EP1007072A4 - Glial cell line-derived neurotrophic factor receptors - Google Patents

Glial cell line-derived neurotrophic factor receptors

Info

Publication number
EP1007072A4
EP1007072A4 EP98920199A EP98920199A EP1007072A4 EP 1007072 A4 EP1007072 A4 EP 1007072A4 EP 98920199 A EP98920199 A EP 98920199A EP 98920199 A EP98920199 A EP 98920199A EP 1007072 A4 EP1007072 A4 EP 1007072A4
Authority
EP
European Patent Office
Prior art keywords
cell line
neurotrophic factor
derived neurotrophic
factor receptors
glial cell
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP98920199A
Other languages
German (de)
French (fr)
Other versions
EP1007072A1 (en
Inventor
Carlos F Ibanez
Urmas Arumae
Hannu Sariola
Petro Suvanto
Miles Trupp
Mart Saarma
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cephalon LLC
Original Assignee
Cephalon LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/861,990 external-priority patent/US6696259B1/en
Application filed by Cephalon LLC filed Critical Cephalon LLC
Publication of EP1007072A1 publication Critical patent/EP1007072A1/en
Publication of EP1007072A4 publication Critical patent/EP1007072A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
EP98920199A 1997-05-22 1998-05-04 Glial cell line-derived neurotrophic factor receptors Withdrawn EP1007072A4 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/861,990 US6696259B1 (en) 1995-11-13 1997-05-22 Assays using glial cell line-derived neurotrophic factor receptors
US861990 1997-05-22
PCT/US1998/009056 WO1998052591A1 (en) 1997-05-22 1998-05-04 Glial cell line-derived neurotrophic factor receptors

Publications (2)

Publication Number Publication Date
EP1007072A1 EP1007072A1 (en) 2000-06-14
EP1007072A4 true EP1007072A4 (en) 2002-06-26

Family

ID=25337323

Family Applications (1)

Application Number Title Priority Date Filing Date
EP98920199A Withdrawn EP1007072A4 (en) 1997-05-22 1998-05-04 Glial cell line-derived neurotrophic factor receptors

Country Status (8)

Country Link
EP (1) EP1007072A4 (en)
JP (1) JP2001527418A (en)
KR (1) KR20010012826A (en)
AU (1) AU741208B2 (en)
CA (1) CA2290426A1 (en)
NO (1) NO995691L (en)
NZ (1) NZ501199A (en)
WO (1) WO1998052591A1 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6677135B1 (en) 1996-05-08 2004-01-13 Biogen, Inc. Ret ligand (RetL) for stimulating neutral and renal growth
DE19816186A1 (en) * 1998-04-14 1999-10-21 Univ Muenchen L Maximilians GDNF-encoding DNA, parts thereof and GDNF variants
FI20030130A0 (en) * 2003-01-29 2003-01-29 Licentia Oy screening method
KR102370762B1 (en) 2016-03-31 2022-03-04 엔지엠 바이오파마슈티컬스, 아이엔씨. Binding proteins and methods of use thereof

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997044356A2 (en) * 1996-05-08 1997-11-27 Biogen, Inc. RET LIGAND (RetL) FOR STIMULATING NEURAL AND RENAL GROWTH
WO1998036072A1 (en) * 1997-02-18 1998-08-20 Genentech, Inc. Neurturin receptor
WO1998046622A1 (en) * 1997-04-17 1998-10-22 Washington University RECEPTORS FOR TGF-β-RELATED NEUROTROPHIC FACTORS
WO1998053069A2 (en) * 1997-05-20 1998-11-26 Human Genome Sciences, Inc. Gdnf receptors
WO1998054213A2 (en) * 1997-05-30 1998-12-03 Amgen Inc. Neurotrophic factor receptors

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997044356A2 (en) * 1996-05-08 1997-11-27 Biogen, Inc. RET LIGAND (RetL) FOR STIMULATING NEURAL AND RENAL GROWTH
WO1998036072A1 (en) * 1997-02-18 1998-08-20 Genentech, Inc. Neurturin receptor
WO1998046622A1 (en) * 1997-04-17 1998-10-22 Washington University RECEPTORS FOR TGF-β-RELATED NEUROTROPHIC FACTORS
WO1998053069A2 (en) * 1997-05-20 1998-11-26 Human Genome Sciences, Inc. Gdnf receptors
WO1998054213A2 (en) * 1997-05-30 1998-12-03 Amgen Inc. Neurotrophic factor receptors

Non-Patent Citations (9)

* Cited by examiner, † Cited by third party
Title
BALOH R H ET AL: "TRNR2, A NOVEL RECEPTOR THAT MEDIATES NEURTURIN AND GDNF SIGNALING THROUGH RET", NEURON, CAMBRIDGE, MA, US, vol. 18, 23 May 1997 (1997-05-23), pages 793 - 802, XP002065821 *
DATABASE EMBL 4 July 1997 (1997-07-04), M. TRUPP ET AL: "rattus novegicus glial cell line-derived neurotrophic factor receptor-beta", XP002196288 *
JING S ET AL: "GDNF-INDUCED ACTIVATION OF THE RET PROTEIN TYROSINE KINASE IS MEDIATED BY GDNFR-ALPHA, A NOVEL RECEPTOR FOR GDNF", CELL, CELL PRESS, CAMBRIDGE, NA, US, vol. 85, 28 June 1996 (1996-06-28), pages 1113 - 1124, XP002036435, ISSN: 0092-8674 *
JING S ET AL: "GFRALPHA-2 AND GFRALPHA-3 ARE TWO NEW RECEPTORS FOR LIGANDS OF THE GDNF FAMILY", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY OF BIOLOGICAL CHEMISTS, BALTIMORE, MD, US, vol. 272, no. 52, 26 December 1997 (1997-12-26), pages 33111 - 33117, XP002065824, ISSN: 0021-9258 *
M. TRUPP ET AL: "Multiple GPI-anchored receptors control GDNF-dependent and independent activation of the c-Ret receptor tyrosine kinase", MOL.CELL. NEUROSCI., vol. 11, no. 1-2, 1998, pages 47 - 63 *
SANICOLA M ET AL: "GLIAL CELL LINE-DERIVED NEUROTROPHIC FACTOR-DEPENDENT RET ACTIVATION CAN BE MEDIATED BY TWO DIFFERENT CELL-SURFACE ACCESSORY PROTEINS", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, NATIONAL ACADEMY OF SCIENCE. WASHINGTON, US, vol. 94, no. 12, 1 June 1997 (1997-06-01), pages 6238 - 6243, XP002059966, ISSN: 0027-8424 *
See also references of WO9852591A1 *
SUVANTO PETRO ET AL: "Cloning, mRNA distribution and chromosomal localisation of the gene for glial cell line-derived neurotrophic factor receptor beta, a homologue to GDNFR-alpha.", HUMAN MOLECULAR GENETICS, vol. 6, no. 8, August 1997 (1997-08-01), pages 1267 - 1273, XP002196287, ISSN: 0964-6906 *
TREANO J J S ET AL: "CHARACTERIZATION OF A MULTICOMPONENT RECEPTOR FOR GDNF", NATURE, MACMILLAN JOURNALS LTD. LONDON, GB, vol. 382, no. 6586, 4 July 1996 (1996-07-04), pages 80 - 83, XP002047616, ISSN: 0028-0836 *

Also Published As

Publication number Publication date
EP1007072A1 (en) 2000-06-14
AU741208B2 (en) 2001-11-22
NZ501199A (en) 2001-12-21
WO1998052591A1 (en) 1998-11-26
CA2290426A1 (en) 1998-11-26
JP2001527418A (en) 2001-12-25
NO995691D0 (en) 1999-11-19
AU7282598A (en) 1998-12-11
NO995691L (en) 2000-01-19
KR20010012826A (en) 2001-02-26

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