EP1139754A4 - 3-heteroarylidenyl-2-indolinone compounds for modulating protein kinase activity and for use in cancer chemotherapy - Google Patents
3-heteroarylidenyl-2-indolinone compounds for modulating protein kinase activity and for use in cancer chemotherapyInfo
- Publication number
- EP1139754A4 EP1139754A4 EP99966725A EP99966725A EP1139754A4 EP 1139754 A4 EP1139754 A4 EP 1139754A4 EP 99966725 A EP99966725 A EP 99966725A EP 99966725 A EP99966725 A EP 99966725A EP 1139754 A4 EP1139754 A4 EP 1139754A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- heteroarylidenyl
- protein kinase
- kinase activity
- cancer chemotherapy
- modulating protein
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US11431398P | 1998-12-31 | 1998-12-31 | |
US114313P | 1998-12-31 | ||
PCT/US1999/031232 WO2000038519A1 (en) | 1998-12-31 | 1999-12-30 | 3-heteroarylidenyl-2-indolinone compounds for modulating protein kinase activity and for use in cancer chemotherapy |
Publications (2)
Publication Number | Publication Date |
---|---|
EP1139754A1 EP1139754A1 (en) | 2001-10-10 |
EP1139754A4 true EP1139754A4 (en) | 2002-12-18 |
Family
ID=22354480
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP99966725A Withdrawn EP1139754A4 (en) | 1998-12-31 | 1999-12-30 | 3-heteroarylidenyl-2-indolinone compounds for modulating protein kinase activity and for use in cancer chemotherapy |
Country Status (10)
Country | Link |
---|---|
EP (1) | EP1139754A4 (en) |
JP (1) | JP2002533360A (en) |
KR (1) | KR20010108063A (en) |
CN (1) | CN1356872A (en) |
AU (1) | AU760964B2 (en) |
BR (1) | BR9916735A (en) |
CA (1) | CA2357042A1 (en) |
IL (1) | IL143920A0 (en) |
MX (1) | MXPA01006742A (en) |
WO (1) | WO2000038519A1 (en) |
Families Citing this family (31)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6569868B2 (en) | 1998-04-16 | 2003-05-27 | Sugen, Inc. | 2-indolinone derivatives as modulators of protein kinase activity |
DK1233943T3 (en) * | 1999-11-24 | 2011-08-15 | Sugen Inc | Ionizable indolinone derivatives and their use as PTK ligands |
US6878733B1 (en) | 1999-11-24 | 2005-04-12 | Sugen, Inc. | Formulations for pharmaceutical agents ionizable as free acids or free bases |
MXPA02008021A (en) * | 2000-02-15 | 2004-04-05 | Sugen Inc | Pyrrole substituted 2 indolinone protein kinase inhibitors. |
BR0108728A (en) * | 2000-02-28 | 2003-12-30 | Aventis Pharma Sa | Pharmaceutical Combination Therapy, and, Method for Treating a Cancer. |
TWI270545B (en) | 2000-05-24 | 2007-01-11 | Sugen Inc | Mannich base prodrugs of 3-(pyrrol-2-ylmethylidene)-2-indolinone derivatives |
US6706709B2 (en) | 2000-06-02 | 2004-03-16 | Sugen, Inc. | Indolinone derivatives as protein kinase/phosphatase inhibitors |
JP2004529904A (en) | 2001-03-14 | 2004-09-30 | ブリストル−マイヤーズ スクイブ カンパニー | Combination of epothilone analogs and chemotherapeutic agents for the treatment of proliferative diseases |
US6599902B2 (en) | 2001-05-30 | 2003-07-29 | Sugen, Inc. | 5-aralkysufonyl-3-(pyrrol-2-ylmethylidene)-2-indolinone derivatives as kinase inhibitors |
AR038957A1 (en) * | 2001-08-15 | 2005-02-02 | Pharmacia Corp | COMBINATION THERAPY FOR CANCER TREATMENT |
WO2003035619A1 (en) * | 2001-10-25 | 2003-05-01 | Merck & Co., Inc. | Tyrosine kinase inhibitors |
WO2003035616A2 (en) * | 2001-10-25 | 2003-05-01 | Merck & Co., Inc. | Tyrosine kinase inhibitors |
WO2003035614A2 (en) * | 2001-10-25 | 2003-05-01 | Merck & Co., Inc. | Tyrosine kinase inhibitors |
AU2002346457A1 (en) * | 2001-11-21 | 2003-06-10 | Pharmacia And Upjohn Company | Pharmaceutical formulations comprising indolinone derivatives |
US6797825B2 (en) | 2001-12-13 | 2004-09-28 | Abbott Laboratories | Protein kinase inhibitors |
US20030187026A1 (en) | 2001-12-13 | 2003-10-02 | Qun Li | Kinase inhibitors |
WO2003057690A1 (en) | 2001-12-27 | 2003-07-17 | Theravance, Inc. | Indolinone derivatives useful as protein kinase inhibitors |
CA2489813A1 (en) | 2002-06-25 | 2003-12-31 | Wyeth | Use of thio-oxindole derivatives in treatment of hormone-related conditions |
RU2005101624A (en) | 2002-06-25 | 2005-06-27 | Уайт (Us) | APPLICATION OF THIOXINDOL DERIVATIVES IN THERAPY OF SKIN DISORDERS |
US8450302B2 (en) | 2002-08-02 | 2013-05-28 | Ab Science | 2-(3-aminoaryl) amino-4-aryl-thiazoles and their use as c-kit inhibitors |
US20050239852A1 (en) | 2002-08-02 | 2005-10-27 | Ab Science | 2-(3-aminoaryl)amino-4-aryl-thiazoles and their use as c-kit inhibitors |
CA2506085A1 (en) * | 2002-11-15 | 2004-06-03 | Ronald Lynn Merriman | Combination chemotherapy comprising a mek inhibitor and capecitabine for treating cancer |
NZ546645A (en) | 2003-10-23 | 2010-02-26 | Ab Science | 2-Aminoaryloxazole compounds as tyrosine kinase inhibitors |
CN100432071C (en) * | 2004-11-05 | 2008-11-12 | 中国科学院上海药物研究所 | Substituted 1H-indole-2-ketone compound and its preparation method and uses |
CA2603826C (en) | 2005-04-04 | 2013-03-12 | Ab Science | Substituted oxazole derivatives and their use as tyrosine kinase inhibitors |
US8246966B2 (en) | 2006-08-07 | 2012-08-21 | University Of Georgia Research Foundation, Inc. | Trypanosome microsome system and uses thereof |
EP2088863A2 (en) | 2006-11-22 | 2009-08-19 | University Of Georgia Research Foundation, Inc. | Tyrosine kinase inhibitors as anti-kinetolastid and anti-apicomplexan agents |
ES2671730T3 (en) * | 2011-11-11 | 2018-06-08 | Eli Lilly And Company | Combination therapy for ovarian cancer |
US11083755B2 (en) | 2015-01-08 | 2021-08-10 | The Board Of Trustees Of The Leland Stanford Junior University | Factors and cells that provide for induction of bone, bone marrow, and cartilage |
LT3288940T (en) | 2015-04-29 | 2021-05-10 | Janssen Pharmaceutica Nv | Azabenzimidazoles and their use as ampa receptor modulators |
CN105585558A (en) * | 2015-12-15 | 2016-05-18 | 贵州大学 | Double-alkoxy pyrimidine jointing 3-ethylenic-bond-oxoindole derivative and preparing method and application thereof |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1998007695A1 (en) * | 1996-08-23 | 1998-02-26 | Sugen, Inc. | Indolinone combinatorial libraries and related products and methods for the treatment of disease |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5880141A (en) * | 1995-06-07 | 1999-03-09 | Sugen, Inc. | Benzylidene-Z-indoline compounds for the treatment of disease |
-
1999
- 1999-12-30 AU AU22215/00A patent/AU760964B2/en not_active Ceased
- 1999-12-30 IL IL14392099A patent/IL143920A0/en unknown
- 1999-12-30 KR KR1020017008453A patent/KR20010108063A/en not_active Application Discontinuation
- 1999-12-30 WO PCT/US1999/031232 patent/WO2000038519A1/en not_active Application Discontinuation
- 1999-12-30 MX MXPA01006742A patent/MXPA01006742A/en unknown
- 1999-12-30 CA CA002357042A patent/CA2357042A1/en not_active Abandoned
- 1999-12-30 CN CN99816376A patent/CN1356872A/en active Pending
- 1999-12-30 EP EP99966725A patent/EP1139754A4/en not_active Withdrawn
- 1999-12-30 JP JP2000590484A patent/JP2002533360A/en not_active Withdrawn
- 1999-12-30 BR BR9916735-2A patent/BR9916735A/en not_active IP Right Cessation
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1998007695A1 (en) * | 1996-08-23 | 1998-02-26 | Sugen, Inc. | Indolinone combinatorial libraries and related products and methods for the treatment of disease |
Also Published As
Publication number | Publication date |
---|---|
MXPA01006742A (en) | 2004-04-21 |
CN1356872A (en) | 2002-07-03 |
IL143920A0 (en) | 2002-04-21 |
AU2221500A (en) | 2000-07-31 |
JP2002533360A (en) | 2002-10-08 |
EP1139754A1 (en) | 2001-10-10 |
AU760964B2 (en) | 2003-05-22 |
BR9916735A (en) | 2001-09-25 |
CA2357042A1 (en) | 2000-07-06 |
WO2000038519A1 (en) | 2000-07-06 |
KR20010108063A (en) | 2001-12-07 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
17P | Request for examination filed |
Effective date: 20010730 |
|
AK | Designated contracting states |
Kind code of ref document: A1 Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE |
|
AX | Request for extension of the european patent |
Free format text: AL;LT;LV;MK;RO;SI |
|
RIN1 | Information on inventor provided before grant (corrected) |
Inventor name: SUN, LI Inventor name: TANG, PENG, CHO Inventor name: SHAWVER, LAURA, KAY Inventor name: LANGECKER, PETER, J. |
|
A4 | Supplementary search report drawn up and despatched |
Effective date: 20021107 |
|
AK | Designated contracting states |
Kind code of ref document: A4 Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE |
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RIC1 | Information provided on ipc code assigned before grant |
Free format text: 7A 01N 43/38 A, 7A 61K 31/40 B, 7A 61K 31/505 B |
|
17Q | First examination report despatched |
Effective date: 20030915 |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN |
|
18D | Application deemed to be withdrawn |
Effective date: 20040126 |