EP1037969A4 - Hybrides d'enzymes de conversion du fibrinogene - Google Patents

Hybrides d'enzymes de conversion du fibrinogene

Info

Publication number
EP1037969A4
EP1037969A4 EP98963813A EP98963813A EP1037969A4 EP 1037969 A4 EP1037969 A4 EP 1037969A4 EP 98963813 A EP98963813 A EP 98963813A EP 98963813 A EP98963813 A EP 98963813A EP 1037969 A4 EP1037969 A4 EP 1037969A4
Authority
EP
European Patent Office
Prior art keywords
fibrinogen
converting enzyme
enzyme hybrids
hybrids
converting
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP98963813A
Other languages
German (de)
English (en)
Other versions
EP1037969A1 (fr
Inventor
Stewart A Cederholm-Williams
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bristol Myers Squibb Co
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of EP1037969A1 publication Critical patent/EP1037969A1/fr
Publication of EP1037969A4 publication Critical patent/EP1037969A4/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6402—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from non-mammals
    • C12N9/6418—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from non-mammals from snakes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biochemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Saccharide Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
EP98963813A 1997-12-09 1998-12-09 Hybrides d'enzymes de conversion du fibrinogene Withdrawn EP1037969A4 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US6797897P 1997-12-09 1997-12-09
US67978P 1997-12-09
PCT/US1998/026086 WO1999029838A1 (fr) 1997-12-09 1998-12-09 Hybrides d'enzymes de conversion du fibrinogene

Publications (2)

Publication Number Publication Date
EP1037969A1 EP1037969A1 (fr) 2000-09-27
EP1037969A4 true EP1037969A4 (fr) 2003-05-21

Family

ID=22079665

Family Applications (1)

Application Number Title Priority Date Filing Date
EP98963813A Withdrawn EP1037969A4 (fr) 1997-12-09 1998-12-09 Hybrides d'enzymes de conversion du fibrinogene

Country Status (6)

Country Link
EP (1) EP1037969A4 (fr)
JP (1) JP2001526027A (fr)
AU (1) AU753458B2 (fr)
CA (1) CA2312476A1 (fr)
NO (1) NO20002937L (fr)
WO (1) WO1999029838A1 (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6261820B1 (en) * 1999-10-01 2001-07-17 Amgen Inc. Fibronolytically active polypeptide
CN100494366C (zh) * 2006-10-19 2009-06-03 康辰医药股份有限公司 血凝酶
DE102014112212A1 (de) 2014-08-26 2016-03-03 Akesion Gmbh Rekombinante Fusionsproteine zur Vorbeugung oder Behandlung von Adhäsionen bei Geweben oder Organen

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1091315A (zh) * 1992-10-08 1994-08-31 E·R·斯奎布父子公司 血纤维蛋白封闭剂组合物及其使用方法
US6551794B1 (en) * 1995-11-09 2003-04-22 E. R. Squibb & Sons, Inc. Stable biotinylated biomolecule composition
US5691152A (en) * 1995-11-09 1997-11-25 E. R. Squibb & Sons, Inc. Stable avidin composition

Non-Patent Citations (13)

* Cited by examiner, † Cited by third party
Title
AIRENNE K J ET AL: "Rapid purification of recombinant proteins fused to chicken avidin", GENE, ELSEVIER BIOMEDICAL PRESS. AMSTERDAM, NL, vol. 167, no. 1, 1995, pages 63 - 68, XP004043018, ISSN: 0378-1119 *
AIRENNE KARI J ET AL: "Production of biologically active recombinant avidin in baculovirus-infected insect cells.", PROTEIN EXPRESSION AND PURIFICATION, vol. 9, no. 1, February 1997 (1997-02-01), pages 100 - 108, XP002232134, ISSN: 1046-5928 *
BAYER E A ET AL: "APPLICATION OF AVIDIN-BIOTIN TECHNOLOGY TO AFFINITY-BASED SEPARATIONS", JOURNAL OF CHROMATOGRAPHY, ELSEVIER SCIENCE PUBLISHERS B.V. AMSTERDAM, NL, vol. 510, 1990, pages 3 - 11, XP001042036, ISSN: 0021-9673 *
CARLSSON J ET AL: "PROTEIN THIOLATION AND REVERSIBLE PROTEIN-PROTEIN CONJUGATION N SUCCINIMIDYL-3-2-PYRIDYL DI THIO PROPIONATE A NEW HETERO BI FUNCTIONAL REAGENT", BIOCHEMICAL JOURNAL, vol. 173, no. 3, 1978, EN, pages 723 - 738, XP001146511, ISSN: 0264-6021 *
HOLMGREN A: "THIOREDOXIN", ANNUAL REVIEW OF BIOCHEMISTRY, PALTO ALTO, CA, US, vol. 54, 1985, pages 237 - 271, XP002914689, ISSN: 0066-4154 *
ITOH N ET AL: "MOLECULAR CLONING AND SEQUENCE ANALYSIS OF CDNA FOR BATROXOBIN, A THROMBIN-LIKE SNAKE VENOM ENZYME", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY OF BIOLOGICAL CHEMISTS, BALTIMORE, MD, US, vol. 262, no. 7, 5 March 1987 (1987-03-05), pages 3132 - 3135, XP002019838, ISSN: 0021-9258 *
LAVALLIE E R ET AL: "A THIOREDOXIN GENE FUSION EXPRESSION SYSTEM THAT CIRCUMVENTS INCLUSION BODY FORMATION IN THE E. COLI CYTOPLASM", BIOTECHNOLOGY. THE INTERNATIONAL MONTHLY FOR INDUSTRIAL BIOLOGY, NATURE PUBLISHING CO. NEW YORK, US, vol. 11, no. 2, February 1993 (1993-02-01), pages 180 - 193, XP000195207, ISSN: 0733-222X *
LAVALLIE E R ET AL: "Thioredoxin as a fusion partner for production of soluble recombinant proteins in Escherichia coli.", METHODS IN ENZYMOLOGY. UNITED STATES 2000, vol. 326, 2000, pages 322 - 340, XP001145875, ISSN: 0076-6879 *
LU ZHIJIAN ET AL: "Histidine patch thioredoxins: Mutant forms of thioredoxin with metal chelating affinity that provide for convenient purifications of thioredoxin fusion proteins.", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 271, no. 9, 1996, pages 5059 - 5065, XP002235781, ISSN: 0021-9258 *
MORRIS JOHN C ET AL: "Molecular cloning and characterization of murine interleukin-11.", EXPERIMENTAL HEMATOLOGY (CHARLOTTESVILLE), vol. 24, no. 12, 1996, pages 1369 - 1376, XP009007251, ISSN: 0301-472X *
NISHIDA SHINJI ET AL: "CDNA cloning and deduced amino acid sequence of prothrombin activator (Ecarin) from Kenyan Echis carinatus venom", BIOCHEMISTRY, AMERICAN CHEMICAL SOCIETY. EASTON, PA, US, vol. 34, no. 5, 1995, pages 1771 - 1779, XP002159171, ISSN: 0006-2960 *
PORTER N A ET AL: "PHOTO-RESVERSIBLE BINDING OF THROMBIN TO AVIDIN BY MEANS OF A PHOTOLABILE INHIBITOR", JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B: BIOLOGY, ELSEVIER SCIENCE S.A., BASEL, CH, vol. 38, no. 1, 1997, pages 61 - 69, XP001145484, ISSN: 1011-1344 *
See also references of WO9929838A1 *

Also Published As

Publication number Publication date
NO20002937D0 (no) 2000-06-08
EP1037969A1 (fr) 2000-09-27
NO20002937L (no) 2000-08-08
JP2001526027A (ja) 2001-12-18
CA2312476A1 (fr) 1999-06-17
WO1999029838A1 (fr) 1999-06-17
AU753458B2 (en) 2002-10-17
AU1905899A (en) 1999-06-28

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