EP1126879A4 - Gentherapie zur regulation des tonus der glatten muskulatur - Google Patents

Gentherapie zur regulation des tonus der glatten muskulatur

Info

Publication number
EP1126879A4
EP1126879A4 EP99942324A EP99942324A EP1126879A4 EP 1126879 A4 EP1126879 A4 EP 1126879A4 EP 99942324 A EP99942324 A EP 99942324A EP 99942324 A EP99942324 A EP 99942324A EP 1126879 A4 EP1126879 A4 EP 1126879A4
Authority
EP
European Patent Office
Prior art keywords
gene therapy
smooth muscle
muscle cell
regulating smooth
cell tone
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
EP99942324A
Other languages
English (en)
French (fr)
Other versions
EP1126879A1 (de
Inventor
George J Christ
Arnold Melman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Albert Einstein College of Medicine
Original Assignee
Albert Einstein College of Medicine
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Albert Einstein College of Medicine filed Critical Albert Einstein College of Medicine
Publication of EP1126879A1 publication Critical patent/EP1126879A1/de
Publication of EP1126879A4 publication Critical patent/EP1126879A4/de
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Epidemiology (AREA)
  • Cell Biology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
EP99942324A 1998-08-18 1999-08-18 Gentherapie zur regulation des tonus der glatten muskulatur Ceased EP1126879A4 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US13584998A 1998-08-18 1998-08-18
US135849 1998-08-18
PCT/US1999/018912 WO2000010604A1 (en) 1998-08-18 1999-08-18 Gene therapy for regulating smooth muscle cell tone

Publications (2)

Publication Number Publication Date
EP1126879A1 EP1126879A1 (de) 2001-08-29
EP1126879A4 true EP1126879A4 (de) 2004-08-04

Family

ID=22469993

Family Applications (1)

Application Number Title Priority Date Filing Date
EP99942324A Ceased EP1126879A4 (de) 1998-08-18 1999-08-18 Gentherapie zur regulation des tonus der glatten muskulatur

Country Status (6)

Country Link
EP (1) EP1126879A4 (de)
JP (1) JP2002523380A (de)
KR (1) KR100596884B1 (de)
AU (1) AU757803B2 (de)
CA (1) CA2339800A1 (de)
WO (1) WO2000010604A1 (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6271211B1 (en) 1997-02-13 2001-08-07 Albert Einstein College Of Medicine Of Yeshiva University Gene therapy for regulating penile smooth muscle tone
US7030096B1 (en) 1997-02-13 2006-04-18 Albert Einstein College Of Medicine Of Yeshiva University Method of enhancing relaxation of penile smooth muscle by introduction of DNA encoding maxi-K potassium channel protein
CN1252261C (zh) * 2000-08-30 2006-04-19 株式会社无细胞科学 无细胞蛋白质合成用转录模板的设计、构建及使用其的稀释分批式麦胚芽无细胞蛋白质的合成法
US7491385B2 (en) 2001-09-05 2009-02-17 Genegrafts Ltd. Nucleic acid constructs and cells, and methods utilizing same for modifying the electrophysiological function of excitable tissues
WO2006084322A1 (en) * 2005-02-09 2006-08-17 Craig Steven Mclachlan Treatment method for modifying tissue passive electrical conductance

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997018308A2 (en) * 1995-11-16 1997-05-22 The Wellcome Trust Limited As Trustee Of The Wellcome Trust K-atp channel protein and methods relating to it
WO1998033905A1 (en) * 1997-01-30 1998-08-06 Isis Innovation Limited K-atp channels, materials and methods relating to cell membrane proteins
WO1998033529A1 (en) * 1997-02-04 1998-08-06 Valentis, Inc. Treatment for urinary incontinence using gene therapy techniques

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5594032A (en) * 1994-11-10 1997-01-14 Gonzalez-Cadavid; Nestor F. Amelioration of human erectile dysfunction by treatment with iNOS, inducers of iNOS or iNOS cDNA

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997018308A2 (en) * 1995-11-16 1997-05-22 The Wellcome Trust Limited As Trustee Of The Wellcome Trust K-atp channel protein and methods relating to it
WO1998033905A1 (en) * 1997-01-30 1998-08-06 Isis Innovation Limited K-atp channels, materials and methods relating to cell membrane proteins
WO1998033529A1 (en) * 1997-02-04 1998-08-06 Valentis, Inc. Treatment for urinary incontinence using gene therapy techniques

Non-Patent Citations (12)

* Cited by examiner, † Cited by third party
Title
AMERICAN JOURNAL OF PHYSIOLOGY, vol. 264, no. 1 PART 1, 1993, pages C80 - C92, ISSN: 0002-9513 *
DATABASE BIOSIS [online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; 1993, CARVALHO A C CAMPOS DE ET AL: "Gap junctions formed of connexin 43 are found between smooth muscle cells of human corpus cavernosum", XP002273927, Database accession no. PREV199396070205 *
DATABASE BIOSIS [online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; 1993, MORENO A P ET AL: "Gap junctions between human corpus cavernosum smooth muscle cells: Gating properties and unitary conductance", XP002273928, Database accession no. PREV199395121407 *
DATABASE BIOSIS [online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; 1997, DAMASER MARGOT S ET AL: "Calcium regulation of urinary bladder function", XP002282784, Database accession no. PREV199799387864 *
DATABASE BIOSIS [online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; 1997, LEVIN ROBERT M ET AL: "Etiology of bladder dysfunction secondary to partial outlet obstruction. Calcium disregulation in bladder power generation and the ability to perform work", XP002282785, Database accession no. PREV199799573741 *
GROSSMAN H BARTON ET AL: "Decreased connexin expression and intercellular communication in human bladder cancer cells", CANCER RESEARCH, vol. 54, no. 11, 1994, pages 3062 - 3065, XP008028667, ISSN: 0008-5472 *
HUARD ET AL: "MYOBLAST INJECTION INTO THE BLADDER WALL: A POSSIBLE METHOD OF MODULATING DETRUSOR CONTRACTILITY AND CELL-MEDIATED GENE THERAPY FOR BLADDER DYSFUNCTION", JOURNAL OF UROLOGY, BALTIMORE, MD, US, vol. 159, no. 5, 30 May 1998 (1998-05-30), pages 16, XP002120829, ISSN: 0022-5347 *
JOURNAL OF UROLOGY, vol. 149, no. 6, 1993, pages 1568 - 1575, ISSN: 0022-5347 *
JOURNAL OF UROLOGY, vol. 157, no. 2, 1997, pages 732 - 738, ISSN: 0022-5347 *
SCANDINAVIAN JOURNAL OF UROLOGY AND NEPHROLOGY SUPPLEMENTUM, vol. 0, no. 184, 1997, pages 43 - 50, ISSN: 0300-8886 *
See also references of WO0010604A1 *
SIEMER CHRISTIANE ET AL: "Characterization of Maxi K channels in smooth muscle cells from rat urinary bladder", PFLUEGERS ARCHIV EUROPEAN JOURNAL OF PHYSIOLOGY, vol. 434, no. 5 SUPPL., 1997, & INTERNATIONAL POTASSIUM CHANNEL CONFERENCE; ULM, GERMANY; JULY 16-19, 1997, pages R102, XP008028610, ISSN: 0031-6768 *

Also Published As

Publication number Publication date
KR100596884B1 (ko) 2006-07-04
JP2002523380A (ja) 2002-07-30
KR20010085416A (ko) 2001-09-07
AU757803B2 (en) 2003-03-06
AU5572899A (en) 2000-03-14
CA2339800A1 (en) 2000-03-02
EP1126879A1 (de) 2001-08-29
WO2000010604A1 (en) 2000-03-02

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Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

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Effective date: 20010221

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RIC1 Information provided on ipc code assigned before grant

Ipc: 7A 61P 13/10 B

Ipc: 7C 12Q 1/68 B

Ipc: 7A 61K 41/00 B

Ipc: 7A 61K 48/00 A

A4 Supplementary search report drawn up and despatched

Effective date: 20040621

17Q First examination report despatched

Effective date: 20051004

RTI1 Title (correction)

Free format text: COMPOSITIONS FOR REGULATING SMOOTH MUSCLE CELL TONE OF THE BLADDER

STAA Information on the status of an ep patent application or granted ep patent

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