EP1150673A4 - Mono-acyloxy aralkyl neuromuscular relaxants - Google Patents

Mono-acyloxy aralkyl neuromuscular relaxants

Info

Publication number
EP1150673A4
EP1150673A4 EP00904621A EP00904621A EP1150673A4 EP 1150673 A4 EP1150673 A4 EP 1150673A4 EP 00904621 A EP00904621 A EP 00904621A EP 00904621 A EP00904621 A EP 00904621A EP 1150673 A4 EP1150673 A4 EP 1150673A4
Authority
EP
European Patent Office
Prior art keywords
acyloxy
aralkyl
mono
neuromuscular relaxants
relaxants
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP00904621A
Other languages
German (de)
French (fr)
Other versions
EP1150673A1 (en
Inventor
Chingmuh Lee
Laszlo Gyermek
Young-Moon Cho
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Newlaxant LLC
Original Assignee
Newlaxant LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Newlaxant LLC filed Critical Newlaxant LLC
Publication of EP1150673A1 publication Critical patent/EP1150673A1/en
Publication of EP1150673A4 publication Critical patent/EP1150673A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/44—Oxygen atoms attached in position 4
    • C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Steroid Compounds (AREA)
EP00904621A 1999-02-01 2000-01-31 Mono-acyloxy aralkyl neuromuscular relaxants Withdrawn EP1150673A4 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US11839299P 1999-02-01 1999-02-01
US118392P 1999-02-01
PCT/US2000/002228 WO2000044377A1 (en) 1999-02-01 2000-01-31 Mono-acyloxy aralkyl neuromuscular relaxants

Publications (2)

Publication Number Publication Date
EP1150673A1 EP1150673A1 (en) 2001-11-07
EP1150673A4 true EP1150673A4 (en) 2002-04-24

Family

ID=22378296

Family Applications (1)

Application Number Title Priority Date Filing Date
EP00904621A Withdrawn EP1150673A4 (en) 1999-02-01 2000-01-31 Mono-acyloxy aralkyl neuromuscular relaxants

Country Status (21)

Country Link
EP (1) EP1150673A4 (en)
JP (1) JP2002535366A (en)
KR (1) KR20010108125A (en)
CN (1) CN1338934A (en)
AR (1) AR022472A1 (en)
AU (1) AU2634900A (en)
BR (1) BR0007863A (en)
CA (1) CA2360790A1 (en)
CO (1) CO5170470A1 (en)
CZ (1) CZ20012780A3 (en)
HK (1) HK1039455A1 (en)
HU (1) HUP0200413A3 (en)
IL (1) IL144249A0 (en)
MX (1) MXPA01007783A (en)
NO (1) NO20013741L (en)
NZ (1) NZ513064A (en)
PE (1) PE20001593A1 (en)
PL (1) PL349099A1 (en)
TR (1) TR200102196T2 (en)
WO (1) WO2000044377A1 (en)
ZA (1) ZA200105882B (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0204087D0 (en) * 2002-02-21 2002-04-10 Legislator 1563 Ltd Di-ester derivatives as short acting neuromuscular blockers

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2746964A (en) * 1953-11-02 1956-05-22 Lakeside Lab Inc Dicarboxylic acid esters of nu-alkyl-3-hydroxypiperidine and salts thereof
AT292702B (en) * 1968-12-29 1971-09-10 Egyt Gyogyszervegyeszeti Gyar Process for the preparation of new N-methyl-piperidine derivatives and the acid addition salts and the onium derivatives of these compounds
US5494898A (en) * 1991-02-13 1996-02-27 Ohmeda Pharmaceutical Products Division Inc. Peptide skeletal muscle relaxants
US5990124A (en) * 1997-10-24 1999-11-23 Gyermek; Laszlo Neuromuscular relaxants

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
L. GYERMEK, C. LEE, N. NGUYEN: "Pharmacology of G-1-64, a new nondepolarizing neuromuscular blocking agent with rapid onset and short duration of action", ACTA ANAESTHESIOLOGICA SCANDINAVICA, XX, XX, vol. 43, no. 6, July 1999 (1999-07-01), pages 651 - 657, XP001056943, ISSN: 0001-5172 *

Also Published As

Publication number Publication date
PL349099A1 (en) 2002-07-01
EP1150673A1 (en) 2001-11-07
CO5170470A1 (en) 2002-06-27
KR20010108125A (en) 2001-12-07
NO20013741L (en) 2001-09-19
HUP0200413A3 (en) 2002-11-28
AU2634900A (en) 2000-08-18
BR0007863A (en) 2001-11-06
JP2002535366A (en) 2002-10-22
WO2000044377A1 (en) 2000-08-03
HK1039455A1 (en) 2002-04-26
CA2360790A1 (en) 2000-08-03
TR200102196T2 (en) 2002-01-21
PE20001593A1 (en) 2001-01-16
NO20013741D0 (en) 2001-07-31
CN1338934A (en) 2002-03-06
ZA200105882B (en) 2003-02-18
CZ20012780A3 (en) 2002-01-16
HUP0200413A2 (en) 2002-06-29
NZ513064A (en) 2003-08-29
IL144249A0 (en) 2002-05-23
MXPA01007783A (en) 2002-08-20
AR022472A1 (en) 2002-09-04

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