EP1158972A4 - Behandlung des Bluthochdrucks mit Verbindungen die die Zerstörung der Enkephaline und der Endorphine hemmen - Google Patents

Behandlung des Bluthochdrucks mit Verbindungen die die Zerstörung der Enkephaline und der Endorphine hemmen

Info

Publication number
EP1158972A4
EP1158972A4 EP00903252A EP00903252A EP1158972A4 EP 1158972 A4 EP1158972 A4 EP 1158972A4 EP 00903252 A EP00903252 A EP 00903252A EP 00903252 A EP00903252 A EP 00903252A EP 1158972 A4 EP1158972 A4 EP 1158972A4
Authority
EP
European Patent Office
Prior art keywords
enkephalins
endorphins
hypertension
destruction
inhibit
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP00903252A
Other languages
English (en)
French (fr)
Other versions
EP1158972A1 (de
Inventor
Seymour Ehrenpreis
Kenneth Blum
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of EP1158972A1 publication Critical patent/EP1158972A1/de
Publication of EP1158972A4 publication Critical patent/EP1158972A4/de
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/401—Proline; Derivatives thereof, e.g. captopril
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Inorganic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
EP00903252A 1999-01-12 2000-01-12 Behandlung des Bluthochdrucks mit Verbindungen die die Zerstörung der Enkephaline und der Endorphine hemmen Withdrawn EP1158972A4 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US11572499P 1999-01-12 1999-01-12
US115724P 1999-01-12
PCT/US2000/000722 WO2000041686A1 (en) 1999-01-12 2000-01-12 Treatment of hypertension with compounds that inhibit the destruction of enkephalins or endorphins

Publications (2)

Publication Number Publication Date
EP1158972A1 EP1158972A1 (de) 2001-12-05
EP1158972A4 true EP1158972A4 (de) 2003-05-02

Family

ID=22363061

Family Applications (1)

Application Number Title Priority Date Filing Date
EP00903252A Withdrawn EP1158972A4 (de) 1999-01-12 2000-01-12 Behandlung des Bluthochdrucks mit Verbindungen die die Zerstörung der Enkephaline und der Endorphine hemmen

Country Status (4)

Country Link
EP (1) EP1158972A4 (de)
AU (1) AU2502700A (de)
CA (1) CA2363847A1 (de)
WO (1) WO2000041686A1 (de)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE476188T1 (de) * 2002-05-14 2010-08-15 Nipro Corp Medikament zur prävention und behandlung von familiärer amyloid polyneuropathie
US9937146B2 (en) 2016-03-23 2018-04-10 Bioadatp, Llc Enkephalin-influencing composition and method

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DD229931A1 (de) * 1984-11-09 1985-11-20 Adw Ddr Verfahren zur herstellung eines mittels mit antistresswirkung
US4749688A (en) * 1986-06-20 1988-06-07 Schering Corporation Use of neutral metalloendopeptidase inhibitors in the treatment of hypertension
GB2286528A (en) * 1994-02-17 1995-08-23 Robert John Woodward Dietary supplement

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5238932A (en) * 1992-05-20 1993-08-24 Merrell Dow Pharmaceuticals Inc. Mercaptoacetylamide tricyclic derivatives useful as inhibitors of enkephalinase
US5420271A (en) * 1992-08-24 1995-05-30 Merrell Dow Pharmaceuticals, Inc. 2-substituted indane-2-mercaptoacetylamide tricyclic derivatives useful as inhibitors of enkephalinase
US5425954A (en) * 1993-09-30 1995-06-20 Curafas Incorporated Topical amino acid - vitamin complex compositions for pharmaceutical and cosmetic use

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DD229931A1 (de) * 1984-11-09 1985-11-20 Adw Ddr Verfahren zur herstellung eines mittels mit antistresswirkung
US4749688A (en) * 1986-06-20 1988-06-07 Schering Corporation Use of neutral metalloendopeptidase inhibitors in the treatment of hypertension
GB2286528A (en) * 1994-02-17 1995-08-23 Robert John Woodward Dietary supplement

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of WO0041686A1 *

Also Published As

Publication number Publication date
CA2363847A1 (en) 2000-07-20
EP1158972A1 (de) 2001-12-05
AU2502700A (en) 2000-08-01
WO2000041686A1 (en) 2000-07-20

Similar Documents

Publication Publication Date Title
HRP20020253A2 (en) Compounds for the treatment of ischemia
EP1147226A4 (de) Materialien und verfahren zur reinigung von polyelektrolyten
ID16493A (id) Perlakuan bahan yang mengandung padatan yang diambil dari efluen
ZA9811507B (en) Combination effective for the treatment of impotence.
AU5089400A (en) Arthritis treatment
AU5038299A (en) Process for the biocidal treatment of surfaces
GB9805419D0 (en) Treatment of liquids
AU2001260834A1 (en) The treatment of herpes
NO20013146D0 (no) Middel for behandling av synscellefunksjonsforstyrrelser
ZA9810027B (en) Treatment of organic materials.
AUPP989499A0 (en) Treated closures 3
HUP0302738A3 (en) Use of sarp-1 for the treatment and/or prevention of scleroderma
EP1158972A4 (de) Behandlung des Bluthochdrucks mit Verbindungen die die Zerstörung der Enkephaline und der Endorphine hemmen
AUPP989299A0 (en) Treated closures 1
AU1940800A (en) Combination therapy for the treatment of sepsis
AUPP989399A0 (en) Treated closures 2
NO20012616L (no) Middel til behandling av erektil malfunksjon
AU5533599A (en) Massaging protrusion structure and hula-hoop using massaging protrusion structures having the massaging protrusion structure
AU2596300A (en) Steam explosion treatment with addition of chemicals
AU3273800A (en) Mini sewage treatment plant and use of the plant
NO20011268D0 (no) Forbindelse til behandling av depresjon
ZA9711116B (en) The treatment of materials.
ZA988304B (en) The treatment of liquids
SI1068199T1 (en) N-aryloxyethyl-indoly-alkylamines for the treatment of depression
HU9802470D0 (en) Impede the destruction of oak tree and chestnuttree

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 20010813

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

AX Request for extension of the european patent

Free format text: AL;LT;LV;MK;RO;SI

RIC1 Information provided on ipc code assigned before grant

Free format text: 7A 61K 45/00 A, 7A 61K 31/198 B, 7A 61K 31/401 B, 7A 61K 31/52 B, 7A 61P 9/12 B

A4 Supplementary search report drawn up and despatched

Effective date: 20030317

17Q First examination report despatched

Effective date: 20030701

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 20040113