EP1037969A4 - Hybrides d'enzymes de conversion du fibrinogene - Google Patents
Hybrides d'enzymes de conversion du fibrinogeneInfo
- Publication number
- EP1037969A4 EP1037969A4 EP98963813A EP98963813A EP1037969A4 EP 1037969 A4 EP1037969 A4 EP 1037969A4 EP 98963813 A EP98963813 A EP 98963813A EP 98963813 A EP98963813 A EP 98963813A EP 1037969 A4 EP1037969 A4 EP 1037969A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- fibrinogen
- converting enzyme
- enzyme hybrids
- hybrids
- converting
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6402—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from non-mammals
- C12N9/6418—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from non-mammals from snakes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- Animal Behavior & Ethology (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Biochemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Peptides Or Proteins (AREA)
- Saccharide Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Enzymes And Modification Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US6797897P | 1997-12-09 | 1997-12-09 | |
US67978P | 1997-12-09 | ||
PCT/US1998/026086 WO1999029838A1 (fr) | 1997-12-09 | 1998-12-09 | Hybrides d'enzymes de conversion du fibrinogene |
Publications (2)
Publication Number | Publication Date |
---|---|
EP1037969A1 EP1037969A1 (fr) | 2000-09-27 |
EP1037969A4 true EP1037969A4 (fr) | 2003-05-21 |
Family
ID=22079665
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP98963813A Withdrawn EP1037969A4 (fr) | 1997-12-09 | 1998-12-09 | Hybrides d'enzymes de conversion du fibrinogene |
Country Status (6)
Country | Link |
---|---|
EP (1) | EP1037969A4 (fr) |
JP (1) | JP2001526027A (fr) |
AU (1) | AU753458B2 (fr) |
CA (1) | CA2312476A1 (fr) |
NO (1) | NO20002937L (fr) |
WO (1) | WO1999029838A1 (fr) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6261820B1 (en) * | 1999-10-01 | 2001-07-17 | Amgen Inc. | Fibronolytically active polypeptide |
CN100494366C (zh) * | 2006-10-19 | 2009-06-03 | 康辰医药股份有限公司 | 血凝酶 |
DE102014112212A1 (de) | 2014-08-26 | 2016-03-03 | Akesion Gmbh | Rekombinante Fusionsproteine zur Vorbeugung oder Behandlung von Adhäsionen bei Geweben oder Organen |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1091315A (zh) * | 1992-10-08 | 1994-08-31 | E·R·斯奎布父子公司 | 血纤维蛋白封闭剂组合物及其使用方法 |
US6551794B1 (en) * | 1995-11-09 | 2003-04-22 | E. R. Squibb & Sons, Inc. | Stable biotinylated biomolecule composition |
US5691152A (en) * | 1995-11-09 | 1997-11-25 | E. R. Squibb & Sons, Inc. | Stable avidin composition |
-
1998
- 1998-12-09 CA CA002312476A patent/CA2312476A1/fr not_active Abandoned
- 1998-12-09 EP EP98963813A patent/EP1037969A4/fr not_active Withdrawn
- 1998-12-09 JP JP2000524411A patent/JP2001526027A/ja active Pending
- 1998-12-09 AU AU19058/99A patent/AU753458B2/en not_active Ceased
- 1998-12-09 WO PCT/US1998/026086 patent/WO1999029838A1/fr not_active Application Discontinuation
-
2000
- 2000-06-08 NO NO20002937A patent/NO20002937L/no not_active Application Discontinuation
Non-Patent Citations (13)
Title |
---|
AIRENNE K J ET AL: "Rapid purification of recombinant proteins fused to chicken avidin", GENE, ELSEVIER BIOMEDICAL PRESS. AMSTERDAM, NL, vol. 167, no. 1, 1995, pages 63 - 68, XP004043018, ISSN: 0378-1119 * |
AIRENNE KARI J ET AL: "Production of biologically active recombinant avidin in baculovirus-infected insect cells.", PROTEIN EXPRESSION AND PURIFICATION, vol. 9, no. 1, February 1997 (1997-02-01), pages 100 - 108, XP002232134, ISSN: 1046-5928 * |
BAYER E A ET AL: "APPLICATION OF AVIDIN-BIOTIN TECHNOLOGY TO AFFINITY-BASED SEPARATIONS", JOURNAL OF CHROMATOGRAPHY, ELSEVIER SCIENCE PUBLISHERS B.V. AMSTERDAM, NL, vol. 510, 1990, pages 3 - 11, XP001042036, ISSN: 0021-9673 * |
CARLSSON J ET AL: "PROTEIN THIOLATION AND REVERSIBLE PROTEIN-PROTEIN CONJUGATION N SUCCINIMIDYL-3-2-PYRIDYL DI THIO PROPIONATE A NEW HETERO BI FUNCTIONAL REAGENT", BIOCHEMICAL JOURNAL, vol. 173, no. 3, 1978, EN, pages 723 - 738, XP001146511, ISSN: 0264-6021 * |
HOLMGREN A: "THIOREDOXIN", ANNUAL REVIEW OF BIOCHEMISTRY, PALTO ALTO, CA, US, vol. 54, 1985, pages 237 - 271, XP002914689, ISSN: 0066-4154 * |
ITOH N ET AL: "MOLECULAR CLONING AND SEQUENCE ANALYSIS OF CDNA FOR BATROXOBIN, A THROMBIN-LIKE SNAKE VENOM ENZYME", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY OF BIOLOGICAL CHEMISTS, BALTIMORE, MD, US, vol. 262, no. 7, 5 March 1987 (1987-03-05), pages 3132 - 3135, XP002019838, ISSN: 0021-9258 * |
LAVALLIE E R ET AL: "A THIOREDOXIN GENE FUSION EXPRESSION SYSTEM THAT CIRCUMVENTS INCLUSION BODY FORMATION IN THE E. COLI CYTOPLASM", BIOTECHNOLOGY. THE INTERNATIONAL MONTHLY FOR INDUSTRIAL BIOLOGY, NATURE PUBLISHING CO. NEW YORK, US, vol. 11, no. 2, February 1993 (1993-02-01), pages 180 - 193, XP000195207, ISSN: 0733-222X * |
LAVALLIE E R ET AL: "Thioredoxin as a fusion partner for production of soluble recombinant proteins in Escherichia coli.", METHODS IN ENZYMOLOGY. UNITED STATES 2000, vol. 326, 2000, pages 322 - 340, XP001145875, ISSN: 0076-6879 * |
LU ZHIJIAN ET AL: "Histidine patch thioredoxins: Mutant forms of thioredoxin with metal chelating affinity that provide for convenient purifications of thioredoxin fusion proteins.", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 271, no. 9, 1996, pages 5059 - 5065, XP002235781, ISSN: 0021-9258 * |
MORRIS JOHN C ET AL: "Molecular cloning and characterization of murine interleukin-11.", EXPERIMENTAL HEMATOLOGY (CHARLOTTESVILLE), vol. 24, no. 12, 1996, pages 1369 - 1376, XP009007251, ISSN: 0301-472X * |
NISHIDA SHINJI ET AL: "CDNA cloning and deduced amino acid sequence of prothrombin activator (Ecarin) from Kenyan Echis carinatus venom", BIOCHEMISTRY, AMERICAN CHEMICAL SOCIETY. EASTON, PA, US, vol. 34, no. 5, 1995, pages 1771 - 1779, XP002159171, ISSN: 0006-2960 * |
PORTER N A ET AL: "PHOTO-RESVERSIBLE BINDING OF THROMBIN TO AVIDIN BY MEANS OF A PHOTOLABILE INHIBITOR", JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B: BIOLOGY, ELSEVIER SCIENCE S.A., BASEL, CH, vol. 38, no. 1, 1997, pages 61 - 69, XP001145484, ISSN: 1011-1344 * |
See also references of WO9929838A1 * |
Also Published As
Publication number | Publication date |
---|---|
NO20002937D0 (no) | 2000-06-08 |
EP1037969A1 (fr) | 2000-09-27 |
NO20002937L (no) | 2000-08-08 |
JP2001526027A (ja) | 2001-12-18 |
CA2312476A1 (fr) | 1999-06-17 |
WO1999029838A1 (fr) | 1999-06-17 |
AU753458B2 (en) | 2002-10-17 |
AU1905899A (en) | 1999-06-28 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
17P | Request for examination filed |
Effective date: 20000710 |
|
AK | Designated contracting states |
Kind code of ref document: A1 Designated state(s): AT BE CH DE DK ES FI FR GB IE IT LI NL PT SE |
|
RIC1 | Information provided on ipc code assigned before grant |
Ipc: 7C 12N 9/64 B Ipc: 7C 07K 14/00 B Ipc: 7C 07H 21/02 B Ipc: 7C 07H 21/04 B Ipc: 7C 12N 15/11 B Ipc: 7C 12N 15/63 B Ipc: 7C 12N 1/21 B Ipc: 7C 12N 15/00 A |
|
A4 | Supplementary search report drawn up and despatched |
Effective date: 20030408 |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION HAS BEEN WITHDRAWN |
|
18W | Application withdrawn |
Effective date: 20030925 |