EP1021445A4 - Carbapenem antibacterial compounds, compositions containing such compounds and methods of treatment - Google Patents

Carbapenem antibacterial compounds, compositions containing such compounds and methods of treatment

Info

Publication number
EP1021445A4
EP1021445A4 EP97939843A EP97939843A EP1021445A4 EP 1021445 A4 EP1021445 A4 EP 1021445A4 EP 97939843 A EP97939843 A EP 97939843A EP 97939843 A EP97939843 A EP 97939843A EP 1021445 A4 EP1021445 A4 EP 1021445A4
Authority
EP
European Patent Office
Prior art keywords
compounds
treatment
methods
compositions containing
carbapenem antibacterial
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP97939843A
Other languages
German (de)
French (fr)
Other versions
EP1021445A1 (en
Inventor
Lovji D Cama
Robert R Wilkening
Ronald W Ratcliffe
Timothy A Blizzard
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9624277.1A external-priority patent/GB9624277D0/en
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of EP1021445A1 publication Critical patent/EP1021445A1/en
Publication of EP1021445A4 publication Critical patent/EP1021445A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
    • C07D477/14—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
EP97939843A 1996-09-12 1997-09-08 Carbapenem antibacterial compounds, compositions containing such compounds and methods of treatment Withdrawn EP1021445A4 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US2618496P 1996-09-12 1996-09-12
US26184P 1996-09-12
GBGB9624277.1A GB9624277D0 (en) 1996-11-22 1996-11-22 Carbapenem antibacterial compounds compositions containing such compounds and methods of treatment
GB9624277 1996-11-22
PCT/US1997/015831 WO1998011108A1 (en) 1996-09-12 1997-09-08 Carbapenem antibacterial compounds, compositions containing such compounds and methods of treatment

Publications (2)

Publication Number Publication Date
EP1021445A1 EP1021445A1 (en) 2000-07-26
EP1021445A4 true EP1021445A4 (en) 2001-02-07

Family

ID=26310455

Family Applications (1)

Application Number Title Priority Date Filing Date
EP97939843A Withdrawn EP1021445A4 (en) 1996-09-12 1997-09-08 Carbapenem antibacterial compounds, compositions containing such compounds and methods of treatment

Country Status (5)

Country Link
EP (1) EP1021445A4 (en)
JP (1) JP2001500862A (en)
AU (1) AU4184497A (en)
CA (1) CA2264147A1 (en)
WO (1) WO1998011108A1 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2335571A1 (en) * 1998-06-25 1999-12-29 Merck & Co. Inc. (heterocyclic) methyl substituted carbapenem antibacterials
EP1090001A4 (en) * 1998-06-25 2002-11-27 Merck & Co Inc (heterocyclic)methyl substituted carbapenem antibacterials
BRPI0512236A (en) 2004-06-18 2008-02-19 Wyeth Corp processes for the preparation of 6-alkyl-5-arylsulfonyl dihydrophenanthridines
CN110156637A (en) * 2019-06-18 2019-08-23 宁波美诺华药业股份有限公司 A kind of preparation method of the chloro- 3- cyano -5- fluobenzoic acid of 2,4- bis-

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0463852A2 (en) * 1990-06-26 1992-01-02 Merck & Co. Inc. 2-Phenanthrenyl-carbapenem antibacterial agents
EP0472306A1 (en) * 1990-08-01 1992-02-26 Merck & Co. Inc. 2-(9-fluorenonyl)-carbapenem antibacterial agents
WO1994028719A1 (en) * 1993-06-10 1994-12-22 Merck & Co., Inc. Bridged carbapenem antibacterial compounds
WO1995021841A1 (en) * 1994-02-15 1995-08-17 Merck & Co., Inc. 1-β-METHYL-CARBAPENEM, COMPOSITIONS CONTAINING SAME AND METHODS OF USE
WO1996002548A1 (en) * 1994-07-20 1996-02-01 Merck & Co., Inc. 3-thioheteroaryl cephalosporin compounds, compositions and methods of use

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5336674A (en) * 1993-01-27 1994-08-09 Merck & Co., Inc. 2-phenanthridinyl carbaphenem antibacterial agent

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0463852A2 (en) * 1990-06-26 1992-01-02 Merck & Co. Inc. 2-Phenanthrenyl-carbapenem antibacterial agents
EP0472306A1 (en) * 1990-08-01 1992-02-26 Merck & Co. Inc. 2-(9-fluorenonyl)-carbapenem antibacterial agents
WO1994028719A1 (en) * 1993-06-10 1994-12-22 Merck & Co., Inc. Bridged carbapenem antibacterial compounds
WO1995021841A1 (en) * 1994-02-15 1995-08-17 Merck & Co., Inc. 1-β-METHYL-CARBAPENEM, COMPOSITIONS CONTAINING SAME AND METHODS OF USE
WO1996002548A1 (en) * 1994-07-20 1996-02-01 Merck & Co., Inc. 3-thioheteroaryl cephalosporin compounds, compositions and methods of use

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
GEORGOPAPADAKOU,N.: "Penicilin-Binding Proteins and Bacterial Resistance to beta-Lactams", ANTIMICROB. AGENTS CHEMOTHER., vol. 37, no. 10, October 1993 (1993-10-01), DETROIT, pages 2045 - 2053, XP000944436 *
RATCLIFFE R W ET AL: "Synthesis and properties of 2-(naphthosultamyl)methyl-carbapenems with potent anti-mrsa activity: discovery of L-786,392", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,GB,OXFORD, vol. 9, no. 5, 8 March 1999 (1999-03-08), pages 679 - 684, XP004157593, ISSN: 0960-894X *
See also references of WO9811108A1 *
WADDELL S T ET AL: "Benzothiazolylthio Carbapenems: Potent Anti-MRSA Agents", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,GB,OXFORD, vol. 5, no. 13, 6 July 1995 (1995-07-06), pages 1427 - 1432, XP004135463, ISSN: 0960-894X *
WILKENING R R ET AL: "Synthesis and activity of 2-(sulfonamido)methyl-carbapenems: discovery of a novel, anti-MRSA 1,8-naphthosultam pharmacophore", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,GB,OXFORD, vol. 9, no. 5, 8 March 1999 (1999-03-08), pages 673 - 678, XP004157592, ISSN: 0960-894X *

Also Published As

Publication number Publication date
EP1021445A1 (en) 2000-07-26
WO1998011108A1 (en) 1998-03-19
AU4184497A (en) 1998-04-02
JP2001500862A (en) 2001-01-23
CA2264147A1 (en) 1998-03-19

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