EP1105160A4 - Lats knock-out animal models and their uses - Google Patents

Lats knock-out animal models and their uses

Info

Publication number
EP1105160A4
EP1105160A4 EP99945126A EP99945126A EP1105160A4 EP 1105160 A4 EP1105160 A4 EP 1105160A4 EP 99945126 A EP99945126 A EP 99945126A EP 99945126 A EP99945126 A EP 99945126A EP 1105160 A4 EP1105160 A4 EP 1105160A4
Authority
EP
European Patent Office
Prior art keywords
lats
knock
animal models
out animal
models
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP99945126A
Other languages
German (de)
French (fr)
Other versions
EP1105160A1 (en
Inventor
Tian Xu
Wufan Tao
John Maie A R St
Xiaolan Fei
Royd K Fukumoto
Sheng Zhang
Gregory S Turenchalk
Rodney A Stewart
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Yale University
Original Assignee
Yale University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yale University filed Critical Yale University
Publication of EP1105160A1 publication Critical patent/EP1105160A1/en
Publication of EP1105160A4 publication Critical patent/EP1105160A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A01K67/0276—Knock-out vertebrates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C07K14/4703—Inhibitors; Suppressors
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/0331—Animal model for proliferative diseases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Environmental Sciences (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Animal Husbandry (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
EP99945126A 1998-08-18 1999-08-18 Lats knock-out animal models and their uses Withdrawn EP1105160A4 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US9699698P 1998-08-18 1998-08-18
US9699798P 1998-08-18 1998-08-18
US96996P 1998-08-18
PCT/US1999/019068 WO2000010602A1 (en) 1998-08-18 1999-08-18 Lats knock-out animal models and their uses
US96997P 2008-09-15

Publications (2)

Publication Number Publication Date
EP1105160A1 EP1105160A1 (en) 2001-06-13
EP1105160A4 true EP1105160A4 (en) 2002-02-06

Family

ID=26792268

Family Applications (1)

Application Number Title Priority Date Filing Date
EP99945126A Withdrawn EP1105160A4 (en) 1998-08-18 1999-08-18 Lats knock-out animal models and their uses

Country Status (4)

Country Link
EP (1) EP1105160A4 (en)
AU (1) AU5781099A (en)
CA (1) CA2340456A1 (en)
WO (1) WO2000010602A1 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5994503A (en) 1995-03-27 1999-11-30 Yale University Nucleotide and protein sequences of lats genes and methods based thereon
GB9921121D0 (en) * 1999-09-07 1999-11-10 Novartis Ag Organic compounds
EP1226441A4 (en) * 1999-10-15 2003-08-06 Human Genome Sciences Inc Protein tyrosine kinase receptor polynucleotides, polypeptides, and antibodies
CN1329024A (en) * 2000-06-21 2002-01-02 上海博德基因开发有限公司 A novel polypeptide-activating GTP enzyme protein negative regulatory factor 11.66 and polynucleotide for coding this polypeptide

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0169672B1 (en) * 1984-06-22 1992-05-13 The President And Fellows Of Harvard College Method for producing transgenic animals

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69518238T2 (en) * 1994-05-16 2001-03-29 Apple Computer, Inc. OBJECT FOR THE DEFINITION OF A DIALOG UNIT INTERFACE
US5994503A (en) * 1995-03-27 1999-11-30 Yale University Nucleotide and protein sequences of lats genes and methods based thereon

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0169672B1 (en) * 1984-06-22 1992-05-13 The President And Fellows Of Harvard College Method for producing transgenic animals

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
See also references of WO0010602A1 *
YANG XIAOLONG ET AL: "Human homologue of Drosophila lats, LATS1, negatively regulate growth by inducing G2/M arrest or apoptosis.", ONCOGENE, vol. 20, no. 45, 2001, pages 6516 - 6523, XP001034046, ISSN: 0950-9232 *

Also Published As

Publication number Publication date
EP1105160A1 (en) 2001-06-13
WO2000010602A1 (en) 2000-03-02
CA2340456A1 (en) 2000-03-02
WO2000010602A9 (en) 2000-09-21
AU5781099A (en) 2000-03-14

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Legal Events

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