EP1165059A4 - Pharmaceutical compositions comprising troponin subunits, fragments and homologs thereof and methods of their use to inhibit angiogenesis - Google Patents

Pharmaceutical compositions comprising troponin subunits, fragments and homologs thereof and methods of their use to inhibit angiogenesis

Info

Publication number
EP1165059A4
EP1165059A4 EP00916329A EP00916329A EP1165059A4 EP 1165059 A4 EP1165059 A4 EP 1165059A4 EP 00916329 A EP00916329 A EP 00916329A EP 00916329 A EP00916329 A EP 00916329A EP 1165059 A4 EP1165059 A4 EP 1165059A4
Authority
EP
European Patent Office
Prior art keywords
homologs
fragments
methods
pharmaceutical compositions
inhibit angiogenesis
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP00916329A
Other languages
German (de)
French (fr)
Other versions
EP1165059A1 (en
Inventor
Richard M Thorn
Marc E Lanser
Marsha A Moses
Dmitri G Wiederschain
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Childrens Medical Center Corp
Alseres Pharmaceuticals Inc
Original Assignee
Childrens Medical Center Corp
Boston Life Sciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/442,099 external-priority patent/US6465431B1/en
Application filed by Childrens Medical Center Corp, Boston Life Sciences Inc filed Critical Childrens Medical Center Corp
Publication of EP1165059A1 publication Critical patent/EP1165059A1/en
Publication of EP1165059A4 publication Critical patent/EP1165059A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4716—Muscle proteins, e.g. myosin, actin

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Genetics & Genomics (AREA)
  • Pulmonology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Ophthalmology & Optometry (AREA)
  • Molecular Biology (AREA)
  • Oncology (AREA)
  • Toxicology (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
EP00916329A 1999-03-15 2000-03-14 Pharmaceutical compositions comprising troponin subunits, fragments and homologs thereof and methods of their use to inhibit angiogenesis Withdrawn EP1165059A4 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US26827499A 1999-03-15 1999-03-15
US442099 1999-11-17
US09/442,099 US6465431B1 (en) 1999-11-17 1999-11-17 Pharmaceutical compositions comprising troponin subunits, fragments and homologs thereof and methods of their use to inhibit angiogenesis
PCT/US2000/006667 WO2000054770A1 (en) 1999-03-15 2000-03-14 Pharmaceutical compositions comprising troponin subunits, fragments and homologs thereof and methods of their use to inhibit angiogenesis
US268274 2008-11-10

Publications (2)

Publication Number Publication Date
EP1165059A1 EP1165059A1 (en) 2002-01-02
EP1165059A4 true EP1165059A4 (en) 2003-03-05

Family

ID=26952984

Family Applications (1)

Application Number Title Priority Date Filing Date
EP00916329A Withdrawn EP1165059A4 (en) 1999-03-15 2000-03-14 Pharmaceutical compositions comprising troponin subunits, fragments and homologs thereof and methods of their use to inhibit angiogenesis

Country Status (5)

Country Link
EP (1) EP1165059A4 (en)
JP (1) JP2002539161A (en)
AU (1) AU774596B2 (en)
CA (1) CA2367611A1 (en)
WO (1) WO2000054770A1 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE602004030898D1 (en) 2003-04-16 2011-02-17 Tasuku Honjo SCREENING METHOD FOR REMEDIES FOR HEART DISEASE AND MEDICAL COMPOSITION FOR THE TREATMENT OF HEART DISEASE
JP2007526763A (en) * 2004-01-27 2007-09-20 コンピュゲン エルティーディー． Novel nucleotide and amino acid sequences and assays and methods using them in the diagnosis of heart disease
WO2010010153A1 (en) * 2008-07-23 2010-01-28 F. Hoffmann-La Roche Ag Identification of subjects being susceptible to anti-angiogenesis therapy
JP5553547B2 (en) * 2009-07-14 2014-07-16 俊一 梶岡 Troponin-containing pharmaceutical composition

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997030085A1 (en) * 1996-02-16 1997-08-21 Children's Medical Center Corporation Troponin subunits and fragments useful as angiogenesis inhibitors

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997030085A1 (en) * 1996-02-16 1997-08-21 Children's Medical Center Corporation Troponin subunits and fragments useful as angiogenesis inhibitors

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
FELDMAN LAURIE ET AL: "Troponin I inhibits capillary endothelial cell proliferation by interaction with the cell's bFGF receptor.", MICROVASCULAR RESEARCH, vol. 63, no. 1, January 2002 (2002-01-01), pages 41 - 49, XP002218582, ISSN: 0026-2862 *
JHA PRAKASH K. ET AL: "Interaction of deletion mutants of troponins I and T: COOH-terminal truncation of troponin T abolishes troponin I binding and reduces Ca-2+ sensitivity of the reconstituted regulatory system", BIOCHEMISTRY, vol. 35, no. 51, 1996, pages 16573 - 16580 *
JHA PRAKASH K. ET AL: "Photo-cross-linking of rabbit skeletal troponin I deletion mutants with troponin C and its thiol mutants: The inhibitory region enhances binding of troponin I fragments to troponin C", BIOCHEMISTRY, vol. 35, no. 34, 1996, pages 11026 - 11035 *
MOSES M A ET AL: "Troponin I is present in human cartilage and inhibits angiogenesis", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, NATIONAL ACADEMY OF SCIENCE. WASHINGTON, US, vol. 96, 16 March 1999 (1999-03-16), pages 2645 - 2650, XP002131230, ISSN: 0027-8424 *
See also references of WO0054770A1 *
VALLINS W J ET AL: "MOLECULAR CLONING OF HUMAN CARDIAC TROPONIN I USING POLYMERASE CHAIN REACTION", FEBS LETTERS, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, vol. 270, no. 1/2, 17 September 1990 (1990-09-17), pages 57 - 61, XP000470204, ISSN: 0014-5793 *

Also Published As

Publication number Publication date
WO2000054770A8 (en) 2001-01-11
AU774596B2 (en) 2004-07-01
EP1165059A1 (en) 2002-01-02
CA2367611A1 (en) 2000-09-21
WO2000054770A1 (en) 2000-09-21
AU3744900A (en) 2000-10-04
JP2002539161A (en) 2002-11-19

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Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 20011011

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

AX Request for extension of the european patent

Free format text: AL;LT;LV;MK;RO;SI

RIN1 Information on inventor provided before grant (corrected)

Inventor name: THORN, RICHARD, M.

Inventor name: MOSES, MARSHA, A.

Inventor name: LANSER, MARC, E.

Inventor name: WIEDERSCHAIN, DMITRI, G.

RIC1 Information provided on ipc code assigned before grant

Free format text: 7A 61K 38/08 A, 7A 61K 38/10 B, 7C 07K 7/06 B, 7C 07K 7/08 B, 7A 61P 35/00 B

A4 Supplementary search report drawn up and despatched

Effective date: 20030120

17Q First examination report despatched

Effective date: 20030702

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 20050906