EP1187934A4 - Cell-based assay for screening cox-2 inhibitors - Google Patents
Cell-based assay for screening cox-2 inhibitorsInfo
- Publication number
- EP1187934A4 EP1187934A4 EP00941446A EP00941446A EP1187934A4 EP 1187934 A4 EP1187934 A4 EP 1187934A4 EP 00941446 A EP00941446 A EP 00941446A EP 00941446 A EP00941446 A EP 00941446A EP 1187934 A4 EP1187934 A4 EP 1187934A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- cox
- inhibitors
- screening
- cell
- based assay
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5011—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing antineoplastic activity
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/26—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/88—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving prostaglandins or their receptors
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
- G01N2500/10—Screening for compounds of potential therapeutic value involving cells
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pathology (AREA)
- Cell Biology (AREA)
- Organic Chemistry (AREA)
- Food Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Physics & Mathematics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Toxicology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biophysics (AREA)
- General Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US13956999P | 1999-06-16 | 1999-06-16 | |
US139569P | 1999-06-16 | ||
PCT/US2000/016486 WO2000077245A1 (en) | 1999-06-16 | 2000-06-15 | Cell-based assay for screening cox-2 inhibitors |
Publications (2)
Publication Number | Publication Date |
---|---|
EP1187934A1 EP1187934A1 (en) | 2002-03-20 |
EP1187934A4 true EP1187934A4 (en) | 2002-07-31 |
Family
ID=22487303
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP00941446A Withdrawn EP1187934A4 (en) | 1999-06-16 | 2000-06-15 | Cell-based assay for screening cox-2 inhibitors |
Country Status (4)
Country | Link |
---|---|
EP (1) | EP1187934A4 (en) |
AU (1) | AU5615200A (en) |
CA (1) | CA2374676A1 (en) |
WO (1) | WO2000077245A1 (en) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
RU2690188C2 (en) * | 2017-05-26 | 2019-05-31 | Общество С Ограниченной Ответственностью "Фарминтерпрайсез" | New multitarget preparation for treating diseases in mammals |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1994014977A1 (en) * | 1992-12-22 | 1994-07-07 | Merck Frosst Canada Inc. | HUMAN CYCLOOXYGENASE-2cDNA AND ASSAY FOR EVALUATING INHIBITION OF CYCLOOXYGENASE-2 |
AT402732B (en) * | 1996-02-16 | 1997-08-25 | Nycomed Austria Gmbh | Use of the human megakaryocytic cell line dami for identifying and determining substances for inhibiting the enzymatic activity of the enzyme cyclooxygenase-1 |
AT402936B (en) * | 1996-05-29 | 1997-09-25 | Nycomed Austria Gmbh | Use of a human cell line for identifying and determining substances for inhibiting the induction of the expression of the cyclooxygenase-2 gene |
-
2000
- 2000-06-15 WO PCT/US2000/016486 patent/WO2000077245A1/en not_active Application Discontinuation
- 2000-06-15 AU AU56152/00A patent/AU5615200A/en not_active Abandoned
- 2000-06-15 CA CA002374676A patent/CA2374676A1/en not_active Abandoned
- 2000-06-15 EP EP00941446A patent/EP1187934A4/en not_active Withdrawn
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1994014977A1 (en) * | 1992-12-22 | 1994-07-07 | Merck Frosst Canada Inc. | HUMAN CYCLOOXYGENASE-2cDNA AND ASSAY FOR EVALUATING INHIBITION OF CYCLOOXYGENASE-2 |
AT402732B (en) * | 1996-02-16 | 1997-08-25 | Nycomed Austria Gmbh | Use of the human megakaryocytic cell line dami for identifying and determining substances for inhibiting the enzymatic activity of the enzyme cyclooxygenase-1 |
AT402936B (en) * | 1996-05-29 | 1997-09-25 | Nycomed Austria Gmbh | Use of a human cell line for identifying and determining substances for inhibiting the induction of the expression of the cyclooxygenase-2 gene |
Non-Patent Citations (2)
Title |
---|
MC DERMOTT JONATHAN M ET AL: "Oncogenic mutant of Galpha12 stimulates cell proliferation through cycloxygenase-2 signaling pathway.", ONCOGENE, vol. 18, no. 51, 2 December 1999 (1999-12-02), pages 7185 - 7189, XP001071176, ISSN: 0950-9232 * |
See also references of WO0077245A1 * |
Also Published As
Publication number | Publication date |
---|---|
AU5615200A (en) | 2001-01-02 |
WO2000077245A1 (en) | 2000-12-21 |
WO2000077245A9 (en) | 2002-06-20 |
EP1187934A1 (en) | 2002-03-20 |
CA2374676A1 (en) | 2000-12-21 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
17P | Request for examination filed |
Effective date: 20020107 |
|
AK | Designated contracting states |
Kind code of ref document: A1 Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE |
|
AX | Request for extension of the european patent |
Free format text: AL;LT;LV;MK;RO;SI |
|
A4 | Supplementary search report drawn up and despatched |
Effective date: 20020617 |
|
AK | Designated contracting states |
Kind code of ref document: A4 Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE |
|
17Q | First examination report despatched |
Effective date: 20040618 |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN |
|
18D | Application deemed to be withdrawn |
Effective date: 20041029 |