EP1180022A4 - Prozess zur massenherstellung von pharmazeutischem material mit einheitlicher löslichkeit - Google Patents

Prozess zur massenherstellung von pharmazeutischem material mit einheitlicher löslichkeit

Info

Publication number
EP1180022A4
EP1180022A4 EP99927538A EP99927538A EP1180022A4 EP 1180022 A4 EP1180022 A4 EP 1180022A4 EP 99927538 A EP99927538 A EP 99927538A EP 99927538 A EP99927538 A EP 99927538A EP 1180022 A4 EP1180022 A4 EP 1180022A4
Authority
EP
European Patent Office
Prior art keywords
bulk material
preparing pharmaceutical
uniform dissolution
pharmaceutical bulk
dissolution
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP99927538A
Other languages
English (en)
French (fr)
Other versions
EP1180022A1 (de
Inventor
Frank Brown Jr
Robert Alan Forbes
Arlette Faye Kreager
Michael Vincent Mullen
Gregory Alan Stephenson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Publication of EP1180022A1 publication Critical patent/EP1180022A1/de
Publication of EP1180022A4 publication Critical patent/EP1180022A4/de
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1688—Processes resulting in pure drug agglomerate optionally containing up to 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
EP99927538A 1999-05-14 1999-06-15 Prozess zur massenherstellung von pharmazeutischem material mit einheitlicher löslichkeit Withdrawn EP1180022A4 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US13421599P 1999-05-14 1999-05-14
US134215P 1999-05-14
PCT/US1999/013481 WO2000069417A1 (en) 1999-05-14 1999-06-15 Process for preparing pharmaceutical bulk material having uniform dissolution

Publications (2)

Publication Number Publication Date
EP1180022A1 EP1180022A1 (de) 2002-02-20
EP1180022A4 true EP1180022A4 (de) 2004-01-07

Family

ID=22462288

Family Applications (1)

Application Number Title Priority Date Filing Date
EP99927538A Withdrawn EP1180022A4 (de) 1999-05-14 1999-06-15 Prozess zur massenherstellung von pharmazeutischem material mit einheitlicher löslichkeit

Country Status (3)

Country Link
EP (1) EP1180022A4 (de)
AU (1) AU4441899A (de)
WO (1) WO2000069417A1 (de)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6465615B1 (en) * 2001-09-10 2002-10-15 Astrazeneca Ab Monohydrate lisinopril
US6468976B1 (en) * 2001-09-10 2002-10-22 Astrazeneca Ab Monohydrate lisinopril

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4713247A (en) * 1983-06-15 1987-12-15 Shionogi & Co., Ltd. Long-acting formulation of cefaclor
US4968508A (en) * 1987-02-27 1990-11-06 Eli Lilly And Company Sustained release matrix
US5516531A (en) * 1987-01-29 1996-05-14 Takeda Chemical Industries, Ltd. Spherical granules having core and their production
US5837292A (en) * 1996-07-03 1998-11-17 Yamanouchi Europe B.V. Granulate for the preparation of fast-disintegrating and fast-dissolving compositions containing a high amount of drug

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1251999B (it) * 1991-11-11 1995-05-27 Opos Biochimica Srl Forma cristallina di un antibiotico cefalosporinico

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4713247A (en) * 1983-06-15 1987-12-15 Shionogi & Co., Ltd. Long-acting formulation of cefaclor
US5516531A (en) * 1987-01-29 1996-05-14 Takeda Chemical Industries, Ltd. Spherical granules having core and their production
US4968508A (en) * 1987-02-27 1990-11-06 Eli Lilly And Company Sustained release matrix
US5837292A (en) * 1996-07-03 1998-11-17 Yamanouchi Europe B.V. Granulate for the preparation of fast-disintegrating and fast-dissolving compositions containing a high amount of drug

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
CHOW ALBERT H L ET AL: "Parameters affecting in-liquid drying microencapsulation and release rate of cefaclor.", INTERNATIONAL JOURNAL OF PHARMACEUTICS (AMSTERDAM), vol. 172, no. 1-2, 15 October 1998 (1998-10-15), pages 113 - 125, XP001147521, ISSN: 0378-5173 *
See also references of WO0069417A1 *

Also Published As

Publication number Publication date
WO2000069417A1 (en) 2000-11-23
EP1180022A1 (de) 2002-02-20
AU4441899A (en) 2000-12-05

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Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

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Effective date: 20011214

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Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

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Ipc: 7A 61K 31/546 B

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Ipc: 7A 61K 9/48 A

A4 Supplementary search report drawn up and despatched

Effective date: 20031110

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 20060103