EP1129108A4 - Caspases et apoptose - Google Patents

Caspases et apoptose

Info

Publication number
EP1129108A4
EP1129108A4 EP99953073A EP99953073A EP1129108A4 EP 1129108 A4 EP1129108 A4 EP 1129108A4 EP 99953073 A EP99953073 A EP 99953073A EP 99953073 A EP99953073 A EP 99953073A EP 1129108 A4 EP1129108 A4 EP 1129108A4
Authority
EP
European Patent Office
Prior art keywords
caspases
apoptosis
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
EP99953073A
Other languages
German (de)
English (en)
Other versions
EP1129108A1 (fr
Inventor
Dennis Lee
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SmithKline Beecham Corp
Original Assignee
SmithKline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SmithKline Beecham Corp filed Critical SmithKline Beecham Corp
Publication of EP1129108A1 publication Critical patent/EP1129108A1/fr
Publication of EP1129108A4 publication Critical patent/EP1129108A4/fr
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
EP99953073A 1998-10-06 1999-10-06 Caspases et apoptose Pending EP1129108A4 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US10342898P 1998-10-06 1998-10-06
US103428P 1998-10-06
PCT/US1999/023271 WO2000020440A1 (fr) 1998-10-06 1999-10-06 Caspases et apoptose

Publications (2)

Publication Number Publication Date
EP1129108A1 EP1129108A1 (fr) 2001-09-05
EP1129108A4 true EP1129108A4 (fr) 2002-01-09

Family

ID=22295125

Family Applications (1)

Application Number Title Priority Date Filing Date
EP99953073A Pending EP1129108A4 (fr) 1998-10-06 1999-10-06 Caspases et apoptose

Country Status (3)

Country Link
EP (1) EP1129108A4 (fr)
JP (1) JP2003524603A (fr)
WO (1) WO2000020440A1 (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006017295A2 (fr) * 2004-07-12 2006-02-16 Idun Pharmaceuticals, Inc. Analogues de tetrapeptide
US7709370B2 (en) 2007-09-20 2010-05-04 International Business Machines Corporation Spin-on antireflective coating for integration of patternable dielectric materials and interconnect structures
US8084862B2 (en) 2007-09-20 2011-12-27 International Business Machines Corporation Interconnect structures with patternable low-k dielectrics and method of fabricating same
US8618663B2 (en) 2007-09-20 2013-12-31 International Business Machines Corporation Patternable dielectric film structure with improved lithography and method of fabricating same
WO2012019003A1 (fr) 2010-08-06 2012-02-09 Bristol-Myers Squibb Company Dérivés d'oxoacétyl pipérazinamide à substitution indole et azaindole
CN110759966B (zh) * 2019-11-22 2021-01-26 中国药科大学 caspase-3抑制剂及用途

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995005192A1 (fr) * 1993-08-13 1995-02-23 Merck & Co., Inc. DERIVES SUBSTITUES DE CETONE INHIBITEURS DE L'ENZYME DE CONVERSION D'INTERLEUKINE-1$g(b)
WO1995035308A1 (fr) * 1994-06-17 1995-12-28 Vertex Pharmaceuticals Incorporated INHIBITEURS DE L'ENZYME DE CONVERSION D'INTERLEUKINE-1$g(b)
GB2292149A (en) * 1994-08-09 1996-02-14 Ferring Res Ltd Peptide inhibitors of pro-interleukin-1beta converting enzyme
WO1998016505A1 (fr) * 1996-10-11 1998-04-23 Warner-Lambert Company INHIBITEURS DE L'ENZYME DE CONVERSION DE L'INTERLEUKINE 1β A BASE DE SULFONAMIDE
WO1998036057A1 (fr) * 1997-02-18 1998-08-20 Dana Farber Cancer Institute Activite d'une thymocyte caspase et selection negative

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5055451A (en) * 1986-12-22 1991-10-08 Syntex Inc. Aryloxy and arylacyloxy methyl ketones as thiol protease inhibitors

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995005192A1 (fr) * 1993-08-13 1995-02-23 Merck & Co., Inc. DERIVES SUBSTITUES DE CETONE INHIBITEURS DE L'ENZYME DE CONVERSION D'INTERLEUKINE-1$g(b)
WO1995035308A1 (fr) * 1994-06-17 1995-12-28 Vertex Pharmaceuticals Incorporated INHIBITEURS DE L'ENZYME DE CONVERSION D'INTERLEUKINE-1$g(b)
GB2292149A (en) * 1994-08-09 1996-02-14 Ferring Res Ltd Peptide inhibitors of pro-interleukin-1beta converting enzyme
WO1998016505A1 (fr) * 1996-10-11 1998-04-23 Warner-Lambert Company INHIBITEURS DE L'ENZYME DE CONVERSION DE L'INTERLEUKINE 1β A BASE DE SULFONAMIDE
WO1998036057A1 (fr) * 1997-02-18 1998-08-20 Dana Farber Cancer Institute Activite d'une thymocyte caspase et selection negative

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of WO0020440A1 *

Also Published As

Publication number Publication date
JP2003524603A (ja) 2003-08-19
EP1129108A1 (fr) 2001-09-05
WO2000020440A1 (fr) 2000-04-13

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