EP0998294A4 - Ganglioside gm3 induced apoptosis of neural cells - Google Patents

Ganglioside gm3 induced apoptosis of neural cells

Info

Publication number
EP0998294A4
EP0998294A4 EP98922465A EP98922465A EP0998294A4 EP 0998294 A4 EP0998294 A4 EP 0998294A4 EP 98922465 A EP98922465 A EP 98922465A EP 98922465 A EP98922465 A EP 98922465A EP 0998294 A4 EP0998294 A4 EP 0998294A4
Authority
EP
European Patent Office
Prior art keywords
ganglioside
induced apoptosis
neural cells
neural
cells
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP98922465A
Other languages
German (de)
French (fr)
Other versions
EP0998294A1 (en
Inventor
Robert H Miller
Elizabeth Noll
Yuji Nakasuji
Peter Mclaren Black
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Case Western Reserve University
Original Assignee
Case Western Reserve University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Case Western Reserve University filed Critical Case Western Reserve University
Publication of EP0998294A1 publication Critical patent/EP0998294A1/en
Publication of EP0998294A4 publication Critical patent/EP0998294A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7032—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a polyol, i.e. compounds having two or more free or esterified hydroxy groups, including the hydroxy group involved in the glycosidic linkage, e.g. monoglucosyldiacylglycerides, lactobionic acid, gangliosides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
EP98922465A 1997-05-22 1998-05-22 Ganglioside gm3 induced apoptosis of neural cells Withdrawn EP0998294A4 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US4743097P 1997-05-22 1997-05-22
US47430P 1997-05-22
PCT/US1998/010390 WO1998052577A1 (en) 1997-05-22 1998-05-22 Ganglioside gm3 induced apoptosis of neural cells

Publications (2)

Publication Number Publication Date
EP0998294A1 EP0998294A1 (en) 2000-05-10
EP0998294A4 true EP0998294A4 (en) 2001-02-07

Family

ID=21948933

Family Applications (1)

Application Number Title Priority Date Filing Date
EP98922465A Withdrawn EP0998294A4 (en) 1997-05-22 1998-05-22 Ganglioside gm3 induced apoptosis of neural cells

Country Status (6)

Country Link
EP (1) EP0998294A4 (en)
JP (1) JP2002510291A (en)
AU (1) AU7500398A (en)
CA (1) CA2290598A1 (en)
IL (1) IL133085A0 (en)
WO (1) WO1998052577A1 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL143596A0 (en) 1998-12-22 2002-04-21 Genentech Inc Vascular endothelial cell growth factor antagonists and uses thereof
MXPA05009480A (en) 2003-03-06 2006-02-22 Neose Technologies Inc Methods and compositions for the enzymatic synthesis of gangliosides.
JP4744187B2 (en) * 2005-05-10 2011-08-10 オリンパス株式会社 Cell observation device
WO2010111530A1 (en) 2009-03-25 2010-09-30 Seneb Biosciences, Inc. Glycolipids as treatment for disease
WO2011145622A1 (en) * 2010-05-17 2011-11-24 国立大学法人東京工業大学 Method for detecting gastric cancer

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61227531A (en) * 1985-03-30 1986-10-09 Sankyo Co Ltd Antitumor agent
JPH06145069A (en) * 1992-11-06 1994-05-24 Nisshin Oil Mills Ltd:The Vascularization inhibitor containing ganglioside gm3 or its related compound as active component
EP0728763A1 (en) * 1994-08-16 1996-08-28 Daikin Industries, Limited Ganglioside gm3 analog having sialic acid residue fluorinated at the 9-position and intermediate therefor

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4710490A (en) * 1985-10-01 1987-12-01 Angio Medical Corporation Compositions containing ganglioside molecules with enhanced angiogenic activity

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61227531A (en) * 1985-03-30 1986-10-09 Sankyo Co Ltd Antitumor agent
JPH06145069A (en) * 1992-11-06 1994-05-24 Nisshin Oil Mills Ltd:The Vascularization inhibitor containing ganglioside gm3 or its related compound as active component
EP0728763A1 (en) * 1994-08-16 1996-08-28 Daikin Industries, Limited Ganglioside gm3 analog having sialic acid residue fluorinated at the 9-position and intermediate therefor

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
DATABASE WPI Section Ch Week 198647, Derwent World Patents Index; Class B03, AN 1986-308516, XP002149606 *
DATABASE WPI Section Ch Week 199425, Derwent World Patents Index; Class B03, AN 1994-206348, XP002149607 *
MERZAK ET AL.: "Gangliosides Modulate Proliferation, Migration, and Invasiveness of Human Brain Tumor Cells in vitro", MOL. CHEM. NEUROPATHOL., 1995, pages 121 - 135, XP000941051 *
See also references of WO9852577A1 *

Also Published As

Publication number Publication date
AU7500398A (en) 1998-12-11
EP0998294A1 (en) 2000-05-10
WO1998052577A1 (en) 1998-11-26
CA2290598A1 (en) 1998-11-26
JP2002510291A (en) 2002-04-02
IL133085A0 (en) 2001-03-19

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