EP1089731A4 - Compositions and methods for treating elevated blood cholesterol - Google Patents

Compositions and methods for treating elevated blood cholesterol

Info

Publication number
EP1089731A4
EP1089731A4 EP99930451A EP99930451A EP1089731A4 EP 1089731 A4 EP1089731 A4 EP 1089731A4 EP 99930451 A EP99930451 A EP 99930451A EP 99930451 A EP99930451 A EP 99930451A EP 1089731 A4 EP1089731 A4 EP 1089731A4
Authority
EP
European Patent Office
Prior art keywords
compositions
methods
blood cholesterol
elevated blood
treating elevated
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP99930451A
Other languages
German (de)
French (fr)
Other versions
EP1089731A1 (en
Inventor
Edward M Scolnick
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9817167.1A external-priority patent/GB9817167D0/en
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of EP1089731A1 publication Critical patent/EP1089731A1/en
Publication of EP1089731A4 publication Critical patent/EP1089731A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A61K31/221—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin with compounds having an amino group, e.g. acetylcholine, acetylcarnitine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/351—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom not condensed with another ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Emergency Medicine (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
EP99930451A 1998-06-24 1999-06-21 Compositions and methods for treating elevated blood cholesterol Withdrawn EP1089731A4 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US9052798P 1998-06-24 1998-06-24
US90527P 1998-06-24
GB9817167 1998-08-06
GBGB9817167.1A GB9817167D0 (en) 1998-08-06 1998-08-06 Compositions and methods for treating elevated blood cholesterol
PCT/US1999/013887 WO1999066929A1 (en) 1998-06-24 1999-06-21 Compositions and methods for treating elevated blood cholesterol

Publications (2)

Publication Number Publication Date
EP1089731A1 EP1089731A1 (en) 2001-04-11
EP1089731A4 true EP1089731A4 (en) 2003-06-18

Family

ID=26314174

Family Applications (1)

Application Number Title Priority Date Filing Date
EP99930451A Withdrawn EP1089731A4 (en) 1998-06-24 1999-06-21 Compositions and methods for treating elevated blood cholesterol

Country Status (5)

Country Link
EP (1) EP1089731A4 (en)
JP (1) JP2002518448A (en)
AU (1) AU754767B2 (en)
CA (1) CA2335366A1 (en)
WO (1) WO1999066929A1 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2209890T3 (en) 1999-05-24 2004-07-01 American River Nutrition, Inc. TOCOTRIENOLES AND GERANILGERANIOL OF SUBPRODUCTS OF BIXA ORELLANA.
AR040588A1 (en) 2002-07-26 2005-04-13 Schering Corp PHARMACEUTICAL FORMULATION INCLUDING AN INHIBITOR OF CHOLESTEROL ABSORPTION AND AN INHIBITOR OF A HMGCO TO REDUCTASE
CA2521149C (en) 2003-04-08 2014-03-25 Barrie Tan Annatto extract compositions, including geranyl geraniols and methods of use
WO2010098906A1 (en) * 2009-02-24 2010-09-02 Madeira Therapeutics Liquid statin formulations
WO2010126579A1 (en) * 2009-04-27 2010-11-04 Beth Israel Deaconess Medical Center Methods and compositions for the treatment and diagnosis of statin-induced myopathy
US9045403B2 (en) 2012-02-29 2015-06-02 Coyote Pharmaceuticals, Inc. Geranyl geranyl acetone (GGA) derivatives and compositions thereof
TW201427938A (en) * 2012-10-01 2014-07-16 Coyote Pharmaceuticals Inc Preparation of GGA and derivatives thereof and their co-crystallization with urea or thiourea
US9119808B1 (en) 2012-10-08 2015-09-01 Coyote Pharmaceuticals, Inc. Treating neurodegenerative diseases with GGA or a derivative thereof

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2055100A (en) * 1979-07-27 1981-02-25 Sankyo Co Monacolin K derivatives
EP0671170A1 (en) * 1994-03-11 1995-09-13 Bristol-Myers Squibb Company Use of pravastatin for slowing progression coronary artery atherosclerosis
US5622985A (en) * 1990-06-11 1997-04-22 Bristol-Myers Squibb Company Method for preventing a second heart attack employing an HMG CoA reductase inhibitor
WO1997019091A1 (en) * 1995-11-23 1997-05-29 Laboratori Baldacci S.P.A. Novel geranylgeranyl-derivatives, process for the preparation thereof and related pharmaceutical compositions
US5691375A (en) * 1994-01-18 1997-11-25 Bristol-Myers Squibb Company Method for preventing or reducing risk of onset of cardiovascular events employing an HMG CoA reductase inhibitor
JPH1087480A (en) * 1996-09-13 1998-04-07 Eisai Co Ltd Therapeutic agent for arteriosclerosis

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4933165A (en) * 1989-01-18 1990-06-12 Merck & Co., Inc. Coenzyme Q10 with HMG-CoA reductase inhibitors
US5316765A (en) * 1989-09-07 1994-05-31 Karl Folkers Foundation For Biomedical And Clinical Research Use of coenzyme Q10 in combination with HMG-CoA reductase inhibitor therapies
DE69026496D1 (en) * 1989-10-13 1996-05-15 Neurofit ANALOGS OF VITAMIN A AND THEIR USE, IN PARTICULAR AS CYTOTROPHIC AND CYTOPROTECTIVE SUBSTANCES AND MEDICINAL PRODUCTS CONTAINING THESE SUBSTANCES
US5639653A (en) * 1993-07-19 1997-06-17 Albert Einstein College Of Medicine Of Yeshiva University, A Division Of Yeshiva Universtiy Method for proliferating Vγ2Vδ2 T cells
US5574025A (en) * 1994-10-26 1996-11-12 Merck & Co., Inc. Inhibitors of prenyl-protein transferases
US5763646A (en) * 1997-03-13 1998-06-09 Ranbaxy Laboratories, Ltd. Process for manufacturing simvastatin from lovastatin or mevinolinic acid

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2055100A (en) * 1979-07-27 1981-02-25 Sankyo Co Monacolin K derivatives
US5622985A (en) * 1990-06-11 1997-04-22 Bristol-Myers Squibb Company Method for preventing a second heart attack employing an HMG CoA reductase inhibitor
US5691375A (en) * 1994-01-18 1997-11-25 Bristol-Myers Squibb Company Method for preventing or reducing risk of onset of cardiovascular events employing an HMG CoA reductase inhibitor
EP0671170A1 (en) * 1994-03-11 1995-09-13 Bristol-Myers Squibb Company Use of pravastatin for slowing progression coronary artery atherosclerosis
WO1997019091A1 (en) * 1995-11-23 1997-05-29 Laboratori Baldacci S.P.A. Novel geranylgeranyl-derivatives, process for the preparation thereof and related pharmaceutical compositions
JPH1087480A (en) * 1996-09-13 1998-04-07 Eisai Co Ltd Therapeutic agent for arteriosclerosis

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
FLINT OLIVER P ET AL: "Inhibition of cholesterol synthesis by squalene synthase inhibitors does not induced myotoxicity in vitro.", TOXICOLOGY AND APPLIED PHARMACOLOGY, vol. 145, no. 1, 1997, pages 91 - 98, XP002237082, ISSN: 0041-008X *
PATENT ABSTRACTS OF JAPAN vol. 199, no. 809 31 July 1998 (1998-07-31) *
See also references of WO9966929A1 *

Also Published As

Publication number Publication date
EP1089731A1 (en) 2001-04-11
AU754767B2 (en) 2002-11-21
AU4698999A (en) 2000-01-10
CA2335366A1 (en) 1999-12-29
WO1999066929A1 (en) 1999-12-29
JP2002518448A (en) 2002-06-25

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