EP1146909A4 - Method of treating cancer by restoration of pp32 function - Google Patents

Method of treating cancer by restoration of pp32 function

Info

Publication number
EP1146909A4
EP1146909A4 EP00905923A EP00905923A EP1146909A4 EP 1146909 A4 EP1146909 A4 EP 1146909A4 EP 00905923 A EP00905923 A EP 00905923A EP 00905923 A EP00905923 A EP 00905923A EP 1146909 A4 EP1146909 A4 EP 1146909A4
Authority
EP
European Patent Office
Prior art keywords
restoration
function
treating cancer
cancer
treating
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP00905923A
Other languages
German (de)
French (fr)
Other versions
EP1146909A1 (en
Inventor
Gary R Pasternack
Jining Bai
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Johns Hopkins University
Original Assignee
Johns Hopkins University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Johns Hopkins University filed Critical Johns Hopkins University
Publication of EP1146909A1 publication Critical patent/EP1146909A1/en
Publication of EP1146909A4 publication Critical patent/EP1146909A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C12Q1/42—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving phosphatase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5011—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing antineoplastic activity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)
    • G01N2333/916—Hydrolases (3) acting on ester bonds (3.1), e.g. phosphatases (3.1.3), phospholipases C or phospholipases D (3.1.4)
EP00905923A 1999-02-03 2000-02-03 Method of treating cancer by restoration of pp32 function Withdrawn EP1146909A4 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US11866799P 1999-02-03 1999-02-03
US118667P 1999-02-03
PCT/US2000/002656 WO2000045852A1 (en) 1999-02-03 2000-02-03 Method of treating cancer by restoration of pp32 function

Publications (2)

Publication Number Publication Date
EP1146909A1 EP1146909A1 (en) 2001-10-24
EP1146909A4 true EP1146909A4 (en) 2004-12-29

Family

ID=22380017

Family Applications (1)

Application Number Title Priority Date Filing Date
EP00905923A Withdrawn EP1146909A4 (en) 1999-02-03 2000-02-03 Method of treating cancer by restoration of pp32 function

Country Status (5)

Country Link
EP (1) EP1146909A4 (en)
JP (1) JP2002536346A (en)
AU (1) AU2751900A (en)
CA (1) CA2361838A1 (en)
WO (1) WO2000045852A1 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008077311A1 (en) * 2006-12-26 2008-07-03 Institute Of Radiation Medicine, Academy Of Military Medical Sciences, Pla Hepatopoietin and use thereof

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5726018A (en) * 1990-08-01 1998-03-10 Johns Hopkins University Nucleic acid based assays to detect a novel mammalian protein associated with uncontrolled cell division
WO1999029906A2 (en) * 1997-12-12 1999-06-17 The Johns Hopkins University Gene family with transformation modulating activity

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5700821A (en) * 1996-07-30 1997-12-23 University Of Pittsburgh Phosphatase inhibitors and methods of use thereof
US5916749A (en) * 1996-12-13 1999-06-29 Incyte Pharmaceuticals, Inc. Human phosphatase inhibitor protein

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5726018A (en) * 1990-08-01 1998-03-10 Johns Hopkins University Nucleic acid based assays to detect a novel mammalian protein associated with uncontrolled cell division
WO1999029906A2 (en) * 1997-12-12 1999-06-17 The Johns Hopkins University Gene family with transformation modulating activity

Non-Patent Citations (10)

* Cited by examiner, † Cited by third party
Title
BRODY JONATHAN R ET AL: "Identification of sequences required for inhibition of oncogene-mediated transformation by pp32", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 274, no. 29, 16 July 1999 (1999-07-16), pages 20053 - 20055, XP002303700, ISSN: 0021-9258 *
CANCER RESEARCH, vol. 53, no. 19, 1993, pages 4720 - 4726, ISSN: 0008-5472 *
CHEN T-H ET AL: "STRUCTURE OF PP32, AN ACIDIC NUCLEAR PROTEIN WHICH INHIBITS ONCOGENE-INDUCED FORMATION OF TRANSFORMED FOCI", MOLECULAR BIOLOGY OF THE CELL, BETHESDA, MD, US, vol. 7, December 1996 (1996-12-01), pages 2045 - 2056, XP002929314, ISSN: 1059-1524 *
DADKOL S S ET AL: "MODULATION OF ONCOGENIC POTENTIAL BY ALTERNATIVE GENE USE IN HUMAN PROSTATE CANCER", NATURE MEDICINE, NATURE PUBLISHING, CO, US, vol. 5, no. 3, March 1999 (1999-03-01), pages 275 - 279, XP002929315, ISSN: 1078-8956 *
DATABASE BIOSIS [online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; 1993, WALENSKY LOREN D ET AL: "A novel M-r 32000 nuclear phosphoprotein is selectively expressed in cells competent for self-renewal", XP002303701, Database accession no. PREV199396138528 *
DATABASE EMBL 3 April 1997 (1997-04-03), XP002106402, Database accession no. U71084 *
DATABASE EMBL 8 January 1998 (1998-01-08), ...., XP002106403, Database accession no. AF008216 *
KOCHEVAR G J ET AL: "The structure of a gene encoding PP32R1, a new transforming protein", MOLECULAR BIOLOGY OF THE CELL, vol. 8, no. SUPPL., November 1997 (1997-11-01), & 37TH ANNUAL MEETING OF THE AMERICAN SOCIETY FOR CELL BIOLOGY; WASHINGTON, D.C., USA; DECEMBER 13-17, 1997, pages 137A, XP008037808, ISSN: 1059-1524 *
LI M ET AL: "MOLECULAR IDENTIFICATION OF I PP2A, A NOVEL POTENT HEAT-STABLE INHIBITOR PROTEIN OF PROTEIN PHOSPHATASE 2A", BIOCHEMISTRY, AMERICAN CHEMICAL SOCIETY. EASTON, PA, US, vol. 35, no. 22, 1996, pages 6998 - 7002, XP002929316, ISSN: 0006-2960 *
See also references of WO0045852A1 *

Also Published As

Publication number Publication date
JP2002536346A (en) 2002-10-29
CA2361838A1 (en) 2000-08-10
EP1146909A1 (en) 2001-10-24
WO2000045852A1 (en) 2000-08-10
AU2751900A (en) 2000-08-25

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