lids and the like may be used.
Claims (17)
- A prefilled telescoping multiple chamber ampoule device separately storing at least two different flowable components, comprising:a container (110; 210; 310; 410) having at least two axially extending chambers (112, 114; 212, 214; 312, 314; 412, 414) arranged in parallel to one another, each chamber having a closed rearward end (116; 216; 316; 415, 417) and an open forward end and an integrally formed circumferential sealing means (120; 220; 320; 420) projecting inwardly from the inner wall of the chamber,a piston unit (150; 250; 350; 450) having at least two pistons (152, 154; 252, 254; 352, 354; 452, 454) and a transversely extending mount (158; 258; 358; 458) integrally adjoining the forward ends of the pistons, each piston having a passage (160; 260; 360; 460) axially extending within the interior of the piston, said passage having an outlet opening (164; 264; 364; 464) at a forward end of the piston and a transverse inlet opening (162; 262; 362; 462) near a rearward end of the piston, and each piston being in alignment with one of said chambers and being inserted, with its rearward end ahead, into the open forward end of one of said chambers and being matingly arranged therein for coaxial telescoping movement of the container (110; 210; 310; 410) and the piston unit (150; 250; 350; 450) towards one another from a closed storage position into an open release position,
wherein, after initial and during telescoping movement into the open release position, the rearward ends of the pistons are moved towards the rearward ends of the chambers whereby the sealing means (120; 220; 320; 420) expose the transverse inlet openings (162; 262; 362; 462) of the passages of the pistons to the reservoirs so as to release the components (132, 134; 232, 234; 332, 334; 432, 434) through the outlet openings (164; 264; 364; 464) of the passages (160; 260; 360; 460) of the pistons as the volumes of the reservoirs are reduced. - The prefilled telescoping multiple chamber ampoule device according to claim 1 wherein said circumferential sealing means is a sealing lip (120; 220; 320; 420) which, in the closed storage position, is in sealing contact with the outer wall of the piston (152, 154; 252, 254; 352, 354; 452, 454) at a location between the rearward end and the transverse inlet opening (162; 262; 362; 462) of the piston.
- The prefilled telescoping multiple chamber ampoule device according to claim 2 wherein said circumferential sealing means comprises a further sealing lip (222; 422) which, in the closed storage position, is in sealing contact with the outer wall of the pistons (252, 254; 452, 454) at a location between the transverse inlet opening (262; 264) and the forward end of the piston (252, 254; 452, 454).
- The prefilled telescoping multiple chamber ampoule device according to any one of the claims 1 to 3 wherein said piston unit (350; 450) further has a collection and mixing compartment (366; 466) integrally formed on top of the forward ends of the pistons (352, 354; 452, 454) and being in fluid communication with each one of the outlet openings (364; 464) of the passages (360; 460) of the pistons (352, 354; 452, 454) for simultaneously receiving each one of the released components (332, 334; 432, 434) during telescoping movement.
- The prefilled telescoping multiple chamber ampoule device according to any one of the claims 1 to 3 wherein said piston unit (550) has at least two separate compartments (566, 567) integrally formed on top of the forwards ends of the pistons, each compartment being in fluid communication with at least one of the outlet openings (564) of the passages of the pistons for receiving at least one of the released components during telescoping movement.
- The prefilled telescoping multiple chamber ampoule device according to claim 4 or 5 further comprising closure means (370) attached to the open forward end of the compartment (366; 466) or the compartments.
- The prefilled telescoping multiple chamber ampoule device according to claim 6 wherein said closure means is or are removably attached so as to allow to dip an applicator tool (272; 384) into the components mixture (336; 436) released into the compartment (366; 466) or dip applicator tools into the components separately released into the compartments.
- The prefilled telescoping multiple chamber ampoule device according to claim 5 further comprising an elongated applicator tool (389) or elongated applicator tools extending through said closure means (385) from the outside of the device into the compartment (366; 466) or the compartments and being detachably connected to the closure means.
- The prefilled telescoping multiple chamber ampoule device according to claim 4 further comprising a dropper means (390) which is attached to an open forward end of the compartment (366; 466).
- The prefilled telescoping multiple chamber ampoule device according to any one of the claims 1 to 3 wherein the container (210) has a peripheral wall (218) having a forward end which extends in the forward direction beyond the forward end of the piston unit (250) so that a forward portion of the peripheral wall (218) of the container forms a collection and mixing compartment (266) being in fluid communication with each one of the outlet openings (264) of the passages (260) of the pistons for simultaneously receiving each one of the released components (232, 234).
- The prefilled telescoping multiple chamber ampoule device according to claim 10 further comprising a closure means (270) that is attached to the open forward end of the container (210) and further comprising an elongated applicator tool (384; 389) extending through the closure means (380; 385) from the outside into the container and being detachably connected to the closure means.
- The prefilled telescoping multiple chamber ampoule device according to claim 10 further comprising a dropper means (390) which is attached to the forward end of the container (210).
- The prefilled telescoping multiple chamber ampoule device according to any one of the claims 1 to 3 further comprising an applicator means (180; 190) which is attached to the forward end of the piston member (150), said applicator means (180) comprising engagement means (183; 187) for manually performing telescoping movement.
- The prefilled telescoping multiple chamber ampoule device according to claim 13 wherein the forward end of the piston unit (150) is fluid-tightly inserted into a rearward end of said applicator means (180; 190).
- The prefilled telescoping multiple chamber ampoule device according to claim 13 wherein said applicator means (180; 190) has a rear portion which defines a mixing chamber (184; 194) together with the front face of the forward end of the piston unit (150) and it has a tubular forward portion being in fluid communication with the mixing chamber.
- The prefilled telescoping multiple chamber ampoule device according to claim 13 wherein said applicator means is a dropper means (190) having a rearward portion which defines a mixing chamber (194) together with the front face of the forward end of the piston unit (150).
- A piston unit for use in a prefilled telescoping multiple chamber ampoule device which comprises a container (310; 410; 510) having at least two axially extending chambers (312, 314; 412, 414; 511, 512, 513, 514) arranged in parallel to one another, said piston unit (350; 450; 550) comprising:at least two pistons (352, 354; 452, 454; 551, 552, 553, 554), each piston being in alignment with one of the chambers (312, 314; 412, 414; 511, 512, 513, 514) of the container (310; 410; 510) and being matingly arranged therein for coaxial telescoping movement of the container (310; 410; 510) and the piston unit (350; 450; 550) towards one another, each piston having a passage (360; 460) axially extending within the interior of the piston, said passage (360; 460) having an outlet opening (364; 464; 564) at a forward end of the piston; andone or more compartments (366; 466; 566, 567) integrally formed on top of the forward ends of the pistons (352, 354; 452, 454; 551, 552, 553, 554) and being in fluid communication with one or more of the outlet openings (364; 464; 564) of the passages (360; 460) of the pistons (352, 354; 452, 454; 551, 552, 553, 554).
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE20019091U | 2000-11-09 | ||
DE20019091U DE20019091U1 (en) | 1999-11-19 | 2000-11-09 | Pre-filled, telescopically collapsible ampoule |
Publications (2)
Publication Number | Publication Date |
---|---|
EP1205196A1 true EP1205196A1 (en) | 2002-05-15 |
EP1205196B1 EP1205196B1 (en) | 2006-06-14 |
Family
ID=7948641
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP01126274A Expired - Lifetime EP1205196B1 (en) | 2000-11-09 | 2001-11-06 | A prefilled telescoping multiple chamber ampoule device |
Country Status (2)
Country | Link |
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US (1) | US6719729B2 (en) |
EP (1) | EP1205196B1 (en) |
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Also Published As
Publication number | Publication date |
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US20020087122A1 (en) | 2002-07-04 |
US6719729B2 (en) | 2004-04-13 |
EP1205196B1 (en) | 2006-06-14 |
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