EP1077705A4 - Potassium channel agonists - Google Patents

Potassium channel agonists

Info

Publication number
EP1077705A4
EP1077705A4 EP99921866A EP99921866A EP1077705A4 EP 1077705 A4 EP1077705 A4 EP 1077705A4 EP 99921866 A EP99921866 A EP 99921866A EP 99921866 A EP99921866 A EP 99921866A EP 1077705 A4 EP1077705 A4 EP 1077705A4
Authority
EP
European Patent Office
Prior art keywords
potassium channel
channel agonists
agonists
potassium
channel
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP99921866A
Other languages
German (de)
French (fr)
Other versions
EP1077705A1 (en
Inventor
Joseph J Salata
Jixin Wang
Michael C Sanguinetti
Nancy K Jurkiewicz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of EP1077705A1 publication Critical patent/EP1077705A1/en
Publication of EP1077705A4 publication Critical patent/EP1077705A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/438—The ring being spiro-condensed with carbocyclic or heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
    • A61K31/5517—1,4-Benzodiazepines, e.g. diazepam or clozapine condensed with five-membered rings having nitrogen as a ring hetero atom, e.g. imidazobenzodiazepines, triazolam
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
EP99921866A 1998-05-15 1999-05-11 Potassium channel agonists Withdrawn EP1077705A4 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US8556298P 1998-05-15 1998-05-15
US85562P 1998-05-15
PCT/US1999/010264 WO1999059594A1 (en) 1998-05-15 1999-05-11 Potassium channel agonists

Publications (2)

Publication Number Publication Date
EP1077705A1 EP1077705A1 (en) 2001-02-28
EP1077705A4 true EP1077705A4 (en) 2002-04-17

Family

ID=22192459

Family Applications (1)

Application Number Title Priority Date Filing Date
EP99921866A Withdrawn EP1077705A4 (en) 1998-05-15 1999-05-11 Potassium channel agonists

Country Status (5)

Country Link
EP (1) EP1077705A4 (en)
JP (1) JP2002515436A (en)
AU (1) AU747340C (en)
CA (1) CA2329916A1 (en)
WO (1) WO1999059594A1 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6743797B2 (en) * 2002-02-22 2004-06-01 Chantest, Inc. Methods for treating cardiac arrhythmia
WO2014138502A1 (en) * 2013-03-06 2014-09-12 Acorda Therapeutics, Inc. Therapeutic dosing of a neuregulin or a fragment thereof for treatment or prophylaxis of heart failure

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995014470A1 (en) * 1993-11-22 1995-06-01 Merck & Co., Inc. Methods of treating cardiac arrhythmia
US5633247A (en) * 1989-12-08 1997-05-27 Merck & Co., Inc. Nitrogen-containing spirocycles

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5733905A (en) * 1993-07-29 1998-03-31 American Cyanamid Company Tricyclic diazepine vasopressin antagonists and oxytocin antagonists

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5633247A (en) * 1989-12-08 1997-05-27 Merck & Co., Inc. Nitrogen-containing spirocycles
WO1995014470A1 (en) * 1993-11-22 1995-06-01 Merck & Co., Inc. Methods of treating cardiac arrhythmia

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
SALATA J. ET AL: "A novel benzodiazepine that activates cardiac slow delayed rectifier K+ currents", MOLECULAR PHARMACOLOGY, vol. 54, no. 1, July 1998 (1998-07-01), pages 220 - 229, XP001027554 *
SANGUINETTI M C, JURKIEWICZ N., SALATA J.: "Novel benzodiazepines that modulate slow delayed rectifier K channels", NAUNYN-SCHMIEDERBERGS ARCHIVES OF PHARMACOLOGY, vol. 358, no. 1(1), September 1998 (1998-09-01), pages sf45, XP001026937 *
See also references of WO9959594A1 *
WILLIAM WM MUIR ET AL: "Antiarrhythmic effects of diazepam during coronary artery occlusion in dogs", AM. J. VET. RES., vol. 36, no. 8, 1975, pages 1203 - 1206, XP001027631 *

Also Published As

Publication number Publication date
AU3897299A (en) 1999-12-06
AU747340C (en) 2003-07-24
WO1999059594A1 (en) 1999-11-25
AU747340B2 (en) 2002-05-16
EP1077705A1 (en) 2001-02-28
CA2329916A1 (en) 1999-11-25
JP2002515436A (en) 2002-05-28

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