EP1185622A4 - Fabrication d'ilots de cellules pancreatiques - Google Patents

Fabrication d'ilots de cellules pancreatiques

Info

Publication number
EP1185622A4
EP1185622A4 EP00941645A EP00941645A EP1185622A4 EP 1185622 A4 EP1185622 A4 EP 1185622A4 EP 00941645 A EP00941645 A EP 00941645A EP 00941645 A EP00941645 A EP 00941645A EP 1185622 A4 EP1185622 A4 EP 1185622A4
Authority
EP
European Patent Office
Prior art keywords
methods
islet cells
pancreatic islet
making pancreatic
making
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP00941645A
Other languages
German (de)
English (en)
Other versions
EP1185622A1 (fr
Inventor
Susan Bonner-Weir
Monica Taneja
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Joslin Diabetes Center Inc
Original Assignee
Joslin Diabetes Center Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Joslin Diabetes Center Inc filed Critical Joslin Diabetes Center Inc
Publication of EP1185622A1 publication Critical patent/EP1185622A1/fr
Publication of EP1185622A4 publication Critical patent/EP1185622A4/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0676—Pancreatic cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/90—Serum-free medium, which may still contain naturally-sourced components
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/117—Keratinocyte growth factors (KGF-1, i.e. FGF-7; KGF-2, i.e. FGF-12)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/22—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from pancreatic cells

Landscapes

  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Cell Biology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
EP00941645A 1999-06-23 2000-06-23 Fabrication d'ilots de cellules pancreatiques Withdrawn EP1185622A4 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US14063999P 1999-06-23 1999-06-23
US140639P 1999-06-23
PCT/US2000/017208 WO2000078929A1 (fr) 1999-06-23 2000-06-23 Fabrication d'ilots de cellules pancreatiques

Publications (2)

Publication Number Publication Date
EP1185622A1 EP1185622A1 (fr) 2002-03-13
EP1185622A4 true EP1185622A4 (fr) 2002-09-18

Family

ID=22492159

Family Applications (1)

Application Number Title Priority Date Filing Date
EP00941645A Withdrawn EP1185622A4 (fr) 1999-06-23 2000-06-23 Fabrication d'ilots de cellules pancreatiques

Country Status (4)

Country Link
EP (1) EP1185622A4 (fr)
AU (1) AU5632600A (fr)
CA (1) CA2375509A1 (fr)
WO (1) WO2000078929A1 (fr)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6610535B1 (en) 2000-02-10 2003-08-26 Es Cell International Pte Ltd. Progenitor cells and methods and uses related thereto
JP2004502425A (ja) * 2000-06-30 2004-01-29 アムサイト，　インコーポレイテッド 指定された中間発生段階を有する膵臓幹細胞の培養
FR2814752A1 (fr) * 2000-10-02 2002-04-05 Chru Lille Procede d'obtention in vitro de cellules insulino- secretrices de mammifere et leurs utilisations
CA2692325C (fr) 2001-12-07 2015-10-20 Geron Corporation Cellules d'ilots pancreatiques provenant de cellules souches embryonnaires humaines
IL162132A0 (en) 2001-12-07 2005-11-20 Geron Corp Chondrocyte precursors derived from human embryonic stem cells
US7101546B2 (en) 2001-12-21 2006-09-05 Amcyte, Inc. In situ maturation of cultured pancreatic stem cells having a specified, intermediate stage of development
WO2004023100A2 (fr) 2002-09-06 2004-03-18 Amcyte Inc. Cellules progenitrices endocrines pancreatiques positives cd56 chez l'etre humain adulte
DE10362002B4 (de) * 2003-06-23 2006-10-12 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Adulte pluripotente Stammzellen
EP1636350B1 (fr) * 2003-06-23 2007-09-12 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Procede pour differencier des cellules souches en cellules qui produisent une hormone pancreatique
US8916184B2 (en) 2003-11-07 2014-12-23 University Of Connecticut Artificial tissue systems and uses thereof
DE102004017476B4 (de) * 2004-04-08 2009-03-26 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Verfahren zur Herstellung einer Epithelzellen enthaltenden Zellzusammensetzung
US20080064034A1 (en) * 2004-05-21 2008-03-13 Fraunhofer-Gesellschaft Zur Förderung Der Angewand Multi-Cellular Test Systems
EP1747264B1 (fr) * 2004-05-21 2012-09-12 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Systemes de culture tissulaire et organique multicellulaires
JP2008520235A (ja) * 2004-11-22 2008-06-19 ラモト アット テル アヴィヴ ユニヴァーシティ リミテッド インスリンを産生可能な拡大され、かつ再分化した成体島β細胞の集団およびその作製方法
WO2007149182A2 (fr) 2006-06-19 2007-12-27 Geron Corporation Différenciation et enrichissement de cellules de type cellules des îlots pancréatiques à partir de cellules souches pluripotentes humaines
WO2013010045A1 (fr) 2011-07-12 2013-01-17 Biotime Inc. Nouveaux procédés et formulations pour thérapie cellulaire orthopédique
US10405961B2 (en) 2013-03-14 2019-09-10 Cell and Molecular Tissue Engineering, LLC Coated surgical mesh, and corresponding systems and methods
US10130288B2 (en) 2013-03-14 2018-11-20 Cell and Molecular Tissue Engineering, LLC Coated sensors, and corresponding systems and methods
CN113308433A (zh) * 2021-04-27 2021-08-27 立沃生物科技（深圳）有限公司 一种胰岛体外培养表面杂细胞处理方法
CN114196614A (zh) * 2021-12-14 2022-03-18 福建省医学科学研究院 pAdM3C感染大鼠胰腺导管细胞促进转分化方法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996040872A1 (fr) * 1995-06-07 1996-12-19 Ontogeny, Inc. Cellules meres du canal biliaire et procedes d'utilisation
US6326201B1 (en) * 1999-02-10 2001-12-04 Curis, Inc. Pancreatic progenitor cells, methods and uses related thereto
WO2002029010A2 (fr) * 2000-10-02 2002-04-11 Centre Hospitalier Regional Universitaire De Lille Procede d'obtention in vitro de cellules insulino-secretrices de mammifere et leurs utilisations

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4439521A (en) * 1981-10-21 1984-03-27 Ontario Cancer Institute Method for producing self-reproducing mammalian pancreatic islet-like structures
US5587309A (en) * 1994-04-29 1996-12-24 The United States Of America As Represented By The Department Of Health And Human Services Method of stimulating proliferation and differentiation of human fetal pancreatic cells ex vivo
US5681587A (en) * 1995-10-06 1997-10-28 Desmos, Inc. Growth of adult pancreatic islet cells

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996040872A1 (fr) * 1995-06-07 1996-12-19 Ontogeny, Inc. Cellules meres du canal biliaire et procedes d'utilisation
US6326201B1 (en) * 1999-02-10 2001-12-04 Curis, Inc. Pancreatic progenitor cells, methods and uses related thereto
WO2002029010A2 (fr) * 2000-10-02 2002-04-11 Centre Hospitalier Regional Universitaire De Lille Procede d'obtention in vitro de cellules insulino-secretrices de mammifere et leurs utilisations

Non-Patent Citations (9)

* Cited by examiner, † Cited by third party
Title
BONNER-WEIR SUSAN ET AL: "Partial pancreatectomy as a model of pancreatic regeneration.", PANCREATIC GROWTH AND REGENERATION., 1997, S. Karger AG;S. Karger AG P.O. Box, Allschwilerstrasse 10, CH-4009 Basel, Switzerland; New York, New York, USA, pages 138 - 153, XP001083955, ISBN: 3-8055-6618-2 *
GMYR V ET AL: "EXPANSION OF HUMAN DUCTAL PANCREATIC STEM CELLS OBTAINED FROM MAIN DUCT, PURIFIED ISLET PREPARATION, OR EXOCRINE TISSUE", ACTA DIABETOLOGICA, SPRINGER INTERNATIONAL, BERLIN, DE, vol. 34, no. 2, 1997, pages 107, XP001010264, ISSN: 0940-5429 *
KERR-CONTE J ET AL: "DUCTAL CYST FORMATION IN COLLAGEN-EMBEDDED ADULT HUMAN ISLET PREPARATIONS A MEANS TO THE REPRODUCTION OF NESIDIOBLASTOSIS IN VITRO", DIABETES, NEW YORK, NY, US, vol. 45, no. 8, August 1996 (1996-08-01), pages 1108 - 1114, XP000939167, ISSN: 0012-1797 *
KERR-CONTE J ET AL: "Model for human islet neogenesis in vitro from adult pancreatic preparations.", TRANSPLANTATION PROCEEDINGS, vol. 27, no. 6, 1995, Fifth Congress of the International Pancreas and Islet Transplant Association: Cure of Diabetes by Transplantation;Miami Beach, Florida, USA; June 18-22, 1995, pages 3268, XP002206387, ISSN: 0041-1345 *
KERR-CONTE J ET AL: "Model for islet cell neogenesis from adult human pancreatic ductal epithelium in vitro", EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY AND DIABETES, JOHANN AMBROSIUS BARTH, DE, vol. 105, no. 4, 1997, pages A28 - A29, XP000925803, ISSN: 0947-7349 *
ROSENBERG L: "IN VIVO CELL TRANSFORMATION: NEOGENESIS OF BETA CELLS FROM PANCREATIC DUCTAL CELLS", CELL TRANSPLANTATION, ELSEVIER SCIENCE, US, vol. 4, no. 4, 1995, pages 371 - 383, XP000939136, ISSN: 0963-6897 *
See also references of WO0078929A1 *
WANG R N ET AL: "PANCREATIC DUCT CELLS EXPRESS GASTRIN AND TGF-ALPHA DURING DUCT TO ISLET-CELL DIFFERENTIATION IN DUCT-LIGATED ADULT RATS", DIABETOLOGIA, BERLIN, DE, vol. 39, no. SUPPL 1, 1996, pages A63, XP000925868, ISSN: 0012-186X *
YUAN S ET AL: "TRANSDIFFERENTIATION OF HUMAN ISLETS TO PANCREATIC DUCTAL CELLS IN COLLAGEN MATRIX CULTURE", DIFFERENTIATION, SPRINGER VERLAG, DE, vol. 61, no. 1, 1996, pages 67 - 75, XP000939119, ISSN: 0301-4681 *

Also Published As

Publication number Publication date
CA2375509A1 (fr) 2000-12-28
WO2000078929A1 (fr) 2000-12-28
EP1185622A1 (fr) 2002-03-13
AU5632600A (en) 2001-01-09

Similar Documents

Publication Publication Date Title
EP1185622A4 (fr) Fabrication d'ilots de cellules pancreatiques
IL149175A (en) Methods for production of pluripotent cells
IL144359A0 (en) Immortalized cell lines and methods of making the same
GB9900396D0 (en) Arrangements of electrochemical cells
AU3867400A (en) Methods of using bioelastomers
AU2557500A (en) Methods of making compounds
EP1226026A4 (fr) Procede de fabrication ameliore de corps cuits
EP1183030A4 (fr) Procede de fabrication et d'application de n-desmethylzopiclone
AU2001268197A1 (en) Human pancreatic islet glucose-6-phosphatase
HUP0105168A3 (en) Transplantation of haematopoietic cells
AU3350201A (en) Pancreatic islet cell growth factors
AU2001233502A1 (en) Pancreatic islet cell growth factors
GB9900398D0 (en) Arrangements of electrochemical cells
AU1082901A (en) Method for modulation of cell phenotype
GB9929061D0 (en) Methods of producing novel enzymes
GB9904773D0 (en) Culture of mycobacteria
PL341752A1 (en) Method of obtaining aryloamino hydroxyantraquinones
GB9924752D0 (en) Method of construction
AU2001234099A1 (en) Artificial pancreatic islet reconstituted from isolated pancreatic endocrine cells
GB9919351D0 (en) Rings of tetrahedra
TW508002U (en) Improved structure of earphone
GB9916363D0 (en) Methods of suppressing cell growth
PL331683A1 (en) Method of obtaining sulphoxides
GB2365815B (en) Manufacture of optical elements
TW415179U (en) Improved structure of earrings

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 20011220

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

AX Request for extension of the european patent

Free format text: AL;LT;LV;MK;RO;SI

RIN1 Information on inventor provided before grant (corrected)

Inventor name: TANEJA, MONICA

Inventor name: BONNER-WEIR, SUSAN

RIC1 Information provided on ipc code assigned before grant

Free format text: 7C 12N 5/00 A, 7C 12N 5/02 B, 7C 12N 5/06 B

A4 Supplementary search report drawn up and despatched

Effective date: 20020802

AK Designated contracting states

Kind code of ref document: A4

Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

RBV Designated contracting states (corrected)

Designated state(s): CH DE DK FR GB LI

17Q First examination report despatched

Effective date: 20050503

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 20080229