EP1194138A4 - Nutritional supplements - Google Patents
Nutritional supplementsInfo
- Publication number
- EP1194138A4 EP1194138A4 EP00936025A EP00936025A EP1194138A4 EP 1194138 A4 EP1194138 A4 EP 1194138A4 EP 00936025 A EP00936025 A EP 00936025A EP 00936025 A EP00936025 A EP 00936025A EP 1194138 A4 EP1194138 A4 EP 1194138A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- fatty acid
- acid compound
- compound
- composition
- derivative
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 235000015872 dietary supplement Nutrition 0.000 title description 7
- 239000000203 mixture Substances 0.000 claims abstract description 166
- 230000006651 lactation Effects 0.000 claims abstract description 35
- 235000016709 nutrition Nutrition 0.000 claims abstract description 32
- 235000020778 linoleic acid Nutrition 0.000 claims abstract description 29
- OYHQOLUKZRVURQ-IXWMQOLASA-N linoleic acid Natural products CCCCC\C=C/C\C=C\CCCCCCCC(O)=O OYHQOLUKZRVURQ-IXWMQOLASA-N 0.000 claims abstract description 29
- 230000007472 neurodevelopment Effects 0.000 claims abstract description 29
- -1 fatty acid compound Chemical class 0.000 claims description 215
- 235000014113 dietary fatty acids Nutrition 0.000 claims description 197
- 229930195729 fatty acid Natural products 0.000 claims description 197
- 239000000194 fatty acid Substances 0.000 claims description 197
- 238000000034 method Methods 0.000 claims description 73
- 150000004665 fatty acids Chemical class 0.000 claims description 66
- 235000020256 human milk Nutrition 0.000 claims description 49
- 210000004251 human milk Anatomy 0.000 claims description 49
- 230000035935 pregnancy Effects 0.000 claims description 46
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Natural products OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims description 38
- OVBPIULPVIDEAO-LBPRGKRZSA-N Folic acid Natural products C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-LBPRGKRZSA-N 0.000 claims description 37
- 150000001875 compounds Chemical class 0.000 claims description 32
- GVJHHUAWPYXKBD-UHFFFAOYSA-N d-alpha-tocopherol Natural products OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims description 32
- 229940088594 vitamin Drugs 0.000 claims description 32
- 239000011782 vitamin Substances 0.000 claims description 32
- 229930003231 vitamin Natural products 0.000 claims description 31
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims description 30
- 235000013343 vitamin Nutrition 0.000 claims description 30
- 241000124008 Mammalia Species 0.000 claims description 27
- 235000020661 alpha-linolenic acid Nutrition 0.000 claims description 26
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- 229910052500 inorganic mineral Inorganic materials 0.000 claims description 25
- 229960004488 linolenic acid Drugs 0.000 claims description 25
- KQQKGWQCNNTQJW-UHFFFAOYSA-N linolenic acid Natural products CC=CCCC=CCC=CCCCCCCCC(O)=O KQQKGWQCNNTQJW-UHFFFAOYSA-N 0.000 claims description 25
- 235000013336 milk Nutrition 0.000 claims description 25
- 239000008267 milk Substances 0.000 claims description 25
- 210000004080 milk Anatomy 0.000 claims description 25
- 239000011707 mineral Substances 0.000 claims description 25
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- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims description 24
- 239000011575 calcium Substances 0.000 claims description 24
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- 235000020669 docosahexaenoic acid Nutrition 0.000 claims description 24
- 229940090949 docosahexaenoic acid Drugs 0.000 claims description 23
- 235000020660 omega-3 fatty acid Nutrition 0.000 claims description 23
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 claims description 22
- 229930003268 Vitamin C Natural products 0.000 claims description 22
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- CYQFCXCEBYINGO-IAGOWNOFSA-N delta1-THC Chemical compound C1=C(C)CC[C@H]2C(C)(C)OC3=CC(CCCCC)=CC(O)=C3[C@@H]21 CYQFCXCEBYINGO-IAGOWNOFSA-N 0.000 claims description 21
- OVBPIULPVIDEAO-UHFFFAOYSA-N N-Pteroyl-L-glutaminsaeure Natural products C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)NC(CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-UHFFFAOYSA-N 0.000 claims description 20
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- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 claims description 19
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- 239000011726 vitamin B6 Substances 0.000 claims description 15
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- 235000011852 gelatine desserts Nutrition 0.000 claims description 12
- 239000012729 immediate-release (IR) formulation Substances 0.000 claims description 12
- FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 claims description 11
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 claims description 11
- FPIPGXGPPPQFEQ-BOOMUCAASA-N Vitamin A Natural products OC/C=C(/C)\C=C\C=C(\C)/C=C/C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-BOOMUCAASA-N 0.000 claims description 11
- 229930003316 Vitamin D Natural products 0.000 claims description 11
- QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 claims description 11
- 235000004626 essential fatty acids Nutrition 0.000 claims description 11
- 239000011777 magnesium Substances 0.000 claims description 11
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- 229940046008 vitamin d Drugs 0.000 claims description 11
- 102100021809 Chorionic somatomammotropin hormone 1 Human genes 0.000 claims description 8
- 101000895818 Homo sapiens Chorionic somatomammotropin hormone 1 Proteins 0.000 claims description 8
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- 229940088623 biologically active substance Drugs 0.000 claims description 7
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- 239000007903 gelatin capsule Substances 0.000 claims description 7
- 230000037396 body weight Effects 0.000 claims description 5
- 229940043430 calcium compound Drugs 0.000 claims description 5
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- 230000007812 deficiency Effects 0.000 claims description 5
- 210000000481 breast Anatomy 0.000 claims description 4
- 239000007894 caplet Substances 0.000 claims description 4
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- 238000013265 extended release Methods 0.000 claims description 4
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- 239000007938 effervescent tablet Substances 0.000 claims description 3
- 150000002681 magnesium compounds Chemical class 0.000 claims description 3
- 239000011859 microparticle Substances 0.000 claims description 3
- 230000008236 biological pathway Effects 0.000 claims description 2
- 239000006186 oral dosage form Substances 0.000 claims 6
- 229940068682 chewable tablet Drugs 0.000 claims 2
- 235000014106 fortified food Nutrition 0.000 claims 2
- 235000011962 puddings Nutrition 0.000 claims 2
- 235000013618 yogurt Nutrition 0.000 claims 2
- OYHQOLUKZRVURQ-HZJYTTRNSA-N Linoleic acid Chemical compound CCCCC\C=C/C\C=C/CCCCCCCC(O)=O OYHQOLUKZRVURQ-HZJYTTRNSA-N 0.000 abstract description 14
- 238000009472 formulation Methods 0.000 description 23
- 229960005069 calcium Drugs 0.000 description 20
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- 239000003921 oil Substances 0.000 description 18
- 241000282849 Ruminantia Species 0.000 description 14
- AUNGANRZJHBGPY-SCRDCRAPSA-N Riboflavin Chemical compound OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-SCRDCRAPSA-N 0.000 description 13
- 229960003284 iron Drugs 0.000 description 13
- DTOSIQBPPRVQHS-PDBXOOCHSA-N alpha-linolenic acid Chemical compound CC\C=C/C\C=C/C\C=C/CCCCCCCC(O)=O DTOSIQBPPRVQHS-PDBXOOCHSA-N 0.000 description 12
- 239000003925 fat Substances 0.000 description 11
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- 239000000126 substance Substances 0.000 description 11
- 239000011720 vitamin B Substances 0.000 description 11
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 10
- YZXBAPSDXZZRGB-DOFZRALJSA-N arachidonic acid Chemical compound CCCCC\C=C/C\C=C/C\C=C/C\C=C/CCCC(O)=O YZXBAPSDXZZRGB-DOFZRALJSA-N 0.000 description 10
- 230000008901 benefit Effects 0.000 description 10
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- 235000015097 nutrients Nutrition 0.000 description 10
- ZUFQODAHGAHPFQ-UHFFFAOYSA-N pyridoxine hydrochloride Chemical compound Cl.CC1=NC=C(CO)C(CO)=C1O ZUFQODAHGAHPFQ-UHFFFAOYSA-N 0.000 description 10
- OYHQOLUKZRVURQ-NTGFUMLPSA-N (9Z,12Z)-9,10,12,13-tetratritiooctadeca-9,12-dienoic acid Chemical compound C(CCCCCCC\C(=C(/C\C(=C(/CCCCC)\[3H])\[3H])\[3H])\[3H])(=O)O OYHQOLUKZRVURQ-NTGFUMLPSA-N 0.000 description 9
- 239000002253 acid Substances 0.000 description 9
- FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 description 9
- 239000002552 dosage form Substances 0.000 description 9
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- 239000013589 supplement Substances 0.000 description 9
- 150000003710 vitamin D derivatives Chemical class 0.000 description 9
- 239000011701 zinc Substances 0.000 description 9
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- LXNHXLLTXMVWPM-UHFFFAOYSA-N pyridoxine Chemical compound CC1=NC=C(CO)C(CO)=C1O LXNHXLLTXMVWPM-UHFFFAOYSA-N 0.000 description 8
- 150000003722 vitamin derivatives Chemical class 0.000 description 8
- 241001465754 Metazoa Species 0.000 description 7
- DFPAKSUCGFBDDF-UHFFFAOYSA-N Nicotinamide Chemical compound NC(=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-UHFFFAOYSA-N 0.000 description 7
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- 235000005152 nicotinamide Nutrition 0.000 description 7
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- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 6
- 239000010949 copper Substances 0.000 description 6
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- 229940108928 copper Drugs 0.000 description 6
- VZCCETWTMQHEPK-QNEBEIHSSA-N gamma-linolenic acid Chemical compound CCCCC\C=C/C\C=C/C\C=C/CCCCC(O)=O VZCCETWTMQHEPK-QNEBEIHSSA-N 0.000 description 6
- PNDPGZBMCMUPRI-UHFFFAOYSA-N iodine Chemical compound II PNDPGZBMCMUPRI-UHFFFAOYSA-N 0.000 description 6
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- AGVAZMGAQJOSFJ-WZHZPDAFSA-M cobalt(2+);[(2r,3s,4r,5s)-5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] [(2r)-1-[3-[(1r,2r,3r,4z,7s,9z,12s,13s,14z,17s,18s,19r)-2,13,18-tris(2-amino-2-oxoethyl)-7,12,17-tris(3-amino-3-oxopropyl)-3,5,8,8,13,15,18,19-octamethyl-2 Chemical compound [Co+2].N#[C-].[N-]([C@@H]1[C@H](CC(N)=O)[C@@]2(C)CCC(=O)NC[C@@H](C)OP(O)(=O)O[C@H]3[C@H]([C@H](O[C@@H]3CO)N3C4=CC(C)=C(C)C=C4N=C3)O)\C2=C(C)/C([C@H](C\2(C)C)CCC(N)=O)=N/C/2=C\C([C@H]([C@@]/2(CC(N)=O)C)CCC(N)=O)=N\C\2=C(C)/C2=N[C@]1(C)[C@@](C)(CC(N)=O)[C@@H]2CCC(N)=O AGVAZMGAQJOSFJ-WZHZPDAFSA-M 0.000 description 5
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- 230000001681 protective effect Effects 0.000 description 1
- 239000008213 purified water Substances 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 210000001525 retina Anatomy 0.000 description 1
- 239000008165 rice bran oil Substances 0.000 description 1
- 235000005713 safflower oil Nutrition 0.000 description 1
- 239000003813 safflower oil Substances 0.000 description 1
- 229940119224 salmon oil Drugs 0.000 description 1
- 235000019512 sardine Nutrition 0.000 description 1
- 235000011803 sesame oil Nutrition 0.000 description 1
- 239000008159 sesame oil Substances 0.000 description 1
- 229940057910 shea butter Drugs 0.000 description 1
- 235000015170 shellfish Nutrition 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- 235000012239 silicon dioxide Nutrition 0.000 description 1
- 208000017520 skin disease Diseases 0.000 description 1
- 238000009491 slugging Methods 0.000 description 1
- APSBXTVYXVQYAB-UHFFFAOYSA-M sodium docusate Chemical compound [Na+].CCCCC(CC)COC(=O)CC(S([O-])(=O)=O)C(=O)OCC(CC)CCCC APSBXTVYXVQYAB-UHFFFAOYSA-M 0.000 description 1
- 239000007909 solid dosage form Substances 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 230000007103 stamina Effects 0.000 description 1
- 238000010561 standard procedure Methods 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 239000002600 sunflower oil Substances 0.000 description 1
- 230000001502 supplementing effect Effects 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 230000009747 swallowing Effects 0.000 description 1
- 239000003765 sweetening agent Substances 0.000 description 1
- 230000001839 systemic circulation Effects 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- DPJRMOMPQZCRJU-UHFFFAOYSA-M thiamine hydrochloride Chemical compound Cl.[Cl-].CC1=C(CCO)SC=[N+]1CC1=CN=C(C)N=C1N DPJRMOMPQZCRJU-UHFFFAOYSA-M 0.000 description 1
- 229960004860 thiamine mononitrate Drugs 0.000 description 1
- 235000019191 thiamine mononitrate Nutrition 0.000 description 1
- 239000011748 thiamine mononitrate Substances 0.000 description 1
- UIERGBJEBXXIGO-UHFFFAOYSA-N thiamine mononitrate Chemical compound [O-][N+]([O-])=O.CC1=C(CCO)SC=[N+]1CC1=CN=C(C)N=C1N UIERGBJEBXXIGO-UHFFFAOYSA-N 0.000 description 1
- 150000003626 triacylglycerols Chemical class 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- 239000001069 triethyl citrate Substances 0.000 description 1
- VMYFZRTXGLUXMZ-UHFFFAOYSA-N triethyl citrate Natural products CCOC(=O)C(O)(C(=O)OCC)C(=O)OCC VMYFZRTXGLUXMZ-UHFFFAOYSA-N 0.000 description 1
- 235000013769 triethyl citrate Nutrition 0.000 description 1
- 239000003981 vehicle Substances 0.000 description 1
- 239000011675 vitamin B5 Substances 0.000 description 1
- 235000019168 vitamin K Nutrition 0.000 description 1
- 239000011712 vitamin K Substances 0.000 description 1
- 150000003721 vitamin K derivatives Chemical class 0.000 description 1
- 229940046010 vitamin k Drugs 0.000 description 1
- 235000019195 vitamin supplement Nutrition 0.000 description 1
- 235000021241 α-lactalbumin Nutrition 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/115—Fatty acids or derivatives thereof; Fats or oils
- A23L33/12—Fatty acids or derivatives thereof
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/14—Drugs for genital or sexual disorders; Contraceptives for lactation disorders, e.g. galactorrhoea
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
- A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Definitions
- Breast milk contains high concentrations of fat-digesting enzymes that allow for highly efficient fat absorption.
- Breast milk, as well as colostrum contain the essential fatty acid linoleic acid. Understanding Nutri tion, Whi tney and Rclfe, 6 th Ed. , 136-40 (1993) .
- a composition comprises a first fatty acid compound selected from the group consisting of linoleic acid, linolenic acid, a derivative thereof and a combination thereof in an amount ranging from 10 mg to 100 mg; a second fatty acid compound selected from the group consisting of a docosahexaenoic acid compound, an omega-3 fatty acid, and omega-2 fatty acid, a derivative thereof and a combination thereof in an amount ranging from about 10 mg to 100 mg; a vitamin B6 compound or derivative thereof in a range of about 20 mg to 125 mg; a folic acid compound or derivative thereof in a range of about 0.1 mg to 3 mg; a calcium compound or derivative thereof in a range of about 100 mg to 1000 mg; a magnesium compound or derivative thereof in a range of about 25 mg to 400 mg; a vitamin C compound or derivative thereof in a range of 25 mg to 400 mg; and a vitamin E compound or derivative thereof in a range of 10 mg to 400 mg.
- the weight selected from the group consisting of
- a composition for administration to a female mammal for enriching the milk of said female mammal to optimize neurological development of a neonate being nursed by the female mammal which comprises about 10 mg to 1000 mg per 55 kg of said mammal's body weight of a first fatty acid compound for each compound selected from the group consisting of a linoleic acid compound, a linolenic acid compound, a derivative thereof and a combination thereof; about 10 mg to 1000 mg of a second fatty acid compound selected from the group consisting of a docosahexaenoic acid compound, an omega-3 fatty acid, an omega-2 fatty acid, a derivative thereof and a combination thereof; and wherein the weight ratio of said first fatty acid compound to said second fatty acid compound is about 1:0.01 to 10.
- composition of the present inventive subject matter may be administered in a partial, i.e., fractional dose, one or more times during a 24 hour period, a single dose during a 24 hour period of time, a double dose during a 24 hour period of time, or more than a double dose during a 24 hour period of time.
- Fractional, double or other multiple doses may be taken simultaneously or at different times during the 24 hour period.
Abstract
Description
Claims
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP06015359A EP1723953A1 (en) | 1999-06-01 | 2000-05-18 | Nutritional supplements |
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US323159 | 1994-10-14 | ||
US09/323,159 US6258846B1 (en) | 1999-06-01 | 1999-06-01 | Nutritional supplements |
PCT/US2000/013581 WO2000072842A1 (en) | 1999-06-01 | 2000-05-18 | Nutritional supplements |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP06015359A Division EP1723953A1 (en) | 1999-06-01 | 2000-05-18 | Nutritional supplements |
Publications (3)
Publication Number | Publication Date |
---|---|
EP1194138A1 EP1194138A1 (en) | 2002-04-10 |
EP1194138A4 true EP1194138A4 (en) | 2004-09-01 |
EP1194138B1 EP1194138B1 (en) | 2007-01-31 |
Family
ID=23257964
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP06015359A Withdrawn EP1723953A1 (en) | 1999-06-01 | 2000-05-18 | Nutritional supplements |
EP00936025A Revoked EP1194138B1 (en) | 1999-06-01 | 2000-05-18 | Nutritional supplements |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP06015359A Withdrawn EP1723953A1 (en) | 1999-06-01 | 2000-05-18 | Nutritional supplements |
Country Status (12)
Country | Link |
---|---|
US (2) | US6258846B1 (en) |
EP (2) | EP1723953A1 (en) |
JP (1) | JP2003500445A (en) |
AT (1) | ATE353012T1 (en) |
AU (1) | AU780504B2 (en) |
BR (1) | BR0011541A (en) |
CA (1) | CA2374310A1 (en) |
DE (1) | DE60033233T2 (en) |
ES (1) | ES2275514T3 (en) |
IL (2) | IL146831A0 (en) |
MX (1) | MXPA01012461A (en) |
WO (1) | WO2000072842A1 (en) |
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- 1999-06-01 US US09/323,159 patent/US6258846B1/en not_active Expired - Lifetime
-
2000
- 2000-05-18 AT AT00936025T patent/ATE353012T1/en not_active IP Right Cessation
- 2000-05-18 CA CA002374310A patent/CA2374310A1/en not_active Abandoned
- 2000-05-18 AU AU51395/00A patent/AU780504B2/en not_active Ceased
- 2000-05-18 JP JP2000620954A patent/JP2003500445A/en active Pending
- 2000-05-18 DE DE60033233T patent/DE60033233T2/en not_active Revoked
- 2000-05-18 MX MXPA01012461A patent/MXPA01012461A/en active IP Right Grant
- 2000-05-18 ES ES00936025T patent/ES2275514T3/en not_active Expired - Lifetime
- 2000-05-18 WO PCT/US2000/013581 patent/WO2000072842A1/en active IP Right Grant
- 2000-05-18 BR BR0011541-0A patent/BR0011541A/en not_active Application Discontinuation
- 2000-05-18 EP EP06015359A patent/EP1723953A1/en not_active Withdrawn
- 2000-05-18 IL IL14683100A patent/IL146831A0/en active IP Right Grant
- 2000-05-18 EP EP00936025A patent/EP1194138B1/en not_active Revoked
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2001
- 2001-06-21 US US09/885,158 patent/US6576666B2/en not_active Expired - Lifetime
- 2001-11-29 IL IL146831A patent/IL146831A/en not_active IP Right Cessation
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EP0611568A1 (en) * | 1993-02-13 | 1994-08-24 | Fresenius AG | Composition for enteral nutrition |
Also Published As
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BR0011541A (en) | 2002-04-30 |
AU5139500A (en) | 2000-12-18 |
DE60033233T2 (en) | 2007-11-08 |
US6258846B1 (en) | 2001-07-10 |
ES2275514T3 (en) | 2007-06-16 |
MXPA01012461A (en) | 2003-07-21 |
US6576666B2 (en) | 2003-06-10 |
JP2003500445A (en) | 2003-01-07 |
US20020032234A1 (en) | 2002-03-14 |
ATE353012T1 (en) | 2007-02-15 |
IL146831A (en) | 2006-12-10 |
WO2000072842A1 (en) | 2000-12-07 |
EP1194138A1 (en) | 2002-04-10 |
EP1194138B1 (en) | 2007-01-31 |
CA2374310A1 (en) | 2000-12-07 |
EP1723953A1 (en) | 2006-11-22 |
IL146831A0 (en) | 2002-07-25 |
DE60033233D1 (en) | 2007-03-22 |
AU780504B2 (en) | 2005-03-24 |
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