EP1075215A4 - Hyaluronan-based imaging agents - Google Patents

Hyaluronan-based imaging agents

Info

Publication number
EP1075215A4
EP1075215A4 EP99921503A EP99921503A EP1075215A4 EP 1075215 A4 EP1075215 A4 EP 1075215A4 EP 99921503 A EP99921503 A EP 99921503A EP 99921503 A EP99921503 A EP 99921503A EP 1075215 A4 EP1075215 A4 EP 1075215A4
Authority
EP
European Patent Office
Prior art keywords
hyaluronan
imaging agents
based imaging
agents
imaging
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP99921503A
Other languages
German (de)
French (fr)
Other versions
EP1075215A1 (en
Inventor
George Harrison Kidd
David John Mikulis
James I Nagy
Eva Anne Turley
Francoise Martine Winnik
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Jagotec AG
Original Assignee
Jagotec AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Jagotec AG filed Critical Jagotec AG
Publication of EP1075215A1 publication Critical patent/EP1075215A1/en
Publication of EP1075215A4 publication Critical patent/EP1075215A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0072—Hyaluronic acid, i.e. HA or hyaluronan; Derivatives thereof, e.g. crosslinked hyaluronic acid (hylan) or hyaluronates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/006—Biological staining of tissues in vivo, e.g. methylene blue or toluidine blue O administered in the buccal area to detect epithelial cancer cells, dyes used for delineating tissues during surgery
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
    • A61K49/1806—Suspensions, emulsions, colloids, dispersions
    • A61K49/1812—Suspensions, emulsions, colloids, dispersions liposomes, polymersomes, e.g. immunoliposomes
EP99921503A 1998-04-28 1999-04-27 Hyaluronan-based imaging agents Withdrawn EP1075215A4 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US8331198P 1998-04-28 1998-04-28
US83311P 1998-04-28
PCT/US1999/009177 WO1999055230A1 (en) 1998-04-28 1999-04-27 Hyaluronan-based imaging agents

Publications (2)

Publication Number Publication Date
EP1075215A1 EP1075215A1 (en) 2001-02-14
EP1075215A4 true EP1075215A4 (en) 2002-04-17

Family

ID=22177514

Family Applications (1)

Application Number Title Priority Date Filing Date
EP99921503A Withdrawn EP1075215A4 (en) 1998-04-28 1999-04-27 Hyaluronan-based imaging agents

Country Status (7)

Country Link
EP (1) EP1075215A4 (en)
JP (1) JP2002512942A (en)
AU (1) AU3870099A (en)
CA (1) CA2328698A1 (en)
NZ (1) NZ507540A (en)
WO (1) WO1999055230A1 (en)
ZA (1) ZA200006067B (en)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6875753B1 (en) 1996-03-14 2005-04-05 The Governors Of The University Of Alberta Methods for cell mobilization using in vivo treatment with hyaluronan (HA)
US6630457B1 (en) 1998-09-18 2003-10-07 Orthogene Llc Functionalized derivatives of hyaluronic acid, formation of hydrogels in situ using same, and methods for making and using same
US6593308B2 (en) * 1999-12-03 2003-07-15 The Regents Of The University Of California Targeted drug delivery with a hyaluronan ligand
DE10141106A1 (en) * 2001-08-22 2003-03-13 Aventis Pharma Gmbh Use of heparinoid derivatives for the treatment and diagnosis of heparinoid-treatable diseases
EP1466629A1 (en) 2003-04-11 2004-10-13 BRACCO IMAGING S.p.A. Adducts between magnetic resonance shift reagents and substrates containing exchangeable protons for "CEST" applications
WO2005117995A1 (en) * 2004-06-03 2005-12-15 Joji Kitayama Application of hyaluronic acid to sentinel lymph node identification
CN101137398B (en) * 2005-01-05 2012-07-04 得克萨斯大学体系董事会 Conjugates for dual imaging and radiochemotherapy: composition, manufacturing, and applications
CN101549161B (en) * 2009-05-13 2010-12-01 中南大学 Liver, spleen specific positive magnetic nuclear resonance contrast agent and method of preparing the same
EP2558108A1 (en) * 2010-04-12 2013-02-20 Ramot at Tel-Aviv University Ltd Iron oxide nanoparticles for use in treating non-infectious inflammatory disorders
CN101862461B (en) * 2010-06-18 2012-01-04 上海纳米技术及应用国家工程研究中心有限公司 Gadolinium-containing macromolecular contrast agent for specific imaging of lymphatic system and preparation method thereof
ES2439167B1 (en) * 2012-06-21 2014-11-17 Consejo Superior De Investigaciones Científicas (Csic) Compounds with magnetic functionality, implants or gels derived from them, and the use of both to determine the enzymatic activity of an enzyme
KR101939880B1 (en) 2016-06-29 2019-01-18 서울대학교산학협력단 Hydrogel based nano emulsion for the selective labeling on cancerous lesions and manufacturing method the same
KR101901986B1 (en) * 2016-11-18 2018-09-27 서울대학교산학협력단 Nanocarriers for selective fluorescence labeling of cancer cells and a process for the preparing the same
CN113440626A (en) * 2020-03-30 2021-09-28 复旦大学附属华山医院 Targeting nano magnetic resonance contrast agent for articular cartilage damage and preparation and application thereof
CN112111552A (en) * 2020-08-05 2020-12-22 青岛科技大学 Fluorescence imaging method of tumor cells
CN114224846B (en) * 2021-11-18 2023-03-14 东华大学 Drug-loaded fiber microsphere and preparation method and application thereof
CN114409275B (en) * 2022-01-14 2023-03-24 大连理工大学 Hyaluronic acid molecular brush modified surface and preparation method and application thereof
CN115554420B (en) * 2022-10-17 2023-08-08 中国科学院长春应用化学研究所 Paramagnetic magnetic resonance contrast agent and preparation method and application thereof

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996004922A1 (en) * 1994-08-10 1996-02-22 Davis, Joanne, T. Method of using hyaluronic acid for the detection, location and diagnosis of tumors

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5707604A (en) * 1986-11-18 1998-01-13 Access Pharmaceuticals, Inc. Vivo agents comprising metal-ion chelates with acidic saccharides and glycosaminoglycans, giving improved site-selective localization, uptake mechanism, sensitivity and kinetic-spatial profiles
US5368840A (en) * 1990-04-10 1994-11-29 Imarx Pharmaceutical Corp. Natural polymers as contrast media for magnetic resonance imaging
US5143716A (en) * 1991-02-01 1992-09-01 Unger Evan C Phosphorylated sugar alcohols, Mono- and Di-Saccharides as contrast agents for use in magnetic resonance imaging of the gastrointestinal region
JPH08501097A (en) * 1992-09-04 1996-02-06 ザ ゼネラル ホスピタル コーポレーション Biocompatible polymers including clinical diagnostic and therapeutic moieties
US5534241A (en) * 1993-07-23 1996-07-09 Torchilin; Vladimir P. Amphipathic polychelating compounds and methods of use

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996004922A1 (en) * 1994-08-10 1996-02-22 Davis, Joanne, T. Method of using hyaluronic acid for the detection, location and diagnosis of tumors

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
See also references of WO9955230A1 *
TRUBETSKOY V S ET AL: "NEW APPROACHES IN THE CHEMICAL DESIGN OG GD-CONTAINING LIPOSOMES FOR USE IN MAGNETIC RESONANCE IMAGING OF LYMPH NODES", JOURNAL OF LIPOSOME RESEARCH, MARCEL DEKKER, NEW YORK, US, vol. 4, no. 2, 1994, pages 961 - 980, XP000619021, ISSN: 0898-2104 *
WINNIK F.M. ET AL: "Hyaluronan-stabilized colloidal superparamagnetic iron oxides: preparation and characterization", ROUND TABLE SERIES-ROYAL SOCIETY OF MEDICINE, vol. 45, 1996, pages 10 - 26, XP001055698 *

Also Published As

Publication number Publication date
NZ507540A (en) 2002-07-26
AU3870099A (en) 1999-11-16
JP2002512942A (en) 2002-05-08
CA2328698A1 (en) 1999-11-04
EP1075215A1 (en) 2001-02-14
ZA200006067B (en) 2001-08-23
WO1999055230A1 (en) 1999-11-04

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