EP1021445A4 - Carbapenem antibacterial compounds, compositions containing such compounds and methods of treatment - Google Patents
Carbapenem antibacterial compounds, compositions containing such compounds and methods of treatmentInfo
- Publication number
- EP1021445A4 EP1021445A4 EP97939843A EP97939843A EP1021445A4 EP 1021445 A4 EP1021445 A4 EP 1021445A4 EP 97939843 A EP97939843 A EP 97939843A EP 97939843 A EP97939843 A EP 97939843A EP 1021445 A4 EP1021445 A4 EP 1021445A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- compounds
- treatment
- methods
- compositions containing
- carbapenem antibacterial
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
- C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
- C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
- C07D477/14—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US2618496P | 1996-09-12 | 1996-09-12 | |
US26184P | 1996-09-12 | ||
GBGB9624277.1A GB9624277D0 (en) | 1996-11-22 | 1996-11-22 | Carbapenem antibacterial compounds compositions containing such compounds and methods of treatment |
GB9624277 | 1996-11-22 | ||
PCT/US1997/015831 WO1998011108A1 (en) | 1996-09-12 | 1997-09-08 | Carbapenem antibacterial compounds, compositions containing such compounds and methods of treatment |
Publications (2)
Publication Number | Publication Date |
---|---|
EP1021445A1 EP1021445A1 (en) | 2000-07-26 |
EP1021445A4 true EP1021445A4 (en) | 2001-02-07 |
Family
ID=26310455
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP97939843A Withdrawn EP1021445A4 (en) | 1996-09-12 | 1997-09-08 | Carbapenem antibacterial compounds, compositions containing such compounds and methods of treatment |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP1021445A4 (en) |
JP (1) | JP2001500862A (en) |
AU (1) | AU4184497A (en) |
CA (1) | CA2264147A1 (en) |
WO (1) | WO1998011108A1 (en) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2335538A1 (en) * | 1998-06-25 | 1999-12-29 | Merck & Co., Inc. | (heterocyclic)methyl substituted carbapenem antibacterials |
JP2002518497A (en) * | 1998-06-25 | 2002-06-25 | メルク エンド カムパニー インコーポレーテッド | (Heterocycle) methyl-substituted carbapenemcarbapenem antibacterial |
AU2005265093A1 (en) | 2004-06-18 | 2006-01-26 | Wyeth | Processes for preparing 6-alkyl-5-arylsulfonyl- dihydrophenanthridines |
CN110156637A (en) * | 2019-06-18 | 2019-08-23 | 宁波美诺华药业股份有限公司 | A kind of preparation method of the chloro- 3- cyano -5- fluobenzoic acid of 2,4- bis- |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0463852A2 (en) * | 1990-06-26 | 1992-01-02 | Merck & Co. Inc. | 2-Phenanthrenyl-carbapenem antibacterial agents |
EP0472306A1 (en) * | 1990-08-01 | 1992-02-26 | Merck & Co. Inc. | 2-(9-fluorenonyl)-carbapenem antibacterial agents |
WO1994028719A1 (en) * | 1993-06-10 | 1994-12-22 | Merck & Co., Inc. | Bridged carbapenem antibacterial compounds |
WO1995021841A1 (en) * | 1994-02-15 | 1995-08-17 | Merck & Co., Inc. | 1-β-METHYL-CARBAPENEM, COMPOSITIONS CONTAINING SAME AND METHODS OF USE |
WO1996002548A1 (en) * | 1994-07-20 | 1996-02-01 | Merck & Co., Inc. | 3-thioheteroaryl cephalosporin compounds, compositions and methods of use |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5336674A (en) * | 1993-01-27 | 1994-08-09 | Merck & Co., Inc. | 2-phenanthridinyl carbaphenem antibacterial agent |
-
1997
- 1997-09-08 CA CA002264147A patent/CA2264147A1/en not_active Abandoned
- 1997-09-08 AU AU41844/97A patent/AU4184497A/en not_active Abandoned
- 1997-09-08 JP JP10513746A patent/JP2001500862A/en active Pending
- 1997-09-08 EP EP97939843A patent/EP1021445A4/en not_active Withdrawn
- 1997-09-08 WO PCT/US1997/015831 patent/WO1998011108A1/en not_active Application Discontinuation
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0463852A2 (en) * | 1990-06-26 | 1992-01-02 | Merck & Co. Inc. | 2-Phenanthrenyl-carbapenem antibacterial agents |
EP0472306A1 (en) * | 1990-08-01 | 1992-02-26 | Merck & Co. Inc. | 2-(9-fluorenonyl)-carbapenem antibacterial agents |
WO1994028719A1 (en) * | 1993-06-10 | 1994-12-22 | Merck & Co., Inc. | Bridged carbapenem antibacterial compounds |
WO1995021841A1 (en) * | 1994-02-15 | 1995-08-17 | Merck & Co., Inc. | 1-β-METHYL-CARBAPENEM, COMPOSITIONS CONTAINING SAME AND METHODS OF USE |
WO1996002548A1 (en) * | 1994-07-20 | 1996-02-01 | Merck & Co., Inc. | 3-thioheteroaryl cephalosporin compounds, compositions and methods of use |
Non-Patent Citations (5)
Title |
---|
GEORGOPAPADAKOU,N.: "Penicilin-Binding Proteins and Bacterial Resistance to beta-Lactams", ANTIMICROB. AGENTS CHEMOTHER., vol. 37, no. 10, October 1993 (1993-10-01), DETROIT, pages 2045 - 2053, XP000944436 * |
RATCLIFFE R W ET AL: "Synthesis and properties of 2-(naphthosultamyl)methyl-carbapenems with potent anti-mrsa activity: discovery of L-786,392", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,GB,OXFORD, vol. 9, no. 5, 8 March 1999 (1999-03-08), pages 679 - 684, XP004157593, ISSN: 0960-894X * |
See also references of WO9811108A1 * |
WADDELL S T ET AL: "Benzothiazolylthio Carbapenems: Potent Anti-MRSA Agents", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,GB,OXFORD, vol. 5, no. 13, 6 July 1995 (1995-07-06), pages 1427 - 1432, XP004135463, ISSN: 0960-894X * |
WILKENING R R ET AL: "Synthesis and activity of 2-(sulfonamido)methyl-carbapenems: discovery of a novel, anti-MRSA 1,8-naphthosultam pharmacophore", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,GB,OXFORD, vol. 9, no. 5, 8 March 1999 (1999-03-08), pages 673 - 678, XP004157592, ISSN: 0960-894X * |
Also Published As
Publication number | Publication date |
---|---|
AU4184497A (en) | 1998-04-02 |
EP1021445A1 (en) | 2000-07-26 |
WO1998011108A1 (en) | 1998-03-19 |
CA2264147A1 (en) | 1998-03-19 |
JP2001500862A (en) | 2001-01-23 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
17P | Request for examination filed |
Effective date: 19990412 |
|
AK | Designated contracting states |
Kind code of ref document: A1 Designated state(s): AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE |
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A4 | Supplementary search report drawn up and despatched |
Effective date: 20001229 |
|
AK | Designated contracting states |
Kind code of ref document: A4 Designated state(s): AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE |
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STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN |
|
18D | Application deemed to be withdrawn |
Effective date: 20010326 |