EP0989860A4 - Methods and compositions for inactivating infectious agents using lactoferrin and related molecules - Google Patents

Methods and compositions for inactivating infectious agents using lactoferrin and related molecules

Info

Publication number
EP0989860A4
EP0989860A4 EP99917408A EP99917408A EP0989860A4 EP 0989860 A4 EP0989860 A4 EP 0989860A4 EP 99917408 A EP99917408 A EP 99917408A EP 99917408 A EP99917408 A EP 99917408A EP 0989860 A4 EP0989860 A4 EP 0989860A4
Authority
EP
European Patent Office
Prior art keywords
lactoferrin
compositions
methods
infectious agents
related molecules
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP99917408A
Other languages
German (de)
French (fr)
Other versions
EP0989860A1 (en
Inventor
Andrew G Plaut
Jiazhou Qiu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
New England Medical Center Hospitals Inc
Original Assignee
New England Medical Center Hospitals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by New England Medical Center Hospitals Inc filed Critical New England Medical Center Hospitals Inc
Publication of EP0989860A1 publication Critical patent/EP0989860A1/en
Publication of EP0989860A4 publication Critical patent/EP0989860A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/102—Pasteurellales, e.g. Actinobacillus, Pasteurella; Haemophilus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/79—Transferrins, e.g. lactoferrins, ovotransferrins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • A61K2039/541—Mucosal route
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16061—Methods of inactivation or attenuation

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Wood Science & Technology (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Microbiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Biophysics (AREA)
  • Mycology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Marine Sciences & Fisheries (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
EP99917408A 1998-04-13 1999-04-12 Methods and compositions for inactivating infectious agents using lactoferrin and related molecules Withdrawn EP0989860A4 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US8156498P 1998-04-13 1998-04-13
US81564P 1998-04-13
PCT/US1999/007931 WO1999052545A1 (en) 1998-04-13 1999-04-12 Methods and compositions for inactivating infectious agents using lactoferrin and related molecules

Publications (2)

Publication Number Publication Date
EP0989860A1 EP0989860A1 (en) 2000-04-05
EP0989860A4 true EP0989860A4 (en) 2000-07-19

Family

ID=22164962

Family Applications (1)

Application Number Title Priority Date Filing Date
EP99917408A Withdrawn EP0989860A4 (en) 1998-04-13 1999-04-12 Methods and compositions for inactivating infectious agents using lactoferrin and related molecules

Country Status (5)

Country Link
EP (1) EP0989860A4 (en)
JP (1) JP2002508009A (en)
AU (1) AU3554099A (en)
CA (1) CA2294018A1 (en)
WO (1) WO1999052545A1 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005046571A2 (en) * 2003-06-06 2005-05-26 Agennix Incorporated Lactoferrin as an adjuvant in cancer vaccines
GB0409748D0 (en) * 2004-04-30 2004-06-09 Chiron Srl Lactoferrin cleavage
ITRM20080163A1 (en) * 2008-03-26 2009-09-27 Maurizio Acri USE OF LATTOFERRINA FOR THE PREVENTION OF NEONATAL SEPSIS IN PREMATURED NEWBORNS
CN107586334B (en) * 2017-08-29 2020-06-23 杭州医学院 Preparation method of serum for treating haemophilus influenzae infection and application of serum

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH03220130A (en) * 1990-01-25 1991-09-27 Snow Brand Milk Prod Co Ltd Agent inhibitory against implantation of pathogenic microorganism and food and drink or the like containing the same inhibitory agent
US5304633A (en) * 1990-09-07 1994-04-19 Morinaga Milk Industry Co., Ltd. Fragments of lactoferrin having potent antimicrobial activity
WO1997005884A1 (en) * 1995-08-07 1997-02-20 New England Medical Center Hospitals, Inc. Infant formula and infant formula additives

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3100005B2 (en) * 1992-07-28 2000-10-16 雪印乳業株式会社 Human immunodeficiency virus infection / growth inhibitor
JP3312946B2 (en) * 1993-03-04 2002-08-12 雪印乳業株式会社 Virus infection / growth inhibitor
WO1995022258A2 (en) * 1994-02-16 1995-08-24 Pharming Bv Isolation of lactoferrin from milk
US5834424A (en) * 1995-07-12 1998-11-10 Gambit International Limited Use of lactoferrin for therapy of acute of chronic infectious diseases by the intracellular gram-positive pathogens streptococcus pyogenes and staphylococcus aureus

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH03220130A (en) * 1990-01-25 1991-09-27 Snow Brand Milk Prod Co Ltd Agent inhibitory against implantation of pathogenic microorganism and food and drink or the like containing the same inhibitory agent
US5304633A (en) * 1990-09-07 1994-04-19 Morinaga Milk Industry Co., Ltd. Fragments of lactoferrin having potent antimicrobial activity
WO1997005884A1 (en) * 1995-08-07 1997-02-20 New England Medical Center Hospitals, Inc. Infant formula and infant formula additives

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
DATABASE WPI Section Ch Week 199145, Derwent World Patents Index; Class B04, AN 1991-329196, XP002138451 *
LEGRAND, D., ET AL.: "Evidence for interactions between the 30kDa N- and 50kDa C-terminal tryptic fragments of human lactotransferrin", BIOCHEM. J., vol. 236, 1986, pages 839 - 844, XP002921478 *
QUI, J., ET AL.: "Human milk lactoferrin extracts the IgA protease precursor from the outer membrane of growing Heamophilus influenzae cells", ABSTRACTS OF THE INTERSCIENCE CONFERENCE ON ANTIMICROBIAL AGENTS AND CHEMOTHERAPY AND MEETING INFO OF THE 35TH INTERSCIENCE CONFERENCE ON ANTIMICROBIAL AGENTS AND CHEMOTHERAPY SAN FRANCISCO, SEPT- 17-20, vol. 35, no. 0, 1995, california, usa, pages 160, XP000886820 *
See also references of WO9952545A1 *
WITTLER, M., ET AL.: "Neutralization of streptococcus sanguis IgA-1 protease by lactoferrin and transferrin", JOURNAL OF DENTAL RESEARCH AND MEETING INFO.: JOINT MEETING OF THE INTERNATIONAL ASSOCIATION FOR DENTAL RESEARCH, THE AMERICAN ASSOCIATION OF DENTAL RESEARCH AND THE CANADIAN ASSOCIATION OF DENTAL RESEARCH CHICAGO, 10-14, 1993, vol. 72, 1993, illinois, usa, pages 327, XP000886807 *

Also Published As

Publication number Publication date
EP0989860A1 (en) 2000-04-05
JP2002508009A (en) 2002-03-12
CA2294018A1 (en) 1999-10-21
WO1999052545A1 (en) 1999-10-21
AU3554099A (en) 1999-11-01

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