EP0998457A4 - Crystalline forms of antibiotic side chain intermediates - Google Patents

Crystalline forms of antibiotic side chain intermediates

Info

Publication number
EP0998457A4
EP0998457A4 EP98933212A EP98933212A EP0998457A4 EP 0998457 A4 EP0998457 A4 EP 0998457A4 EP 98933212 A EP98933212 A EP 98933212A EP 98933212 A EP98933212 A EP 98933212A EP 0998457 A4 EP0998457 A4 EP 0998457A4
Authority
EP
European Patent Office
Prior art keywords
side chain
crystalline forms
antibiotic side
chain intermediates
intermediates
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP98933212A
Other languages
German (de)
French (fr)
Other versions
EP0998457A1 (en
Inventor
Karel M J Brands
Ronald B Jobson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sharp and Dohme LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9800463.3A external-priority patent/GB9800463D0/en
Application filed filed Critical
Publication of EP0998457A1 publication Critical patent/EP0998457A1/en
Publication of EP0998457A4 publication Critical patent/EP0998457A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
EP98933212A 1997-07-10 1998-07-07 Crystalline forms of antibiotic side chain intermediates Withdrawn EP0998457A4 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US5219797P 1997-07-10 1997-07-10
US52197P 1997-07-10
GBGB9800463.3A GB9800463D0 (en) 1998-01-09 1998-01-09 Crystalline forms of antibiotic side chain intermediates
GB9800463 1998-01-09
PCT/US1998/014036 WO1999002492A1 (en) 1997-07-10 1998-07-07 Crystalline forms of antibiotic side chain intermediates

Publications (2)

Publication Number Publication Date
EP0998457A1 EP0998457A1 (en) 2000-05-10
EP0998457A4 true EP0998457A4 (en) 2010-03-10

Family

ID=26312922

Family Applications (1)

Application Number Title Priority Date Filing Date
EP98933212A Withdrawn EP0998457A4 (en) 1997-07-10 1998-07-07 Crystalline forms of antibiotic side chain intermediates

Country Status (5)

Country Link
EP (1) EP0998457A4 (en)
JP (1) JP3378021B2 (en)
AU (1) AU736136B2 (en)
CA (1) CA2294341C (en)
WO (1) WO1999002492A1 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1620433A (en) * 2000-07-19 2005-05-25 霍夫曼-拉罗奇有限公司 Pyrrolidine derivatives as inhibitors of endothelin-converting enzyme
CN102264744A (en) * 2008-12-25 2011-11-30 株式会社钟化 Improved process for producing intermediate for side chain of carbapenem

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999002531A1 (en) * 1997-07-09 1999-01-21 Merck & Co., Inc. Process for synthesizing carbapenem side chain intermediates

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9202298D0 (en) * 1992-02-04 1992-03-18 Ici Plc Antibiotic compounds

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999002531A1 (en) * 1997-07-09 1999-01-21 Merck & Co., Inc. Process for synthesizing carbapenem side chain intermediates

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of WO9902492A1 *

Also Published As

Publication number Publication date
AU736136B2 (en) 2001-07-26
JP2002504157A (en) 2002-02-05
WO1999002492A1 (en) 1999-01-21
CA2294341C (en) 2007-09-25
EP0998457A1 (en) 2000-05-10
CA2294341A1 (en) 1999-01-21
AU8292098A (en) 1999-02-08
JP3378021B2 (en) 2003-02-17

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Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

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17P Request for examination filed

Effective date: 20000210

AK Designated contracting states

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Designated state(s): AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE

A4 Supplementary search report drawn up and despatched

Effective date: 20100210

RAP1 Party data changed (applicant data changed or rights of an application transferred)

Owner name: MERCK SHARP & DOHME CORP.

RIC1 Information provided on ipc code assigned before grant

Ipc: C07D 207/16 20060101AFI20100204BHEP

17Q First examination report despatched

Effective date: 20100416

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 20101027