EP1116024A1 - Method and system for producing a substance or a signal with coagulating or anticoagulant effect - Google Patents

Method and system for producing a substance or a signal with coagulating or anticoagulant effect

Info

Publication number
EP1116024A1
EP1116024A1 EP99946226A EP99946226A EP1116024A1 EP 1116024 A1 EP1116024 A1 EP 1116024A1 EP 99946226 A EP99946226 A EP 99946226A EP 99946226 A EP99946226 A EP 99946226A EP 1116024 A1 EP1116024 A1 EP 1116024A1
Authority
EP
European Patent Office
Prior art keywords
signal
substance
transducer
anticoagulant
coagulating
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
EP99946226A
Other languages
German (de)
French (fr)
Inventor
Jacques Benveniste
Didier Guillonnet
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Digibio SA
Original Assignee
Digibio SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR9812058A external-priority patent/FR2783605A1/en
Application filed by Digibio SA filed Critical Digibio SA
Publication of EP1116024A1 publication Critical patent/EP1116024A1/en
Ceased legal-status Critical Current

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N37/00—Details not covered by any other group of this subclass
    • G01N37/005—Measurement methods not based on established scientific theories
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid

Definitions

  • the present invention relates to a method and a system for producing a substance or a signal, in particular an electrical signal, having a coagulant or anticoagulant effect.
  • the invention also relates to such a substance or such a signal and to their therapeutic effects.
  • the invention also relates to a method and a system for testing the coagulant or anticoagulant effect of a substance or signal. We know, since the research work of Mr.
  • electrical signal characteristic of the biological and / or chemical activity or of the biological and / or chemical behavior of a substance or of an active element contained in said substance any electrical signal riveted by scanning and / or signal processing.
  • characteristic is used in the sense that the physical parameters of the electrical signal are specific to the substance or to the active element contained in said substance.
  • the application of this electrical signal, via a transducer, to a biological control system makes it possible: (i) to induce biological and / or chemical activity on said system biological control in relation to that of the original substance or of the active element which it contains,
  • Patent application WO 94/17406 published on August 4, 1994, describes a method and a device for capturing "an electromagnetic signal characteristic of a biological and / or chemical activity or of a biological and / or chemical behavior" from of an active biological and / or chemical element such as a chemical compound, a cell or a microorganism, or from a substance containing this active element such as a purified preparation, a biological sample, a living being .
  • the inventors have since discovered that it is possible to improve the quality of the electromagnetic signal picked up as well as the reliability of the process for producing this signal and that it is therefore possible to produce a characteristic electrical signal capable of industrial applications.
  • the method according to the invention for producing a substance having a coagulating or anticoagulant effect, from a source substance having a coagulating effect, in particular Ca ++ ions, or anticoagulant, in particular heparin comprises at least the steps following.
  • step 1 is to transform the electromagnetic field originating from said source substance into a signal, in particular a signal electrical characteristic, by means of a transducer-receiver capturing said electromagnetic field.
  • step 2 is to apply to a receiving substance, in particular water or a water-ethanol mixture or homeopathic granules, said signal coming from said transducer-receiver, by means of a transducer-transmitter.
  • a receiving substance in particular water or a water-ethanol mixture or homeopathic granules
  • the receptor substance initially inactive, exhibits coagulant or anticoagulant activity.
  • the receptor substance thus treated will hereinafter be called the "treated substance”.
  • the concentration of the active elements in the source substance in particular the concentration of Ca ++ ions having a coagulant effect or of heparin having an anticoagulant effect, can be of the order of 1 ⁇ M. It can also be very low and reach 10 "14 M.
  • the source substance may also consist of homeopathic products, diluted if necessary in water for injection.
  • said source substance is placed in a zone subjected to an excitation field of an electrical, magnetic and / or electromagnetic nature and,
  • the fields resulting from the interaction of the excitation field and said source substance are transformed into an electrical signal, by means of a transducer-receiver capturing said resulting fields.
  • the system according to the invention for producing a substance having a coagulating or anticoagulant effect, from a source substance having a coagulating effect, in particular Ca ++ ions, or anticoagulant, in particular heparin comprises at least the elements below defined.
  • a transducer-receiver receives the electromagnetic field from of said source substance. Said transducer-receiver transforms said electromagnetic field into a signal, in particular an electrical signal.
  • a transducer-transmitter makes it possible to apply the signal coming from said transducer-receiver to a receiving substance, in particular water or a water-ethanol mixture or homeopathic granules.
  • the receptor substance After the treatment implemented by the system defined above, the receptor substance, initially inactive, exhibits coagulant or anticoagulant activity.
  • the system according to the invention further comprises an emitter generating an excitation field of an electrical, magnetic and / or electromagnetic nature in an area where said source substance is located.
  • a transducer-receiver receiving the fields resulting from the interaction of said excitation field and said source substance, transforms said resulting fields into a signal, in particular an electrical signal.
  • Substance according to the invention having a coagulant or anticoagulant effect
  • the invention also relates to a substance having a coagulant or anticoagulant effect.
  • Said substance in particular water or a water-ethanol mixture or homeopathic granules, is characterized in that it has been treated by means of an electrical or electromagnetic signal originating from a source substance having coagulant effects, in particular Ca ++ ions, or anticoagulant, in particular heparin.
  • the invention also relates to the therapeutic applications of such a substance.
  • the substance according to the invention can be used in the treatment of thromboembolic disease. It can also be used to carry out coagulation exploration tests.
  • the invention also relates to a method for testing a substance having a coagulating effect, in particular Ca " ⁇ ions, or anticoagulant, including heparin.
  • the method includes at least the following steps.
  • step 1 is to transform the electromagnetic field originating from said substance, into a signal, in particular an electrical signal, by means of a transducer-receiver sensing said electromagnetic field.
  • step 2 is to apply said signal from said transducer-receiver to a sensitive biological system, directly or indirectly.
  • a sensitive biological system directly or indirectly.
  • said substance is placed in a zone subjected to an excitation field of an electrical, magnetic and / or electromagnetic nature
  • the sensitive biological system can be blood or plasma to which the said signal is applied by means of a transducer-transmitter.
  • the sensitive biological system is an animal, in particular a rabbit, to which is administered, in particular under the tongue, a substance, in particular water, treated by said signal by means of a transducer- transmitter.
  • the method according to the invention for testing the coagulant or anticoagulant effect of a substance can be applied to the control of production of homeopathic products.
  • the method according to the invention for producing a signal, in particular an electrical or electromagnetic signal, having a coagulant or anticoagulant effect, from a source substance having a coagulant effect, in particular Ca ++ ions, or anticoagulant, in particular of the heparin comprises at least the step of transforming the electromagnetic field originating from said source substance, into a signal, in particular an electrical signal, by means of a transducer-receiver capturing said electromagnetic field.
  • said source substance is placed in an area subjected to an excitation field of an electrical, magnetic and / or electromagnetic nature
  • the fields resulting from the interaction of the excitation field and the source substance are transformed into a signal, in particular an electrical signal, by means of a transducer-receiver capturing said resulting fields.
  • the method according to the invention for producing a signal further comprises the step of checking the correlations between on the one hand, the signal coming from said transducer - receptor and on the other hand, the coagulating or anticoagulant activity of said source substance, by applying, directly or indirectly, said signal to a biological control system and by verifying that said biological control system reacts in accordance with the coagulating activity or anticoagulant of the source substance from which the signal comes.
  • the biological control system is blood or plasma to which said signal is applied by means of a transducer-transmitter. It is also advantageous to use plasma rich in platelets.
  • the biological control system is an animal, in particular a rabbit, to which is administered, in particular under the tongue, a substance, in particular water, treated by said signal by means of a transducer - transmitter.
  • the present invention also relates to a system for producing a signal, in particular an electrical or electromagnetic signal, having a coagulant or anticoagulant effect, from a source substance having a coagulant effect, in particular Ca " ⁇ ions, or anticoagulant, in particular of heparin.
  • Said system comprises a transducer-receiver receiving the electromagnetic field originating from said source substance, said transducer-receiver transforming said electromagnetic field into a signal, in particular an electrical signal.
  • the system according to the invention further comprises an emitter generating an excitation field of an electrical, magnetic and / or electromagnetic nature in an area where said source substance is located, said transducer-receiver, receiving the fields resulting from the interaction of said excitation field and said source substance , transforms said resulting fields into a signal, in particular an electrical signal ique.
  • the system according to the invention further comprises control means for controlling the correlations between on the one hand, the signal coming from said transducer-receiver and on the other hand, the coagulant or anticoagulant activity of said source substance .
  • Said control means comprise a transducer-transmitter applying, directly or indirectly, said signal to a biological control system.
  • Said control means further comprise verification means for verifying that the biological control system reacts in accordance with the coagulant or anticoagulant activity of the source substance which is issued the signal.
  • the biological control system is blood or plasma to which said signal is applied by means of said transducer-transmitter.
  • the biological control system is an animal, in particular a rabbit, to which a substance, in particular water, is administered, in particular under the tongue, treated by said signal by means of said transducer-transmitter.
  • Signal according to the invention having a coagulant or anticoagulant effect
  • the present invention also relates to a signal proper, in particular an electrical or electromagnetic signal, having a coagulant or anticoagulant effect.
  • Said signal is obtained from a source substance having a coagulating effect, in particular Ca " ⁇ ions, or anticoagulant, in particular heparin, by implementing the methods or the systems described above.
  • Said signal is characterized in that a biological control system reacts, after direct or indirect application of said signal, in accordance with the coagulant or anticoagulant activity of the source substance from which the signal is derived.
  • the biological control system is blood or plasma to which said signal is applied by means of a transducer-transmitter. It is also advantageous to use platelet-rich plasma.
  • the biological control system is an animal, in particular a rabbit, to which one administers, in particular under the tongue, a substance, in particular water, treated by said signal by means of a transducer-transmitter. s therapeutic applications of such a signal.
  • the signal according to the invention can be used, directly or indirectly via a receptor material, in the treatment of thromboembolic diseases. It can also be used, directly or indirectly via a receiving material, to carry out tests for exploring coagulation. Method according to the invention for testing the coagulant or anticoagulant effect of a signal
  • the invention also relates to a method for testing a signal having a coagulant or anticoagulant effect.
  • Said signal is obtained from a source substance having a coagulating effect, in particular Ca ++ ions, or anticoagulant, in particular heparin, by implementing the methods or systems previously described.
  • the method according to the invention comprises the step of applying said signal, directly or indirectly, to a biological test system and of verifying that the biological test system reacts in accordance with the coagulant or anticoagulant activity of the source substance from which the signal.
  • the biological test system is blood or plasma to which said signal is applied by means of a transducer-transmitter.
  • a transducer-transmitter One can also advantageously use plasma rich in platelets.
  • the biological test system is an animal, in particular a rabbit, to which is administered, in particular under the tongue, a substance, in particular water, treated by said signal by means of a transducer- transmitter.
  • the method according to the invention for testing the coagulant or anticoagulant effect of a signal can be applied to the control of production of homeopathic products.
  • FIG. 1 shows a diagram of an exemplary embodiment of a system for producing a characteristic electrical signal, and applying the characteristic electrical signal thus produced to a receptor substance or to a biological control system or to a system sensitive biological,
  • FIG. 1a represents a detailed perspective view of a part of the device for producing the electrical signal, showing the excitation field transmitter and the transducer-receiver receiving the resulting fields,
  • FIG. 1b represents in block diagram form the type of microcomputer used either to generate the excitation fields, or to record and transmit in digitized form the characteristic electrical signal
  • FIG. le represents a detailed perspective view of part of a transducer-transmitter intended to apply the characteristic electrical signal to a receptor substance or to a biological control system or to a sensitive biological system.
  • the system comprises a device 10 for producing an electrical signal characteristic of the biological and / or chemical activity or of the biological and / or chemical behavior of a substance 1 or of an active element contained in said substance.
  • said substance 1 is: either Ca ++ ions in solution at 1 ⁇ M in water for injectable preparation (for example of the Biosédra brand ), or heparin at a concentration of 2.5 IU / ml in the same quality of water.
  • the device 10 located in Paris for example, produces a characteristic electrical signal which is digitized after analog-digital conversion.
  • the signal thus digitized is, in a manner known per se, transmitted remotely, for example by a computer communication network of the internet type using radio links 11.
  • the digitized signal thus transmitted is received by an applicator 12, located in New York for example.
  • the applicator 12 comprises transmission means 13.
  • the transmission means 13 make it possible to apply the characteristic signal (after digital-analog conversion) to a receiving substance or to a biological control system or to a sensitive biological system.
  • the means provided for digitizing and transmitting remotely the electrical signal characteristic of the Ca ++ ion or of heparin are not essential to the realization of the invention.
  • the receiving substance is water or a water-ethanol mixture or homeopathic granules
  • the biological control system or the sensitive biological system is blood or plasma.
  • I The device producing the signal characteristic of the Ca ⁇ ion or heparin
  • the signal production device 10 comprises an enclosure D, 2 provided with an electrical and magnetic shielding isolating it from the stray fields coming from the environment.
  • the shielded cylindrical enclosure is made up of three superimposed layers: copper, soft iron, mumetal, made of sheet metal 1 mm thick.
  • the enclosure has an internal diameter of 65 mm and a height of 100 mm.
  • the enclosure is closed by a shielded cover 5.
  • a tank 3 of glass or plastic having the dimension 10 mm x 10 mm x 45 mm.
  • This tank 3 contains 1 ml of substance 1. That is to say: either Ca ++ ions in solution at 1 ⁇ M in water for injection (for example of the Biosédra brand),
  • a transmitter 4 is located inside the enclosure. It generates a specific excitation field of an electromagnetic nature.
  • the transmitter is powered by a generator 14.
  • the transmitter 4 comprises a coil advantageously supplemented by a soft iron magnetic core.
  • the emitting coil 4 has an impedance of 300 ohms, an inside diameter of 6 mm, an outside diameter of 16 mm, a length of 6 mm.
  • the soft iron magnetic core is placed in contact with the outer walls of the tank 3. Said substance 1 is thus subjected to the excitation field emitted by the transmitter 4.
  • the generator 14 is designed to generate a low frequency signal in particular square or sinusoidal low frequency signals, pink noise or, advantageously, white noise.
  • the spectrum of the excitation signal supplying the emitting coil 4 corresponds substantially to the spectrum of audible frequencies (20 Hz - 20,000 Hz).
  • the generator 14 can be an analog signal generator of known type, using for example a read only memory (ROM, PROM, EPROM, EEPROM in English terminology) containing the digital signal of the desired noise. This memory is connected in a manner known per se to a digital-analog converter.
  • ROM read only memory
  • PROM PROM
  • EPROM EEPROM in English terminology
  • the digital analog converter 41 of the sound card 25 has an output terminal 8.
  • the output terminal 8 of the microcomputer sound card 14 is connected to the input terminal 8 'of the transmitter 4, via an amplifier 15 whose characteristics are the following: bandwidth from 10 Hz to 20 kHz, gain 1 to 10, input sensitivity +/- 1 V.
  • the transducer-receiver 6 located inside the enclosure 2, receives the fields resulting from the interaction of said specific excitation field and said substance 1.
  • the transducer-receiver 6 transforms said fields resulting in an electrical signal.
  • This electrical signal is present, at the output terminals 9 ′ of the transducer-receiver 6, in the form of a difference of variable potential or of an electric current of variable intensity.
  • the transducer-receiver 6 comprises a coil having a soft iron core. This coil has an impedance of 300 ohms, an inside diameter of 6 mm, an outside diameter of 16 mm, a length of 6 mm.
  • the soft iron magnetic core is placed in contact with the outer walls of the tank 3.
  • the characteristic electrical signal available at the output of the transducer-receiver 6 is amplified by an amplifier-preamplifier 16.
  • the amplifier-preamplifier 16 has the following characteristics: bandwidth from 10 Hz to 20 kHz, gain 10 to
  • an excitation field transmitter 4 In the case of the variant embodiment described with reference to FIGS. 1, 1a, 1b, there is provided an excitation field transmitter 4.
  • the use of such a transmitter 4 promotes the production of an electrical signal characteristic of the Ca ++ ion or heparin.
  • Recording of the characteristic electrical signal • • Analog recording
  • the recording of the characteristic electrical signal can be carried out in analog by a signal recorder, in particular on magnetic tape, adapted to the frequencies of the characteristic electrical signal at the output of the transducer. receiver 6. Since the bandwidth used corresponds to the audio band, it is possible in particular to use a tape recorder.
  • the output terminal 9 'of the transducer-receiver 6 is connected to the microphone input or to the line input of such a tape recorder. During reading, the recorded characteristic electrical signal is collected at a output terminal, in particular at the line output or at the speaker output of the tape recorder.
  • a digital recording of the characteristic electrical signal is carried out after analog-digital conversion of said signal.
  • a microcomputer 17 is used, provided with a signal acquisition card 25.
  • the microcomputer 17 further comprises a microprocessor 27, an input / output interface 29, a controller 31 of a mass memory 33 and a video 35 connected by one or more bus interface 37.
  • a PC type computer 17 operating under the WINDOWS ® operating system 95 of the MICROSOFT Company
  • This microcomputer can be of the same type as that used to generate the excitation field. It can be the same microcomputer.
  • the output 9 'of the transducer-receiver 6 or of the amplifier-preamplifier 16 is connected to the input 9 of the analog-digital converter 39 of the card 25 of the computer 17.
  • the analog-digital converter 39 has a resolution higher than 12 bits. It is advantageously equal to 16 bits.
  • the analog-digital converter 39 has a sampling frequency twice the maximum frequency that it is desired to be able to digitize, for example 44 kHz.
  • a characteristic electrical signal is acquired for a duration for example between 1 and 60 s (for example 6 sec) and the digital file is recorded in a mass memory 33, for example in the form of a sound file at WAV format. All connections are made with shielded cable. All devices are grounded.
  • the digital file may possibly undergo digital processing, such as for example digital amplification for signal level calibration, filtering for the elimination of unwanted frequencies, or be transformed into sound spectrum by a discrete FOURIER transform, preferably by the fast FOURIER transform algorithm (FTT in Anglo-Saxon te ⁇ ninology).
  • FTP fast FOURIER transform algorithm
  • the duration of the signal produced can be increased by repeating a fragment or all of the file originally produced in a file several times.
  • Means for processing the characteristic electrical signal can be used to improve the performance of the characteristic electrical signal.
  • a second transducer-receiver of the same type is provided as that previously described. In the absence of said substance, this second transducer-receiver transforms the excitation field into an electrical signal. This electrical signal is subtracted by a series connection opposite to the signal from the first transducer-receiver. This gives a characteristic electrical signal more representative of the interaction of the specific excitation field and the substance.
  • the processing means take into account the characteristics of the specific excitation field and reprocess the characteristic electrical signal in the following manner.
  • neutral phases we mean phases not originating from a source substance exhibiting biological activity.
  • the file of the electrical signal characteristic of the Ca ++ ion or of heparin, recorded in digital form as just described, possibly after processing, can be transferred remotely by a computer communication network.
  • This network may include radio links 11.
  • the file of the electrical signal characteristic of the Ca ++ ion or of heparin, thus transmitted, is recorded by the mass memory of a microcomputer 18. It is possible, for example use a PC type computer, operating under the WINDOWS ® 95 operating system from MICROSOFT.
  • This microcomputer 18 can be of the same type as that used to generate the excitation field.
  • the digitized characteristic electrical signal file, thus recorded by the remote microcomputer 18, can be used, in a manner known per se, to produce an analog characteristic electrical signal.
  • the file, if any processed, is transformed by a digital-analog converter 41 of the card 25 (or of a separate card) of the computer 18.
  • the digital-analog converter 41 delivers on its output 8 an analog electric signal characteristic of the biological activity Ca ++ ion or the heparin from which it is derived.
  • This analog electrical signal can be transformed, as will be described below, into an electromagnetic field and applied to a receptor substance or to a biological control system or to a sensitive biological system. read.
  • the container 50 contains the receptor biological system.
  • the container 50 contains:
  • a receptor substance such as water or a water-ethanol mixture or homeopathic granules, or - a biological control system or a sensitive biological system such as blood or plasma.
  • the container 50 is placed in an electromagnetic field radiated by a transducer-transmitter 51, typically a coil.
  • the coil has for example a length of 80 mm, an inside diameter of 50 mm, an outside diameter of 55 mm. It presents 300 turns of a wire of diameter
  • the coil 51 is connected to ground. Without this representing any limiting character, the coil 51 of the transducer-transmitter has a vertical axis allowing the introduction of the container 50 containing the receiving biological system. Terminals input 8 'of this coil 51 are connected, in the case of the embodiment described, to output 8 of the analog-digital converter 41 of the microcomputer 18 via an amplifier 19 having the following characteristics: bandwidth of 10 Hz to 20 kHz, gain 1 to 20, input sensitivity 250 mV, RMS 60W output power at 8 ohms, signal to noise ratio 80 dB. The voltage across the coil 51 has an amplitude of 10 Volts rms and the signal is applied for 10 min.
  • the input terminals 8 ′ of the applicator can also be, in the case of certain variant embodiments, directly connected to the output of the preamplifier 16 or to the output 8 of the digital-analog converter
  • Heparin (25,000 IU / 5 ml, Choay Laboratory, Sanofi Winthrop) is an anticoagulant that works by inhibiting the transformation of prothrombin into thrombin. At the site of action, the effect of heparin is immediate. It acts through a natural inhibitor called a cofactor, or antithrombin III.
  • Protamine sulphate (10,000 IU / 10 ml, Choay Laboratory, Sanofi Winthrop) forms a salt with heparin and causes a unit for unit suppression of its anticoagulant effect. 1 ml of protamine solution neutralizes the anticoagulant activity of 1000 units of heparin.
  • the calcium ion Ca ⁇ is an essential ion for coagulation. Source substances and materials used
  • the characteristic electrical signals were recorded from samples of 1 ml of the following solutions: - Ca ++ in solution at 1 ⁇ M in water for injection (for example of Biosédra brand)
  • the transducer-receiver 6 has the characteristics described.
  • the transducer-transmitter 51 making it possible to apply the characteristic electrical signal to a receiving substance or to a biological control system or to a sensitive biological system, is an electromagnetic coil having the following characteristics:
  • Protocol No. 1 "In vitro" experiment: Coagulating or anticoagulant action of characteristic electrical signals on Platelet Rich Plasma (PRP).
  • PRP Platelet Rich Plasma
  • the method and the system described make it possible to produce an electrical signal characteristic of the Ca ++ ion and of heparin having respectively a coagulating or anticoagulant effect
  • the method and the described system make it possible to test an electrical signal having respectively a coagulating or anticoagulant effect.
  • rabbit As a biological control system for revealing the electrical signal characteristic of the Ca ++ ion and heparin, or as a sensitive biological system for testing the coagulant or anticoagulant effect of an electrical signal, rabbit (or human).
  • the blood of a "New-Zealand White" rabbit is taken from the artery of the ear and collected on an ACD anticoagulant (9 vol. Blood / 1 vol. ACD), the composition of which is as follows: citric acid 0.8% , sodium citrate 2.2%, anhydrous glucose 2.23%.
  • the blood After centrifugation (180 g, 15 minutes) at room temperature, the blood is divided into 3 layers: from top to bottom, the Plasma Rich Plasma (PRP), the buffy coat and the pellet of red blood cells.
  • the PRP is taken by pipette by gentle suction.
  • n number of values
  • Avg average
  • SD standard deviation
  • heparin signal has an effect of inhibiting the coagulation of the PRP.
  • the PRP not exposed to a signal or the PRP exposed to a control signal such as for example that of the heparin + protamine complex, does not have an inhibiting effect.
  • This coagulation inhibiting effect is particularly notable for a Ca ++ concentration of between 2 and 3 mM.
  • the biological control system constituted by plasma rich in platelets makes it possible to control that the characteristic signal of heparin has an anticoagulant effect.
  • the sensitive biological system constituted by plasma rich in platelets makes it possible to test whether a characteristic signal has an anticoagulant effect.
  • 1 ml of PRP is placed in a tube in the center of an electromagnetic coil to be exposed to the signal applied for 10 min with a voltage of 10 V across the coil.
  • the biological control system constituted by plasma rich in platelets makes it possible to control that the characteristic signal of calcium
  • Ca ++ has a coagulating effect.
  • the sensitive biological system consisting of plasma rich in platelets allows us to test whether a characteristic signal has a coagulating effect.
  • Protocol 2 "In vivo" experience: Coagulating action or anticoagulant of characteristic electrical signals.
  • the method and the system described make it possible to test a substance having respectively a coagulant or anticoagulant effect.
  • a rabbit As a biological control system making it possible to reveal the coagulating or anticoagulant effect of the treated substance, or as a sensitive biological system making it possible to test the coagulating or anticoagulant effect of a substance, a rabbit is used which is administered, sublingually, treated water by means of an electrical signal characteristic of the source substance.
  • the water used is water for injection Biosédra in ampoules of 10 ml.
  • the water (10 ml) is placed in a tube 50 in the center of an electromagnetic coil 51.
  • the water is exposed to the characteristic signal considered for 10 min with a voltage at the terminals of the coil of 10 V.
  • the water is then stirred for 15 seconds at the maximum speed of the vortex. 3.
  • the rabbit is administered sublingually 1 ml of the water thus treated by the characteristic signal considered. Blood samples (1 ml) are taken from glass tubes at the artery of the ear, before administration, then 1, 5, 10, 15 and 30 minutes after administration of the treated water. The results obtained are presented in the table below
  • the biological control system constituted by an animal makes it possible to control that a receptor substance treated by the characteristic signal of heparin, in particular of water, has an anticoagulant effect.
  • the sensitive biological system constituted by an animal makes it possible to test, by controlling the characteristic signal of a substance (for example the heparin + protamine complex), whether this substance has a coagulant or anticoagulant effect.

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Abstract

The invention concerns a method and a system for producing a signal, in particular an electric signal, or a substance having a coagulating or anticoagulant effect. The method is characterised in that it is based on a source substance with coagulating effect, in particular, Ca++ ions, or an anticoagulant effect, in particular heparin. The method consists in: transforming (10) the electromagnetic field derived from said source substance located in the chamber (D), into a signal, in particular an electric signal, using a transducer-receiver sensing the electromagnetic field; applying (12) to a receiving substance located in the chamber (E), in particular water or a water-ethanol mixture or homeopathic granules, said signal derived from said transducer-receiver, using a transducer-transmitter. After said treatment, the receiving substance, initially inactive, has a coagulating or anticoagulant effect.

Description

Procédé et système pour produire une substance ou un signal ayant un effet coagulant ou anticoagulant.Method and system for producing a substance or signal having a coagulant or anticoagulant effect.
La présente invention concerne un procédé et un système pour produire une substance ou un signal, notamment un signal électrique, ayant un effet coagulant ou anticoagulant. L'invention concerne également une telle substance ou un tel signal et leurs effets thérapeutiques. L'invention concerne également un procédé et un système pour tester l'effet coagulant ou anticoagulant d'une substance ou d'un signal. On sait, depuis les travaux de recherche de Monsieur Jacques Benveniste, notamment ceux décrits dans la demande de brevet WO 94/17406 publiée le 4 août 1994, que l'on peut capter à partir d'un élément biologique et/ou chimique actif tel qu'un composé chimique, une cellule ou un microorganisme, ou à partir d'une substance contenant cet élément actif, un "signal électromagnétique caractéristique de l'activité biologique et/ ou chimique ou du comportement biologique et/ou chimique'' de ladite substance et/ou dudit élément actif contenu dans ladite substance. On sait également qu'il est possible de transformer, notamment au moyen d'un transducteur, un tel signal électromagnétique en un signal électrique. Dans la suite du texte, on entend également par "signal électrique caractéristique de l'activité biologique et/ou chimique ou du comportement biologique et/ou chimique d'une substance ou d'un élément actif contenu dans ladite substance" tout signal électrique dérivé par numérisation et/ou traitement de signal. Dans cette expression, on emploie "caractéristique" dans le sens où les paramètres physiques du signal électrique sont spécifiques à la substance ou à l'élément actif contenu dans ladite substance. Autrement dit, l'application de ce signal électrique, via un transducteur, à un système biologique de contrôle permet : (i) d'induire une activité biologique et/ou chimique sur ledit système biologique de contrôle en rapport avec celle de la substance d'origine ou de l'élément actif qu'elle contient,The present invention relates to a method and a system for producing a substance or a signal, in particular an electrical signal, having a coagulant or anticoagulant effect. The invention also relates to such a substance or such a signal and to their therapeutic effects. The invention also relates to a method and a system for testing the coagulant or anticoagulant effect of a substance or signal. We know, since the research work of Mr. Jacques Benveniste, especially those described in patent application WO 94/17406 published on August 4, 1994, that we can capture from an active biological and / or chemical element such that a chemical compound, a cell or a microorganism, or from a substance containing this active element, an "electromagnetic signal characteristic of the biological and / or chemical activity or of the biological and / or chemical behavior" of said substance and / or of said active element contained in said substance. It is also known that it is possible to transform, in particular by means of a transducer, such an electromagnetic signal into an electrical signal. "electrical signal characteristic of the biological and / or chemical activity or of the biological and / or chemical behavior of a substance or of an active element contained in said substance" any electrical signal riveted by scanning and / or signal processing. In this expression, "characteristic" is used in the sense that the physical parameters of the electrical signal are specific to the substance or to the active element contained in said substance. In other words, the application of this electrical signal, via a transducer, to a biological control system makes it possible: (i) to induce biological and / or chemical activity on said system biological control in relation to that of the original substance or of the active element which it contains,
(ii) de révéler une caractéristique de la substance ou de l'élément actif qu'elle contient, à l'origine dudit signal électrique. La demande de brevet WO 94/17406, publiée le 4 août 1994, décrit un procédé et un dispositif pour capter "un signal électromagnétique caractéristique d'une activité biologique et/ou chimique ou d'un comportement biologique et/ou chimique" à partir d'un élément biologique et/ou chimique actif tel qu'un composé chimique, une cellule ou un micro-organisme, ou à partir d'une substance contenant cet élément actif tel qu'une préparation purifiée, un prélèvement biologique, un être vivant.(ii) to reveal a characteristic of the substance or of the active element which it contains, at the origin of said electrical signal. Patent application WO 94/17406, published on August 4, 1994, describes a method and a device for capturing "an electromagnetic signal characteristic of a biological and / or chemical activity or of a biological and / or chemical behavior" from of an active biological and / or chemical element such as a chemical compound, a cell or a microorganism, or from a substance containing this active element such as a purified preparation, a biological sample, a living being .
Les inventeurs ont depuis découvert qu'il est possible d'améliorer la qualité du signal électromagnétique capté ainsi que la fiabilité du procédé de production de ce signal et qu'il est par conséquent possible de produire un signal électrique caractéristique susceptible d'applications industrielles.The inventors have since discovered that it is possible to improve the quality of the electromagnetic signal picked up as well as the reliability of the process for producing this signal and that it is therefore possible to produce a characteristic electrical signal capable of industrial applications.
Ces développements ont été décrits dans la demande françaiseThese developments have been described in the French application
FR 98 12 058 déposée le 23 septembre 1998. En tant que de besoin, les éléments de cette demande, non encore publiés à ce jour, utiles à la compréhension de la présente invention, seront extraits et insérés dans la présente demande.FR 98 12 058 filed on September 23, 1998. As necessary, the elements of this request, not yet published to date, useful for understanding the present invention, will be extracted and inserted in the present request.
Procédé et système selon l'invention pour produire une substance ayant un effet coagulant ou anticoagulant.Method and system according to the invention for producing a substance having a coagulant or anticoagulant effect.
Le procédé selon l'invention pour produire une substance ayant un effet coagulant ou anticoagulant, à partir d'une substance source ayant un effet coagulant, notamment des ions Ca++, ou anticoagulant, notamment de l'héparine, comporte au moins les étapes suivantes.The method according to the invention for producing a substance having a coagulating or anticoagulant effect, from a source substance having a coagulating effect, in particular Ca ++ ions, or anticoagulant, in particular heparin, comprises at least the steps following.
L'étape 1 a pour objet de transformer le champ électromagnétique provenant de ladite substance source en un signal, notamment un signal caractéristique électrique, au moyen d'un transducteur- récepteur captant ledit champ électromagnétique.The purpose of step 1 is to transform the electromagnetic field originating from said source substance into a signal, in particular a signal electrical characteristic, by means of a transducer-receiver capturing said electromagnetic field.
L'étape 2 a pour objet d'appliquer à une substance réceptrice, notamment de l'eau ou un mélange eau-éthanol ou des granules homéopathiques, ledit signal provenant dudit transducteur- récepteur, au moyen d'un transducteur-émetteur.The purpose of step 2 is to apply to a receiving substance, in particular water or a water-ethanol mixture or homeopathic granules, said signal coming from said transducer-receiver, by means of a transducer-transmitter.
On constate qu'après le traitement ci-dessus défini, la substance réceptrice, initialement inactive, présente une activité coagulante ou anticoagulante. La substance réceptrice ainsi traitée sera ci-après appelée la "substance traitée".It is noted that after the above-defined treatment, the receptor substance, initially inactive, exhibits coagulant or anticoagulant activity. The receptor substance thus treated will hereinafter be called the "treated substance".
La concentration des éléments actifs dans la substance source, notamment la concentration des ions Ca++ ayant un effet coagulant ou de l'héparine ayant un effet anticoagulant, peut être de l'ordre de lμM. Elle peut aussi être très faible et atteindre 10"14 M. La substance source pourra aussi être constituée de produits homéopathiques, dilués si besoin dans l'eau pour préparation injectable.The concentration of the active elements in the source substance, in particular the concentration of Ca ++ ions having a coagulant effect or of heparin having an anticoagulant effect, can be of the order of 1 μM. It can also be very low and reach 10 "14 M. The source substance may also consist of homeopathic products, diluted if necessary in water for injection.
De préférence, pour transformer le champ électromagnétique provenant de ladite substance source en un signal électrique :Preferably, to transform the electromagnetic field coming from said source substance into an electrical signal:
- on place ladite substance source dans une zone soumise à un champ d'excitation de nature électrique, magnétique et/ou électromagnétique et,said source substance is placed in a zone subjected to an excitation field of an electrical, magnetic and / or electromagnetic nature and,
- on transforme les champs résultants de l'interaction du champ d'excitation et de ladite substance source en un signal électrique, au moyen d'un transducteur-récepteur captant lesdits champs résultants. Le système selon l'invention pour produire une substance ayant un effet coagulant ou anticoagulant, à partir d'une substance source ayant un effet coagulant, notamment des ions Ca++, ou anticoagulant, notamment de l'héparine, comprend au moins les éléments ci-après définis. Un transducteur-récepteur reçoit le champ électromagnétique provenant de ladite substance source. Ledit transducteur-récepteur transforme ledit champ électromagnétique en un signal, notamment un signal électrique. Un transducteur-émetteur permet d'appliquer le signal provenant dudit transducteur-récepteur à une substance réceptrice, notamment de l'eau ou un mélange eau-éthanol ou des granules homéopathiques.- The fields resulting from the interaction of the excitation field and said source substance are transformed into an electrical signal, by means of a transducer-receiver capturing said resulting fields. The system according to the invention for producing a substance having a coagulating or anticoagulant effect, from a source substance having a coagulating effect, in particular Ca ++ ions, or anticoagulant, in particular heparin, comprises at least the elements below defined. A transducer-receiver receives the electromagnetic field from of said source substance. Said transducer-receiver transforms said electromagnetic field into a signal, in particular an electrical signal. A transducer-transmitter makes it possible to apply the signal coming from said transducer-receiver to a receiving substance, in particular water or a water-ethanol mixture or homeopathic granules.
Après le traitement mis en oeuvre par le système ci-dessus défini, la substance réceptrice, initialement inactive, présente une activité coagulante ou anticoagulante. De préférence, le système selon l'invention comprend en outre un émetteur générant un champ d'excitation de nature électrique, magnétique et/ou électromagnétique dans une zone où est située ladite substance source. Un transducteur- récepteur, recevant les champs résultants de l'interaction dudit champ d'excitation et de ladite substance source, transforme lesdits champs résultants en un signal, notamment un signal électrique. Substance selon l'invention ayant un effet coagulant ou anticoagulantAfter the treatment implemented by the system defined above, the receptor substance, initially inactive, exhibits coagulant or anticoagulant activity. Preferably, the system according to the invention further comprises an emitter generating an excitation field of an electrical, magnetic and / or electromagnetic nature in an area where said source substance is located. A transducer-receiver, receiving the fields resulting from the interaction of said excitation field and said source substance, transforms said resulting fields into a signal, in particular an electrical signal. Substance according to the invention having a coagulant or anticoagulant effect
L'invention concerne également un substance ayant un effet coagulant ou anticoagulant. Ladite substance, notamment de l'eau ou un mélange eau- éthanol ou des granules homéopathiques, est caractérisée en ce qu'elle a été traitée au moyen d'un signal électrique ou électromagnétique provenant d'une substance source ayant des effets coagulants, notamment des ions Ca++, ou anticoagulant, notamment de l'héparine. L'invention concerne également les applications thérapeutiques d'une telle substance. La substance selon l'invention peut être utilisée dans le traitement de la maladie thrombo embolique. Elle peut être aussi utilisée pour procéder à des tests d'exploration de la coagulation.The invention also relates to a substance having a coagulant or anticoagulant effect. Said substance, in particular water or a water-ethanol mixture or homeopathic granules, is characterized in that it has been treated by means of an electrical or electromagnetic signal originating from a source substance having coagulant effects, in particular Ca ++ ions, or anticoagulant, in particular heparin. The invention also relates to the therapeutic applications of such a substance. The substance according to the invention can be used in the treatment of thromboembolic disease. It can also be used to carry out coagulation exploration tests.
Procédé selon l'invention pour tester l'effet coagulant ou anticoagulant d'une substanceMethod according to the invention for testing the coagulant or anticoagulant effect of a substance
L'invention concerne également un procédé pour tester une substance ayant un effet coagulant, notamment des ions Ca"^, ou anticoagulant, notamment de l'héparine. Le procédé comporte au moins les étapes suivantes.The invention also relates to a method for testing a substance having a coagulating effect, in particular Ca " ^ ions, or anticoagulant, including heparin. The method includes at least the following steps.
L'étape 1 a pour objet de transformer le champ électromagnétique provenant de ladite substance, en un signal, notamment un signal électrique, au moyen d'un transducteur- récepteur captant ledit champ électromagnétique .The purpose of step 1 is to transform the electromagnetic field originating from said substance, into a signal, in particular an electrical signal, by means of a transducer-receiver sensing said electromagnetic field.
L'étape 2 a pour objet d'appliquer à un système biologique sensible, directement ou indirectement, ledit signal provenant dudit transducteur- récepteur. De préférence, selon l'invention pour transformer le champ électromagnétique provenant de ladite substance en un signal électrique :The purpose of step 2 is to apply said signal from said transducer-receiver to a sensitive biological system, directly or indirectly. Preferably, according to the invention for transforming the electromagnetic field originating from said substance into an electrical signal:
- on place ladite substance dans une zone soumise à un champ d'excitation de nature électrique, magnétique et/ou électromagnétique,said substance is placed in a zone subjected to an excitation field of an electrical, magnetic and / or electromagnetic nature,
- on transforme les champs résultants de l'interaction du champ d'excitation et de ladite substance source en un signal électrique, au moyen d'un transducteur-récepteur captant lesdits champs résultants. Avantageusement, le système biologique sensible peut être du sang ou du plasma auquel on applique ledit signal au moyen d'un transducteur- émetteur. On peut aussi utiliser avantageusement du plasma riche en plaquettes.- The fields resulting from the interaction of the excitation field and said source substance are transformed into an electrical signal, by means of a transducer-receiver capturing said resulting fields. Advantageously, the sensitive biological system can be blood or plasma to which the said signal is applied by means of a transducer-transmitter. One can also advantageously use plasma rich in platelets.
Avantageusement, selon une autre variante de réalisation, le système biologique sensible est un animal, notamment un lapin, auquel on administre, notamment sous la langue, une substance, notamment de l'eau, traitée par ledit signal au moyen d'un transducteur-émetteur. Le procédé selon l'invention pour tester l'effet coagulant ou anticoagulant d'une substance peut être appliqué au contrôle de production de produits homéopathiques.Advantageously, according to another alternative embodiment, the sensitive biological system is an animal, in particular a rabbit, to which is administered, in particular under the tongue, a substance, in particular water, treated by said signal by means of a transducer- transmitter. The method according to the invention for testing the coagulant or anticoagulant effect of a substance can be applied to the control of production of homeopathic products.
Procédé et système selon l'invention pour produire un signal ayant un effet coagulant ou anticoagulant. Le procédé selon l'invention pour produire un signal, notamment un signal électrique ou électromagnétique, ayant un effet coagulant ou anticoagulant, à partir d'une substance source ayant un effet coagulant, notamment des ions Ca++, ou anticoagulant, notamment de l'héparine, comporte au moins l'étape de transformer le champ électromagnétique provenant de ladite substance source, en un signal, notamment un signal électrique, au moyen d'un transducteur- récepteur captant ledit champ électromagnétique .Method and system according to the invention for producing a signal having a coagulant or anticoagulant effect. The method according to the invention for producing a signal, in particular an electrical or electromagnetic signal, having a coagulant or anticoagulant effect, from a source substance having a coagulant effect, in particular Ca ++ ions, or anticoagulant, in particular of the heparin, comprises at least the step of transforming the electromagnetic field originating from said source substance, into a signal, in particular an electrical signal, by means of a transducer-receiver capturing said electromagnetic field.
De préférence, pour transformer le champ électromagnétique provenant de ladite substance source en un signal électrique :Preferably, to transform the electromagnetic field coming from said source substance into an electrical signal:
- on place ladite substance source dans une zone soumise à un champ d'excitation de nature électrique, magnétique et/ou électromagnétique,said source substance is placed in an area subjected to an excitation field of an electrical, magnetic and / or electromagnetic nature,
- on transforme les champs résultants de l'interaction du champ d'excitation et de la substance source, en un signal, notamment un signal électrique, au moyen d'un transducteur-récepteur captant lesdits champs résultants.- The fields resulting from the interaction of the excitation field and the source substance are transformed into a signal, in particular an electrical signal, by means of a transducer-receiver capturing said resulting fields.
De préférence également, le procédé selon l'invention pour produire un signal, notamment un signal électrique ou électromagnétique, ayant un effet coagulant ou anticoagulant, comprend en outre l'étape de contrôler les corrélations entre d'une part, le signal provenant dudit transducteur- récepteur et d'autre part, l'activité coagulante ou anticoagulante de ladite substance source, en appliquant, directement ou indirectement, ledit signal à un système biologique de contrôle et en vérifiant que ledit système biologique de contrôle réagit conformément à l'activité coagulante ou anticoagulante de la substance source dont est issu le signal. Avantageusement, le système biologique de contrôle est du sang ou du plasma auquel on applique ledit signal au moyen d'un transducteur- émetteur. On peut aussi utiliser avantageusement du plasma riche en plaquettes.Preferably also, the method according to the invention for producing a signal, in particular an electrical or electromagnetic signal, having a coagulant or anticoagulant effect, further comprises the step of checking the correlations between on the one hand, the signal coming from said transducer - receptor and on the other hand, the coagulating or anticoagulant activity of said source substance, by applying, directly or indirectly, said signal to a biological control system and by verifying that said biological control system reacts in accordance with the coagulating activity or anticoagulant of the source substance from which the signal comes. Advantageously, the biological control system is blood or plasma to which said signal is applied by means of a transducer-transmitter. It is also advantageous to use plasma rich in platelets.
Avantageusement, dans une autre variante de réalisation, le système biologique de contrôle est un animal, notamment un lapin, auquel on administre, notamment sous la langue, une substance, notamment de l'eau, traitée par ledit signal au moyen d'un transducteur- émetteur.Advantageously, in another alternative embodiment, the biological control system is an animal, in particular a rabbit, to which is administered, in particular under the tongue, a substance, in particular water, treated by said signal by means of a transducer - transmitter.
La présente invention concerne également un système pour produire un signal, notamment un signal électrique ou électromagnétique, ayant un effet coagulant ou anticoagulant, à partir d'une substance source ayant un effet coagulant, notamment des ions Ca"^, ou anticoagulant, notamment de l'héparine. Ledit système comprend un transducteur-récepteur recevant le champ électromagnétique provenant de ladite substance source, ledit transducteur-récepteur transformant ledit champ électromagnétique en un signal, notamment un signal électrique. De préférence, le système selon l'invention comprend en outre un émetteur générant un champ d'excitation de nature électrique, magnétique et/ou électromagnétique dans une zone où est située ladite substance source. Ledit transducteur-récepteur, recevant les champs résultants de l'interaction dudit champ d'excitation et de ladite substance source, transforme lesdits champs résultants en un signal, notamment un signal électrique.The present invention also relates to a system for producing a signal, in particular an electrical or electromagnetic signal, having a coagulant or anticoagulant effect, from a source substance having a coagulant effect, in particular Ca " ^ ions, or anticoagulant, in particular of heparin. Said system comprises a transducer-receiver receiving the electromagnetic field originating from said source substance, said transducer-receiver transforming said electromagnetic field into a signal, in particular an electrical signal. Preferably, the system according to the invention further comprises an emitter generating an excitation field of an electrical, magnetic and / or electromagnetic nature in an area where said source substance is located, said transducer-receiver, receiving the fields resulting from the interaction of said excitation field and said source substance , transforms said resulting fields into a signal, in particular an electrical signal ique.
De préférence également, le système selon l'invention comprend en outre des moyens de contrôle pour contrôler les corrélations entre d'une part, le signal provenant dudit transducteur-récepteur et d'autre part, l'activité coagulante ou anticoagulante de ladite substance source. Lesdits moyens de contrôle comprennent un transducteur-émetteur appliquant, directement ou indirectement, ledit signal à un système biologique de contrôle. Lesdits moyens de contrôle comprennent en outre des moyens de vérification pour vérifier que le système biologique de contrôle réagit conformément à l'activité coagulante ou anticoagulante de la substance source dont est issu le signal.Preferably also, the system according to the invention further comprises control means for controlling the correlations between on the one hand, the signal coming from said transducer-receiver and on the other hand, the coagulant or anticoagulant activity of said source substance . Said control means comprise a transducer-transmitter applying, directly or indirectly, said signal to a biological control system. Said control means further comprise verification means for verifying that the biological control system reacts in accordance with the coagulant or anticoagulant activity of the source substance which is issued the signal.
Avantageusement, le système biologique de contrôle est du sang ou du plasma auquel on applique ledit signal au moyen dudit transducteur- émetteur. On peut aussi utiliser avantageusement du plasma riche en plaquettes.Advantageously, the biological control system is blood or plasma to which said signal is applied by means of said transducer-transmitter. One can also advantageously use plasma rich in platelets.
Avantageusement dans une autre variante de réalisation, le système biologique de contrôle est un animal, notamment un lapin, auquel on administre, notamment sous la langue, une substance, notamment de l'eau, traitée par ledit signal au moyen dudit transducteur-émetteur. Signal selon l'invention ayant un effet coagulant ou anticoagulantAdvantageously in another alternative embodiment, the biological control system is an animal, in particular a rabbit, to which a substance, in particular water, is administered, in particular under the tongue, treated by said signal by means of said transducer-transmitter. Signal according to the invention having a coagulant or anticoagulant effect
La présente invention concerne également un signal proprement dit, notamment un signal électrique ou électromagnétique, ayant un effet coagulant ou anticoagulant. Ledit signal est obtenu à partir d'une substance source ayant un effet coagulant, notamment des ions Ca"^, ou anticoagulant, notamment de l'héparine, en mettant en oeuvre les procédés ou les systèmes ci-dessus décrits. Ledit signal est caractérisé en ce qu'un système biologique de contrôle réagit, après application directe ou indirecte dudit signal, conformément à l'activité coagulante ou anticoagulante de la substance source dont est issu le signal. Avantageusement, le système biologique de contrôle est du sang ou du plasma auquel on applique ledit signal au moyen d'un transducteur- émetteur. On peut aussi utiliser avantageusement du plasma riche en plaquettes. Avantageusement dans une autre variante de réalisation, le système biologique de contrôle est un animal, notamment un lapin, auquel on administre, notamment sous la langue, une substance, notamment de l'eau, traitée par ledit signal au moyen d'un transducteur-émetteur. L'invention concerne également les applications thérapeutiques d'un tel signal. Le signal selon l'invention peut être utilisé, directement ou indirectement par l'intermédiaire d'une matière réceptrice, dans le traitement des maladies thrombo emboliques. Il peut être aussi utilisé, directement ou indirectement par l'intermédiaire d'une matière réceptrice, pour procéder à des tests d'exploration de la coagulation. Procédé selon l'invention pour tester l'effet coagulant ou anticoagulant d'un signalThe present invention also relates to a signal proper, in particular an electrical or electromagnetic signal, having a coagulant or anticoagulant effect. Said signal is obtained from a source substance having a coagulating effect, in particular Ca " ^ ions, or anticoagulant, in particular heparin, by implementing the methods or the systems described above. Said signal is characterized in that a biological control system reacts, after direct or indirect application of said signal, in accordance with the coagulant or anticoagulant activity of the source substance from which the signal is derived. Advantageously, the biological control system is blood or plasma to which said signal is applied by means of a transducer-transmitter. It is also advantageous to use platelet-rich plasma. Advantageously in another variant embodiment, the biological control system is an animal, in particular a rabbit, to which one administers, in particular under the tongue, a substance, in particular water, treated by said signal by means of a transducer-transmitter. s therapeutic applications of such a signal. The signal according to the invention can be used, directly or indirectly via a receptor material, in the treatment of thromboembolic diseases. It can also be used, directly or indirectly via a receiving material, to carry out tests for exploring coagulation. Method according to the invention for testing the coagulant or anticoagulant effect of a signal
L'invention concerne également un procédé pour tester un signal ayant un effet coagulant ou anticoagulant. Ledit signal est obtenu à partir d'une substance source ayant un effet coagulant, notamment des ions Ca++, ou anticoagulant, notamment de l'héparine, en mettant en oeuvre les procédés ou les systèmes précédemment décrits. Le procédé selon l'invention comprend l'étape d'appliquer ledit signal, directement ou indirectement, à un système biologique test et de vérifier que le système biologique test réagit conformément à l'activité coagulante ou anticoagulante de la substance source dont est issu le signal.The invention also relates to a method for testing a signal having a coagulant or anticoagulant effect. Said signal is obtained from a source substance having a coagulating effect, in particular Ca ++ ions, or anticoagulant, in particular heparin, by implementing the methods or systems previously described. The method according to the invention comprises the step of applying said signal, directly or indirectly, to a biological test system and of verifying that the biological test system reacts in accordance with the coagulant or anticoagulant activity of the source substance from which the signal.
Avantageusement, le système biologique test est du sang ou du plasma auquel on applique ledit signal au moyen d'un transducteur-émetteur. On peut aussi utiliser avantageusement du plasma riche en plaquettes. Avantageusement, selon une autre variante de réalisation, le système biologique test est un animal, notamment un lapin, auquel on administre, notamment sous la langue, une substance, notamment de l'eau, traitée par ledit signal au moyen d'un transducteur-émetteur.Advantageously, the biological test system is blood or plasma to which said signal is applied by means of a transducer-transmitter. One can also advantageously use plasma rich in platelets. Advantageously, according to another alternative embodiment, the biological test system is an animal, in particular a rabbit, to which is administered, in particular under the tongue, a substance, in particular water, treated by said signal by means of a transducer- transmitter.
Le procédé selon l'invention pour tester l'effet coagulant ou anticoagulant d'un signal peut être appliqué au contrôle de production de produits homéopathiques.The method according to the invention for testing the coagulant or anticoagulant effect of a signal can be applied to the control of production of homeopathic products.
D'autres caractéristiques et avantages de l'invention apparaîtront à la lecture de la description de variantes de réalisation de l'invention, données à titre d'exemple indicatif et non limitatif, ainsi qu'à la lecture des exemples d'expérimentations ayant permis de valider le procédé de production d'une substance ou d'un signal électrique caractéristique, ayant des effets coagulants ou anticoagulants. La description se réfère aux dessins annexés dans lesquels :Other characteristics and advantages of the invention will appear on reading the description of variant embodiments of the invention, given by way of non-limiting example, as well as on reading the examples of experiments which have enabled to validate the production process of a substance or characteristic electrical signal, having coagulant or anticoagulant effects. The description refers to the accompanying drawings in which:
- la figure 1 représente un schéma d'un exemple de réalisation d'un système permettant de produire un signal électrique caractéristique, et d'appliquer le signal électrique caractéristique ainsi produit à une substance réceptrice ou à un système biologique de contrôle ou à un système biologique sensible,- Figure 1 shows a diagram of an exemplary embodiment of a system for producing a characteristic electrical signal, and applying the characteristic electrical signal thus produced to a receptor substance or to a biological control system or to a system sensitive biological,
- la figure la représente une vue détaillée en perspective d'une partie du dispositif de production du signal électrique, montrant l'émetteur de champ d'excitation et le transducteur-récepteur recevant les champs résultants,FIG. 1a represents a detailed perspective view of a part of the device for producing the electrical signal, showing the excitation field transmitter and the transducer-receiver receiving the resulting fields,
- la figure lb représente sous forme de bloc diagramme le type de micro-ordinateur utilisé soit pour générer les champs d'excitation, soit pour enregistrer et transmettre sous forme numérisée le signal électrique caractéristique,FIG. 1b represents in block diagram form the type of microcomputer used either to generate the excitation fields, or to record and transmit in digitized form the characteristic electrical signal,
- la figure le représente une vue détaillée en perspective d'une partie d'un transducteur-émetteur destiné à appliquer le signal électrique caractéristique à une substance réceptrice ou à un système biologique de contrôle ou à un système biologique sensible.- Figure le represents a detailed perspective view of part of a transducer-transmitter intended to apply the characteristic electrical signal to a receptor substance or to a biological control system or to a sensitive biological system.
Schéma général du systèmeGeneral scheme of the system
On va maintenant décrire, en se référant aux figures 1, la, lb et le, un exemple de réalisation d'un système permettant (i) de produire - à partir d'ions Ca"^ un signal électrique caractéristique ayant un effet coagulants, ouWe will now describe, with reference to FIGS. 1, 1a, 1b and 1c, an exemplary embodiment of a system making it possible (i) to produce - from Ca " ^ ions a characteristic electrical signal having a coagulant effect, or
- à partir d'héparine un signal électrique caractéristique ayant un effet anticoagulant et,- from heparin a characteristic electrical signal having an anticoagulant effect and,
(ii) d'appliquer un tel signal caractéristique à une substance réceptrice ou à un système biologique de contrôle ou à un système biologique sensible.(ii) to apply such a characteristic signal to a substance receptor or a biological control system or a sensitive biological system.
Le système comprend un dispositif 10 pour produire un signal électrique caractéristique de l'activité biologique et/ou chimique ou du comportement biologique et/ou chimique d'une substance 1 ou d'un élément actif contenu dans ladite substance. Dans le cas de la variante décrite en se référant aux figures 1, la, lb et le, ladite substance 1 est : soit des ions Ca++ en solution à lμM dans de l'eau pour préparation injectable (par ex. de marque Biosédra), -soit de l'héparine à la concentration de 2.5 U.I./ml dans la même qualité d'eau.The system comprises a device 10 for producing an electrical signal characteristic of the biological and / or chemical activity or of the biological and / or chemical behavior of a substance 1 or of an active element contained in said substance. In the case of the variant described with reference to FIGS. 1, la, lb and le, said substance 1 is: either Ca ++ ions in solution at 1 μM in water for injectable preparation (for example of the Biosédra brand ), or heparin at a concentration of 2.5 IU / ml in the same quality of water.
Le dispositif 10, localisé à Paris par exemple, produit un signal électrique caractéristique qui est numérisé après conversion analogique-numérique. Le signal ainsi numérisé est, de manière connue en soi, transmis à distance, par exemple par un réseau de communication informatique du type internet mettant en oeuvre des liaisons hertziennes 11. Le signal numérisé ainsi transmis est reçu par un applicateur 12, situé à New York par exemple. L'applicateur 12 comporte des moyens d'émission 13. Les moyens d'émission 13 permettent d'appliquer le signal caractéristique (après conversion numérique-analogique) à une substance réceptrice ou à un système biologique de contrôle ou à un système biologique sensible. Les moyens prévus pour numériser et transmettre à distance le signal électrique caractéristique de l'ion Ca++ ou de l'héparine ne sont pas indispensables à la réalisation de l'invention. Ils ont été décrits pour mettre en évidence les avantages techniques et commerciaux liés à la possibilité de produire un signal électrique caractéristique de l'ion Ca++ ou de l'héparine ayant, comme les substances sources dont ils sont issus, des effets coagulants ou anticoagulants. Dans le cas de la variante décrite en se référant aux figures 1, la, lb et le, - la substance réceptrice est de l'eau ou un mélange eau-éthanol ou des granules homéopathiques,The device 10, located in Paris for example, produces a characteristic electrical signal which is digitized after analog-digital conversion. The signal thus digitized is, in a manner known per se, transmitted remotely, for example by a computer communication network of the internet type using radio links 11. The digitized signal thus transmitted is received by an applicator 12, located in New York for example. The applicator 12 comprises transmission means 13. The transmission means 13 make it possible to apply the characteristic signal (after digital-analog conversion) to a receiving substance or to a biological control system or to a sensitive biological system. The means provided for digitizing and transmitting remotely the electrical signal characteristic of the Ca ++ ion or of heparin are not essential to the realization of the invention. They have been described to highlight the technical and commercial advantages linked to the possibility of producing an electrical signal characteristic of the Ca ++ ion or of heparin having, like the source substances from which they originate, coagulant or anti coagulants. In the case of the variant described with reference to FIGS. 1, la, lb and le, - the receiving substance is water or a water-ethanol mixture or homeopathic granules,
- le système biologique de contrôle ou le système biologique sensible est du sang ou du plasma. I Le dispositif de production du signal caractéristique de l'ion Ca^ ou de l'héparine- the biological control system or the sensitive biological system is blood or plasma. I The device producing the signal characteristic of the Ca ^ ion or heparin
• L'enceinte• The enclosure
Le dispositif de production du signal 10 comprend une enceinte D, 2 munie d'un blindage électrique et magnétique l'isolant des champs parasites provenant de l'environnement. L'enceinte cylindrique blindée est composée de trois couches superposées : cuivre, fer doux, mumétal, réalisées en tôle de 1 mm d'épaisseur. L'enceinte a un diamètre intérieur de 65 mm et une hauteur de 100 mm. L'enceinte est fermée par un couvercle blindé 5. Dans l'enceinte 2 est placée une cuve 3 en verre ou en plastique ayant pour dimension 10 mm x 10 mm x 45 mm. Cette cuve 3 contient 1 ml de la substance 1. C'est-à-dire : soit des ions Ca++ en solution à lμM dans de l'eau pour préparation injectable (par ex. de marque Biosédra),The signal production device 10 comprises an enclosure D, 2 provided with an electrical and magnetic shielding isolating it from the stray fields coming from the environment. The shielded cylindrical enclosure is made up of three superimposed layers: copper, soft iron, mumetal, made of sheet metal 1 mm thick. The enclosure has an internal diameter of 65 mm and a height of 100 mm. The enclosure is closed by a shielded cover 5. In the enclosure 2 is placed a tank 3 of glass or plastic having the dimension 10 mm x 10 mm x 45 mm. This tank 3 contains 1 ml of substance 1. That is to say: either Ca ++ ions in solution at 1 μM in water for injection (for example of the Biosédra brand),
-soit de l'héparine à la concentration de 2.5 U.I./ml dans la même qualité d'eau.- or heparin at a concentration of 2.5 IU / ml in the same quality of water.
• L'émetteur du champ d'excitation spécifique• The transmitter of the specific excitation field
Un émetteur 4 est situé à l'intérieur de l'enceinte. Il génère un champ d'excitation spécifique de nature électromagnétique. L'émetteur est alimenté par un générateur 14. L'émetteur 4 comporte une bobine avantageusement complétée par un noyau magnétique en fer doux. La bobine émettrice 4 a une impédance de 300 ohms, un diamètre intérieur de 6 mm, un diamètre extérieur de 16 mm, une longueur de 6 mm. Le noyau magnétique en fer doux est placé au contact des parois extérieures de la cuve 3. Ladite substance 1 est ainsi soumise au champ d'excitation émis par l'émetteur 4. Le générateur 14 est conçu pour générer un signal basse fréquence notamment des signaux carrés ou sinusoïdaux basse fréquence, du bruit rose ou, avantageusement, du bruit blanc. Le spectre du signal d'excitation alimentant la bobine émettrice 4 correspond sensiblement au spectre des fréquences audibles (20 Hz - 20 000 Hz). Le générateur 14 peut être un générateur de signal analogique de type connu, utilisant par exemple une mémoire morte (ROM, PROM, EPROM, EEPROM en terminologie anglo-saxonne) contenant le signal numérique du bruit désiré. Cette mémoire est reliée de manière connue en soi à un convertisseur numérique-analogique. On peut utiliser aussi un micro-ordinateur 14, muni d'une carte son 25 comportant un convertisseur numérique-analogique 41. On peut par exemple utiliser un ordinateur 14 de type PC, opérant sous le système d'exploitation WINDOWS® 95 de la Société MICROSOFT et comportant, outre la carte son 25 un microprocesseur 27, une interface d'entrée/sortie 29, un contrôleur 31 d'une mémoire de masse 33 et une interface vidéo 35 reliés par un ou plusieurs bus 37. Le convertisseur numérique analogique 41 de la carte son 25 comporte une borne de sortie 8. La borne de sortie 8 de la carte son du micro-ordinateur 14 est reliée à la borne d'entrée 8' de l'émetteur 4, via un amplificateur 15 dont les caractéristiques sont les suivantes : bande passante de 10 Hz à 20 kHz, gain 1 à 10, sensibilité d'entrée +/- 1 V. Parmi les cartes son 25 que l'on peut utiliser, on peut citer par exemple la carte Soundblaster 16 vendue par ; la Société CREATIVE LABS. • Le transducteur-récepteur Le transducteur- récepteur 6, situé à l'intérieur de l'enceinte 2, reçoit les champs résultants de l'interaction dudit champ d'excitation spécifique et de ladite substance 1. Le transducteur- récepteur 6 transforme lesdits champs résultants en un signal électrique. Ce signal électrique se présente, aux bornes de sortie 9' du transducteur- récepteur 6, sous la forme d'une différence de potentiel variable ou d'un courant électrique d'intensité variable. Le transducteur-récepteur 6 comporte une bobine ayant un noyau en fer doux. Cette bobine a une impédance de 300 ohms, un diamètre intérieur de 6 mm, un diamètre extérieur de 16 mm, une longueur de 6 mm. Le noyau magnétique en fer doux est placé au contact des parois extérieures de la cuve 3.A transmitter 4 is located inside the enclosure. It generates a specific excitation field of an electromagnetic nature. The transmitter is powered by a generator 14. The transmitter 4 comprises a coil advantageously supplemented by a soft iron magnetic core. The emitting coil 4 has an impedance of 300 ohms, an inside diameter of 6 mm, an outside diameter of 16 mm, a length of 6 mm. The soft iron magnetic core is placed in contact with the outer walls of the tank 3. Said substance 1 is thus subjected to the excitation field emitted by the transmitter 4. The generator 14 is designed to generate a low frequency signal in particular square or sinusoidal low frequency signals, pink noise or, advantageously, white noise. The spectrum of the excitation signal supplying the emitting coil 4 corresponds substantially to the spectrum of audible frequencies (20 Hz - 20,000 Hz). The generator 14 can be an analog signal generator of known type, using for example a read only memory (ROM, PROM, EPROM, EEPROM in English terminology) containing the digital signal of the desired noise. This memory is connected in a manner known per se to a digital-analog converter. One can also use a microcomputer 14 provided with a sound card 25 having a digital to analog converter 41. One can for example use a computer 14 of the PC type, operating under the WINDOWS ® operating system 95 of the Company MICROSOFT and comprising, in addition to the sound card 25 a microprocessor 27, an input / output interface 29, a controller 31 of a mass memory 33 and a video interface 35 connected by one or more buses 37. The digital analog converter 41 of the sound card 25 has an output terminal 8. The output terminal 8 of the microcomputer sound card 14 is connected to the input terminal 8 'of the transmitter 4, via an amplifier 15 whose characteristics are the following: bandwidth from 10 Hz to 20 kHz, gain 1 to 10, input sensitivity +/- 1 V. Among the 25 sound cards that can be used, we can cite for example the Soundblaster 16 card sold by ; CREATIVE LABS. • The transducer-receiver The transducer-receiver 6, located inside the enclosure 2, receives the fields resulting from the interaction of said specific excitation field and said substance 1. The transducer-receiver 6 transforms said fields resulting in an electrical signal. This electrical signal is present, at the output terminals 9 ′ of the transducer-receiver 6, in the form of a difference of variable potential or of an electric current of variable intensity. The transducer-receiver 6 comprises a coil having a soft iron core. This coil has an impedance of 300 ohms, an inside diameter of 6 mm, an outside diameter of 16 mm, a length of 6 mm. The soft iron magnetic core is placed in contact with the outer walls of the tank 3.
Avantageusement, le signal électrique caractéristique disponible à la sortie du transducteur-récepteur 6 est amplifié par un amplificateur- préamplificateur 16. L'amplificateur-préamplificateur 16 présente les caractéristiques suivantes : bande passante de 10 Hz à 20 kHz, gain 10 àAdvantageously, the characteristic electrical signal available at the output of the transducer-receiver 6 is amplified by an amplifier-preamplifier 16. The amplifier-preamplifier 16 has the following characteristics: bandwidth from 10 Hz to 20 kHz, gain 10 to
100, sensibilité d'entrée +/-100 mV.100, input sensitivity +/- 100 mV.
Dans le cas de la variante de réalisation décrite en se référant aux figures 1, la, lb, le il est prévu un émetteur 4 de champ d'excitation. L'utilisation d'un tel émetteur 4 favorise la production d'un signal électrique caractéristique de l'ion Ca++ ou de l'héparine. Toutefois, on peut également capter, au moyen d'un transducteur- récepteur 6, un signal caractéristique de l'ion Ca++ ou de l'héparine, sans mettre en oeuvre un champ d'excitation et sans utiliser d'enceinte blindée. • L'enregistrement du signal électrique caractéristique • • Enregistrement analogiqueIn the case of the variant embodiment described with reference to FIGS. 1, 1a, 1b, there is provided an excitation field transmitter 4. The use of such a transmitter 4 promotes the production of an electrical signal characteristic of the Ca ++ ion or heparin. However, it is also possible to receive, by means of a transducer-receiver 6, a signal characteristic of the Ca ++ ion or of heparin, without using an excitation field and without using a shielded enclosure. • Recording of the characteristic electrical signal • • Analog recording
L'enregistrement du signal électrique caractéristique, ou celui du signal électrique qui en dérive après amplification ou traitement, peut être effectué en analogique par un enregistreur de signal, notamment sur bande magnétique, adapté aux fréquences du signal électrique caractéristique à la sortie du transducteur-récepteur 6. Comme la bande passante utilisée correspond à la bande audio, on peut notamment utiliser un magnétophone. La borne de sortie 9' du transducteur-récepteur 6 est reliée à l'entrée microphone ou à l'entrée ligne d'un tel magnétophone. Lors de la lecture, le signal électrique caractéristique enregistré est recueilli à une borne de sortie, notamment à la sortie ligne ou à la sortie haut-parleur du magnétophone.The recording of the characteristic electrical signal, or that of the electrical signal which derives therefrom after amplification or processing, can be carried out in analog by a signal recorder, in particular on magnetic tape, adapted to the frequencies of the characteristic electrical signal at the output of the transducer. receiver 6. Since the bandwidth used corresponds to the audio band, it is possible in particular to use a tape recorder. The output terminal 9 'of the transducer-receiver 6 is connected to the microphone input or to the line input of such a tape recorder. During reading, the recorded characteristic electrical signal is collected at a output terminal, in particular at the line output or at the speaker output of the tape recorder.
• • Enregistrement numérique• • Digital recording
De préférence, on effectue un enregistrement numérique du signal électrique caractéristique après conversion analogique-numérique dudit signal. A cet effet, on utilise un micro-ordinateur 17, muni d'une carte d'acquisition de signal 25. Le micro-ordinateur 17 comporte en outre un microprocesseur 27, une interface d'entrée/sortie 29, un contrôleur 31 d'une mémoire de masse 33 et une interface vidéo 35 reliés par un ou plusieurs bus 37. On peut par exemple utiliser un ordinateur de type PC 17, opérant sous le système d'exploitation WINDOWS® 95 de la Société MICROSOFT Ce micro- ordinateur peut être du même type que celui utilisé pour générer le champ d'excitation. Ce peut être le même micro-ordinateur. La sortie 9' du transducteur-récepteur 6 ou de l' amplificateur-préamplificateur 16 est connectée à l'entrée 9 du convertisseur analogique-numérique 39 de la carte 25 de l'ordinateur 17. De préférence, le convertisseur analogique- numérique 39 a une résolution supérieure à 12 bits. Elle est avantageusement égale à 16 bits. De préférence également, le convertisseur analogique-numérique 39 a une fréquence d'échantillonnage double de la fréquence maximale que l'on veut pouvoir numériser, par exemple 44 kHz.Preferably, a digital recording of the characteristic electrical signal is carried out after analog-digital conversion of said signal. For this purpose, a microcomputer 17 is used, provided with a signal acquisition card 25. The microcomputer 17 further comprises a microprocessor 27, an input / output interface 29, a controller 31 of a mass memory 33 and a video 35 connected by one or more bus interface 37. it can for example use a PC type computer 17, operating under the WINDOWS ® operating system 95 of the MICROSOFT Company This microcomputer can be of the same type as that used to generate the excitation field. It can be the same microcomputer. The output 9 'of the transducer-receiver 6 or of the amplifier-preamplifier 16 is connected to the input 9 of the analog-digital converter 39 of the card 25 of the computer 17. Preferably, the analog-digital converter 39 has a resolution higher than 12 bits. It is advantageously equal to 16 bits. Preferably also, the analog-digital converter 39 has a sampling frequency twice the maximum frequency that it is desired to be able to digitize, for example 44 kHz.
On procède à une acquisition de signal électrique caractéristique pendant une durée par exemple comprise entre 1 et 60 s (par exemple 6 sec) et on enregistre le fichier numérique dans une mémoire de masse 33, par exemple sous la forme d'un fichier son au format WAV. Toutes les liaisons sont réalisées en câble blindé. Tous les appareils sont mis à la masse.A characteristic electrical signal is acquired for a duration for example between 1 and 60 s (for example 6 sec) and the digital file is recorded in a mass memory 33, for example in the form of a sound file at WAV format. All connections are made with shielded cable. All devices are grounded.
• Traitement du signal électrique caractéristique• Characteristic electrical signal processing
Pour le traitement du signal électrique caractéristique ou du signal qui en dérive, on utilise avantageusement le logiciel Matlab de la société "The Math Works".For processing the characteristic electrical signal or the signal derived therefrom, the Matlab software from the company "The Math Works ".
Le fichier numérique, enregistré comme il a été ci-dessus décrit, peut éventuellement subir un traitement numérique, comme par exemple une amplification numérique pour calibrage du niveau de signal, un filtrage pour l'élimination de fréquences non désirées, ou être transformé en son spectre par une transformée de FOURIER discrète, de préférence par l'algorithme de transformée de FOURIER rapide (FTT en teπninologie anglo-saxonne). La durée du signal produit peut être augmentée en répétant dans un fichier plusieurs fois un fragment ou la totalité du fichier- son produit originalement.The digital file, recorded as described above, may possibly undergo digital processing, such as for example digital amplification for signal level calibration, filtering for the elimination of unwanted frequencies, or be transformed into sound spectrum by a discrete FOURIER transform, preferably by the fast FOURIER transform algorithm (FTT in Anglo-Saxon teπninology). The duration of the signal produced can be increased by repeating a fragment or all of the file originally produced in a file several times.
Des moyens de traitement du signal électrique caractéristique peuvent être utilisés pour améliorer les perfoπnances du signal électrique caractéristique. Dans le cas d'une première variante de réalisation, il est prévu un second transducteur-récepteur du même type que celui précédemment décrit. En l'absence de ladite substance, ce second transducteur-récepteur transforme le champ d'excitation en un signal électrique. Ce signal électrique est soustrait par un branchement en série opposition au signal provenant du premier transducteur-récepteur. On obtient ainsi un signal électrique caractéristique plus représentatif de l'interaction du champ d'excitation spécifique et de la substance.Means for processing the characteristic electrical signal can be used to improve the performance of the characteristic electrical signal. In the case of a first alternative embodiment, a second transducer-receiver of the same type is provided as that previously described. In the absence of said substance, this second transducer-receiver transforms the excitation field into an electrical signal. This electrical signal is subtracted by a series connection opposite to the signal from the first transducer-receiver. This gives a characteristic electrical signal more representative of the interaction of the specific excitation field and the substance.
Dans le cas d'une deuxième variante de réalisation, les moyens de traitement prennent en compte les caractéristiques du champ d'excitation spécifique et retraitent le signal électrique caractéristique de la manière suivante. On procède tout d'abord au calcul de la répartition de la puissance spectrale (PSD). Puis on tronque cette puissance spectrale en ne conservant que la bande des fréquences allant par exemple de 140 Hz à 14 kHz, on reconstitue un signal à partir de cette puissance spectrale et de phases neutres, par exemple générées aléatoirement, enfin on calibre la puissance du signal ainsi produit. Par phases neutres, on désigne des phases ne provenant pas d'une substance source présentant une activité biologique.In the case of a second variant embodiment, the processing means take into account the characteristics of the specific excitation field and reprocess the characteristic electrical signal in the following manner. We first of all calculate the distribution of the spectral power (PSD). Then we truncate this spectral power while keeping only the frequency band going for example from 140 Hz to 14 kHz, we reconstitute a signal from this spectral power and neutral phases, for example randomly generated, finally we calibrate the power of the signal thus produced. By neutral phases, we mean phases not originating from a source substance exhibiting biological activity.
Dans le cas de la variante de réalisation décrite en se référant aux figures 1, la, lb, le, il est prévu de numériser, d'enregistrer et de traiter le signal électrique caractéristique avant de l'appliquer à une substance réceptrice ou un système biologique de contrôle ou à un système biologique sensible. Ces opérations ne sont pas indispensables à l'exploitation du signal électrique caractéristique de l'ion Ca++ ou de l'héparine, même si elles en favorisent la mise en oeuvre. Le signal électrique caractéristique disponible à la sortie du transducteur- récepteur 6 et le cas échéant du préamplificateur 16 constitue déjà en soi un produit susceptible d'applications industrielles. On verra ci-après pour quelles applications il peut être notamment mis en oeuvre au moyen d'un applicateur 12 permettant de les appliquer à une substance réceptrice ou à un système biologique de contrôle ou à un système biologique sensible.In the case of the variant embodiment described with reference to FIGS. 1, la, lb, le, provision is made to digitize, record and process the characteristic electrical signal before applying it to a receptor substance or a system biological control or to a sensitive biological system. These operations are not essential for the exploitation of the electrical signal characteristic of the Ca ++ ion or of heparin, even if they favor the implementation thereof. The characteristic electrical signal available at the output of the transducer-receiver 6 and, where appropriate, of the preamplifier 16 already constitutes in itself a product capable of industrial applications. We will see below for which applications it can be implemented in particular by means of an applicator 12 making it possible to apply them to a receptor substance or to a biological control system or to a sensitive biological system.
IL Transmission à distance du signal électrique caractéristique Le fichier du signal électrique caractéristique de l'ion Ca++ ou de l'héparine, enregistré sous forme numérique comme il vient d'être décrit, éventuellement après traitement, peut être transféré à distance par un réseau de communication informatique. Ce réseau peut comporter des liaisons hertziennes 11. Le fichier du signal électrique caractéristique de l'ion Ca++ ou de l'héparine, ainsi transmis, est enregistré par la mémoire de masse d'un micro-ordinateur 18. On peut par exemple utiliser un ordinateur de type PC, opérant sous le système d'exploitation WINDOWS® 95 de la Société MICROSOFT. Ce micro-ordinateur 18 peut être du même type que celui utilisé pour générer le champ d'excitation. Le fichier du signal électrique caractéristique numérisé, ainsi enregistré par le micro-ordinateur 18 distant, peut être exploité, de manière connue en soi, pour produire un signal électrique caractéristique analogique. Le fichier, éventuellement traité, est transformé par un convertisseur numérique-analogique 41 de la carte 25 (ou d'une carte séparée) de l'ordinateur 18. Le convertisseur numérique-analogique 41 délivre sur sa sortie 8 un signal électrique analogique caractéristique de l'activité biologique de l'ion Ca++ ou de l'héparine dont il est issu. Ce signal électrique analogique peut être transformé, comme il sera ci-après décrit, en champ électromagnétique et appliqué à une substance réceptrice ou à un système biologique de contrôle ou à un système biologique sensible. lu. L'applicateur du signal caractéristique de l'ion Ca " " ou de l'héparineIL Remote transmission of the characteristic electrical signal The file of the electrical signal characteristic of the Ca ++ ion or of heparin, recorded in digital form as just described, possibly after processing, can be transferred remotely by a computer communication network. This network may include radio links 11. The file of the electrical signal characteristic of the Ca ++ ion or of heparin, thus transmitted, is recorded by the mass memory of a microcomputer 18. It is possible, for example use a PC type computer, operating under the WINDOWS ® 95 operating system from MICROSOFT. This microcomputer 18 can be of the same type as that used to generate the excitation field. The digitized characteristic electrical signal file, thus recorded by the remote microcomputer 18, can be used, in a manner known per se, to produce an analog characteristic electrical signal. The file, if any processed, is transformed by a digital-analog converter 41 of the card 25 (or of a separate card) of the computer 18. The digital-analog converter 41 delivers on its output 8 an analog electric signal characteristic of the biological activity Ca ++ ion or the heparin from which it is derived. This analog electrical signal can be transformed, as will be described below, into an electromagnetic field and applied to a receptor substance or to a biological control system or to a sensitive biological system. read. The signal applicator characteristic of the ion Ca "" or heparin
On va maintenant décrire, en se référant à la figure le, un exemple de réalisation d'un système permettant d'appliquer le signal électrique caractéristique de l'ion Ca++ ou de l'héparine à un système biologique récepteur et d'en modifier le comportement chimique. Le récipent 50 contient le système biologique récepteur. Dans le cas de la variante décrite en se référant aux figures 1, la, lb et le, le récipient 50 contient :A description will now be given, with reference to FIG. 1 a, of an embodiment of a system making it possible to apply the electrical signal characteristic of the Ca ++ ion or of heparin to a receptive biological system and modify the chemical behavior. The container 50 contains the receptor biological system. In the case of the variant described with reference to FIGS. 1, la, lb and le, the container 50 contains:
- une substance réceptrice telle que de l'eau ou un mélange eau- éthanol ou des granules homéopathiques, ou - un système biologique de contrôle ou un système biologique sensible tel du sang ou du plasma.- a receptor substance such as water or a water-ethanol mixture or homeopathic granules, or - a biological control system or a sensitive biological system such as blood or plasma.
Le récipient 50 est disposé dans un champ électromagnétique rayonné par un transducteur-émetteur 51, typiquement une bobine. La bobine a par exemple une longueur de 80 mm, un diamètre intérieur de 50 mm, un diamètre extérieur de 55 mm. Elle présente 300 spires d'un fil de diamètreThe container 50 is placed in an electromagnetic field radiated by a transducer-transmitter 51, typically a coil. The coil has for example a length of 80 mm, an inside diameter of 50 mm, an outside diameter of 55 mm. It presents 300 turns of a wire of diameter
0,5 mm. Son impédance est de 4 ohms. La bobine 51 est connectée à la masse. Sans que cela représente un quelconque caractère limitatif, la bobine 51 du transducteur-émetteur a un axe vertical permettant l'introduction du récipient 50 contenant le système biologique récepteur. Les bornes d'entrée 8' de cette bobine 51 sont reliées, dans le cas de la variante de réalisation décrite, à la sortie 8 du convertisseur analogique-numérique 41 du micro-ordinateur 18 via un amplificateur 19 ayant les caractéristiques suivantes : bande passante de 10 Hz à 20 kHz, gain 1 à 20, sensibilité d'entrée 250 mV, puissance de sortie RMS 60W sous 8 ohms, rapport signal sur bruit 80 dB. La tension aux bornes de la bobine 51 a une amplitude de 10 Volts efficaces et le signal est appliqué pendant 10 min. Les bornes d'entrée 8' de l'applicateur peuvent être également, dans le cas de certaines variantes de réalisation, directement connectées à la sortie du préamplificateur 16 ou à la sortie 8 du convertisseur numérique-analogique0.5 mm. Its impedance is 4 ohms. The coil 51 is connected to ground. Without this representing any limiting character, the coil 51 of the transducer-transmitter has a vertical axis allowing the introduction of the container 50 containing the receiving biological system. Terminals input 8 'of this coil 51 are connected, in the case of the embodiment described, to output 8 of the analog-digital converter 41 of the microcomputer 18 via an amplifier 19 having the following characteristics: bandwidth of 10 Hz to 20 kHz, gain 1 to 20, input sensitivity 250 mV, RMS 60W output power at 8 ohms, signal to noise ratio 80 dB. The voltage across the coil 51 has an amplitude of 10 Volts rms and the signal is applied for 10 min. The input terminals 8 ′ of the applicator can also be, in the case of certain variant embodiments, directly connected to the output of the preamplifier 16 or to the output 8 of the digital-analog converter
41 de l'ordinateur 17. Expérimentations Afin d'illustrer une variante de réalisation,41 of the computer 17. Experiments In order to illustrate an alternative embodiment,
- d'un procédé et d'un système selon l'invention pour produire une substance ayant un effet coagulant ou anticoagulant,- a method and a system according to the invention for producing a substance having a coagulant or anticoagulant effect,
- d'une substance selon l'invention ayant un effet coagulant ou anticoagulant,- a substance according to the invention having a coagulant or anticoagulant effect,
- d'un procédé selon l'invention pour tester l'effet coagulant ou anticoagulant d'une substance et de son application à la production de produits homéopathiques,a method according to the invention for testing the coagulant or anticoagulant effect of a substance and its application to the production of homeopathic products,
- d'un procédé et d'un système selon l'invention pour produire un signal ayant un effet coagulant ou anticoagulant,- a method and a system according to the invention for producing a signal having a coagulant or anticoagulant effect,
- d'un signal selon l'invention ayant un effet coagulant ou anticoagulant - d'un procédé selon l'invention pour tester l'effet coagulant / anticoagulant d'un signal et de son application à la production de produits homéopathiques, les expériences suivantes on été réalisées. Rappel des effets de l'héparine et des ions Ca→ sur la coagulation du plasma humain ou du lapin- a signal according to the invention having a coagulant or anticoagulant effect - a method according to the invention for testing the coagulant / anticoagulant effect of a signal and its application to the production of homeopathic products, the following experiments we were carried out. Reminder of the effects of heparin and Ca → ions on the coagulation of human or rabbit plasma
L'héparine (25 000 U.I. / 5 ml, Laboratoire Choay, Sanofi Winthrop) est un anticoagulant agissant par inhibition de la transformation de la prothrombine en thrombine. Au site d'action, l'effet de l'héparine est immédiat. Elle agit par l'intermédiaire d'un inhibiteur naturel dénommé cofacteur, ou antithrombine III.Heparin (25,000 IU / 5 ml, Choay Laboratory, Sanofi Winthrop) is an anticoagulant that works by inhibiting the transformation of prothrombin into thrombin. At the site of action, the effect of heparin is immediate. It acts through a natural inhibitor called a cofactor, or antithrombin III.
Le sulfate de protamine (10 000 U.I. / 10 ml, Laboratoire Choay, Sanofi Winthrop) forme un sel avec l'héparine et entraîne une suppression unité pour unité de l'effet anticoagulant de celle-ci. 1 ml de solution de protamine neutralise l'activité anticoagulante de 1000 unités d'héparine.Protamine sulphate (10,000 IU / 10 ml, Choay Laboratory, Sanofi Winthrop) forms a salt with heparin and causes a unit for unit suppression of its anticoagulant effect. 1 ml of protamine solution neutralizes the anticoagulant activity of 1000 units of heparin.
L'ion calcium Ca^ est un ion indispensable à la coagulation. Substances sources et matériels utilisésThe calcium ion Ca ^ is an essential ion for coagulation. Source substances and materials used
Les signaux électriques caractéristiques ont été enregistrés à partir d'échantillons de 1 ml des solutions suivantes : - Ca++ en solution à lμM dans de l'eau pour préparation injectable (par exemple de marque Biosédra)The characteristic electrical signals were recorded from samples of 1 ml of the following solutions: - Ca ++ in solution at 1 μM in water for injection (for example of Biosédra brand)
- Mg++ en solution à lμM dans la même qualité d'eau,- Mg ++ in solution at 1 μM in the same quality of water,
- héparine en solution à la concentration de 2.5 U.I./ml dans la même qualité d'eau, - complexe héparine + protamine (respectivement 2.5 U.I./ml et- heparin in solution at a concentration of 2.5 IU / ml in the same quality of water, - heparin + protamine complex (respectively 2.5 IU / ml and
0.025 mg/ml), en solution dans la même qualité d'eau. Le matériel employé a été décrit en se référant aux figures la, lb, le. Le transducteur-récepteur 6 présente les caractéristiques décrites. Le transducteur-émetteur 51, permettant d'appliquer le signal électrique caractéristique à une substance réceptrice ou à un système biologique de contrôle ou à un système biologique sensible, est une bobine électromagnétique ayant les caractéristiques suivantes :0.025 mg / ml), in solution in the same quality of water. The equipment used has been described with reference to Figures la, lb, le. The transducer-receiver 6 has the characteristics described. The transducer-transmitter 51, making it possible to apply the characteristic electrical signal to a receiving substance or to a biological control system or to a sensitive biological system, is an electromagnetic coil having the following characteristics:
- longueur : 80 mm,- length: 80 mm,
- diamètre intérieur : 50 mm, - nombre de spires : 300 spires,- inside diameter: 50 mm, - number of turns: 300 turns,
- impédance : 4 ohms.- impedance: 4 ohms.
Une évaluation de la coagulation a été faite en utilisant la notation suivante : - coagulation importante : 2A coagulation assessment was made using the following notation: - significant coagulation: 2
- coagulation modérée : 1- moderate coagulation: 1
- aucune coagulation : 0- no coagulation: 0
Protocole n°l. Expérience "in vitro" : Action coagulante ou anticoagulante de signaux électriques caractéristiques sur du Plasma Riche en Plaquettes (PRP).Protocol No. 1. "In vitro" experiment: Coagulating or anticoagulant action of characteristic electrical signals on Platelet Rich Plasma (PRP).
Ce protocole a pour objet de mettre en évidence que :The purpose of this protocol is to demonstrate that:
- d'une part, le procédé et le système décrit permettent de produire un signal électrique caractéristique de l'ion Ca++ et de l'héparine ayant respectivement un effet coagulant ou anticoagulant, et - d'autre part, le procédé et le système décrit permettent de tester un signal électrique ayant respectivement un effet coagulant ou anticoagulant.- on the one hand, the method and the system described make it possible to produce an electrical signal characteristic of the Ca ++ ion and of heparin having respectively a coagulating or anticoagulant effect, and - on the other hand, the method and the described system make it possible to test an electrical signal having respectively a coagulating or anticoagulant effect.
Comme système biologique de contrôle permettant de révéler le signal électrique caractéristique de l'ion Ca++ et de l'héparine, ou comme système biologique sensible permettant de tester l'effet coagulant ou anticoagulant d'un signal électrique, on utilise du plasma de lapin (ou humain). Le sang d'un lapin "New-Zealand White" est prélevé à l'artère de l'oreille et recueilli sur un anticoagulant ACD (9 vol. sang / 1 vol. ACD) dont la composition est la suivante : acide citrique 0.8%, citrate de sodium 2.2%, glucose anhydre 2.23%.As a biological control system for revealing the electrical signal characteristic of the Ca ++ ion and heparin, or as a sensitive biological system for testing the coagulant or anticoagulant effect of an electrical signal, rabbit (or human). The blood of a "New-Zealand White" rabbit is taken from the artery of the ear and collected on an ACD anticoagulant (9 vol. Blood / 1 vol. ACD), the composition of which is as follows: citric acid 0.8% , sodium citrate 2.2%, anhydrous glucose 2.23%.
Après centrifugation (180 g, 15 minutes) à température ambiante, le sang se répartit en 3 couches : de haut en bas, le Plasma Riche en Plaquettes (PRP), la couche leucocytaire et le culot de globules rouges. Le PRP est prélevé à la pipette par aspiration douce. Effet anticoagulant d'un signai, effet anticoagulant du signal électrique caractéristique de l'héparineAfter centrifugation (180 g, 15 minutes) at room temperature, the blood is divided into 3 layers: from top to bottom, the Plasma Rich Plasma (PRP), the buffy coat and the pellet of red blood cells. The PRP is taken by pipette by gentle suction. Anticoagulant effect of a signal, anticoagulant effect of the electrical signal characteristic of heparin
5 ml de PRP sont placés dans un tube 50 au centre d'une bobine électromagnétique 51 pour être exposés au signal appliqué pendant 10 mn avec une tension de 10V aux bornes de la bobine.5 ml of PRP are placed in a tube 50 in the center of an electromagnetic coil 51 to be exposed to the signal applied for 10 min with a voltage of 10V across the terminals of the coil.
Des échantillons de 1 ml de PRP ainsi traités sont placés dans quatre tubes.1 ml samples of PRP thus treated are placed in four tubes.
On délivre dans chaque tube 20μl de Ca++ (50, 100, 150 et 200 mM) pour obtenir des concentrations finales de calcium dans le PRP de (1, 2, 3 et 4 mM). Puis on laisse incuber 15 à 20 minutes.20 μl of Ca ++ (50, 100, 150 and 200 mM) are delivered in each tube to obtain final concentrations of calcium in the PRP of (1, 2, 3 and 4 mM). Then incubate for 15 to 20 minutes.
Les résultats obtenus sont présentés dans le tableau ci-après :The results obtained are presented in the table below:
n : nombre de valeurs ; Moy : moyenne ; SD : déviation standard n: number of values; Avg: average; SD: standard deviation
On observe qu'une application du signal de l'héparine a un effet d'inhibition de la coagulation du PRP .Dans les mêmes conditions, le PRP non exposé à un signal ou le PRP exposé à un signal de contrôle, comme par exemple celui du complexe héparine+protamine, ne présente pas d'effet d'inhibition. Cet effet d'inhibition de la coagulation est particulièrement notable pour une concentration en Ca++ comprise entre 2 et 3 mM.It is observed that an application of the heparin signal has an effect of inhibiting the coagulation of the PRP. Under the same conditions, the PRP not exposed to a signal or the PRP exposed to a control signal, such as for example that of the heparin + protamine complex, does not have an inhibiting effect. This coagulation inhibiting effect is particularly notable for a Ca ++ concentration of between 2 and 3 mM.
Ainsi donc, le système biologique de contrôle constitué par du plasma riche en plaquettes permet de contrôler que le signal caractéristique de l'héparine a un effet anticoagulant. Ainsi donc, le système biologique sensible constitué par du plasma riche en plaquettes permet de tester si un signal caractéristique a un effet anticoagulant.Thus, the biological control system constituted by plasma rich in platelets makes it possible to control that the characteristic signal of heparin has an anticoagulant effect. Thus, the sensitive biological system constituted by plasma rich in platelets makes it possible to test whether a characteristic signal has an anticoagulant effect.
Effet coagulant d'un signal, effet coagulant du signal électrique caractéristique de l'ion calcium (Ca++)Coagulating effect of a signal, coagulating effect of the electrical signal characteristic of the calcium ion (Ca ++ )
1 ml de PRP est placé dans un tube au centre d'une bobine électromagnétique pour être exposé au signal appliqué pendant 10 mn avec une tension de 10 V aux bornes de la bobine.1 ml of PRP is placed in a tube in the center of an electromagnetic coil to be exposed to the signal applied for 10 min with a voltage of 10 V across the coil.
Les résultats obtenus sont présentés dans le tableau ci-aprèsThe results obtained are presented in the table below
InterprétationInterpretation
On observe qu'une application du signal du calcium Ca++ a un effet de coagulation du PRP comparable à celui du calcium Ca++ proprement dit.It is observed that an application of the Ca ++ calcium signal has a PRP coagulation effect comparable to that of Ca ++ calcium proper.
On observe qu'une application du signal du magnésium Mg++ n'induit aucun effet de coagulation du PRP.It is observed that an application of the signal of magnesium Mg ++ does not induce any coagulation effect of the PRP.
Ainsi donc, le système biologique de contrôle constitué par du plasma riche en plaquettes permet de contrôler que le signal caractéristique du calciumThus, the biological control system constituted by plasma rich in platelets makes it possible to control that the characteristic signal of calcium
Ca++ à un effet coagulant.Ca ++ has a coagulating effect.
Ainsi donc, le système biologique sensible constitué par du plasma riche en plaquettes pennet de tester si un signal caractéristique a un effet coagulant.Thus, the sensitive biological system consisting of plasma rich in platelets allows us to test whether a characteristic signal has a coagulating effect.
Protocole n°2. Expérience "in vivo": Action coagulante ou anticoagulante de signaux électriques caractéristiques.Protocol 2. "In vivo" experience: Coagulating action or anticoagulant of characteristic electrical signals.
Ce protocole a pour objet de mettre en évidence que :The purpose of this protocol is to demonstrate that:
- d'une part, le procédé et le système décrits permettent- on the one hand, the process and the system described allow
* de produire un signal électrique caractéristique de l'ion Ca++ et de l'héparine, et* to produce an electrical signal characteristic of the Ca ++ ion and of heparin, and
* d'appliquer ce signal électrique à une substance réceptrice présentant après traitement respectivement un effet coagulant ou anticoagulant, et* to apply this electrical signal to a receiving substance having, after treatment, respectively a coagulating or anticoagulant effect, and
- d'autre part, le procédé et le système décrit permettent de tester une substance ayant respectivement un effet coagulant ou anticoagulant.- on the other hand, the method and the system described make it possible to test a substance having respectively a coagulant or anticoagulant effect.
Comme système biologique de contrôle permettant de révéler l'effet coagulant ou anticoagulant de la substance traitée, ou comme système biologique sensible permettant de tester l'effet coagulant ou anticoagulant d'une substance, on utilise un lapin auquel on administre, par voie sublinguale, de l'eau traitée au moyen d'un signal électrique caractéristique de la substance source.As a biological control system making it possible to reveal the coagulating or anticoagulant effect of the treated substance, or as a sensitive biological system making it possible to test the coagulating or anticoagulant effect of a substance, a rabbit is used which is administered, sublingually, treated water by means of an electrical signal characteristic of the source substance.
L'eau utilisée est de l'eau pour préparation injectable Biosédra en ampoules de 10 ml.The water used is water for injection Biosédra in ampoules of 10 ml.
1. L'eau (10 ml) est placée dans un tube 50 au centre d'une bobine électromagnétique 51. L'eau est exposée au signal caractéristique considéré pendant 10 mn avec une tension aux bornes de la bobine de 10 V.1. The water (10 ml) is placed in a tube 50 in the center of an electromagnetic coil 51. The water is exposed to the characteristic signal considered for 10 min with a voltage at the terminals of the coil of 10 V.
2. On agite ensuite l'eau pendant 15 secondes à la vitesse maximale du vortex. 3. On administre au lapin par voie sublinguale 1 ml de l'eau ainsi traitée par le signal caractéristique considéré. Des échantillons de sang (1 ml) sont prélevés sur des tubes en verre à l'artère de l'oreille, avant administration, puis 1, 5, 10, 15 et 30 minutes après administration de l'eau traitée. Les résultats obtenus sont présentés dans le tableau ci-après2. The water is then stirred for 15 seconds at the maximum speed of the vortex. 3. The rabbit is administered sublingually 1 ml of the water thus treated by the characteristic signal considered. Blood samples (1 ml) are taken from glass tubes at the artery of the ear, before administration, then 1, 5, 10, 15 and 30 minutes after administration of the treated water. The results obtained are presented in the table below
InterprétationInterpretation
On observe qu'une administration d'eau traitée par le signal caractéristique de l'héparine a un effet d'inhibition sur la coagulation sanguine pendant quinze minutes. En revanche, une administration d'eau traitée par le signal du complexe héparine+protamine ne produit aucun effet d'inhibition. Ainsi donc, le système biologique de contrôle constitué par un animal permet de contrôler qu'une substance réceptrice traitée par le signal caractéristique de l'héparine, notamment de l'eau, a un effet anticoagulant. Ainsi donc, le système biologique sensible constitué par un animal permet de tester, en contrôlant le signal caractéristique d'une substance (par exemple le complexe héparine+protamine), si cette substance présente un effet coagulant ou anticoagulant.It is observed that an administration of water treated by the characteristic signal of heparin has an inhibiting effect on blood coagulation for fifteen minutes. On the other hand, administration of water treated by the signal of the heparin + protamine complex does not produce any inhibiting effect. Thus, the biological control system constituted by an animal makes it possible to control that a receptor substance treated by the characteristic signal of heparin, in particular of water, has an anticoagulant effect. Thus, the sensitive biological system constituted by an animal makes it possible to test, by controlling the characteristic signal of a substance (for example the heparin + protamine complex), whether this substance has a coagulant or anticoagulant effect.
Il est donc ainsi établi que l'on peut contrôler la production de produits homéopathiques par l'utilisation de substances à l'effet connu (comme l'héparine) et en contrôlant que les produits homéopathiques (granules, solutions, ...) produits à partir de cette substance présentent eux aussi, en bout de chaine, l'activité correspondante (dans l'exemple décrit, l'activité d' anticoagulation).. Le signal caractéristique d'un médicament ou une substance réceptrice traitée par le signal caractéristique d'un médicament a les mêmes effets biologiques que le médicament source du signal considéré.It is thus thus established that one can control the production of homeopathic products by the use of substances with known effect (like heparin) and by controlling that the homeopathic products (granules, solutions, ...) from this substance also present, at the end of the chain, the corresponding activity (in the example described, the anticoagulation activity). The signal characteristic of a drug or a receptor substance treated by the signal characteristic of a drug has the same biological effects as the source drug of the signal considered.
De la même manière, des effets anticoagulants similaires sont obtenus avec l'hirudine sur du sang ou du plasma de lapin ou humain. Les signaux provenant de l'hirudine présentent un effet anticoagulant plus important que ceux provenant de l'héparine.Likewise, similar anticoagulant effects are obtained with hirudin on rabbit or human blood or plasma. Signals from hirudin have a stronger anticoagulant effect than those from heparin.
On trouvera ci-après les résulats obtenus avec de l'hirudine et du sang de lapin :The results obtained with hirudin and rabbit blood are given below:
On trouvera ci-après les résulats obtenus avec de l'hirudine et du sang humain :The results obtained with hirudin and human blood are given below:

Claims

Revendications claims
1. Procédé pour produire une substance ayant un effet coagulant ou anticoagulant, à partir d'une substance source ayant un effet coagulant, notamment des ions Ca++, ou anticoagulant, notamment de l'héparine, ledit procédé comportant les étapes :1. Method for producing a substance having a coagulating or anticoagulant effect, from a source substance having a coagulating effect, in particular Ca ++ ions, or anticoagulant, in particular heparin, said method comprising the steps:
- de transformer le champ électromagnétique provenant de ladite substance source, en un signal, notamment un signal électrique, au moyen d'un transducteur-récepteur captant ledit champ électromagnétique,transforming the electromagnetic field originating from said source substance into a signal, in particular an electrical signal, by means of a transducer-receiver sensing said electromagnetic field,
- d'appliquer à une substance réceptrice, notamment de l'eau ou un mélange eau-éthanol ou des granules homéopathiques, ledit signal provenant dudit transducteur-récepteur, au moyen d'un transducteur- émetteur,applying to a receiving substance, in particular water or a water-ethanol mixture or homeopathic granules, said signal coming from said transducer-receiver, by means of a transducer-transmitter,
(de telle sorte qu'après le traitement ci-dessus défini, la substance réceptrice, initialement inactive, présente une activité coagulante ou anticoagulante ; ladite substance réceptrice ainsi traitée étant ci-après appelée la "substance traitée").(such that after the treatment defined above, the receptor substance, initially inactive, exhibits coagulant or anticoagulant activity; said receptor substance thus treated being hereinafter called the "treated substance").
2. Procédé selon la revendication 1 tel que pour transformer le champ électromagnétique provenant de ladite substance source en un signal électrique : - on place ladite substance source dans une zone soumise à un champ d'excitation de nature électrique, magnétique et/ou électromagnétique,2. Method according to claim 1, such as for transforming the electromagnetic field coming from said source substance into an electrical signal: - placing said source substance in an area subjected to an excitation field of electrical, magnetic and / or electromagnetic nature,
- on transforme les champs résultants de l'interaction du champ d'excitation et de ladite substance source en un signal électrique, au moyen d'un transducteur-récepteur captant lesdits champs résultants.- The fields resulting from the interaction of the excitation field and said source substance are transformed into an electrical signal, by means of a transducer-receiver capturing said resulting fields.
3. Système pour produire une substance ayant un effet coagulant ou anticoagulant, à partir d'une substance source ayant un effet coagulant, notamment des ions Ca++, ou anticoagulant, notamment de l'héparine, ledit système comprenant : - un transducteur-récepteur recevant le champ électromagnétique provenant de ladite substance source, ledit transducteur-récepteur transformant ledit champ électromagnétique en un signal, notamment un signal électrique, - un transducteur-émetteur pour appliquer ledit signal provenant dudit transducteur-récepteur à une substance réceptrice, notamment de l'eau ou un mélange eau-éthanol ou des granules homéopathiques, (de telle sorte qu'après le traitement ci-dessus défini, la substance réceptrice, initialement inactive, présente une activité coagulante ou anticoagulante ; ladite substance réceptrice ainsi traitée étant ci-après appelée la "substance traitée").3. System for producing a substance having a coagulating or anticoagulant effect, from a source substance having a coagulating effect, in particular Ca ++ ions, or anticoagulant, in particular heparin, said system comprising: - a transducer-receiver receiving the electromagnetic field originating from said source substance, said transducer-receiver transforming said electromagnetic field into a signal, in particular an electrical signal, - a transducer-transmitter for applying said signal originating from said transducer-receiver to a receiving substance , in particular water or a water-ethanol mixture or homeopathic granules, (so that after the treatment defined above, the receptor substance, initially inactive, has coagulant or anticoagulant activity; said receptor substance thus treated being hereinafter called the "treated substance").
4. Système selon la revendication 3 tel qu'il comprend en outre :4. System according to claim 3 such that it further comprises:
- un émetteur générant un champ d'excitation de nature électrique, magnétique et/ou électromagnétique dans une zone où est située ladite substance source, ledit transducteur-récepteur, recevant les champs résultants de l'interaction dudit champ d'excitation et de ladite substance source, transformant lesdits champs résultants en un signal, notamment un signal électrique.- an emitter generating an excitation field of an electrical, magnetic and / or electromagnetic nature in an area where said source substance, said transducer-receiver is located, receiving the fields resulting from the interaction of said excitation field and said substance source, transforming said resulting fields into a signal, in particular an electrical signal.
5. Substance ayant un effet coagulant ou anticoagulant : ladite substance5. Substance having a coagulant or anticoagulant effect: the said substance
- pouvant être notamment de l'eau ou un mélange eau-éthanol ou des granules homéopathiques, et- which can in particular be water or a water-ethanol mixture or homeopathic granules, and
- ayant été traitée au moyen d'un signal électrique ou électromagnétique provenant d'une substance source ayant des effets coagulants, notamment des ions Ca++, ou anticoagulants, notamment de l'héparine.- having been treated by means of an electrical or electromagnetic signal coming from a source substance having coagulating effects, in particular Ca ++ ions, or anticoagulants, in particular heparin.
6. Application de la substance selon la revendication 5 :6. Application of the substance according to claim 5:
- au traitement de la maladie thrombo embolique, ou - à l'exploration de la coagulation.- treatment of thromboembolic disease, or - exploring coagulation.
7. Procédé pour tester une substance ayant un effet coagulant, notamment des ions Ca++, ou anticoagulant, notamment de l'héparine, ledit procédé comportant les étapes : - de transformer le champ électromagnétique provenant de ladite substance, en un signal, notamment un signal électrique, au moyen d'un transducteur-récepteur captant ledit champ électromagnétique,7. Method for testing a substance having a coagulating effect, in particular Ca ++ ions, or anticoagulant, in particular heparin, said method comprising the steps: - of transforming the electromagnetic field coming from said substance, into a signal, in particular an electrical signal, by means of a transducer-receiver sensing said electromagnetic field,
- d'appliquer à un système biologique sensible, directement ou indirectement, ledit signal provenant dudit transducteur-récepteur. - Apply to a sensitive biological system, directly or indirectly, said signal from said transducer-receiver.
8. Procédé selon la revendication 7 tel que pour transformer le champ électromagnétique provenant de ladite substance en un signal électrique :8. The method as claimed in claim 7, such as for transforming the electromagnetic field originating from said substance into an electrical signal:
- on place ladite substance dans une zone soumise à un champ d'excitation de nature électrique, magnétique et/ou électromagnétique,said substance is placed in a zone subjected to an excitation field of an electrical, magnetic and / or electromagnetic nature,
- on transforme les champs résultants de l'interaction du champ d'excitation et de ladite substance source en un signal électrique, au moyen d'un transducteur-récepteur captant lesdits champs résultants. - The fields resulting from the interaction of the excitation field and said source substance are transformed into an electrical signal, by means of a transducer-receiver capturing said resulting fields.
9. Procédé selon l'une quelconque des revendications 7 ou 8, tel que le système biologique sensible est du sang ou du plasma auquel on applique ledit signal au moyen d'un transducteur-émetteur. 9. Method according to any one of claims 7 or 8, such that the sensitive biological system is blood or plasma to which said signal is applied by means of a transducer-transmitter.
10. Procédé selon l'une quelconque des revendications 7 ou 8, tel que le système biologique sensible est un animal, notamment un lapin, auquel on administre, notamment sous la langue, une substance, notamment de l'eau, traitée par ledit signal au moyen d'un transducteur-émetteur.10. Method according to any one of claims 7 or 8, such that the sensitive biological system is an animal, in particular a rabbit, to which is administered, in particular under the tongue, a substance, in particular water, treated by said signal by means of a transducer-transmitter.
11. Application du procédé selon l'une quelconque des revendications 7 à 10 au contrôle de production de produits homéopathiques.11. Application of the method according to any one of claims 7 to 10 to the control of production of homeopathic products.
12. Procédé pour produire un signal, notamment un signal électrique ou électromagnétique, ayant un effet coagulant ou anticoagulant, à partir d'une substance source ayant un effet coagulant, notamment des ions Ca++, ou anticoagulant, notamment de l'héparine, ledit procédé comportant les étapes :12. Method for producing a signal, in particular an electrical or electromagnetic signal, having a coagulating or anticoagulant effect, from a source substance having a coagulating effect, in particular Ca ++ ions, or anticoagulant, in particular heparin, said process comprising the steps:
- de transformer le champ électromagnétique provenant de ladite substance source, en un signal, notamment un signal électrique, au moyen d'un transducteur-récepteur captant ledit champ électromagnétique, transforming the electromagnetic field originating from said source substance into a signal, in particular an electrical signal, by means of a transducer-receiver sensing said electromagnetic field,
13. Procédé selon la revendication 12 tel que pour transformer le champ électromagnétique provenant de ladite substance source en un signal électrique :13. The method as claimed in claim 12, such as for transforming the electromagnetic field originating from said source substance into an electrical signal:
- on place ladite substance source dans une zone soumise à un champ d'excitation de nature électrique, magnétique et/ou électromagnétique,said source substance is placed in an area subjected to an excitation field of an electrical, magnetic and / or electromagnetic nature,
- on transforme les champs résultants de l'interaction du champ d'excitation et de la substance source, en un signal, notamment un signal électrique, au moyen d'un transducteur-récepteur captant lesdits champs résultants. - The fields resulting from the interaction of the excitation field and the source substance are transformed into a signal, in particular an electrical signal, by means of a transducer-receiver capturing said resulting fields.
14. Procédé selon l'une quelconque des revendications 12 ou 13, comprenant en outre l'étape :14. Method according to any one of claims 12 or 13, further comprising the step:
- de contrôler les corrélations entre d'une part, le signal provenant dudit transducteur-récepteur et d'autre part, l'activité coagulante ou anticoagulante de ladite substance source, en appliquant, directement ou indirectement, ledit signal à un système biologique de contrôle et en vérifiant que ledit système biologique de contrôle réagit conformément à l'activité coagulante ou anticoagulante de la substance source dont est issu le signal.- to control the correlations between on the one hand, the signal coming from said transducer-receiver and on the other hand, the coagulant or anticoagulant activity of said source substance, by applying, directly or indirectly, said signal to a biological control system and verifying that said biological control system reacts in accordance with the coagulating or anticoagulant activity of the source substance from which the signal is derived.
15. Procédé selon la revendication 14, tel que le système biologique de contrôle est du sang ou du plasma auquel on applique ledit signal au moyen d'un transducteur-émetteur.15. The method of claim 14, such that the biological control system is blood or plasma to which said signal is applied by means of a transducer-transmitter.
16. Procédé selon la revendication 14, tel que le système biologique de contrôle est un animal, notamment un lapin, auquel on administre, notamment sous la langue, une substance, notamment de l'eau, traitée par ledit signal au moyen d'un transducteur-émetteur.16. The method of claim 14, such that the biological control system is an animal, in particular a rabbit, to which is administered, in particular under the tongue, a substance, in particular water, treated with said signal by means of a transducer-transmitter.
17. Système pour produire un signal, notamment un signal électrique ou électromagnétique, ayant un effet coagulant ou anticoagulant, à partir d'une substance source ayant un effet coagulant, notamment des ions Ca++, ou anticoagulant, notamment de l'héparine, ledit système comprend un transducteur-récepteur recevant le champ électromagnétique provenant de ladite substance source, ledit transducteur-récepteur transformant ledit champ électromagnétique en un signal, notamment un signal électrique, 17. System for producing a signal, in particular an electrical or electromagnetic signal, having a coagulating or anticoagulant effect, from a source substance having a coagulating effect, in particular Ca ++ ions, or anticoagulant, in particular heparin, said system comprises a transducer-receiver receiving the electromagnetic field coming from said source substance, said transducer-receiver transforming said electromagnetic field into a signal, in particular an electrical signal,
18. Système selon la revendication 17 tel qu'il comprend en outre :18. The system of claim 17 as it further comprises:
- un émetteur générant un champ d'excitation de nature électrique, magnétique et/ou électromagnétique dans une zone où est située ladite substance source, ledit transducteur-récepteur, recevant les champs résultants de l'interaction dudit champ d'excitation et de ladite substance source, transformant lesdits champs résultants en un signal, notamment un signal électrique.- an emitter generating an excitation field of an electrical, magnetic and / or electromagnetic nature in an area where said source substance, said transducer-receiver is located, receiving the fields resulting from the interaction of said excitation field and said substance source, transforming said resulting fields into a signal, in particular an electrical signal.
19. Système selon l'une quelconque des revendications 17 ou 18, comprenant en outre :19. System according to any one of claims 17 or 18, further comprising:
- des moyens de contrôle pour contrôler les corrélations entre d'une part, le signal provenant dudit transducteur-récepteur et d'autre part, l'activité coagulante ou anticoagulante de ladite substance source, lesdits moyens de contrôle comprenant un transducteur-émetteur appliquant, directement ou indirectement, ledit signal à un système biologique de contrôle, lesdits moyens de contrôle comprenant en outre des moyens de vérification pour vérifier que le système biologique de contrôle réagit conformément à l'activité coagulante ou anticoagulante de la substance source dont est issu le signal.control means for controlling the correlations between on the one hand, the signal coming from said transducer-receiver and on the other hand, the coagulating or anticoagulant activity of said source substance, said control means comprising a transducer-transmitter applying, directly or indirectly, said signal to a biological control system, said control means further comprising verification means for verifying that the biological control system reacts in accordance with the coagulant or anticoagulant activity of the source substance from which the signal is derived .
20. Système selon la revendication 19, tel que le système biologique de contrôle est du sang ou du plasma auquel on applique ledit signal au moyen dudit transducteur-émetteur.20. The system of claim 19, such as the biological system of control is blood or plasma to which said signal is applied by means of said transducer-transmitter.
21. Système selon la revendication 19, tel que le système biologique de contrôle est un animal, notamment un lapin, auquel on administre, notamment sous la langue, une substance, notamment de l'eau, traitée par ledit signal au moyen dudit transducteur-émetteur.21. The system of claim 19, such that the biological control system is an animal, in particular a rabbit, to which is administered, in particular under the tongue, a substance, in particular water, treated by said signal by means of said transducer. transmitter.
22. Signal, notamment signal électrique ou électromagnétique, ayant un effet coagulant ou anticoagulant, ledit signal étant obtenu au moyen du procédé selon l'une quelconque des revendications 12 à 16 ou du système selon l'une quelconque des revendications 17 à 21, à partir d'une substance source ayant un effet coagulant, notamment des ions Ca++, ou anticoagulant, notamment de l'héparine ledit signal étant caractérisé en ce qu'un système biologique de contrôle réagit, après application directe ou indirecte dudit signal, conformément à l'activité coagulante ou anticoagulante de la substance source dont est issu le signal.22. Signal, in particular electrical or electromagnetic signal, having a coagulating or anticoagulant effect, said signal being obtained by means of the method according to any one of claims 12 to 16 or of the system according to any one of claims 17 to 21, starting from a source substance having a coagulating effect, in particular Ca ++ ions, or anticoagulant, in particular heparin said signal being characterized in that a biological control system reacts, after direct or indirect application of said signal, in accordance the coagulating or anticoagulant activity of the source substance from which the signal is derived.
23. Signal selon la revendication 22, tel que le système biologique de contrôle est du sang ou du plasma auquel on applique ledit signal au moyen d'un transducteur-émetteur.23. The signal as claimed in claim 22, such that the biological control system is blood or plasma to which said signal is applied by means of a transducer-transmitter.
24. Signal selon la revendication 22, tel que le système biologique de contrôle est un animal, notamment un lapin, auquel on administre, notamment sous la langue, une substance, notamment de l'eau, traitée par ledit signal au moyen d'un transducteur-émetteur. 24. The signal as claimed in claim 22, such that the biological control system is an animal, in particular a rabbit, to which is administered, in particular under the tongue, a substance, in particular water, treated by said signal by means of a transducer-transmitter.
25. Application du signal selon l'une quelconque des revendications 22 à25. Application of the signal according to any one of claims 22 to
24, directement ou indirectement par l'intermédiaire d'une matière réceptrice,24, directly or indirectly via a receiving material,
- au traitement de la maladie thrombo embolique,- treatment of thromboembolic disease,
- à l'exploration de la coagulation. - exploring coagulation.
26. Procédé pour tester un signal ayant un effet coagulant ou anticoagulant, ledit signal étant obtenu au moyen de procédé selon l'une quelconque des revendications 12 à 16 ou au moyen du système selon l'une quelconque des revendications 17 à 21, à partir d'une substance source ayant un effet coagulant, notamment des ions Ca++, ou anticoagulant, notamment de l'héparine, ledit procédé comprenant l'étape d'appliquer ledit signal, directement ou indirectement, à un système biologique test et de vérifier que le système biologique test réagit conformément à l'activité coagulante ou anticoagulante de la substance source dont est issu le signal.26. A method for testing a signal having a coagulating or anticoagulant effect, said signal being obtained by means of the method according to any one of claims 12 to 16 or by means of the system according to any one of claims 17 to 21, from a source substance having a coagulating effect, in particular Ca ++ ions, or an anticoagulant, in particular heparin, said method comprising the step of applying said signal, directly or indirectly, to a biological test system and of verifying the test biological system reacts in accordance with the coagulant or anticoagulant activity of the source substance from which the signal is derived.
27. Procédé selon la revendication 26, tel que le système biologique test est du sang ou du plasma auquel on applique ledit signal au moyen d'un transducteur-émetteur. 27. The method of claim 26, such that the test biological system is blood or plasma to which said signal is applied by means of a transducer-transmitter.
28. Procédé selon la revendication 26, tel que le système biologique test est un animal, notamment un lapin, auquel on administre, notamment sous la langue, uns substance, notamment de l'eau, traitée par ledit signal au moyen d'un transducteur-émetteur. 28. The method of claim 26, such that the biological test system is an animal, in particular a rabbit, to which is administered, in particular under the tongue, a substance, in particular water, treated by said signal by means of a transducer -transmitter.
29. Application du procédé selon l'une quelconque des revendications 26 à 28 au contrôle de production de produits homéopathiques. 29. Application of the method according to any one of claims 26 to 28 to the control of production of homeopathic products.
EP99946226A 1998-09-23 1999-09-23 Method and system for producing a substance or a signal with coagulating or anticoagulant effect Ceased EP1116024A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
FR9812058A FR2783605A1 (en) 1998-09-23 1998-09-23 Production of electromagnetic signals from a biological or chemical sample, characteristic of their active ingredients, which can then be transmitted to a remote location
FR9812058 1998-09-23
FR9902329 1999-02-22
FR9902329A FR2783606B1 (en) 1998-09-23 1999-02-22 METHOD AND SYSTEM FOR PRODUCING A SUBSTANCE OR SIGNAL HAVING A COAGULATING OR ANTICOAGULATING EFFECT. THERAPEUTIC APPLICATIONS OF SAID SUBSTANCE OR SIGNAL
PCT/FR1999/002269 WO2000017637A1 (en) 1998-09-23 1999-09-23 Method and system for producing a substance or a signal with coagulating or anticoagulant effect

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