EP1154801A4 - Integration of transplanted neural progenitor cells into neural tissue of immature and mature dystrophic recipients - Google Patents

Integration of transplanted neural progenitor cells into neural tissue of immature and mature dystrophic recipients

Info

Publication number
EP1154801A4
EP1154801A4 EP00907260A EP00907260A EP1154801A4 EP 1154801 A4 EP1154801 A4 EP 1154801A4 EP 00907260 A EP00907260 A EP 00907260A EP 00907260 A EP00907260 A EP 00907260A EP 1154801 A4 EP1154801 A4 EP 1154801A4
Authority
EP
European Patent Office
Prior art keywords
immature
recipients
integration
progenitor cells
neural
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP00907260A
Other languages
German (de)
French (fr)
Other versions
EP1154801A1 (en
Inventor
Michael J Young
Fred H Gage
Jasodhara Ray
Simon J Whiteley
Henry Klassen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Schepens Eye Research Institute Inc
Salk Institute for Biological Studies
Original Assignee
Schepens Eye Research Institute Inc
Salk Institute for Biological Studies
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schepens Eye Research Institute Inc, Salk Institute for Biological Studies filed Critical Schepens Eye Research Institute Inc
Publication of EP1154801A1 publication Critical patent/EP1154801A1/en
Publication of EP1154801A4 publication Critical patent/EP1154801A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0618—Cells of the nervous system
    • C12N5/0623—Stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/115—Basic fibroblast growth factor (bFGF, FGF-2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00—Genetically modified cells

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Addiction (AREA)
  • Psychiatry (AREA)
  • Diabetes (AREA)
  • Ophthalmology & Optometry (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Pain & Pain Management (AREA)
  • Biotechnology (AREA)
  • Psychology (AREA)
  • Hematology (AREA)
  • Hospice & Palliative Care (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Developmental Biology & Embryology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cell Biology (AREA)
  • Cardiology (AREA)
  • Microbiology (AREA)
EP00907260A 1999-02-11 2000-02-11 Integration of transplanted neural progenitor cells into neural tissue of immature and mature dystrophic recipients Withdrawn EP1154801A4 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US11964299P 1999-02-11 1999-02-11
US119642P 1999-02-11
PCT/US2000/003534 WO2000047238A1 (en) 1999-02-11 2000-02-11 Integration of transplanted neural progenitor cells into neural tissue of immature and mature dystrophic recipients

Publications (2)

Publication Number Publication Date
EP1154801A1 EP1154801A1 (en) 2001-11-21
EP1154801A4 true EP1154801A4 (en) 2002-08-21

Family

ID=22385498

Family Applications (1)

Application Number Title Priority Date Filing Date
EP00907260A Withdrawn EP1154801A4 (en) 1999-02-11 2000-02-11 Integration of transplanted neural progenitor cells into neural tissue of immature and mature dystrophic recipients

Country Status (5)

Country Link
EP (1) EP1154801A4 (en)
JP (1) JP2002536423A (en)
AU (1) AU2878400A (en)
CA (1) CA2362476A1 (en)
WO (1) WO2000047238A1 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002036749A2 (en) * 2000-11-06 2002-05-10 The Salk Institute For Biological Studies Postmortem stem cells
CA2493849A1 (en) 2002-07-12 2004-01-22 University Of Washington Methods and systems for extended in vitro culture of neuronal cells
US20060134078A1 (en) * 2002-12-02 2006-06-22 Anges Mg, Inc. Method for culturing neural stem cells using hepatocyte growth factor
WO2007130060A2 (en) 2006-05-03 2007-11-15 Schepens Eye Research Isolation and therapeutic application of adult retinal stem cells collected from extra-retinal tissues
US9061017B2 (en) 2006-05-03 2015-06-23 The Schepens Eye Research Institute, Inc. Isolation and therapeutic application of adult retinal stem cells collected from extra-retinal tissues
JO3626B1 (en) * 2012-02-23 2020-08-27 Merial Inc Topical compositions comprising fipronil and permethrin and methods of use

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
GAGE F H ET AL: "SURVIVAL AND DIFFERENTIATION OF ADULT NEURONAL PROGENITOR CELLS TRANSPLANTED TO THE ADULT BRAIN", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, NATIONAL ACADEMY OF SCIENCE. WASHINGTON, US, vol. 92, 1 December 1995 (1995-12-01), pages 11879 - 11883, XP002034681, ISSN: 0027-8424 *
See also references of WO0047238A1 *
SUHONEN JAANA O ET AL: "Differentiation of adult hippocampus-derived progenitors into olfactory neurons in vivo.", NATURE (LONDON), vol. 383, no. 6601, 1996, pages 624 - 627, XP002203051, ISSN: 0028-0836 *
TAKAHASHI M ET AL: "WIDESPREAD INTEGRATION AND SURVIVAL OF ADULT-DERIVED NEURAL PROGENITOR CELLS IN THE DEVELOPING OPTIC RETINA", MOLECULAR AND CELLULAR NEUROSCIENCES, SAN DIEGO, US, vol. 12, December 1998 (1998-12-01), pages 340 - 348, XP002926797, ISSN: 1044-7431 *

Also Published As

Publication number Publication date
CA2362476A1 (en) 2000-08-17
AU2878400A (en) 2000-08-29
WO2000047238A1 (en) 2000-08-17
EP1154801A1 (en) 2001-11-21
JP2002536423A (en) 2002-10-29
WO2000047238A9 (en) 2001-07-26

Similar Documents

Publication Publication Date Title
IL137946A0 (en) Intracardiac cell delivery and cell transplantation
IL149387A0 (en) Hematopoietic differentiation of human embryonic stem cells
AU2730497A (en) Cryopreservation and extensive subculturing of human mesenchymal stem cells
AU2900792A (en) Neomorphogenesis of urological structures in vivo from cell culture
GB9900396D0 (en) Arrangements of electrochemical cells
AU2001278877A1 (en) A composition for the delivery of live cells and methods of use
EP0793501A4 (en) In vivo activation of tumor-specific cytotoxic t cells
AU2951599A (en) Synthesis of biologically active compounds in cells
IL149043A0 (en) Methods of producing differentiated progenitor cells and lineage-defective embryonic stem cells
EP1176986A4 (en) Differentiation of monocytes into functional dendritic cells
AU2001260847A1 (en) Compositions isolated from skin cells and methods for their use
AU4751297A (en) Solid electrolytes containing toughening agents and electrolytic cells produced therefrom
AU2002323526A1 (en) Use of recipient endothelial cells for enhanced vascularization of tissue and tissue-engineered construct transplants
AU1478000A (en) (in utero) transplantation of human mesenchymal stem cells
EP1185555A4 (en) Compositions isolated from skin cells and methods for their use
GB9925964D0 (en) Hair transplantation
IL139435A0 (en) Antibodies to dendritic cells and human dendritic cell populations and uses thereof
EP1154801A4 (en) Integration of transplanted neural progenitor cells into neural tissue of immature and mature dystrophic recipients
HK1045329A1 (en) Generation and characterization of a dendritic cell isolated from human peripheral blood mononuclear cells
AU4378996A (en) Cell compositions for use in transplantation and ex vivo gene therapy
GB9900398D0 (en) Arrangements of electrochemical cells
GB9916790D0 (en) Storage of microorganisms,cells and tissue
AU2001217686A1 (en) Method of establishing cultures of human dendritic cells and use thereof
AU4299696A (en) Use of the hepatocyte growth factor to induce proliferation and differentiation of hemopoietic cells
AU1284999A (en) (in vitro) differentiation of vascular smooth muscle cells, methods and reagentsrelated thereto

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 20010911

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

AX Request for extension of the european patent

Free format text: AL;LT;LV;MK;RO;SI

A4 Supplementary search report drawn up and despatched

Effective date: 20020708

AK Designated contracting states

Kind code of ref document: A4

Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 20030902