EP1071472A4 - Peptide für einen effizienten gentransfer - Google Patents

Peptide für einen effizienten gentransfer

Info

Publication number
EP1071472A4
EP1071472A4 EP99919987A EP99919987A EP1071472A4 EP 1071472 A4 EP1071472 A4 EP 1071472A4 EP 99919987 A EP99919987 A EP 99919987A EP 99919987 A EP99919987 A EP 99919987A EP 1071472 A4 EP1071472 A4 EP 1071472A4
Authority
EP
European Patent Office
Prior art keywords
peptides
gene transfer
efficient gene
efficient
transfer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP99919987A
Other languages
English (en)
French (fr)
Other versions
EP1071472A1 (de
Inventor
Jeffrey F Bonadio
Vinod D Labhasetwar
Robert J Levy
Kevin G Rice
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Michigan
Original Assignee
University of Michigan
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Michigan filed Critical University of Michigan
Publication of EP1071472A1 publication Critical patent/EP1071472A1/de
Publication of EP1071472A4 publication Critical patent/EP1071472A4/de
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Microbiology (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
EP99919987A 1998-04-23 1999-04-23 Peptide für einen effizienten gentransfer Withdrawn EP1071472A4 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US6589198A 1998-04-23 1998-04-23
US65891 1998-04-23
PCT/US1999/008884 WO1999053961A1 (en) 1998-04-23 1999-04-23 Peptides for efficient gene transfer

Publications (2)

Publication Number Publication Date
EP1071472A1 EP1071472A1 (de) 2001-01-31
EP1071472A4 true EP1071472A4 (de) 2002-04-17

Family

ID=22065830

Family Applications (1)

Application Number Title Priority Date Filing Date
EP99919987A Withdrawn EP1071472A4 (de) 1998-04-23 1999-04-23 Peptide für einen effizienten gentransfer

Country Status (3)

Country Link
EP (1) EP1071472A4 (de)
AU (1) AU3758199A (de)
WO (1) WO1999053961A1 (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6551618B2 (en) * 1994-03-15 2003-04-22 University Of Birmingham Compositions and methods for delivery of agents for neuronal regeneration and survival
AU6097100A (en) * 1999-07-13 2001-01-30 Regents Of The University Of Michigan, The Crosslinked dna condensate compositions and gene delivery methods
US6770740B1 (en) 1999-07-13 2004-08-03 The Regents Of The University Of Michigan Crosslinked DNA condensate compositions and gene delivery methods
EP1294908B1 (de) 2000-06-28 2006-03-08 Max-Delbrück-Centrum Für Molekulare Medizin Verfahren zur verbesserung der transfektionseffizienz
WO2008014979A2 (en) 2006-07-31 2008-02-07 Curevac Gmbh NUCLEIC ACID OF FORMULA (I): GIXmGn, OR (II): CIXmCn, IN PARTICULAR AS AN IMMUNE-STIMULATING AGENT/ADJUVANT
WO2009030254A1 (en) 2007-09-04 2009-03-12 Curevac Gmbh Complexes of rna and cationic peptides for transfection and for immunostimulation
HUE025027T2 (en) 2008-01-31 2016-07-28 Curevac Gmbh (NuGiXmGnNv) nucleic acids and derivatives of the formula as immunostimulants / adjuvants
WO2010037408A1 (en) 2008-09-30 2010-04-08 Curevac Gmbh Composition comprising a complexed (m)rna and a naked mrna for providing or enhancing an immunostimulatory response in a mammal and uses thereof
US20110053829A1 (en) 2009-09-03 2011-03-03 Curevac Gmbh Disulfide-linked polyethyleneglycol/peptide conjugates for the transfection of nucleic acids
MX336839B (es) * 2010-07-30 2016-02-03 Curevac Gmbh Formacion de complejos de acidos nucleicos con componentes cationicos entrelazados por disulfuro para transfeccion e inmunoestimulacion.
WO2013113326A1 (en) 2012-01-31 2013-08-08 Curevac Gmbh Pharmaceutical composition comprising a polymeric carrier cargo complex and at least one protein or peptide antigen
CN102614529B (zh) * 2012-04-26 2013-12-18 中南大学 一种治疗鼻咽癌药物递送系统及其构建和应用方法
SG11201510746WA (en) 2013-08-21 2016-03-30 Curevac Ag Respiratory syncytial virus (rsv) vaccine
EP3129050A2 (de) 2014-04-01 2017-02-15 CureVac AG Polymerträger-cargo-komplex zur verwendung als immunstimulierendes mittel oder als ein adjuvans

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997046100A1 (en) * 1996-06-03 1997-12-11 Case Western Reserve University Serpin enzyme complex receptor-mediated gene transfer
WO1998019711A1 (en) * 1996-11-04 1998-05-14 Regents Of The University Of Michigan Peptides for gene delivery

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5354844A (en) * 1989-03-16 1994-10-11 Boehringer Ingelheim International Gmbh Protein-polycation conjugates
US5763416A (en) * 1994-02-18 1998-06-09 The Regent Of The University Of Michigan Gene transfer into bone cells and tissues
AU700903B2 (en) * 1994-10-12 1999-01-14 Focal, Inc. Targeted delivery via biodegradable polymers
US5736392A (en) * 1995-06-07 1998-04-07 Life Technologies, Inc. Peptide-enhanced cationic lipid transfections

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997046100A1 (en) * 1996-06-03 1997-12-11 Case Western Reserve University Serpin enzyme complex receptor-mediated gene transfer
WO1998019711A1 (en) * 1996-11-04 1998-05-14 Regents Of The University Of Michigan Peptides for gene delivery

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
ADAMI ROGER C ET AL: "Stability of peptide-condensed plasmid DNA formulations", JOURNAL OF PHARMACEUTICAL SCIENCES, AMERICAN PHARMACEUTICAL ASSOCIATION. WASHINGTON, US, vol. 87, no. 6, June 1998 (1998-06-01), pages 678 - 683, XP002165043, ISSN: 0022-3549 *
KWOK KY ET AL: "Formulation of highly soluble poly(ethylene glycol)-peptide DNA condensates", JOURNAL OF PHARMACEUTICAL SCIENCES, AMERICAN PHARMACEUTICAL ASSOCIATION. WASHINGTON, US, vol. 88, no. 10, October 1999 (1999-10-01), pages 996 - 1003, XP002165042, ISSN: 0022-3549 *
See also references of WO9953961A1 *
SMITH L C ET AL: "SYNTHETIC PEPTIDE-BASED DNA COMPLEXES FOR NONVIRAL GENE DELIVERY", ADVANCED DRUG DELIVERY REVIEWS, AMSTERDAM, NL, vol. 30, no. 1-3, 2 March 1998 (1998-03-02), pages 115 - 131, XP000990852, ISSN: 0169-409X *
WOLFERT M A ET AL: "CHARACTERIZATION OF VECTORS FOR GENE THERAPY FORMED BY SELF- ASSEMBLY OF DNA WITH SYNTHETIC BLOCK CO-POLYMERS", HUMAN GENE THERAPY, XX, XX, vol. 7, 10 November 1996 (1996-11-10), pages 2123 - 2133, XP002915739, ISSN: 1043-0342 *

Also Published As

Publication number Publication date
AU3758199A (en) 1999-11-08
WO1999053961A1 (en) 1999-10-28
WO1999053961A9 (en) 2000-09-08
EP1071472A1 (de) 2001-01-31

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