EP1192128A4 - Thiol derivative, metallo-beta-lactamase inhibitors - Google Patents

Thiol derivative, metallo-beta-lactamase inhibitors

Info

Publication number
EP1192128A4
EP1192128A4 EP00941349A EP00941349A EP1192128A4 EP 1192128 A4 EP1192128 A4 EP 1192128A4 EP 00941349 A EP00941349 A EP 00941349A EP 00941349 A EP00941349 A EP 00941349A EP 1192128 A4 EP1192128 A4 EP 1192128A4
Authority
EP
European Patent Office
Prior art keywords
metallo
beta
lactamase inhibitors
thiol derivative
thiol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP00941349A
Other languages
German (de)
French (fr)
Other versions
EP1192128A1 (en
Inventor
James M Balkovec
Mark L Greenlee
Milton L Hammond
James V Heck
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of EP1192128A1 publication Critical patent/EP1192128A1/en
Publication of EP1192128A4 publication Critical patent/EP1192128A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/91—Dibenzofurans; Hydrogenated dibenzofurans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/56—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C327/00—Thiocarboxylic acids
    • C07C327/20—Esters of monothiocarboxylic acids
    • C07C327/32—Esters of monothiocarboxylic acids having sulfur atoms of esterified thiocarboxyl groups bound to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/56—Amides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
EP00941349A 1999-06-15 2000-06-12 Thiol derivative, metallo-beta-lactamase inhibitors Withdrawn EP1192128A4 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US13929799P 1999-06-15 1999-06-15
US139297P 1999-06-15
PCT/US2000/016070 WO2000076962A1 (en) 1999-06-15 2000-06-12 Thiol derivative, metallo-beta-lactamase inhibitors

Publications (2)

Publication Number Publication Date
EP1192128A1 EP1192128A1 (en) 2002-04-03
EP1192128A4 true EP1192128A4 (en) 2003-07-02

Family

ID=22485978

Family Applications (1)

Application Number Title Priority Date Filing Date
EP00941349A Withdrawn EP1192128A4 (en) 1999-06-15 2000-06-12 Thiol derivative, metallo-beta-lactamase inhibitors

Country Status (4)

Country Link
EP (1) EP1192128A4 (en)
JP (1) JP2003521476A (en)
CA (1) CA2374555A1 (en)
WO (1) WO2000076962A1 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2620675C (en) 2005-09-22 2015-04-14 Meiji Seika Kaisha, Ltd. Metallo-.beta.-lactamase inhibitors
JP2008019233A (en) * 2006-06-14 2008-01-31 Hitachi Chem Co Ltd Graft polymer having sulfur atom in side chain, and method for producing the same
GB201310542D0 (en) * 2013-06-13 2013-07-31 Antabio Sas Compounds
GB201317619D0 (en) 2013-10-04 2013-11-20 Uni I Oslo Compounds
GB201613946D0 (en) 2016-08-15 2016-09-28 Univ Oslo Compounds
JP7318950B2 (en) * 2018-05-14 2023-08-01 国立大学法人東海国立大学機構 beta-lactamase inhibitor

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2657136A (en) * 1951-03-30 1953-10-27 Eastman Kodak Co Photographic antiplumming agents and compositions containing them

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2679564A1 (en) * 1991-07-23 1993-01-29 Inst Nat Sante Rech Med NOVEL ACYLMERCAPTOALCANOLDIPEPTIDES, THEIR PREPARATION AND THE COMPOSITIONS CONTAINING THEM.
GB9323165D0 (en) * 1993-11-10 1994-01-05 Chiros Ltd Compounds

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2657136A (en) * 1951-03-30 1953-10-27 Eastman Kodak Co Photographic antiplumming agents and compositions containing them

Non-Patent Citations (21)

* Cited by examiner, † Cited by third party
Title
ACTA CHEM SCAND, vol. 19, 1965, pages 1490 - 1491 *
BIOORG MED CHEM LETT, vol. 6, no. 19, 1996, pages 2317 - 2322 *
CHEM ZENTRALBL GE, vol. 102, no. I, 1931, pages 3577 *
DATABASE CROSSFIRE BEILSTEIN [online] Beilstein Institut zur Förderung der Chemischen Wissenschaften, Frankfurt am Main, DE; XP002239861, Database accession no. 1761137, 1768628 *
DATABASE CROSSFIRE BEILSTEIN [online] Beilstein Institut zur Förderung der Chemischen Wissenschaften, Frankfurt am Main, DE; XP002239862, Database accession no. 135888 *
DATABASE CROSSFIRE BEILSTEIN [online] Beilstein Institut zur Förderung der Chemischen Wissenschaften, Frankfurt am Main, DE; XP002239863, Database accession no. 1721734 *
DATABASE CROSSFIRE BEILSTEIN [online] Beilstein Institut zur Förderung der Chemischen Wissenschaften, Frankfurt am Main, DE; XP002239864, Database accession no. 1721756 *
DATABASE CROSSFIRE BEILSTEIN [online] Beilstein Institut zur Förderung der Chemischen Wissenschaften, Frankfurt am Main, DE; XP002239865, Database accession no. 1760765 *
DATABASE CROSSFIRE BEILSTEIN [online] Beilstein Institut zur Förderung der Chemischen Wissenschaften, Frankfurt am Main, DE; XP002239866, Database accession no. 1875071 *
DATABASE CROSSFIRE BEILSTEIN [online] Beilstein Institut zur Förderung der Chemischen Wissenschaften, Frankfurt am Main, DE; XP002239867, Database accession no. 2441533 *
DATABASE CROSSFIRE BEILSTEIN [online] Beilstein Institut zur Förderung der Chemischen Wissenschaften, Frankfurt am Main, DE; XP002239868, Database accession no. 7689555 *
DATABASE CROSSFIRE BEILSTEIN [online] Beilstein Institut zur Förderung der Chemischen Wissenschaften, Frankfurt am Main, DE; XP002239869, Database accession no. 5553205 *
GOTO M ET AL: "INHIBITION OF THE METALLO-BETA-LACTAMASE PRODUCED FROM SERRATIA MARCESCENS BY THIOL COMPOUNDS", BIOLOGICAL & PHARMACEUTICAL BULLETIN (OF JAPAN), PHARMACEUTICAL SOCIETY OF JAPAN, JP, vol. 20, no. 11, 1997, pages 1136 - 1140, XP001147705, ISSN: 0918-6158 *
GREENLEE, MARK L. ET AL: "Synthesis and SAR of thioester and thiol inhibitors of IMP-1 metallo-.beta.- lactamase", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 9, no. 17, 6 September 1999 (1999-09-06), pages 2549 - 2554, XP002239910 *
HAMMOND, G. G. ET AL: "Inhibition of IMP-1 metallo-.beta.- lactamase and sensitization of IMP-1-producing bacteria by thioester derivatives", FEMS MICROBIOLOGY LETTERS, vol. 179, no. 2, 15 October 1999 (1999-10-15), pages 289 - 296, XP002239859 *
HELV CHIM ACTA, vol. 40, 1957, pages 2148,2154 *
J BIOL CHEM, vol. 75, 1927, pages 344 *
J ORG CHEM, vol. 25, 1960, pages 164 - 1168 *
J ORG CHEM, vol. 51, no. 19, 1986 *
MONATSH. CHEM., vol. 49, 1928, pages 125 *
See also references of WO0076962A1 *

Also Published As

Publication number Publication date
EP1192128A1 (en) 2002-04-03
CA2374555A1 (en) 2000-12-21
JP2003521476A (en) 2003-07-15
WO2000076962A1 (en) 2000-12-21

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