EP1190094A1 - Antisense modulation of beta catenin expression - Google Patents
Antisense modulation of beta catenin expressionInfo
- Publication number
- EP1190094A1 EP1190094A1 EP00939896A EP00939896A EP1190094A1 EP 1190094 A1 EP1190094 A1 EP 1190094A1 EP 00939896 A EP00939896 A EP 00939896A EP 00939896 A EP00939896 A EP 00939896A EP 1190094 A1 EP1190094 A1 EP 1190094A1
- Authority
- EP
- European Patent Office
- Prior art keywords
- acid
- antisense
- beta catenin
- oligonucleotides
- antisense compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
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- 229960004528 vincristine Drugs 0.000 description 1
- OGWKCGZFUXNPDA-UHFFFAOYSA-N vincristine Natural products C1C(CC)(O)CC(CC2(C(=O)OC)C=3C(=CC4=C(C56C(C(C(OC(C)=O)C7(CC)C=CCN(C67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)CN1CCC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-UHFFFAOYSA-N 0.000 description 1
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- 229940124024 weight reducing agent Drugs 0.000 description 1
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- XOOUIPVCVHRTMJ-UHFFFAOYSA-L zinc stearate Chemical class [Zn+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O XOOUIPVCVHRTMJ-UHFFFAOYSA-L 0.000 description 1
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/31—Chemical structure of the backbone
- C12N2310/315—Phosphorothioates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/32—Chemical structure of the sugar
- C12N2310/321—2'-O-R Modification
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/33—Chemical structure of the base
- C12N2310/334—Modified C
- C12N2310/3341—5-Methylcytosine
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/34—Spatial arrangement of the modifications
- C12N2310/341—Gapmers, i.e. of the type ===---===
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/34—Spatial arrangement of the modifications
- C12N2310/346—Spatial arrangement of the modifications having a combination of backbone and sugar modifications
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/582—Recycling of unreacted starting or intermediate materials
Abstract
Description
Claims
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US344519 | 1999-06-25 | ||
US09/344,519 US6066500A (en) | 1999-06-25 | 1999-06-25 | Antisense modulation of Beta catenin expression |
PCT/US2000/016488 WO2001000872A1 (en) | 1999-06-25 | 2000-06-15 | Antisense modulation of beta catenin expression |
Publications (1)
Publication Number | Publication Date |
---|---|
EP1190094A1 true EP1190094A1 (en) | 2002-03-27 |
Family
ID=23350867
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP00939896A Withdrawn EP1190094A1 (en) | 1999-06-25 | 2000-06-15 | Antisense modulation of beta catenin expression |
Country Status (4)
Country | Link |
---|---|
US (1) | US6066500A (en) |
EP (1) | EP1190094A1 (en) |
AU (1) | AU5490500A (en) |
WO (1) | WO2001000872A1 (en) |
Families Citing this family (31)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20030143204A1 (en) * | 2001-07-27 | 2003-07-31 | Lewis David L. | Inhibition of RNA function by delivery of inhibitors to animal cells |
EP1297186A4 (en) * | 2000-06-30 | 2005-06-29 | Univ Utah Res Found | Method of screening for chemotherapeutic treatments for cancer |
US7662791B2 (en) | 2000-08-02 | 2010-02-16 | University Of Southern California | Gene silencing using mRNA-cDNA hybrids |
EP1222933A1 (en) * | 2001-01-15 | 2002-07-17 | Academisch Ziekenhuis Leiden h.o.d.n., Leids Universitair Medisch Centrum | Generation and/or reduction of new lung tissue in an affected lung, by modulation of the Wnt-pathway |
US7101995B2 (en) * | 2001-08-27 | 2006-09-05 | Mirus Bio Corporation | Compositions and processes using siRNA, amphipathic compounds and polycations |
GB0123379D0 (en) * | 2001-09-28 | 2001-11-21 | Lorantis Ltd | Modulators |
AU2004220556B2 (en) | 2003-03-07 | 2009-05-07 | Alnylam Pharmaceuticals, Inc. | Therapeutic compositions |
EP1615611B1 (en) * | 2003-04-09 | 2013-02-13 | Alnylam Pharmaceuticals Inc. | iRNA CONJUGATES |
CA2535897A1 (en) * | 2003-08-14 | 2005-02-24 | Exelixis, Inc. | Sulfs as modifiers of the beta catenin pathway and methods of use |
US20060246459A1 (en) * | 2003-08-14 | 2006-11-02 | Exelixis, Inc. | Ups as modifiers of the beta catenin pathway and methods of use |
JP5601756B2 (en) * | 2004-12-17 | 2014-10-08 | ベス イスラエル デアコネス メディカル センター, インコーポレイテッド | Compositions for bacteria-mediated gene silencing and methods of use thereof |
EP1864134A4 (en) * | 2005-02-07 | 2010-10-20 | Univ Columbia | Methods to treat or prevent hormone-resistant prostate cancer using sirna specific for protocadherin-pc, or other inhibitors of protocadherin-pc expression or activity |
CA2596845C (en) * | 2005-02-10 | 2016-11-08 | Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Method of diagnosing and treating cancer using b-catenin splice variants |
EA018986B1 (en) * | 2007-05-01 | 2013-12-30 | Сантарис Фарма А/С | Rna antagonist compounds for the modulation of beta-catenin |
EP2321414B1 (en) * | 2008-07-25 | 2018-01-10 | Alnylam Pharmaceuticals, Inc. | Enhancement of sirna silencing activity using universal bases or mismatches in the sense strand |
KR101881596B1 (en) | 2008-12-02 | 2018-07-24 | 웨이브 라이프 사이언시스 재팬 인코포레이티드 | Method for the synthesis of phosphorous atom modified nucleic acids |
IN2012DN00720A (en) | 2009-07-06 | 2015-06-19 | Ontorii Inc | |
US10428019B2 (en) | 2010-09-24 | 2019-10-01 | Wave Life Sciences Ltd. | Chiral auxiliaries |
BR112014001244A2 (en) | 2011-07-19 | 2017-02-21 | Wave Life Sciences Pte Ltd | methods for the synthesis of functionalized nucleic acids |
EP2873674B1 (en) | 2012-07-13 | 2020-05-06 | Shin Nippon Biomedical Laboratories, Ltd. | Chiral nucleic acid adjuvant |
EP2872147B1 (en) | 2012-07-13 | 2022-12-21 | Wave Life Sciences Ltd. | Method for making chiral oligonucleotides |
BR112015000784A8 (en) | 2012-07-13 | 2018-04-03 | Wave Life Sciences Japan | ASYMMETRICAL AUXILIARY GROUP |
WO2014065849A1 (en) * | 2012-10-25 | 2014-05-01 | Phaserx, Inc. | Rna targeted to beta catenin |
WO2015108047A1 (en) | 2014-01-15 | 2015-07-23 | 株式会社新日本科学 | Chiral nucleic acid adjuvant having immunity induction activity, and immunity induction activator |
JPWO2015108048A1 (en) | 2014-01-15 | 2017-03-23 | 株式会社新日本科学 | Chiral nucleic acid adjuvant and antitumor agent having antitumor activity |
JPWO2015108046A1 (en) | 2014-01-15 | 2017-03-23 | 株式会社新日本科学 | Chiral nucleic acid adjuvant and antiallergic agent having antiallergic action |
KR20230152178A (en) | 2014-01-16 | 2023-11-02 | 웨이브 라이프 사이언시스 리미티드 | Chiral design |
AU2016226069A1 (en) | 2015-03-04 | 2017-09-21 | The University Of Chicago | Beta-catenin inhibitors in cancer immunotherapy |
MA43072A (en) | 2015-07-22 | 2018-05-30 | Wave Life Sciences Ltd | COMPOSITIONS OF OLIGONUCLEOTIDES AND RELATED PROCESSES |
JP2021509669A (en) | 2018-01-05 | 2021-04-01 | ディセルナ ファーマシューティカルズ インコーポレイテッド | Reduced expression of beta-catenin and IDO to enhance immunotherapy |
US10961534B2 (en) | 2018-07-13 | 2021-03-30 | University of Pittsburgh—of the Commonwealth System of Higher Education | Methods of treating porphyria |
-
1999
- 1999-06-25 US US09/344,519 patent/US6066500A/en not_active Expired - Lifetime
-
2000
- 2000-06-15 WO PCT/US2000/016488 patent/WO2001000872A1/en not_active Application Discontinuation
- 2000-06-15 EP EP00939896A patent/EP1190094A1/en not_active Withdrawn
- 2000-06-15 AU AU54905/00A patent/AU5490500A/en not_active Abandoned
Non-Patent Citations (1)
Title |
---|
See references of WO0100872A1 * |
Also Published As
Publication number | Publication date |
---|---|
US6066500A (en) | 2000-05-23 |
AU5490500A (en) | 2001-01-31 |
WO2001000872A1 (en) | 2001-01-04 |
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