EP1019091A4 - 50 human secreted proteins - Google Patents
50 human secreted proteinsInfo
- Publication number
- EP1019091A4 EP1019091A4 EP98943536A EP98943536A EP1019091A4 EP 1019091 A4 EP1019091 A4 EP 1019091A4 EP 98943536 A EP98943536 A EP 98943536A EP 98943536 A EP98943536 A EP 98943536A EP 1019091 A4 EP1019091 A4 EP 1019091A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- secreted proteins
- human secreted
- human
- proteins
- secreted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Physical Education & Sports Medicine (AREA)
- Dermatology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Rheumatology (AREA)
- Psychiatry (AREA)
- Heart & Thoracic Surgery (AREA)
- Psychology (AREA)
- Cardiology (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Pain & Pain Management (AREA)
- Zoology (AREA)
- Biophysics (AREA)
- Urology & Nephrology (AREA)
- Virology (AREA)
- Hospice & Palliative Care (AREA)
- Toxicology (AREA)
- Vascular Medicine (AREA)
- Gastroenterology & Hepatology (AREA)
Applications Claiming Priority (15)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US5766397P | 1997-09-05 | 1997-09-05 | |
US5762697P | 1997-09-05 | 1997-09-05 | |
US5766997P | 1997-09-05 | 1997-09-05 | |
US57663P | 1997-09-05 | ||
US57669P | 1997-09-05 | ||
US57626P | 1997-09-05 | ||
US5866697P | 1997-09-12 | 1997-09-12 | |
US5897497P | 1997-09-12 | 1997-09-12 | |
US5897397P | 1997-09-12 | 1997-09-12 | |
US5866797P | 1997-09-12 | 1997-09-12 | |
US58974P | 1997-09-12 | ||
US58666P | 1997-09-12 | ||
US58973P | 1997-09-12 | ||
US58667P | 1997-09-12 | ||
PCT/US1998/018360 WO1999011293A1 (en) | 1997-09-05 | 1998-09-03 | 50 human secreted proteins |
Publications (2)
Publication Number | Publication Date |
---|---|
EP1019091A1 EP1019091A1 (en) | 2000-07-19 |
EP1019091A4 true EP1019091A4 (en) | 2005-05-11 |
Family
ID=27568129
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP98943536A Withdrawn EP1019091A4 (en) | 1997-09-05 | 1998-09-03 | 50 human secreted proteins |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP1019091A4 (en) |
JP (2) | JP2001514024A (en) |
AU (1) | AU9130498A (en) |
CA (1) | CA2302808C (en) |
WO (1) | WO1999011293A1 (en) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20040002591A1 (en) | 1997-09-05 | 2004-01-01 | Human Genome Sciences, Inc. | 50 human secreted proteins |
US6503730B1 (en) | 1997-06-19 | 2003-01-07 | Schering Corporation | Nucleic acids encoding a cysteine rich protein |
IL139219A0 (en) * | 1998-04-24 | 2001-11-25 | Genentech Inc | Fizz proteins |
WO2000064920A1 (en) * | 1999-04-27 | 2000-11-02 | The Trustees Of The University Of Pennsylvania | Compositions, methods, and kits relating to resistin |
WO2001053352A2 (en) * | 2000-01-19 | 2001-07-26 | University Of Virginia Patent Foundation | Sperm specific proteins |
AU2001234100A1 (en) * | 2000-02-21 | 2001-08-27 | Kureha Chemical Industry Co. Ltd. | Novel proteins and novel genes encoding the same |
EP1138768A3 (en) * | 2000-03-27 | 2002-08-07 | Leadd B.V. | Apoptin-associating protein AAP-5 |
EP1138765A1 (en) * | 2000-03-27 | 2001-10-04 | Leadd B.V. | Apoptin-associating proteins AAP-5 and AAP-6 |
ATE480622T1 (en) | 2000-11-06 | 2010-09-15 | Cancer Rec Tech Ltd | IMAGING PROCEDURES, DIAGNOSIS AND TREATMENT OF DISEASES |
WO2002057420A2 (en) * | 2001-01-18 | 2002-07-25 | Human Genome Sciences, Inc. | 50 human secreted proteins |
WO2002087507A2 (en) * | 2001-04-27 | 2002-11-07 | Sunnybrook & Women's College Health Sciences Centre | Breast cancer-associated genes and uses thereof |
US7109302B1 (en) | 2002-04-01 | 2006-09-19 | Human Genome Sciences, Inc. | Antibodies that specifically bind to GMAD |
US20060099143A1 (en) | 2002-11-20 | 2006-05-11 | Roy Bicknell | Antibodies binding to human magic roundabout (mr), polypeptides and uses thereof for inhibition angiogenesis |
KR20090114443A (en) | 2007-02-09 | 2009-11-03 | 제넨테크, 인크. | Anti-Robo4 Antibodies and Uses Therefor |
JP2010534652A (en) * | 2007-07-26 | 2010-11-11 | イプセン ファルマ ソシエテ パ アクシオンス シンプリフィエ | Chemokine analog |
KR20200003102A (en) | 2017-06-02 | 2020-01-08 | 후지필름 도야마 케미컬 가부시키가이샤 | Amyloid β Protein Amount Reducing Agent |
AU2018277981B2 (en) | 2017-06-02 | 2021-04-08 | Fujifilm Toyama Chemical Co., Ltd. | Agent for preventing or treating spinocerebellar ataxia |
JPWO2018221728A1 (en) | 2017-06-02 | 2020-04-02 | 富士フイルム富山化学株式会社 | Agent for preventing or treating Alzheimer's disease |
US11951092B2 (en) | 2017-06-02 | 2024-04-09 | Fujifilm Toyama Chemical Co., Ltd. | Agent for preventing or treating brain atrophy |
US11548878B2 (en) * | 2017-10-30 | 2023-01-10 | Fujifilm Toyama Chemical Co., Ltd. | Emopamil binding protein binding agent and use thereof |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1386931A1 (en) * | 1998-03-25 | 2004-02-04 | Genentech, Inc. | Human neurotrimin homologue |
-
1998
- 1998-09-03 EP EP98943536A patent/EP1019091A4/en not_active Withdrawn
- 1998-09-03 WO PCT/US1998/018360 patent/WO1999011293A1/en not_active Application Discontinuation
- 1998-09-03 CA CA2302808A patent/CA2302808C/en not_active Expired - Fee Related
- 1998-09-03 JP JP2000508394A patent/JP2001514024A/en active Pending
- 1998-09-03 AU AU91304/98A patent/AU9130498A/en not_active Abandoned
-
2008
- 2008-12-17 JP JP2008321654A patent/JP2009131263A/en active Pending
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1386931A1 (en) * | 1998-03-25 | 2004-02-04 | Genentech, Inc. | Human neurotrimin homologue |
Non-Patent Citations (8)
Title |
---|
ADAMS M E ET AL: "Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence", NATURE (LONDON), vol. 377, no. 6547 SUPPL., 1995, pages 3 - 174, XP002916734, ISSN: 0028-0836 * |
DATABASE OMIM XP002318683, retrieved from OMIM accession no. 605158 * |
GUBLER AND HOFFMAN: "A SIMPLE AND VERY EFFICIENT METHOD FOR GENERATING cDNA LIBRARIES", GENE, ELSEVIER BIOMEDICAL PRESS. AMSTERDAM, NL, vol. 25, 1983, pages 263 - 269, XP002144172, ISSN: 0378-1119 * |
HEIJNE VON G: "A NEW METHOD FOR PREDICTING SIGNAL SEQUENCE CLEAVAGE SITES", NUCLEIC ACIDS RESEARCH, OXFORD UNIVERSITY PRESS, SURREY, GB, vol. 14, no. 11, 1986, pages 4683 - 4690, XP001189533, ISSN: 0305-1048 * |
KIDD T ET AL: "Roundabout controls axon crossing of the CNS midline and defines a novel subfamily of evolutionarily conserved guidance receptors", CELL, CELL PRESS, CAMBRIDGE, NA, US, vol. 92, 23 January 1998 (1998-01-23), pages 205 - 215, XP002094383, ISSN: 0092-8674 * |
NIELSEN H ET AL: "IDENTIFICATION OF PROKARYOTIC AND EUKARYOTIC SIGNAL PEPTIDES AND PREDICTION OF THEIR CLEAVAGE SITES", PROTEIN ENGINEERING, OXFORD UNIVERSITY PRESS, SURREY, GB, vol. 10, no. 1, 1997, pages 1 - 6, XP002072638, ISSN: 0269-2139 * |
See also references of WO9911293A1 * |
ZHANG W-R ET AL: "MOLECULAR CLONING AND EXPRESSION OF A UNIQUE RECEPTOR-LIKE PROTEIN-TYROSINE-PHOSPHATASE IN THE LEUCOCYTE-COMMON-ANTIGEN-RELATED PHOSPHATASE FAMILY", BIOCHEMICAL JOURNAL, PORTLAND PRESS, LONDON, GB, vol. 302, no. PART 1, 15 August 1994 (1994-08-15), pages 39 - 47, XP009024545, ISSN: 0264-6021 * |
Also Published As
Publication number | Publication date |
---|---|
JP2009131263A (en) | 2009-06-18 |
AU9130498A (en) | 1999-03-22 |
WO1999011293A1 (en) | 1999-03-11 |
JP2001514024A (en) | 2001-09-11 |
EP1019091A1 (en) | 2000-07-19 |
CA2302808C (en) | 2010-05-18 |
CA2302808A1 (en) | 1999-03-11 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
EP1039801A4 (en) | 207 human secreted proteins | |
EP1000084A4 (en) | 123 human secreted proteins | |
EP1088071A4 (en) | 94 human secreted proteins | |
EP1100869A4 (en) | 98 human secreted proteins | |
EP1040117A4 (en) | 110 human secreted proteins | |
AU6552198A (en) | 28 human secreted proteins | |
EP1078046A4 (en) | 97 human secreted proteins | |
EP1109821A4 (en) | 49 human secreted proteins | |
EP1140970A4 (en) | 47 human secreted proteins | |
AU6952998A (en) | 20 human secreted proteins | |
EP1051426A4 (en) | 67 human secreted proteins | |
EP1064297A4 (en) | 95 human secreted proteins | |
EP1019091A4 (en) | 50 human secreted proteins | |
EP1005544A4 (en) | 70 human secreted proteins | |
AU8066998A (en) | 86 human secreted proteins | |
EP1044211A4 (en) | 36 human secreted proteins | |
EP1097199A4 (en) | 71 human secreted proteins | |
EP1115735A4 (en) | 31 human secreted proteins | |
EP1124850A4 (en) | 12 human secreted proteins | |
EP1032838A4 (en) | 125 human secreted proteins | |
EP1027430A4 (en) | 64 human secreted proteins | |
EP1009766A4 (en) | 19 human secreted proteins | |
EP1062236A4 (en) | 31 human secreted proteins | |
EP1159284A4 (en) | 33 human secreted proteins | |
EP1002132A4 (en) | 90 human secreted proteins |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
17P | Request for examination filed |
Effective date: 20000324 |
|
AK | Designated contracting states |
Kind code of ref document: A1 Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE |
|
A4 | Supplementary search report drawn up and despatched |
Effective date: 20050322 |
|
17Q | First examination report despatched |
Effective date: 20050602 |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN |
|
18D | Application deemed to be withdrawn |
Effective date: 20060905 |