EP1071645A4 - Phosphodiesterase isoenzyme denominated 4 (pde 4) inhibiting compounds - Google Patents
Phosphodiesterase isoenzyme denominated 4 (pde 4) inhibiting compoundsInfo
- Publication number
- EP1071645A4 EP1071645A4 EP99919814A EP99919814A EP1071645A4 EP 1071645 A4 EP1071645 A4 EP 1071645A4 EP 99919814 A EP99919814 A EP 99919814A EP 99919814 A EP99919814 A EP 99919814A EP 1071645 A4 EP1071645 A4 EP 1071645A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- pde
- inhibiting compounds
- phosphodiesterase isoenzyme
- denominated
- isoenzyme denominated
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/42—One nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
- C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
- C07C217/74—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with rings other than six-membered aromatic rings being part of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/46—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino or carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/51—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition
- C07C45/511—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition involving transformation of singly bound oxygen functional groups to >C = O groups
- C07C45/513—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition involving transformation of singly bound oxygen functional groups to >C = O groups the singly bound functional group being an etherified hydroxyl group
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/56—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds
- C07C45/57—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds with oxygen as the only heteroatom
- C07C45/59—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds with oxygen as the only heteroatom in five-membered rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
- C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C47/00—Compounds having —CHO groups
- C07C47/38—Unsaturated compounds having —CHO groups bound to carbon atoms of rings other than six—membered aromatic rings
- C07C47/47—Unsaturated compounds having —CHO groups bound to carbon atoms of rings other than six—membered aromatic rings containing ether groups, groups, groups, or groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
- C07C49/753—Unsaturated compounds containing a keto groups being part of a ring containing ether groups, groups, groups, or groups
- C07C49/755—Unsaturated compounds containing a keto groups being part of a ring containing ether groups, groups, groups, or groups a keto group being part of a condensed ring system with two or three rings, at least one ring being a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/04—Systems containing only non-condensed rings with a four-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US8170298P | 1998-04-14 | 1998-04-14 | |
US81702P | 1998-04-14 | ||
PCT/US1999/007995 WO1999052847A1 (en) | 1998-04-14 | 1999-04-13 | Phosphodiesterase isoenzyme denominated 4 (pde 4) inhibiting compounds |
Publications (2)
Publication Number | Publication Date |
---|---|
EP1071645A1 EP1071645A1 (en) | 2001-01-31 |
EP1071645A4 true EP1071645A4 (en) | 2003-04-02 |
Family
ID=22165846
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP99919814A Withdrawn EP1071645A4 (en) | 1998-04-14 | 1999-04-13 | Phosphodiesterase isoenzyme denominated 4 (pde 4) inhibiting compounds |
Country Status (4)
Country | Link |
---|---|
EP (1) | EP1071645A4 (en) |
JP (1) | JP2002511438A (en) |
CA (1) | CA2328250A1 (en) |
WO (1) | WO1999052847A1 (en) |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3345405A (en) * | 1964-03-31 | 1967-10-03 | Smith Kline French Lab | 1-amino-2(and 3)-phenylcyclobutane-1-carboxylic acids |
WO1991015451A1 (en) * | 1990-04-05 | 1991-10-17 | Smithkline Beecham Pharma Gmbh | Novel derivatives of phenyl-cycloalkanes and -cycloalkenes |
US5187192A (en) * | 1992-03-13 | 1993-02-16 | Abbott Laboratories | Cyclobutyl derivatives having lipoxygenase inhibitory activity |
WO1996031485A1 (en) * | 1995-04-06 | 1996-10-10 | Janssen Pharmaceutica N.V. | 1,3-dihydro-1-(phenylalkyl)-2h-imidazol-2-one derivatives having pdeiv and cytokine activity |
-
1999
- 1999-04-13 EP EP99919814A patent/EP1071645A4/en not_active Withdrawn
- 1999-04-13 CA CA002328250A patent/CA2328250A1/en not_active Abandoned
- 1999-04-13 JP JP2000543410A patent/JP2002511438A/en not_active Withdrawn
- 1999-04-13 WO PCT/US1999/007995 patent/WO1999052847A1/en not_active Application Discontinuation
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3345405A (en) * | 1964-03-31 | 1967-10-03 | Smith Kline French Lab | 1-amino-2(and 3)-phenylcyclobutane-1-carboxylic acids |
WO1991015451A1 (en) * | 1990-04-05 | 1991-10-17 | Smithkline Beecham Pharma Gmbh | Novel derivatives of phenyl-cycloalkanes and -cycloalkenes |
US5187192A (en) * | 1992-03-13 | 1993-02-16 | Abbott Laboratories | Cyclobutyl derivatives having lipoxygenase inhibitory activity |
WO1996031485A1 (en) * | 1995-04-06 | 1996-10-10 | Janssen Pharmaceutica N.V. | 1,3-dihydro-1-(phenylalkyl)-2h-imidazol-2-one derivatives having pdeiv and cytokine activity |
Non-Patent Citations (2)
Title |
---|
HONDA T ET AL: "CHIRAL SYNTHESIS OF PHOSPHODIESTERASE INHIBITOR, (R)-(-)-ROLIPRAM, BY MEANS OF ENANTIOSELECTIVE DEPROTONATION STRATEGY", HETEROCYCLES, ELSEVIER SCIENCE PUBLISHERS B.V. AMSTERDAM, NL, vol. 42, no. 1, January 1996 (1996-01-01), pages 109 - 111, XP002921368, ISSN: 0385-5414 * |
See also references of WO9952847A1 * |
Also Published As
Publication number | Publication date |
---|---|
CA2328250A1 (en) | 1999-10-21 |
JP2002511438A (en) | 2002-04-16 |
EP1071645A1 (en) | 2001-01-31 |
WO1999052847A1 (en) | 1999-10-21 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
17P | Request for examination filed |
Effective date: 20001017 |
|
AK | Designated contracting states |
Kind code of ref document: A1 Designated state(s): BE CH DE ES FR GB IT LI NL |
|
A4 | Supplementary search report drawn up and despatched |
Effective date: 20030220 |
|
RIC1 | Information provided on ipc code assigned before grant |
Ipc: 7C 07D 239/42 B Ipc: 7C 07C 229/46 B Ipc: 7C 07C 217/74 B Ipc: 7C 07C 47/47 B Ipc: 7C 07C 45/68 B Ipc: 7C 07C 45/59 B Ipc: 7C 07C 45/51 B Ipc: 7C 07C 49/755 B Ipc: 7C 07C 49/115 B Ipc: 7C 07C 49/105 B Ipc: 7C 07C 49/23 A |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN |
|
18D | Application deemed to be withdrawn |
Effective date: 20021101 |