EP1023281A4 - Inhibiteurs de la vih integrase - Google Patents

Inhibiteurs de la vih integrase

Info

Publication number
EP1023281A4
EP1023281A4 EP98904970A EP98904970A EP1023281A4 EP 1023281 A4 EP1023281 A4 EP 1023281A4 EP 98904970 A EP98904970 A EP 98904970A EP 98904970 A EP98904970 A EP 98904970A EP 1023281 A4 EP1023281 A4 EP 1023281A4
Authority
EP
European Patent Office
Prior art keywords
hiv integrase
integrase inhibitors
inhibitors
hiv
integrase
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP98904970A
Other languages
German (de)
English (en)
Other versions
EP1023281A1 (fr
Inventor
Gerald F Bills
Russell B Lingham
Ali Shafiee
Keith C Silverman
Sheo Bux Singh
Deborah L Zink
Fernando Pelaez
Ana M Teran
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9707492.6A external-priority patent/GB9707492D0/en
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of EP1023281A1 publication Critical patent/EP1023281A1/fr
Publication of EP1023281A4 publication Critical patent/EP1023281A4/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/78—Ring systems having three or more relevant rings
    • C07D311/80—Dibenzopyrans; Hydrogenated dibenzopyrans

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
EP98904970A 1997-02-06 1998-02-03 Inhibiteurs de la vih integrase Withdrawn EP1023281A4 (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US3690297P 1997-02-06 1997-02-06
US36902P 1997-02-06
GBGB9707492.6A GB9707492D0 (en) 1997-04-14 1997-04-14 HIV integrase inhibitors
GB9707492 1997-04-14
PCT/US1998/002292 WO1998034932A1 (fr) 1997-02-06 1998-02-03 Inhibiteurs de la vih integrase

Publications (2)

Publication Number Publication Date
EP1023281A1 EP1023281A1 (fr) 2000-08-02
EP1023281A4 true EP1023281A4 (fr) 2000-08-02

Family

ID=26311374

Family Applications (1)

Application Number Title Priority Date Filing Date
EP98904970A Withdrawn EP1023281A4 (fr) 1997-02-06 1998-02-03 Inhibiteurs de la vih integrase

Country Status (4)

Country Link
EP (1) EP1023281A4 (fr)
AU (1) AU6271098A (fr)
CA (1) CA2280518A1 (fr)
WO (1) WO1998034932A1 (fr)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1367784A (zh) * 1999-06-02 2002-09-04 盐野义制药株式会社 新的取代丙烯酮衍生物的制备方法
GB0200957D0 (en) * 2002-01-17 2002-03-06 Secr Defence Novel polymer and uses thereof
CA2542984A1 (fr) * 2003-07-07 2005-01-27 David H. Wagner Methodes de prediction du developpement de maladies auto-immunes et traitement associe
US8283366B2 (en) 2010-01-22 2012-10-09 Ambrilia Biopharma, Inc. Derivatives of pyridoxine for inhibiting HIV integrase
CN113717145B (zh) * 2021-09-18 2023-05-26 中国热带农业科学院热带作物品种资源研究所 双萘并r-吡喃酮类化合物及其在抗植物炭疽菌中的应用

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
KOYAMA K. NATORI S. IITAKA Y.: "configuration of chaetochromin a and related bis-naphtho-gamma-pyrone mold metabolites", CHEMICAL & PHARMACEUTICAL BULLETIN, vol. 35, 1987, pages 4049 - 4055, XP000882789 *
KOYAMA K. NATORI S.: "isolation from natural product", CHEM.PHARM.BULL., vol. 35, no. 2, 1987, pages 578 - 584, XP002135522 *
See also references of WO9834932A1 *
TSUCHIYA T. SEKITA S. KOYAMA K. NATORIS. TAKAHASHI A: "effect of chaetochromin D and ustilaginoidin a bisnaphtho-gamma-pyrone derivatives on the mouse embryo limb bud and midbrain cells in culture", CONGENITAL ANOMALIES, vol. 27, 1987, pages 245 - 250, XP000881950 *

Also Published As

Publication number Publication date
CA2280518A1 (fr) 1998-08-13
EP1023281A1 (fr) 2000-08-02
WO1998034932A1 (fr) 1998-08-13
AU6271098A (en) 1998-08-26

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Legal Events

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