EP1198468A4 - Stabilized viral envelope proteins and uses thereof - Google Patents

Stabilized viral envelope proteins and uses thereof

Info

Publication number
EP1198468A4
EP1198468A4 EP00944801A EP00944801A EP1198468A4 EP 1198468 A4 EP1198468 A4 EP 1198468A4 EP 00944801 A EP00944801 A EP 00944801A EP 00944801 A EP00944801 A EP 00944801A EP 1198468 A4 EP1198468 A4 EP 1198468A4
Authority
EP
European Patent Office
Prior art keywords
envelope proteins
viral envelope
stabilized viral
stabilized
proteins
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP00944801A
Other languages
German (de)
French (fr)
Other versions
EP1198468A1 (en
Inventor
James M Binley
Norbert Schuelke
William C Olson
Paul J Maddon
John P Dept Of Microbiol Moore
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Progenics Pharmaceuticals Inc
Aaron Diamond AIDS Research Center
Original Assignee
Progenics Pharmaceuticals Inc
Aaron Diamond AIDS Research Center
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Progenics Pharmaceuticals Inc, Aaron Diamond AIDS Research Center filed Critical Progenics Pharmaceuticals Inc
Publication of EP1198468A1 publication Critical patent/EP1198468A1/en
Publication of EP1198468A4 publication Critical patent/EP1198468A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
    • C07K16/1036—Retroviridae, e.g. leukemia viruses
    • C07K16/1045—Lentiviridae, e.g. HIV, FIV, SIV
    • C07K16/1063—Lentiviridae, e.g. HIV, FIV, SIV env, e.g. gp41, gp110/120, gp160, V3, PND, CD4 binding site
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/53—DNA (RNA) vaccination
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • AIDS & HIV (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Hematology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
EP00944801A 1999-06-25 2000-06-23 Stabilized viral envelope proteins and uses thereof Withdrawn EP1198468A4 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US340992 1994-11-17
US34099299A 1999-06-25 1999-06-25
PCT/US2000/017267 WO2001000648A1 (en) 1999-06-25 2000-06-23 Stabilized viral envelope proteins and uses thereof

Publications (2)

Publication Number Publication Date
EP1198468A1 EP1198468A1 (en) 2002-04-24
EP1198468A4 true EP1198468A4 (en) 2003-07-30

Family

ID=23335807

Family Applications (1)

Application Number Title Priority Date Filing Date
EP00944801A Withdrawn EP1198468A4 (en) 1999-06-25 2000-06-23 Stabilized viral envelope proteins and uses thereof

Country Status (6)

Country Link
EP (1) EP1198468A4 (en)
JP (1) JP2003509013A (en)
AU (1) AU782123B2 (en)
CA (1) CA2370517A1 (en)
HK (1) HK1046911A1 (en)
WO (1) WO2001000648A1 (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6710173B1 (en) 1999-06-25 2004-03-23 Progenics Pharmaceuticals, Inc. Stabilized viral envelope proteins and uses thereof
US20050089526A1 (en) * 2001-09-06 2005-04-28 Moore John P. Human immunodeficiency virus envelope clycoprotein mutants and uses thereof
EP1463521A4 (en) * 2001-12-17 2009-06-24 Us Gov Health & Human Serv Gp41 inhibitor
US20060051373A1 (en) * 2002-04-05 2006-03-09 Olson William C Particle-bound human immunodeficiency virus envelope glycoproteins and related compositions and methods
CN1809381A (en) * 2003-06-12 2006-07-26 瓦克斯根公司 HIV-1 envelope glycoproteins having unusual disulfide structure
KR100560468B1 (en) 2003-09-16 2006-03-13 삼성에스디아이 주식회사 Image display and display panel thereof
WO2007107090A1 (en) * 2006-03-17 2007-09-27 Huawei Technologies Co., Ltd. Method and apparatus for enabling soft handoff in an ofdma-based communication system
CA2667358A1 (en) 2006-10-23 2008-05-29 Progenics Pharmaceuticals, Inc. Modified gp140 envelope polypeptides of hiv-1 isolates, compositions, stabilized trimeric complexes, and uses thereof
RU2015101081A (en) * 2012-06-18 2016-08-10 Новартис Аг STABILIZED GP120
WO2020079586A1 (en) 2018-10-17 2020-04-23 Glaxosmithkline Biologicals Sa Modified cytomegalovirus proteins and stabilized complexes

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5886163A (en) * 1993-03-26 1999-03-23 Progenics Pharmaceuticals, Inc. HIV-1 antigens, antibody compositions related thereto, and therapeutic and prophylactic uses thereof

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0502160A1 (en) * 1990-09-25 1992-09-09 Peptech (Uk) Limited Aids therapy and vaccine

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5886163A (en) * 1993-03-26 1999-03-23 Progenics Pharmaceuticals, Inc. HIV-1 antigens, antibody compositions related thereto, and therapeutic and prophylactic uses thereof

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
BINLEY J M ET AL: "A RECOMBINANT HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 ENVELOPE GLYCOPROTEIN COMPLEX STABILIZED BY AN INTERMOLECULAR DISULFIDE BOND BETWEEN THE GP120 AND GP41 SUBUNITS IS AN ANTIGENIC MIMIC OF THE TRIMERIC VIRION-ASSOCIATED STRUCTURE", JOURNAL OF VIROLOGY, THE AMERICAN SOCIETY FOR MICROBIOLOGY, US, vol. 74, no. 2, January 2000 (2000-01-01), pages 627 - 643, XP002939087, ISSN: 0022-538X *
BURTON DENNIS R ET AL: "Efficient neutralization of primary isolates of HIV-1 by a recombinant human monoclonal antibody.", SCIENCE (WASHINGTON D C), vol. 266, no. 5187, 1994, pages 1024 - 1027, XP001147878, ISSN: 0036-8075 *
FARZAN M ET AL: "Stabilization of human immunodeficiency virus type 1 envelope glycoprotei trimers by disulfide bonds introduced into the gp41 glycoprotein ectodomain", JOURNAL OF VIROLOGY, THE AMERICAN SOCIETY FOR MICROBIOLOGY, US, vol. 72, no. 9, September 1998 (1998-09-01), pages 7620 - 7625, XP002097559, ISSN: 0022-538X *
LABRANCHE C C ET AL: "Biological, molecular, and structural analysis of a cytopathic variant from a molecularly cloned simian immunodeficiency virus.", JOURNAL OF VIROLOGY. UNITED STATES NOV 1994, vol. 68, no. 11, November 1994 (1994-11-01), pages 7665 - 7667, XP009010815, ISSN: 0022-538X *
LABRANCHE CELIA C ET AL: "Biological, molecular, and structural analysis of a cytopathic variant from a molecularly cloned simian immunodeficiency virus.", JOURNAL OF VIROLOGY, vol. 68, no. 9, 1994, pages 5509 - 5522, XP009010814, ISSN: 0022-538X *
See also references of WO0100648A1 *
TRKOLA ALEXANDRA ET AL: "Human monoclonal antibody 2G12 defines a distinctive neutralization epitope on the gp 120 glycoprotein of human immunodeficiency virus type 1.", JOURNAL OF VIROLOGY, vol. 70, no. 2, 1996, pages 1100 - 1108, XP002241179, ISSN: 0022-538X *

Also Published As

Publication number Publication date
EP1198468A1 (en) 2002-04-24
AU5884200A (en) 2001-01-31
WO2001000648A1 (en) 2001-01-04
JP2003509013A (en) 2003-03-11
HK1046911A1 (en) 2003-01-30
AU782123B2 (en) 2005-07-07
CA2370517A1 (en) 2001-01-04

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Legal Events

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Inventor name: BINLEY, JAMES, M.

Inventor name: MOORE, JOHN, P., DEPT OF MICROBIOLOGY AND IMMUNOL

Inventor name: SCHUELKE, NORBERT

Inventor name: MADDON, PAUL, J.

Inventor name: OLSON, WILLIAM, C.

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