Classifications

• • A—HUMAN NECESSITIES
  • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
  • A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
  • A23G3/00—Sweetmeats; Confectionery; Marzipan; Coated or filled products
  • A23G3/34—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof
  • A23G3/36—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof characterised by the composition containing organic or inorganic compounds
• • A—HUMAN NECESSITIES
  • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
  • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
  • A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
  • A23L2/52—Adding ingredients
  • A23L2/56—Flavouring or bittering agents
• • A—HUMAN NECESSITIES
  • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
  • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
  • A23L27/00—Spices; Flavouring agents or condiments; Artificial sweetening agents; Table salts; Dietetic salt substitutes; Preparation or treatment thereof
  • A23L27/20—Synthetic spices, flavouring agents or condiments
  • A23L27/202—Aliphatic compounds
  • A23L27/2024—Aliphatic compounds having oxygen as the only hetero atom
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
  • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
  • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K8/00—Cosmetics or similar toiletry preparations
  • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K8/00—Cosmetics or similar toiletry preparations
  • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
  • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
  • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K9/00—Medicinal preparations characterised by special physical form
  • A61K9/0012—Galenical forms characterised by the site of application
  • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K9/00—Medicinal preparations characterised by special physical form
  • A61K9/20—Pills, tablets, discs, rods
  • A61K9/2004—Excipients; Inactive ingredients
  • A61K9/2013—Organic compounds, e.g. phospholipids, fats
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
  • A61Q19/00—Preparations for care of the skin
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
  • A61Q19/00—Preparations for care of the skin
  • A61Q19/005—Preparations for sensitive skin
• • C—CHEMISTRY; METALLURGY
  • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
  • C12G—WINE; PREPARATION THEREOF; ALCOHOLIC BEVERAGES; PREPARATION OF ALCOHOLIC BEVERAGES NOT PROVIDED FOR IN SUBCLASSES C12C OR C12H
  • C12G3/00—Preparation of other alcoholic beverages
  • C12G3/04—Preparation of other alcoholic beverages by mixing, e.g. for preparation of liqueurs
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
  • A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
  • A61K2800/24—Thermal properties
  • A61K2800/244—Endothermic; Cooling; Cooling sensation
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
  • A61K2800/74—Biological properties of particular ingredients
  • A61K2800/75—Anti-irritant
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K9/00—Medicinal preparations characterised by special physical form
  • A61K9/0012—Galenical forms characterised by the site of application
  • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
  • A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K9/00—Medicinal preparations characterised by special physical form
  • A61K9/10—Dispersions; Emulsions
  • A61K9/12—Aerosols; Foams

Definitions

• This invention relates to techniques for the production of soothing, cooling sensations in tissues such as sensitive skin areas and mucous membranes.
• Chloroform was once widely used for this purpose, but is no longer used because of its carcinogenic potential.
• Camphor and aromatic oils have distinct flavors and odors and are sometimes irritating or sensitizing to certain tissues.
• dimethyl ether (CH 3 -O-CH 3 ) is effective in producing a sensation of esthetic cooling.
• Dimethyl ether may be applied to the target tissues in the form of a liquid or a gas arising from a liquid that is sprayed, swallowed, or applied with a bandage or other dressing. Alternatively, it may be applied as a lozenge, suppository, or other solid dosage form that releases the dimethyl ether to the target tissue.
• the intensity and duration of the esthetic cooling effect is obtained when the dimethyl ether is applied at concentrations of as little as 1.0%, or even lower in formulations where availability and delivery to tissues is heightened or enhanced. It has also been discovered that this technique can enhance the perception of flavor of foods, beverage, and candies.
• Dimethyl ether is a well-known and well-characterized chemical entity. Its principal commercial use is as a propellant for aerosols such as hair sprays. See, for example, "A New Era In Aerosol Propellants” J.J. Daily, Drug Cosmet. Ind.. Vol. 134, No. 2, Page 40 (1984). Because of its high volatility, it has also been used as a cryogenic agent for removing skin lesions. See U.S. Patent No. 5,516,505. Some of Dimethyl ether's physical properties are shown in Table 1.
• dimethyl ether can be applied to skin and sensitive tissues to produce a sensation of esthetic cooling. This should not be confused with an actual lowering of temperature by means of evaporation or volatilization as described in U.S. Patent No. 5,516,505, as dimethyl ether is capable of producing this effect even in areas where evaporative cooling is not possible, such as the throat. Indeed, some of the preferred embodiments of this invention call for dimethyl ether to be applied in a manner which tends to produce very little evaporative cooling.
• dimethyl ether Because of its high solubility in water, dimethyl ether is conveniently applied to the target tissue in the form of an aqueous solution. It can also be delivered in other suitable solvents or in systems where the gas is absorbed or entrapped. Aqueous solutions in excess of 30% by weight can be prepared and are useful in this invention. However, solutions of much lower concentration are typically employed.
• Dimethyl ether is available from a variety of sources and is marketed by the E.I. DuPont Company under the trade name DYMEL A.
• DME Dimethyl either
• compounds such as viscosity builders which prolong its delivery and sensate effect, or compounds such as ethanol, carbon dioxide and others which can speed and heighten its delivery and sensate effect.
• compounds known to create their own type of sensate effect on tissues such as menthol, glycyrrhizin, aromatic oils, capsaicin, and others, which can contribute to DME's unique sensate effect.
• aqueous solution of dimethyl ether was prepared in the following manner.
• DYMEL A brand dimethyl ether was obtained in the form of a cylinder of compressed gas.
• a length of tubing was attached to the regulator valve of the tank and run into a 250 milliliter erlenmeyer flask containing 125 milliliters of distilled water. The tubing terminated in a fritted glass gas diffuser. The flask was maintained in an ice water bath to minimize evaporative loss.
• Dimethyl ether gas was bubbled through the liquid, allowing the dimethyl ether to dissolve in the water. This process was used to produce solutions of approximately 2%, 5% and 10% by weight of dimethyl ether. Aliquots of these solutions were used in the following experiments to demonstrate the ability of dimethyl ether to produce a sensation of esthetic cooling.
• a subject sipped a small volume of 2%, 5% and 10% dimethyl ether solutions and reported a distinct, penetrating sensation of esthetic cooling in the mouth and throat. Aliquots of these solutions were diluted to produce 1.0% and 0.5% dimethyl ether solutions and was again sipped by the subject. The sensation of esthetic cooling was still noticeable though less intense.
• dimethyl ether solution An aliquot of 2% dimethyl ether solution was diluted to 1.0% and 0.5% and applied to sensitive skin areas including irritated eyelids, psoriatic skin, eczematous skin and fresh surgical sites. In each case, the subject reported a pleasant sensation of esthetic cooling.
• Other liquid forms of dimethyl ether solutions have been prepared and found effective in the present invention.
• dimethyl ether prepared in the manner described above, the following compositions were prepared: Three and 6% dimethyl ether solutions in a benzalkonium chloride anti-bacterial mouthwash, a 3% dimethyl ether solution in a syrup, a 2.0% dimethyl ether solution in a nasal spray of 1% penylephrine decongestant, a 1.0% and 2.5% dimethyl ether solutions in an aqueous phosphate enema solution and a 1.0% and 2.5% dimethyl ether solutions in a 5% vinegar vaginal douche.
• the ordinary action of these preparations was supplemented by a pleasant and soothing sensation of esthetic cooling.
• Confections, drops, troches, lozenges, gums and the like incorporating dimethyl ether can be formulated. These are useful as cough drops or cough lozenges, and are useful in cases of gum or mouth irritation and oral ulcers or sores. (This can also be accomplished by direct introduction of aqueous solutions of dimethyl ether described above or dimethyl ether solutions together with other solvents.)
• Dermatological delivery systems containing dimethyl ether have been compounded by introducing dimethyl ether solution into the following products to obtain 4% concentrations: an oil-in-water moisturizing lotion, an oil-in-water anti-inflammatory hydrocortisone cream, a water-in-oil emulsion skin emollient lotion, and a protective diaper ointment.
• an oil-in-water moisturizing lotion an oil-in-water anti-inflammatory hydrocortisone cream
• a water-in-oil emulsion skin emollient lotion a protective diaper ointment.
• Each of these dermatological products was used to treat sensitive skin in the areas of the chest, neck, groin, thighs and buttocks, and, in addition to their ordinary therapeutic action, produced a pleasant and soothing sensation of esthetic cooling.
• the present invention may also be used in topical analgesics, including capsaicin on civamide containing preparations to enhance their effectiveness or appeal.
• the taste sensation produced by various foods was enhanced by the addition of dimethyl ether.
• the taste of liquors such as Gran Marnier and B&B were enhanced by the addition of 1% and 2% dimethyl ether. Similar effects can be obtained by introducing satiable concentrations of dimethyl ether into sodas, candies, and confections.

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• Medicinal Chemistry (AREA)
• Dermatology (AREA)
• Pharmacology & Pharmacy (AREA)
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• General Engineering & Computer Science (AREA)
• Birds (AREA)
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• 1999
  • 1999-07-01 WO PCT/US1999/015173 patent/WO2000001321A1/en not_active Application Discontinuation
  • 1999-07-01 CA CA002303094A patent/CA2303094A1/en not_active Abandoned
  • 1999-07-01 EP EP99933697A patent/EP1017334A1/de not_active Withdrawn

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