EP1034290A4 - Flavivirus expression and delivery system - Google Patents

Flavivirus expression and delivery system

Info

Publication number
EP1034290A4
EP1034290A4 EP98959672A EP98959672A EP1034290A4 EP 1034290 A4 EP1034290 A4 EP 1034290A4 EP 98959672 A EP98959672 A EP 98959672A EP 98959672 A EP98959672 A EP 98959672A EP 1034290 A4 EP1034290 A4 EP 1034290A4
Authority
EP
European Patent Office
Prior art keywords
delivery system
flavivirus expression
flavivirus
expression
delivery
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP98959672A
Other languages
German (de)
French (fr)
Other versions
EP1034290A1 (en
Inventor
Edwin G Westaway
Alexander Khromykh
Andrei Varnavski
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
QIMR Berghofer Medical Research Institute
Original Assignee
Queensland Institute of Medical Research QIMR
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from AUPP0627A external-priority patent/AUPP062797A0/en
Priority claimed from AUPP6096A external-priority patent/AUPP609698A0/en
Application filed by Queensland Institute of Medical Research QIMR filed Critical Queensland Institute of Medical Research QIMR
Publication of EP1034290A1 publication Critical patent/EP1034290A1/en
Publication of EP1034290A4 publication Critical patent/EP1034290A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/24011—Flaviviridae
    • C12N2770/24111—Flavivirus, e.g. yellow fever virus, dengue, JEV
    • C12N2770/24141—Use of virus, viral particle or viral elements as a vector
    • C12N2770/24143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/60—Vector systems having a special element relevant for transcription from viruses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/80—Vector systems having a special element relevant for transcription from vertebrates
    • C12N2830/85—Vector systems having a special element relevant for transcription from vertebrates mammalian
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2840/00—Vectors comprising a special translation-regulating system
    • C12N2840/20—Vectors comprising a special translation-regulating system translation of more than one cistron
    • C12N2840/203—Vectors comprising a special translation-regulating system translation of more than one cistron having an IRES

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Virology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
EP98959672A 1997-11-28 1998-11-30 Flavivirus expression and delivery system Withdrawn EP1034290A4 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
AUPP0627A AUPP062797A0 (en) 1997-11-28 1997-11-28 Flavivirus expression system
AUPP062797 1997-11-28
AUPP609698 1998-09-23
AUPP6096A AUPP609698A0 (en) 1998-09-23 1998-09-23 Flavivirus expression system
PCT/AU1998/000993 WO1999028487A1 (en) 1997-11-28 1998-11-30 Flavivirus expression and delivery system

Publications (2)

Publication Number Publication Date
EP1034290A1 EP1034290A1 (en) 2000-09-13
EP1034290A4 true EP1034290A4 (en) 2004-09-15

Family

ID=25645666

Family Applications (1)

Application Number Title Priority Date Filing Date
EP98959672A Withdrawn EP1034290A4 (en) 1997-11-28 1998-11-30 Flavivirus expression and delivery system

Country Status (5)

Country Link
EP (1) EP1034290A4 (en)
JP (2) JP2002500003A (en)
CA (1) CA2311395C (en)
NZ (1) NZ504725A (en)
WO (1) WO1999028487A1 (en)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1035205A1 (en) * 1999-03-08 2000-09-13 Stichting Dienst Landbouwkundig Onderzoek Non-spreading pestivirus
US6589531B1 (en) 2000-01-21 2003-07-08 The Regents Of The University Of California Recombinant yellow fever virus and method of use thereof
EP1195438A1 (en) * 2000-10-06 2002-04-10 Rijksuniversiteit te Groningen Genetic immunisation against cervical carcinoma
KR20020059856A (en) * 2001-01-08 2002-07-16 김철중 Preparation of hiv-like particles
WO2002072803A2 (en) 2001-03-09 2002-09-19 The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Subgenomic replicons of the flavivirus dengue
GB2372991B (en) * 2001-03-09 2004-11-17 Fiocruz Fundacao Oswaldo Cruz Flavivirus expression vector
FR2829149B1 (en) * 2001-09-06 2004-09-24 Pasteur Institut NEUROVIRULENT STRAIN OF WEST NILE VIRUS AND ITS APPLICATIONS
US7871814B2 (en) * 2001-05-10 2011-01-18 The Regents Of The University Of California Recombinant bicistronic flaviviruses and methods of use thereof
NZ533237A (en) * 2001-11-26 2005-11-25 Univ Queensland Flavivirus vaccine delivery system
EP1593738A4 (en) * 2003-01-30 2006-05-31 Shanghai Tengen Biomedical Co Virus-like particle vaccine containing dengue virus recombinant replicon as its carrier
CN103088038B (en) * 2004-07-12 2015-06-24 美国天甲生物医药有限公司 Flavivirus vaccine
BRPI0504945B8 (en) * 2005-10-31 2022-08-02 Fundacao Oswaldo Cruz METHOD FOR PRODUCTION OF RECOMBINANT FLAVIVIRUS CONTAINING NUCLEOTIDE SEQUENCES ENCODING A HETEROLOGOUS PROTEIN, DNA CONSTRUCT, FLAVIVIRUS, AND, VACCINE COMPOSITION TO IMMUNIZE AGAINST FLAVIVIRUS AND/OR OTHER PATHOGENS.
AU2007217352B2 (en) 2006-02-27 2013-09-26 The Board Of Regents Of The University Of Texas System Pseudoinfectious flavivirus and uses thereof
MX2010010034A (en) 2008-03-14 2010-12-06 Sanofi Pasteur Biologics Co Replication-defective flavivirus vaccines and vaccine vectors.
HUE047796T2 (en) 2010-07-06 2020-05-28 Glaxosmithkline Biologicals Sa Delivery of rna to trigger multiple immune pathways
WO2012006378A1 (en) 2010-07-06 2012-01-12 Novartis Ag Liposomes with lipids having an advantageous pka- value for rna delivery
CA2804492A1 (en) 2010-07-06 2012-01-12 Novartis Ag Immunisation of large mammals with low doses of rna
PT4066856T (en) 2010-08-31 2023-01-02 Glaxosmithkline Biologicals Sa Pegylated liposomes for delivery of immunogen-encoding rna
CN103269713B (en) 2010-10-11 2016-01-20 诺华有限公司 Antigen delivery platform
BE1023557B1 (en) 2014-02-10 2017-05-03 Univercells Sa SYSTEM, APPARATUS AND METHOD FOR PRODUCING BIOMOLECULES
EP3061826A1 (en) 2015-02-27 2016-08-31 Novartis AG Flavivirus replicons

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
FROLOV ILYA ET AL: "Sindbis virus replicons and Sindbis virus: Assembly of chimeras and of particles deficient in virus RNA", JOURNAL OF VIROLOGY, vol. 71, no. 4, April 1997 (1997-04-01), pages 2819 - 2829, XP002289356, ISSN: 0022-538X *
FROLOVA ELENA ET AL: "Packaging signals in alphaviruses", JOURNAL OF VIROLOGY, vol. 71, no. 1, January 1997 (1997-01-01), pages 248 - 258, XP002289429, ISSN: 0022-538X *
KHROMYKH A A ET AL: "SUBGENOMIC REPLICONS OF THE FLAVIVIRUS KUNJIN: CONSTRUCTION AND APPLICATIONS", JOURNAL OF VIROLOGY, THE AMERICAN SOCIETY FOR MICROBIOLOGY, US, vol. 71, no. 2, February 1997 (1997-02-01), pages 1497 - 1505, XP000938940, ISSN: 0022-538X *
See also references of WO9928487A1 *

Also Published As

Publication number Publication date
EP1034290A1 (en) 2000-09-13
JP2002500003A (en) 2002-01-08
CA2311395C (en) 2006-11-28
CA2311395A1 (en) 1999-06-10
NZ504725A (en) 2003-02-28
WO1999028487A1 (en) 1999-06-10
JP2008113666A (en) 2008-05-22

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Legal Events

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Owner name: THE COUNCIL OF THE QUEENSLAND INSTITUTE OF MEDICAL

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Effective date: 20040803

17Q First examination report despatched

Effective date: 20060831

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Owner name: REPLIKUN BIOTECH PTY LTD

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