EP1001739A1

EP1001739A1 - Use of a 2-amino-alkane polyol as agent for treating skin ageing signs

Info

Publication number: EP1001739A1
Application number: EP98941554A
Authority: EP
Inventors: Michel Philippe; Bruno Bernard; Quintino Gaetani
Original assignee: LOreal SA
Current assignee: LOreal SA
Priority date: 1997-08-07
Filing date: 1998-08-06
Publication date: 2000-05-24
Also published as: JP2001513490A; WO1999007337A1; CA2299171A1; FR2767056A1; US20020006420A1

Abstract

The invention concerns the use, as main active principle in a composition or for preparing a pharmaceutical composition, of an effective amount of at least a 2-amino-alkane polyol, or one of its derivatives for treating skin ageing signs.

Description

USE OF A 2-AMINO-ALKANE POLYOL FOR THE TREATMENT OF SKIN AGING

The present invention relates to the use, as active principle in a cosmetic composition or for the preparation of a pharmaceutical composition, of an effective amount of at least one 2-amino-alkane-1, 3-diol, or of one of its derivatives, intended for treating the signs of skin aging as well as a non-therapeutic method for treating skin aging. Skin aging, resulting from effects on the skin of intrinsic or extrinsic factors, is manifested by the appearance of fine lines and wrinkles, by the yellowing of the skin which develops a parchment appearance accompanied by the appearance of pigment spots, by the disorganization of the elastin and collagen fibers leading to a loss of elasticity, flexibility and firmness and by the appearance of telangiectasias.

Some of these signs of aging are more particularly linked to intrinsic or physiological aging, that is to say to “normal” aging linked to age, while others are more specific to extrinsic aging, ie that is to say aging generally caused by the environment; this is more particularly photo-aging due to exposure to the sun, light or any other radiation.

The invention is concerned with intrinsic or physiological aging as well as extrinsic aging.

The skin changes resulting from intrinsic or physiological aging are the consequence of genetically programmed senescence in which endogenous factors intervene. This intrinsic aging notably causes a slowing down of the renewal of skin cells. Histologically the skin is generally thinned, both epidermally and dermally. The density of the fibrous macromolecules of the dermis (elastin and collagen) is reduced.

On the contrary, extrinsic aging leads to clinical alterations such as thick wrinkles and the formation of soft and / or tanned skin, and histopathological changes such as an excessive accumulation of elastic material in the upper dermis and degeneration of the fibers. collagen.

For many years, research has been carried out in the cosmetic or pharmaceutical industry on substances which make it possible to suppress or reduce the effect of skin aging, and in particular to counteract the slowing down of the renewal of skin cells.

Various agents are known in the prior art intended to combat skin aging.

Thus, US Pat. No. 4,603,146 describes the use of retinoic acid and its derivatives in cosmetic compositions, with a view to combating skin aging. In addition, numerous patents and publications (see for example application EP-A-413 528) as well as many commercial cosmetic compositions teach the use of α-hydroxy acids such as lactic acid, glycolic acid or else citric acid to treat skin aging.

Finally, beta-hydroxy acids and more particularly salicylic acid and its derivatives are known for their flaking properties (see documents WO-A-93/10756 and US-A-4 767 750).

All of these compounds have an action against aging of the skin, consisting of desquamation, that is to say the elimination of "dead" cells located on the surface of the stratum corneum. This desquamating property is also called, often wrongly, keratolytic property. But these compounds also have side effects, which consist of tingling, tightness, overheating and redness unpleasant for the user.

It is therefore found that there remains the need for anti-aging agents having an action at least as effective as that of the compounds of the prior art, but not having their drawbacks.

Surprisingly, the applicant has now discovered that certain compounds of the 2-amino-alkane polyol type have an effect on the aging of the skin.

The subject of the invention is therefore the use of a 2-amino-alkane polyol of formula (I) (below), or of one of its derivatives, in a cosmetic or dermatological composition for topical application, intended to treat certain signs of endogenous and / or exogenous aging.

This treatment can be carried out as a preventive and / or curative measure.

Compounds of the 2-amino-alkane polyol type or their derivatives can be part of these tissue compounds which are called by the very general term of sphingolipids.

Among these sphingolipids, the N-acylated derivatives based on sphinganine [(2S, 3R) -2-amino-1, 3-octadecanediol] are ceramides predominantly present in the hair, while analogous derivatives based on phytosphingosine [(2S , 3S, 4R) -2-amino-1, 3,4-octadecane-triol), other ceramides, are part of the lipids mainly present in the stratum corneum of the skin. Ceramides are used in cosmetics in natural or synthetic form in compositions intended for example to reinforce the barrier effect of the stratum corneum in order to reduce the loss of water and therefore the drying of the skin (GB 2 178 312, GB 2 213 723 , EP 227 994, EP 282 616, EP 556 957).

They are also used in cosmetic compositions for their properties giving the skin better elasticity (EP 500 437) or in compositions for hair use to strengthen the hair and / or repair the damage caused by the continual assaults that this one undergoes.

To the knowledge of the applicant, it has never been described or even suggested for the 2-amino-alkane polyols of formula (I), or their derivatives, an effect on the proliferation of cells and even less of keratinocytes.

It is on the basis of this new property of these amino polyols that the applicant has been able to show that these compounds also have an effect on skin aging.

The invention relates to the use in a cosmetic composition or for the preparation of a pharmaceutical composition intended for treating the signs of skin aging, of at least one compound of general formula (I):

in which R- | represents a linear or branched hydrocarbon radical, optionally hydroxylated, saturated or unsaturated, having 4 to 28 carbon atoms, R2 represents a hydrogen atom or the radical

, o

in which R3 represents a linear or branched, saturated or unsaturated hydrocarbon-based radical having from 1 to 11 carbon atoms or a linear or branched, hydroxylated, saturated or unsaturated hydrocarbon-based radical having from 1 to 29 carbon atoms, the hydroxyl being capable of be esterified by an acyl chain having from 2 to 30 carbon atoms, linear or branched, saturated or unsaturated;

X represents a hydrogen atom or the OH radical; or at least one of its optical isomers or one of the diastereoisomers.

R-1 preferably contains from 6 to 22 carbon atoms and even more preferably from 10 to 18 carbon atoms. preferably R2 represents H or a radical

.R,

O and R3 represents a linear or branched, saturated or unsaturated hydrocarbon radical having from 1 to 9 carbon atoms or a linear or branched, hydroxylated, saturated or unsaturated hydrocarbon radical, having from 1 to 21 carbon atoms.

Preferably, Ri represents a saturated and / or linear hydrocarbon radical, more particularly a saturated linear hydrocarbon radical. Preferably, R- | represents a saturated hydrocarbon radical having 14 carbon atoms, and even more preferably R ^ represents a linear, saturated hydrocarbon radical having 14 carbon atoms.

The agent promoting the care and / or prevention of aging can be a mixture of compounds of formula (I), for which R, and / or R ₂ are chains of different lengths.

These compounds can be used in the form of a pure isomer or a mixture of isomers.

These compounds have the advantage of not inducing annoying side effects, which makes their use without risk for the user.

Mention may be made, as compounds of formula (I) which can be used according to the invention:

- 2-amino-octadecane-1, 3-diol,

- 2-N-acetylamino-octadecane-1, 3-diol,

- 2-N-octanoylamino-octadecane-1, 3-diol,

- 2-N- (2-hydroxy-hexadecanoyl) -amino-octadecane-1, 3-diol, - 2-N- (2-hydroxy-docosanoyi) -amino-octadecane-1, 3-diol,

- 2-amino-octadecane-1, 3,4-triol,

- 2-N- (2-hydroxy-hexadecanoyl) -amino-octadecane-1, 3,4-triol

- 2-N-hexanoylamino-octadecane-1, 3-diol

- 2-N-octanoylamino-octadecane-1, 3,4-triol.

Preferably, according to the invention, 2-N-acetylamino-octadecane-1, 3-diol or 2-N-octanoylamino-octadecane-1, 3-diol is used.

A subject of the invention is therefore the use of a 2-amino-alkane-1, 3-diol of formula (I) (below), or of one of its derivatives, in a cosmetic or dermatological composition for topical application, intended to treat wrinkles and / or fine lines and / or yellowing of the skin and / or the parchment appearance of the skin and / or pigmented spots of the skin and / or telangiectasias and or loss elasticity, flexibility and / or firmness of the skin.

The amount of compounds of formula (I) which can be used according to the invention depends, of course, on the nature of the compound used, on its physicochemical properties and on its mode of application. A person skilled in the art knows how to adjust the amount of compound of formula (I) to be used as required.

By way of indication, the compounds of formula (I) can be used at concentrations by weight of between 10 ^% and 20%, and preferably between 10 ^"3 % and 10% in the composition.

When the compound of formula (I) is used in a composition which must be applied to the skin, this composition can be in all the galenical forms normally used. For a topical application to the skin, the composition may take the form in particular of an aqueous, alcoholic, hydroalcoholic or oily solution or of dispersion of the lotion or serum type, of an emulsion of liquid or semi-liquid consistency of the milk type, obtained by dispersing a fatty phase in an aqueous phase (O / W) or vice versa (W / O), or a suspension or an emulsion of soft consistency of the cream, foam or aqueous or anhydrous gel type, or still microcapsules or microparticles, or a vesicular dispersion of the ionic and / or nonionic type. It can also take the form of an aerosol composition also comprising a pressurized propellant.

Whatever its form, this composition is prepared according to the usual methods. The amounts of the various constituents of the composition according to the invention are those conventionally used in the fields considered.

When the composition is an emulsion, the proportion of the fatty phase can range from 5% to 80% by weight, and preferably from 5% to 50% by weight relative to the total weight of the composition. The oils, waxes, emulsifiers and co-emulsifiers used in the composition in the form of an emulsion are chosen from those conventionally used in the cosmetic field. The emulsifier and the co-emulsifier are present in the composition in a proportion ranging from 0.3% to 30% by weight, and preferably from 0.5 to 20% by weight relative to the total weight of the composition . The emulsion may, in addition, contain lipid vesicles.

When the composition is an oily solution or gel, the fatty phase can represent more than 90% of the total weight of the composition.

It is also conceivable that the composition comprising at least one compound of formula (I) as active principle intended to treat and / or prevent aging of the skin is in iiposomal form, as notably described in patent application WO 94 / 22468 filed October 13, 1994 ^" by Anti Cancer Inc.

This composition can also contain adjuvants customary in the cosmetic field, such as hydrophilic or iipophilic gelling agents, hydrophilic or Iipophilic additives, preservatives, antioxidants, solvents, perfumes, fillers, filters, odor absorbers and coloring matters. The amounts of these various adjuvants are those conventionally used in the cosmetic field, and for example from 0.01% to 10% of the total weight of the composition. These adjuvants, depending on their nature, can be introduced into the fatty phase, into the aqueous phase and / or into the lipid spherules.

As oils or waxes which can be used in the invention, mention may be made of mineral oils (petroleum jelly oil), vegetable oils (liquid fraction of butter from shea, sunflower oil), animal oils (perhydrosqualene), synthetic oils (purceliin oil), silicone oils or waxes (cyclomethicone) and fluorinated oils (perfluoropolyethers), beeswax, carnauba or paraffin . Fatty alcohols and fatty acids (stearic acid) can be added to these oils.

As emulsifiers which can be used in the invention, there may be mentioned for example glycerol stearate, polysorbate 60 and the mixture of PEG-6 / PEG-32 / Glycol Stearate sold under the name Tefose ^ 63 by the company Gattefosse.

As solvents which can be used in the invention, mention may be made of lower alcohols, in particular ethanol and isopropanol, propylene glycol.

As hydrophilic gelling agents which can be used in the invention, mention may be made of carboxyvinyl polymers (carbomers), acrylic copolymers such as acrylate / alkylacrylate copolymers, polyacrylamides, polysaccharides such as hydroxypropylcellulose, natural gums and clays, and, as lipophilic gelling agents, mention may be made of modified clays such as bentones, metal salts of fatty acids such as aluminum stearates and hydrophobic silica, ethylcellulose, polyethylene.

The composition may contain other hydrophilic active agents such as proteins or protein hydrolysates, amino acids, polyols, urea, allantoin, sugars and sugar derivatives, water-soluble vitamins, plant extracts and hydroxy acids.

As lipophilic active agents, retinol (vitamin A) and its derivatives, tocopherol (vitamin E) and its derivatives, essential fatty acids, ceramides other than the compounds of formula (I), essential oils, salicylic acid and its derivatives.

In particular, it is also possible to use, in combination with the compound of formula (I) used according to the invention, compounds which further improve the activity on the care and / or prevention of aging, and which have already been described for this purpose. activity.

Among these latter compounds, there may be more particularly mentioned, without implying any limitation:

- keratolytic agents such as alpha- and beta-hydroxycarboxylic or beta-ketocarboxylic acids, their salts, amides or esters and more particularly hydroxy acids such as glycolic acid, lactic acid, salicylic acid, acid citric and generally fruit acids, and n-octanoyl-5-salicylic acid;

- anti-free radical agents, such as alpha-tocopherol or its esters, superoxide dismutases, certain metal chelating agents or ascorbic acid and its esters;

- anti-acne drugs such as retinoic acid or benzoyl peroxide. It is also possible to combine the compounds of formula (I) with antagonists of substance P and / or of CGRP (Calcitonin Gene Related Peptide or peptide linked to the calcitonin gene) such as Iris Pallida and strontium salts, in particular strontium chlorides and nitrates, or substance P and / or CGRP antagonists such as those described in French patent applications FR-2719474 and FR-2729855. Such an association makes it possible to guarantee perfect tolerance of these compositions, even for very sensitive skin.

It is possible to use at least one of the compounds corresponding to formula (I) in the preparation of a pharmaceutical composition, particularly a dermatological composition, intended for treating and / or preventing skin aging.

In general, these pharmaceutical compositions are distinguished in particular from cosmetic compositions by the amount of active agent which they contain. Those skilled in the art, in this case, know how to determine the quantity of active agent which can be used as a function of the desired result but also of the mode of administration envisaged. As an indication, the compound of formula (I) can be used in the preparation of a pharmaceutical composition at a concentration of between 0.01% and 20% and preferably between 0.1% and 10% by weight relative to the weight of composition.

The cosmetic or pharmaceutical composition according to the invention can be applied to the skin, generally the skin of the face and / or the neck and / or the hands, and optionally left in contact for several hours and optionally rinsed off. One can, for example, apply the composition containing an effective amount of at least one compound of formula (I), in the evening, keep it in contact overnight and possibly perform a wash in the morning. These applications can be renewed daily for one or more months depending on the individual.

Thus, the subject of the present invention is also a method of cosmetic treatment of human skin, characterized in that it consists in applying to at least part of the skin of the human body, a cosmetic composition comprising an effective amount of at least one compound of formula (I), to leave it in contact with the skin, and optionally to rinse.

The following examples and compositions illustrate the invention without limiting it in any way. In the compositions the proportions indicated are percentages by weight unless otherwise indicated.

Example 1: Measurement of the proliferative effect of 2-amino-octadecane-1, 3-diol and its derivatives on cultured keratinocytes:

HaCat cells (Boukamp et al., J. Cell Biol. Vol. 106, March 1988, 761-771) are cultured in DMEM medium (Gibco Company) containing amino acids (mixture of nonessential amino acids) at the concentration 0.1 mM, penicillin and streptomycin at respective concentrations of 50 International Units per milliliter and 50 μg / ml, glutamine at 2 mM concentration, sodium pyruvate at 1 mM concentration and 10% fetal calf serum. These cells were seeded at a density of 10,000 cells per well, in the 24 wells of multi-well type plates (Costar, France).

24 hours after inoculation, the cells are brought into contact with the various compounds tested in a KBM medium (Clonetics company) containing 0.15 mM of calcium ion, insulin at 5 μg / ml, hydrocortisone at 0 , 5 μg / ml, and delipidated bovine serum albumin at 1 μg / ml.

A cell count is carried out 5 days after the addition of the different ceramides using a cell counter of the Coulter Counter type.

The different compounds are tested at 0.5 nM, 5 nM, 50 nM and 500 nM.

The results expressed as a percentage represent the increase in the number of cells relative to the control, that is to say relative to a culture carried out under the same conditions in the absence of sphinganine.

The different compounds tested are: A: 2-amino-octadecane-1, 3-diol, B: 2-N- (2-hydroxy-hexadecanoyl) -amino-octadecane-1, 3-diol, C: 2-N- acetylamino-octadecane-1, 3-diol, D: 2-N-octanoylamino-octadecane-1, 3-diol.

A B C D

0.5 nM 7 26 17 15

5 nM 15 36 34 18

50 nM 17 42 29 31

500 nM 30 22 35 27

These results show that 2-amino-octadecane-1, 3-diol and its derivatives have a proliferative activity on keratinocytes in culture.

Example 2: Measurement of the effect of 2-amino-octadecane-1, 3-diol and its derivatives on cell viability:

HaCat cells are cultured as before. They are then seeded at a density of 20,000 cells per well, in the 24 wells of multi-well plates (Costar, France). 24 hours after inoculation, the cells are brought into contact with the various compounds tested in a KBM medium (Clonetics company) containing insulin at 5 μg / ml and hydrocortisone at 0.5 μg / ml. Cell viability is evaluated 48 hours later by measuring the mitochondrial respiration. This is carried out using an XTT kit, sold by the company Boehringer and according to the supplier's instructions.

Compounds A and B of the previous example were tested at a concentration of 50 nM, as well as a derivative based on sphingenine: N-palmitoylsphingenine from Sigma (C16H).

The results expressed as a percentage represent the increase in the number of cells relative to the control, that is to say relative to a culture carried out under the same conditions in the absence of alkane-diol compounds.

Control 0__

A +17

B +20

C16H -25

The results show that 2-amino-octadecane-1, 3-diol (A) and 2-N- (2-hydroxy-hexadecanoyl) - amino-octadecane-1, 3-diol (B) increase the viability of keratinocytes in culture, while N-paimitoylsphingenine (C16H) has a cytotoxic effect on cells in culture.

Example 3: Measurement of the effect of 2-amino-octadecane-1, 3-diol and its derivatives on the cell cycle:

HaCat cells are cultured as before.

They are then seeded at a density of 20,000 cells per well, in the 24 wells of multi-well plates (Costar, France).

24 hours after inoculation, the cells are brought into contact with the various compounds tested in a KBM medium (Clonetics company) containing insulin at 5 μg / ml and hydrocortisone at 0.5 μg / ml and 5- bromo-2 'deoxyuridine (BrdU) at 1μ.M The cell cycle phase is evaluated 48 hours later by measuring the incorporation of BrdU in genomic deoxyribonucleic acid. This is carried out using a "BrdU fast" kit, sold by the company Boehringer and according to the supplier's instructions.

Compounds A and B of the previous example were tested at a concentration of 50 nM.

The results expressed as a percentage represent the increase in the number of cells entered in phase S relative to the control, that is to say relative to a culture carried out under the same conditions in the absence of alkane-diol compounds.

72 hours 96 hours Control 0 0

A 36 41

B 17 43

The results show that 2-amino-octadecane-1, 3-diol (A), and 2-N- (2-hydroxy-hexadecanoyl) -amino-octadecane-1,3-diol (B) increase the number of keratinocytes entered into phase S, thus indicating a stimulation of cellular mitotic activity.

Example 4 Effect of 2-amino-octadecane-1, 3-diol and its derivatives on cell viability in the presence of a sphingenine-based compound, N-acetyl sphingenine.

HaCat cells are cultured as in Example 2.

24 hours after seeding, the cells are brought into contact with the various compounds tested in a KBM medium (Clonetics company) containing insulin at 5 μg / ml and hydrocortisone at 0.5 μg / ml.

The cells are cultured in the presence of 2-amino-octadecane-1, 3-diol to be tested until the evaluation of cell viability.

N-acetyl sphingenine at a concentration of 10 μM is added to the culture medium for 2 hours at the start of the experiment.

Cell viability is evaluated 48 hours later by measuring mitochondrial respiration. This is carried out using an XTT kit, sold by the company Boehringer and according to the supplier's instructions.

The experiment was carried out with the following compounds at the concentration of

50 nM:

C: 2-amino-octadecane-1, 3-diol,

D: 2-N- (2-hydroxy-hexadecanoyl) -amino-octadecane-1, 3-diol, in comparison with the culture medium without alkane diol and without N-acetyl sphingenine (A), and with a medium not containing only N-acetyl sphingenine

(B).

The results expressed as a percentage represent the number of cells relative to the control (A), that is to say relative to a culture carried out under the same conditions in the absence of alkane-diol compounds and of N-acetyl sphingenine.

100

B 57

C 72

D 78

N-acetyl sphingenine causes a decrease in cell viability. The „„, _, „, _Λ

PCT / FR98 / 01755

presence in the culture medium of a 2-amino-octadecane-1, 3-diol tends to counter this effect.

Example 5: Examples of compositions to be applied to the skin. These compositions can be prepared by simple mixing. The percentages are given by weight of active material relative to the total weight of the composition.

Oil in hydrating water emulsion: Corn germ oil 2%

Glycerol monostearate 3%

Polyethylene glycol 400 3%

Carbopol 491 ® sold by the company GOODRICH H 0.2%

Isopropyl myristate 3% N-octanoylamino-octadecane-1, 3-diol 0.1%

Cetyl alcohol 3%

Stearic alcohol 3%

NaOH 0.008 0 // o

Propylene glycol 5 / o Preservatives qs

Water qs 100

Water in moisturizing oil emulsion: Vaseline oil 10%

Protegin X marketed by Goldschmidt 20%

Sunflower oil 15%

Aromatic composition 1%

N-acetylamino-octadecane-1, 3-diol 0.05 0 // o Magnesium sulfate 0.5%

Glycerol 5%

Cétrol HE marketed by Henkel 4%

Conservative qs

Demineralized water qsp100

Aqueous gel

Carbopol 940 ® marketed by the company GOODRICH 0.6 0 // o

Transcutol ® marketed by GATTEFOSSE 5 / o

Triethanolamine 0.3 0 // o Propylene glycol 3 0 // o

NaOH 0.007 / o

N-octanoylamino-octadecane-1, 3-diol 0.1 0 // o

Conservative qs

Water qs 100

Nonionic liposome cream Carbopol 940 ® marketed by the company GOODRICH 0.2% Transcutol ® marketed by the company GATTEFOSSE 3% Triethanolamine 0.2% Polyglyceryl-3-cetyl ether 3.8% β sitosterol 3.8% Diketyl phosphate 0.4% NaOH 0.007 %

N-acetylamino-octadecane-1, 3-diol 0.15% Sunflower oil 35% Perfume qs Preservative qs Water qsp100

Claims

1. Use in a cosmetic composition or for the preparation of a pharmaceutical composition intended for treating the signs of skin aging, of an effective amount of at least one compound of general formula (I):

in which R- _| represents a linear or branched hydrocarbon radical, optionally hydroxylated, saturated or unsaturated, having from 4 to 28 carbon atoms; R2 represents a hydrogen atom or the radical

Υ R,

O

2. Use according to claim 1, characterized in that R- | represents a hydrocarbon radical having from 6 to 22 carbon atoms.

3. Use according to any one of claims 1 or 2, characterized in that R- | represents a saturated hydrocarbon radical.

4. Use according to any one of the preceding claims, characterized in that R ^ represents a hydrocarbon radical having from 10 to 18 carbon atoms.

5. Use according to any one of claims 1 to 4, characterized in that R-j represents a linear hydrocarbon radical.

6. Use according to any one of the preceding claims, characterized in that R2 represents H

7. Use according to any one of claims 1 to 5, characterized in that R2 represents a radical and R3 represents a linear or branched, saturated or unsaturated, hydrocarbon-based radical having from 1 to 9 carbon atoms or a linear or branched, hydroxylated, saturated or unsaturated, hydrocarbon-based radical having from 1 to 21 carbon atoms.

8. Use according to any one of the preceding claims, characterized in that the amount of compound of formula (I) is between 10 ^" % and 20% by weight relative to the weight of the composition.

9. Use according to the preceding claim, characterized in that the amount of compound of formula (I) is between 10 ^"3 % and 10% by weight relative to the weight of the composition.

10. Use according to any one of the preceding claims, characterized in that the compound of formula (I) is chosen from:

- 2-amino-octadecane-1, 3-diol,

- 2-N-acetylamino-octadecane-1, 3-diol,

- 2-Noctanoylamino-octadecane-1, 3-diol,

- 2-N- (2-hydroxy-hexadecanoyl) -amino-octadecane-1, 3-diol,

- 2-N- (2-hydroxy-docosanoyl) -amino-octadecane-1, 3-diol,

- 2-amino-octadecane-1, 3,4-triol,

- 2-N- (2-hydroxy-hexadecanoyl) -amino-octadecane-1, 3,4-triol

- 2-N-hexanoylamino-octadecane-1,3-diol

- 2-N-octanoylamino-octadecane-1, 3,4-triol.

11. Use according to the preceding claim, characterized in that the compound of formula (I) is chosen from 2-N-acetylamino-octadecane-1, 3-diol and 2-N-octanoylamino-octadecane-1, 3 -diol.

12. Use according to any one of the preceding claims, characterized in that it is intended for treating wrinkles and / or fine lines.

13. Use according to any one of the preceding claims, characterized in that it is intended to treat yellowing of the skin.

14. Use according to any one of the preceding claims, characterized in that it is intended to treat the parchment appearance of the skin.

15. Use according to any one of the preceding claims, characterized in that it is intended for treating pigmentary spots on the skin.

16. Use according to any one of the preceding claims, characterized in that it is intended to treat telangiectasias.

17. Use according to any one of the preceding claims, characterized in that it is intended to treat the loss of elasticity, flexibility and / or firmness of the skin.

18. A method of cosmetic treatment of human skin, characterized in that it consists in applying to at least part of the skin of the human body, a cosmetic composition comprising an effective amount of at least one compound of formula (I ) as defined in any one of claims 1 to 11, to leave it in contact with the skin, and optionally to rinse.