EP1194527A4 - Stress-responsive induction of a therapeutic agent and methods of use - Google Patents

Stress-responsive induction of a therapeutic agent and methods of use

Info

Publication number
EP1194527A4
EP1194527A4 EP00948536A EP00948536A EP1194527A4 EP 1194527 A4 EP1194527 A4 EP 1194527A4 EP 00948536 A EP00948536 A EP 00948536A EP 00948536 A EP00948536 A EP 00948536A EP 1194527 A4 EP1194527 A4 EP 1194527A4
Authority
EP
European Patent Office
Prior art keywords
stress
methods
therapeutic agent
responsive induction
responsive
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP00948536A
Other languages
German (de)
French (fr)
Other versions
EP1194527A1 (en
Inventor
Amy S Lee
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Southern California USC
Original Assignee
University of Southern California USC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Southern California USC filed Critical University of Southern California USC
Publication of EP1194527A1 publication Critical patent/EP1194527A1/en
Publication of EP1194527A4 publication Critical patent/EP1194527A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2799/00—Uses of viruses
    • C12N2799/02—Uses of viruses as vector
    • C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
    • C12N2799/027—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from a retrovirus

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
EP00948536A 1999-06-28 2000-06-28 Stress-responsive induction of a therapeutic agent and methods of use Withdrawn EP1194527A4 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US14150599P 1999-06-28 1999-06-28
US141505P 1999-06-28
PCT/US2000/017885 WO2001000791A1 (en) 1999-06-28 2000-06-28 Stress-responsive induction of a therapeutic agent and methods of use

Publications (2)

Publication Number Publication Date
EP1194527A1 EP1194527A1 (en) 2002-04-10
EP1194527A4 true EP1194527A4 (en) 2004-04-14

Family

ID=22495982

Family Applications (1)

Application Number Title Priority Date Filing Date
EP00948536A Withdrawn EP1194527A4 (en) 1999-06-28 2000-06-28 Stress-responsive induction of a therapeutic agent and methods of use

Country Status (5)

Country Link
EP (1) EP1194527A4 (en)
AU (1) AU6201500A (en)
CA (1) CA2377434A1 (en)
HK (1) HK1044568A1 (en)
WO (1) WO2001000791A1 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6656732B1 (en) 2001-05-18 2003-12-02 Isis Pharmaceuticals, Inc. Antisense inhibition of src-c expression
ATE451459T1 (en) * 2003-09-08 2009-12-15 Univ Queensland INDUCIBLE BACTERIAL EXPRESSION SYSTEM USING THE SSPA PROMOTER FROM SALMONELLA

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994017208A1 (en) * 1993-01-21 1994-08-04 President And Fellows Of Harvard College Methods and diagnostic kits utilizing mammalian stress promoters to determine toxicity of a compound

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
KYU SEONG KIM ET AL: "EXPRESSION OF THE GLUCOSE-REGULATED PROTEINS (GRP94 AN GRP78) IN DIFFERENTIATED AND UNDIFFERENTIATED MOUSE EMBRYONIC CELLS AND THE USE OF THE GRP78 PROMOTER AS AN EXPRESSION SYSTEM IN EMBRYONIC CELLS", DIFFERENTIATION, SPRINGER VERLAG, DE, vol. 42, no. 3, February 1990 (1990-02-01), pages 153 - 159, XP001077510, ISSN: 0301-4681 *
ROY B ET AL: "THE MAMMALIAN ENDOPLASMIC RETICULUM STRESS RESPONSE ELEMENT CONSISTS OF AN EVOLUTIONARILY CONSERVED TRIPARTITE STRUCTURE AND INTERACTS WITH A NOVEL STRESS-INDUCIBLE COMPLEX", NUCLEIC ACIDS RESEARCH, OXFORD UNIVERSITY PRESS, SURREY, GB, vol. 27, no. 6, 1999, pages 1437 - 1443, XP000887379, ISSN: 0305-1048 *
See also references of WO0100791A1 *
YOSHIDA H ET AL: "IDENTIFICATION OF THE CIS-ACTING ENDOPLASMIC RETICULUM STRESS RESPONSE ELEMENT RESPONSIBLE FOR TRANSCRIPTIONAL INDUCTION OF MAMMALIAN GLUCOSE-REGULATED PROTEINS", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY OF BIOLOGICAL CHEMISTS, BALTIMORE, MD, US, vol. 273, no. 50, 1998, pages 33741 - 33749, XP000887378, ISSN: 0021-9258 *

Also Published As

Publication number Publication date
HK1044568A1 (en) 2002-10-25
EP1194527A1 (en) 2002-04-10
AU6201500A (en) 2001-01-31
WO2001000791A1 (en) 2001-01-04
WO2001000791A9 (en) 2002-07-25
CA2377434A1 (en) 2001-01-04

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