EP1180937A4 - Strains of bacteriophage useful for rescuing patients infected with vancomycin-resistant enterococcus faecium - Google Patents

Strains of bacteriophage useful for rescuing patients infected with vancomycin-resistant enterococcus faecium

Info

Publication number
EP1180937A4
EP1180937A4 EP00931911A EP00931911A EP1180937A4 EP 1180937 A4 EP1180937 A4 EP 1180937A4 EP 00931911 A EP00931911 A EP 00931911A EP 00931911 A EP00931911 A EP 00931911A EP 1180937 A4 EP1180937 A4 EP 1180937A4
Authority
EP
European Patent Office
Prior art keywords
vancomycin
strains
enterococcus faecium
patients infected
resistant enterococcus
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP00931911A
Other languages
German (de)
French (fr)
Other versions
EP1180937A1 (en
Inventor
Carl R Merril
Richard M Carlton
Sankar Adhya
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
National Institutes of Health NIH
Exponential Biotherapies Inc
Original Assignee
National Institutes of Health NIH
Exponential Biotherapies Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by National Institutes of Health NIH, Exponential Biotherapies Inc filed Critical National Institutes of Health NIH
Publication of EP1180937A1 publication Critical patent/EP1180937A1/en
Publication of EP1180937A4 publication Critical patent/EP1180937A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/09—Lactobacillales, e.g. aerococcus, enterococcus, lactobacillus, lactococcus, streptococcus
    • A61K39/092—Streptococcus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/76—Viruses; Subviral particles; Bacteriophages
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2795/00—Bacteriophages
    • C12N2795/00011—Details
    • C12N2795/10011—Details dsDNA Bacteriophages
    • C12N2795/10311—Siphoviridae
    • C12N2795/10332—Use of virus as therapeutic agent, other than vaccine, e.g. as cytolytic agent

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Virology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)
EP00931911A 1999-05-13 2000-05-12 Strains of bacteriophage useful for rescuing patients infected with vancomycin-resistant enterococcus faecium Withdrawn EP1180937A4 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US13405599P 1999-05-13 1999-05-13
US134055P 1999-05-13
PCT/US2000/006718 WO2000069269A1 (en) 1999-05-13 2000-05-12 Strains of bacteriophage useful for rescuing patients infected with vancomycin-resistant enterococcus faecium

Publications (2)

Publication Number Publication Date
EP1180937A1 EP1180937A1 (en) 2002-02-27
EP1180937A4 true EP1180937A4 (en) 2004-08-04

Family

ID=22461568

Family Applications (1)

Application Number Title Priority Date Filing Date
EP00931911A Withdrawn EP1180937A4 (en) 1999-05-13 2000-05-12 Strains of bacteriophage useful for rescuing patients infected with vancomycin-resistant enterococcus faecium

Country Status (5)

Country Link
EP (1) EP1180937A4 (en)
JP (1) JP2002543816A (en)
AU (1) AU4971900A (en)
CA (1) CA2373486A1 (en)
WO (1) WO2000069269A1 (en)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1230206C (en) * 2000-01-11 2005-12-07 内立蒂克斯股份有限公司 Polymer blends as biodegradable matrices for preparing biocomposites
US6759229B2 (en) 2001-12-18 2004-07-06 President & Fellows Of Harvard College Toxin-phage bacteriocide antibiotic and uses thereof
GB0209680D0 (en) * 2002-04-27 2002-06-05 Univ Strathclyde Immobilisation and stabilisation of bacteriophage
WO2004052274A2 (en) 2002-12-09 2004-06-24 Phage Biopharm Llc Production of bacteriophage compositions for use in phage therapy
DE10342071B4 (en) * 2003-09-10 2006-01-19 Fleischmann, Wilhelm, Dr.med. Device and method for applying substances to a wound surface
EP2004800B1 (en) 2006-04-04 2014-01-15 Henry Morris Krisch Process of production of bacteriophage compositions and methods in phage therapy field
KR100958139B1 (en) * 2008-03-31 2010-05-18 주식회사 인트론바이오테크놀로지 Novel Bacteriophage Having Killing Activity Specific to Enterococcus faecalis
KR100988771B1 (en) * 2008-09-29 2010-10-20 주식회사 인트론바이오테크놀로지 Novel Lysin Protein Having Killing Activity Specific to Enterococcus and Streptococcus
PL215522B1 (en) 2008-09-29 2013-12-31 Inst Immunologii I Terapii Doswiadczalnej Pan New strains of bacteriophages for treatment of bacterial infections, preferably by means of the strains of drug-resistant bacterias of the Enterococcus type
CA3019013C (en) * 2009-02-06 2020-12-15 Technophage, Investigacao E Desenvolvimento Em Biotecnologia, Sa Antibacterial phage, phage peptides and methods of use thereof
US20190307818A1 (en) 2016-04-08 2019-10-10 The Trustees Of Princeton University Novel antimicrobial compositions and methods of use
KR101822812B1 (en) * 2017-02-22 2018-01-29 주식회사 인트론바이오테크놀로지 Novel Enterococcus faecium bacteriophage Ent-FAP-4 and its use for preventing proliferation of Enterococcus faecium
KR101957266B1 (en) * 2017-02-22 2019-03-13 주식회사 인트론바이오테크놀로지 Novel antibacterial protein EFAL-2 having lytic activity against Enterococcus faecium
GB201712733D0 (en) 2017-08-08 2017-09-20 Snipr Tech Ltd Methods & cells
KR102203679B1 (en) * 2018-12-26 2021-01-15 주식회사 옵티팜 Novel Enterococcus faecium specific bacteriophage EF44 and antibacterial composition comprising the same
GB201901099D0 (en) 2019-01-27 2019-03-13 Snipr Biome Aps Methods, uses and compositions
WO2022264035A1 (en) * 2021-06-15 2022-12-22 Ferring B.V. Bacteriophages against vancomycin-resistant enterococci
EP4392550A1 (en) 2022-06-29 2024-07-03 SNIPR Biome ApS. Targeting e coli cells
GB202209518D0 (en) 2022-06-29 2022-08-10 Snipr Biome Aps Treating & preventing E coli infections

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5766892A (en) * 1994-04-05 1998-06-16 Exponential Biotherapies, Inc. Antibacterial therapy with bacteriophage genotypically modified to delay inactivation by the host defense system together with an antibiotic

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5766892A (en) * 1994-04-05 1998-06-16 Exponential Biotherapies, Inc. Antibacterial therapy with bacteriophage genotypically modified to delay inactivation by the host defense system together with an antibiotic

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
ALISKY J ET AL: "BACTERIOPHAGE SHOW PROMISE AS ANTIMICROBIAL AGENTS", JOURNAL OF INFECTION, ACADEMIC PRESS, LONDON, GB, vol. 36, 1998, pages 5 - 15, XP000993238, ISSN: 0163-4453 *
See also references of WO0069269A1 *

Also Published As

Publication number Publication date
JP2002543816A (en) 2002-12-24
AU4971900A (en) 2000-12-05
EP1180937A1 (en) 2002-02-27
WO2000069269A1 (en) 2000-11-23
CA2373486A1 (en) 2000-11-23
WO2000069269A9 (en) 2002-02-21

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