EP1003480A4 - Conjugated peptide nucleic acids having enhanced cellular uptake - Google Patents
Conjugated peptide nucleic acids having enhanced cellular uptakeInfo
- Publication number
- EP1003480A4 EP1003480A4 EP98923819A EP98923819A EP1003480A4 EP 1003480 A4 EP1003480 A4 EP 1003480A4 EP 98923819 A EP98923819 A EP 98923819A EP 98923819 A EP98923819 A EP 98923819A EP 1003480 A4 EP1003480 A4 EP 1003480A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- nucleic acids
- peptide nucleic
- cellular uptake
- enhanced cellular
- conjugated peptide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
- C07K14/003—Peptide-nucleic acids (PNAs)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
- A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
- A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers with substantial amounts of non-phosphatidyl, i.e. non-acylglycerophosphate, surfactants as bilayer-forming substances, e.g. cationic lipids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Virology (AREA)
- Epidemiology (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dispersion Chemistry (AREA)
- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US864765 | 1992-04-07 | ||
US86476597A | 1997-05-28 | 1997-05-28 | |
PCT/US1998/010804 WO1998053801A1 (en) | 1997-05-28 | 1998-05-28 | Conjugated peptide nucleic acids having enhanced cellular uptake |
Publications (2)
Publication Number | Publication Date |
---|---|
EP1003480A1 EP1003480A1 (en) | 2000-05-31 |
EP1003480A4 true EP1003480A4 (en) | 2002-04-17 |
Family
ID=25344022
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP98923819A Withdrawn EP1003480A4 (en) | 1997-05-28 | 1998-05-28 | Conjugated peptide nucleic acids having enhanced cellular uptake |
Country Status (7)
Country | Link |
---|---|
EP (1) | EP1003480A4 (en) |
JP (1) | JP2001501975A (en) |
AU (1) | AU745309B2 (en) |
CA (1) | CA2291839A1 (en) |
IL (1) | IL133087A0 (en) |
NZ (1) | NZ501289A (en) |
WO (1) | WO1998053801A1 (en) |
Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6723560B2 (en) | 1998-10-08 | 2004-04-20 | Mayo Foundation For Medical Education And Research | Using polyamide nucleic acid oligomers to engender a biological response |
US6989270B1 (en) | 1997-10-17 | 2006-01-24 | Mayo Foundation For Medical Education And Research | Using polyamide nucleic acid oligomers to engender a biological response |
US6472209B1 (en) | 1997-10-17 | 2002-10-29 | Mayo Foundation For Medical Education And Research | Using polyamide nucleic acid oligomers to engender a biological response |
DE19909373A1 (en) * | 1999-03-03 | 2000-10-05 | Ugichem | New PNA monomers, resulting PNA oligomers and their use |
DE10038169A1 (en) * | 2000-08-04 | 2002-03-07 | November Ag Molekulare Medizin | Synthetic particle for marking a substance |
AU2003260289A1 (en) * | 2002-09-11 | 2004-04-30 | Santaris Pharma A/S | Modified pna molecules |
AU2009323766B2 (en) | 2008-12-02 | 2016-10-06 | Wave Life Sciences Ltd. | Method for the synthesis of phosphorus atom modified nucleic acids |
IN2012DN00720A (en) | 2009-07-06 | 2015-06-19 | Ontorii Inc | |
US10428019B2 (en) | 2010-09-24 | 2019-10-01 | Wave Life Sciences Ltd. | Chiral auxiliaries |
CN103796657B (en) | 2011-07-19 | 2017-07-11 | 波涛生命科学有限公司 | The method for synthesizing functionalization nucleic acid |
PL2872485T3 (en) | 2012-07-13 | 2021-05-31 | Wave Life Sciences Ltd. | Asymmetric auxiliary group |
AU2013287630B2 (en) | 2012-07-13 | 2017-05-25 | Shin Nippon Biomedical Laboratories, Ltd. | Chiral nucleic acid adjuvant |
ES2940887T3 (en) | 2012-07-13 | 2023-05-12 | Wave Life Sciences Ltd | Chiral Oligonucleotide Preparation Method |
US10149905B2 (en) | 2014-01-15 | 2018-12-11 | Shin Nippon Biomedical Laboratories, Ltd. | Chiral nucleic acid adjuvant having antitumor effect and antitumor agent |
US10144933B2 (en) | 2014-01-15 | 2018-12-04 | Shin Nippon Biomedical Laboratories, Ltd. | Chiral nucleic acid adjuvant having immunity induction activity, and immunity induction activator |
WO2015108046A1 (en) | 2014-01-15 | 2015-07-23 | 株式会社新日本科学 | Chiral nucleic acid adjuvant having anti-allergic activity, and anti-allergic agent |
SG10201912897UA (en) | 2014-01-16 | 2020-02-27 | Wave Life Sciences Ltd | Chiral design |
DE102014007158A1 (en) * | 2014-05-16 | 2015-11-19 | Ugichem Gmbh | New peptide-nucleic acid monomers and oligomers |
EP3160959B1 (en) * | 2014-06-24 | 2023-08-30 | Translate Bio, Inc. | Stereochemically enriched compositions for delivery of nucleic acids |
JP2022541650A (en) * | 2019-07-24 | 2022-09-26 | ザ・トラスティーズ・オブ・コロンビア・ユニバーシティ・イン・ザ・シティ・オブ・ニューヨーク | Methods and compositions for treating cancer using peptide nucleic acid-based agents |
CN114315835B (en) * | 2021-11-30 | 2023-03-03 | 华南农业大学 | 6-benzyladenine hapten, artificial antigen, antibody and preparation method and application thereof |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1992020702A1 (en) * | 1991-05-24 | 1992-11-26 | Ole Buchardt | Peptide nucleic acids |
WO1996004000A1 (en) * | 1994-08-05 | 1996-02-15 | The Regents Of The University Of California | PEPTIDE-BASED NUCLEIC ACID MIMICS (PENAMs) |
WO1996011205A1 (en) * | 1994-10-06 | 1996-04-18 | Isis Pharmaceuticals, Inc. | Peptide nucleic acid conjugates |
WO1996019240A1 (en) * | 1994-12-21 | 1996-06-27 | Novartis Ag | Oligonucleotide-dendrimer conjugates |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5539082A (en) * | 1993-04-26 | 1996-07-23 | Nielsen; Peter E. | Peptide nucleic acids |
ATE362546T1 (en) * | 1995-10-12 | 2007-06-15 | Lansdorp Peter M | METHOD FOR DETECTING MULTIPLE COPIES OF A REPEAT SEQUENCE IN A NUCLEIC ACID MOLECULE |
-
1998
- 1998-05-28 EP EP98923819A patent/EP1003480A4/en not_active Withdrawn
- 1998-05-28 WO PCT/US1998/010804 patent/WO1998053801A1/en not_active Application Discontinuation
- 1998-05-28 CA CA002291839A patent/CA2291839A1/en not_active Abandoned
- 1998-05-28 JP JP11500871A patent/JP2001501975A/en active Pending
- 1998-05-28 NZ NZ501289A patent/NZ501289A/en not_active IP Right Cessation
- 1998-05-28 AU AU76021/98A patent/AU745309B2/en not_active Ceased
- 1998-05-28 IL IL13308798A patent/IL133087A0/en unknown
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1992020702A1 (en) * | 1991-05-24 | 1992-11-26 | Ole Buchardt | Peptide nucleic acids |
WO1996004000A1 (en) * | 1994-08-05 | 1996-02-15 | The Regents Of The University Of California | PEPTIDE-BASED NUCLEIC ACID MIMICS (PENAMs) |
WO1996011205A1 (en) * | 1994-10-06 | 1996-04-18 | Isis Pharmaceuticals, Inc. | Peptide nucleic acid conjugates |
WO1996019240A1 (en) * | 1994-12-21 | 1996-06-27 | Novartis Ag | Oligonucleotide-dendrimer conjugates |
Non-Patent Citations (2)
Title |
---|
See also references of WO9853801A1 * |
WITTUNG, P. ET AL.: "Phospholipid Membrane Permeability of Peptide Nucleic Acid", FEBS LETTERS, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, vol. 365, no. 1, 22 May 1995 (1995-05-22), pages 27 - 29, XP001056078 * |
Also Published As
Publication number | Publication date |
---|---|
NZ501289A (en) | 2001-06-29 |
EP1003480A1 (en) | 2000-05-31 |
WO1998053801A1 (en) | 1998-12-03 |
CA2291839A1 (en) | 1998-12-03 |
IL133087A0 (en) | 2001-03-19 |
AU745309B2 (en) | 2002-03-21 |
AU7602198A (en) | 1998-12-30 |
JP2001501975A (en) | 2001-02-13 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
17P | Request for examination filed |
Effective date: 19991222 |
|
AK | Designated contracting states |
Kind code of ref document: A1 Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE |
|
A4 | Supplementary search report drawn up and despatched |
Effective date: 20020306 |
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AK | Designated contracting states |
Kind code of ref document: A4 Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE |
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RIC1 | Information provided on ipc code assigned before grant |
Free format text: 7C 07K 14/00 A, 7A 61K 47/48 B, 7A 61K 9/127 B, 7A 61K 31/70 B, 7A 61K 38/00 B, 7C 07H 21/00 B, 7C 07K 1/00 B, 7C 07K 1/13 B, 7C 07K 2/00 B, 7C 12N 5/00 B, 7C 12Q 1/68 B |
|
17Q | First examination report despatched |
Effective date: 20031229 |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN |
|
18D | Application deemed to be withdrawn |
Effective date: 20050624 |