EP1200567A4 - Compounds and methods for identifying compounds which inhibit a new class of aspartyl proteases - Google Patents

Compounds and methods for identifying compounds which inhibit a new class of aspartyl proteases

Info

Publication number
EP1200567A4
EP1200567A4 EP00947169A EP00947169A EP1200567A4 EP 1200567 A4 EP1200567 A4 EP 1200567A4 EP 00947169 A EP00947169 A EP 00947169A EP 00947169 A EP00947169 A EP 00947169A EP 1200567 A4 EP1200567 A4 EP 1200567A4
Authority
EP
European Patent Office
Prior art keywords
compounds
inhibit
methods
new class
aspartyl proteases
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP00947169A
Other languages
German (de)
French (fr)
Other versions
EP1200567A1 (en
Inventor
Ronald K Taylor
Christian F Lapointe
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Dartmouth College
Original Assignee
Dartmouth College
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dartmouth College filed Critical Dartmouth College
Publication of EP1200567A1 publication Critical patent/EP1200567A1/en
Publication of EP1200567A4 publication Critical patent/EP1200567A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/52—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
    • C08K3/00—Use of inorganic substances as compounding ingredients
    • C08K3/34—Silicon-containing compounds
    • C08K3/346—Clay
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
    • C08K7/00—Use of ingredients characterised by shape
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
    • C08K9/00—Use of pretreated ingredients
    • C08K9/04—Ingredients treated with organic substances

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Polymers & Plastics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Dispersion Chemistry (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
EP00947169A 1999-07-12 2000-07-11 Compounds and methods for identifying compounds which inhibit a new class of aspartyl proteases Withdrawn EP1200567A4 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US14335599P 1999-07-12 1999-07-12
US143355P 1999-07-12
PCT/US2000/018775 WO2001004277A1 (en) 1999-07-12 2000-07-11 Compounds and methods for identifying compounds which inhibit a new class of aspartyl proteases

Publications (2)

Publication Number Publication Date
EP1200567A1 EP1200567A1 (en) 2002-05-02
EP1200567A4 true EP1200567A4 (en) 2003-02-26

Family

ID=22503710

Family Applications (1)

Application Number Title Priority Date Filing Date
EP00947169A Withdrawn EP1200567A4 (en) 1999-07-12 2000-07-11 Compounds and methods for identifying compounds which inhibit a new class of aspartyl proteases

Country Status (3)

Country Link
EP (1) EP1200567A4 (en)
CA (1) CA2379269A1 (en)
WO (1) WO2001004277A1 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10032709A1 (en) * 2000-07-07 2002-01-24 Boehringer Ingelheim Pharma Aspartyl protease

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995012408A1 (en) * 1993-11-04 1995-05-11 Brigham & Women's Hospital Plasmin-independent fibrinolysis
US5872210A (en) * 1995-10-05 1999-02-16 The United States Of America As Represented By The Department Of Health And Human Services Transframe peptide inhibitor of viral protease

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995012408A1 (en) * 1993-11-04 1995-05-11 Brigham & Women's Hospital Plasmin-independent fibrinolysis
US5872210A (en) * 1995-10-05 1999-02-16 The United States Of America As Represented By The Department Of Health And Human Services Transframe peptide inhibitor of viral protease

Non-Patent Citations (10)

* Cited by examiner, † Cited by third party
Title
BILLICH S ET AL: "Synthetic peptides as substrates and inhibitors of human immune deficiency virus-1 protease.", THE JOURNAL OF BIOLOGICAL CHEMISTRY. UNITED STATES 5 DEC 1988, vol. 263, no. 34, 5 December 1988 (1988-12-05), pages 17905 - 17908, XP002224206, ISSN: 0021-9258 *
BIOTECHNOLOGY LETTERS, vol. 19, no. 4, 1997, pages 325 - 329, ISSN: 0141-5492 *
DATABASE BIOSIS [online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; 1997, SIDDIQUI KHAWAR SOHAIL ET AL: "Thermostabilization of carboxymethylcellulase from Aspergillus niger by carboxyl group modification.", XP002224404, Database accession no. PREV199799523783 *
DATABASE MEDLINE [online] 1994, STROM M S ET AL: "Posttranslational processing of type IV prepilin and homologs by PilD of Pseudomonas aeruginosa.", XP002224403, Database accession no. NLM8057924 *
HUMBLET C C ET AL: "Characterization of two structurally novel HIV-1 protease inhibitors identified by rational selection.", ANTIVIRAL RESEARCH, vol. 21, no. 1, 1993, pages 73 - 84, XP009002114, ISSN: 0166-3542 *
KAUFMAN M R ET AL: "PROCESSING OF TCP PILIN BY TCPJ TYPIFIES A COMMON STEP INTRINSIC TO A NEWLY RECOGNIZED PATHWAY OF EXTRACELLULAR PROTEIN SECRETION BY GRAM-NEGATIVE BACTERIA", GENES & DEVELOPMENT, vol. 5, no. 10, 1991, pages 1834 - 1846, XP009002002, ISSN: 0890-9369 *
KICK E K ET AL: "STRUCTURE-BASED DESIGN AND COMBINATORIAL CHEMISTRY YIELD LOW NANOMOLAR INHIBITORS OF CATHEPSIN D", CHEMISTRY AND BIOLOGY, CURRENT BIOLOGY, LONDON, GB, vol. 4, no. 4, 1997, pages 297 - 307, XP002065985, ISSN: 1074-5521 *
METHODS IN ENZYMOLOGY. UNITED STATES 1994, vol. 235, 1994, pages 527 - 540, ISSN: 0076-6879 *
See also references of WO0104277A1 *
TOOGOOD H S ET AL: "A pepstatin-insensitive aspartic proteinase from a thermophilic Bacillus sp.", THE BIOCHEMICAL JOURNAL. ENGLAND 1 MAY 1995, vol. 307 ( Pt 3), 1 May 1995 (1995-05-01), pages 783 - 789, XP009002116, ISSN: 0264-6021 *

Also Published As

Publication number Publication date
CA2379269A1 (en) 2001-01-18
EP1200567A1 (en) 2002-05-02
WO2001004277A1 (en) 2001-01-18
WO2001004277A9 (en) 2002-07-11

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Legal Events

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