EP0985667A4 - Novel dihydropyridine derivative - Google Patents

Novel dihydropyridine derivative

Info

Publication number
EP0985667A4
EP0985667A4 EP98917654A EP98917654A EP0985667A4 EP 0985667 A4 EP0985667 A4 EP 0985667A4 EP 98917654 A EP98917654 A EP 98917654A EP 98917654 A EP98917654 A EP 98917654A EP 0985667 A4 EP0985667 A4 EP 0985667A4
Authority
EP
European Patent Office
Prior art keywords
dihydropyridine derivative
calcium channels
novel dihydropyridine
type
novel
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP98917654A
Other languages
German (de)
French (fr)
Other versions
EP0985667A1 (en
Inventor
Hisayuki Uneyama
Seiji Niwa
Tomoyuki Onishi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ajinomoto Co Inc
Original Assignee
Ajinomoto Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ajinomoto Co Inc filed Critical Ajinomoto Co Inc
Publication of EP0985667A1 publication Critical patent/EP0985667A1/en
Publication of EP0985667A4 publication Critical patent/EP0985667A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Pulmonology (AREA)
  • Psychiatry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Addiction (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

A novel dihydropyridine derivative represented by formula (I), analogues thereof, and pharmaceutically acceptable salts of these can exhibit selective inhibitory activities against type N calcium channels and are usable as remedies for various diseases related to type N calcium channels, such as cerebral infarction, encephalopathy caused by ischemia occurring in an acute phase after the onset of cerebral hemorrhage, and Alzheimer's disease.
EP98917654A 1997-04-25 1998-04-23 Novel dihydropyridine derivative Withdrawn EP0985667A4 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP10928397 1997-04-25
JP10928397 1997-04-25
PCT/JP1998/001878 WO1998049144A1 (en) 1997-04-25 1998-04-23 Novel dihydropyridine derivative

Publications (2)

Publication Number Publication Date
EP0985667A1 EP0985667A1 (en) 2000-03-15
EP0985667A4 true EP0985667A4 (en) 2000-03-22

Family

ID=14506250

Family Applications (1)

Application Number Title Priority Date Filing Date
EP98917654A Withdrawn EP0985667A4 (en) 1997-04-25 1998-04-23 Novel dihydropyridine derivative

Country Status (9)

Country Link
US (2) US6350766B1 (en)
EP (1) EP0985667A4 (en)
JP (1) JP4332902B2 (en)
KR (1) KR20010020267A (en)
CN (1) CN1261348A (en)
AU (1) AU7080698A (en)
CA (1) CA2288083A1 (en)
TW (1) TW446700B (en)
WO (1) WO1998049144A1 (en)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6350766B1 (en) * 1997-04-25 2002-02-26 Ajinomoto Co., Inc. Dihydropyridine derivative
WO1999032446A1 (en) * 1997-12-22 1999-07-01 Ajinomoto Co., Inc. Novel dihydropyridine derivative
WO2000024716A1 (en) * 1998-10-23 2000-05-04 Ajinomoto Co., Inc. Dihydropyridine derivatives and drug compositions containing the same
AU5568300A (en) 1999-06-23 2001-01-09 Ajinomoto Co., Inc. Novel dihydropyridine derivative
WO2000078719A1 (en) * 1999-06-23 2000-12-28 Ajinomoto Co., Inc. Dihydropyridine derivative
EP1193259A4 (en) 1999-06-23 2003-01-29 Ajinomoto Kk Dihydropyrimidine derivatives
JP4623354B2 (en) * 2000-09-14 2011-02-02 味の素株式会社 Novel pyrimidine derivatives and novel pyridine derivatives
JP4428053B2 (en) 2002-02-05 2010-03-10 味の素株式会社 Pharmaceutical composition containing gabapentin or pregabalin and N-type calcium channel antagonist
JP2005343790A (en) * 2002-05-31 2005-12-15 Ajinomoto Co Inc Medicinal composition containing calcium channel antagonist
AU2003259846A1 (en) * 2002-08-16 2004-03-03 The General Hospital Corporation Non-invasive functional imaging of peripheral nervous system activation in humans and animals
EP1952824A1 (en) * 2003-11-21 2008-08-06 Memory Pharmaceuticals Corporation Compositions and methods of treatment using L-type calcium channel blockers and cholinesterase inhibitors
WO2006105237A2 (en) * 2005-03-29 2006-10-05 The University Of Maryland, Baltimore Inhibitors for extracellular signal-regulated kinase docking domains and uses therefor
WO2006109164A2 (en) * 2005-04-15 2006-10-19 Research & Innovation Soc. Coop. A R.L. A method for preventing, delaying or reverting abnormal amyloid deposition
CN105237465B (en) * 2015-11-13 2017-07-21 吉林大学 A kind of compound and medical application with neuroprotection

Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2407115A1 (en) * 1973-02-20 1974-10-10 Yamanouchi Pharma Co Ltd NEW 1,4-DIHYDROPYRIDE DERIVATIVES
DE2658804A1 (en) * 1976-12-24 1978-07-06 Bayer Ag Compsn. with circulatory and cardiac activity - contains a 3-cyano-1,2-di:hydro-pyridine deriv.
EP0110073A1 (en) * 1982-10-23 1984-06-13 Bayer Ag Process for the preparation of tetrahydropyridines
JPS6475467A (en) * 1987-09-16 1989-03-22 Nippon Shoji Kk 3-aminocarbonyl-1,4-dihydropyridine-5-carboxylic acid ester derivative
EP0315018A2 (en) * 1987-11-04 1989-05-10 Bayer Ag Fluoromethoxyphenyl-dihydropyridines, process for their preparation and their use in drugs
JPH03240773A (en) * 1990-02-16 1991-10-28 Sanyo Kagaku Kenkyusho:Kk Production of nicardipine hydrochloride
EP0622368A1 (en) * 1993-04-27 1994-11-02 Bayer Ag Quinolyl-dihydropyridine esters for treatment of cardio-circulatory diseases
EP0657429A1 (en) * 1992-08-31 1995-06-14 Mercian Corporation Optically active 1,4-dihydropyridine compound and process for producing the same
WO1996006829A1 (en) * 1994-08-29 1996-03-07 Mercian Corporation 1,4-dihydropyridine derivative

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60233058A (en) 1984-05-04 1985-11-19 Fujirebio Inc 1,4-dihydropyridine derivative
DE3432563A1 (en) * 1984-09-05 1986-03-13 Bayer Ag, 5090 Leverkusen NEW PYRIDYLETHYL DIHYDROPYRIDINE, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE IN MEDICINAL PRODUCTS
DE3712371A1 (en) 1987-04-11 1988-10-27 Bayer Ag SUBSTITUTED 1,4-DIHYDROPYRIDINE, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE
JPH02121967A (en) * 1988-10-31 1990-05-09 Fujirebio Inc 1,4-dihydropyridine derivative
SG50624A1 (en) 1991-12-30 1998-07-20 Neurex Corp Methods of producing analgesia and enhancing opiate analgesia
US6350766B1 (en) * 1997-04-25 2002-02-26 Ajinomoto Co., Inc. Dihydropyridine derivative

Patent Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2407115A1 (en) * 1973-02-20 1974-10-10 Yamanouchi Pharma Co Ltd NEW 1,4-DIHYDROPYRIDE DERIVATIVES
DE2658804A1 (en) * 1976-12-24 1978-07-06 Bayer Ag Compsn. with circulatory and cardiac activity - contains a 3-cyano-1,2-di:hydro-pyridine deriv.
EP0110073A1 (en) * 1982-10-23 1984-06-13 Bayer Ag Process for the preparation of tetrahydropyridines
JPS6475467A (en) * 1987-09-16 1989-03-22 Nippon Shoji Kk 3-aminocarbonyl-1,4-dihydropyridine-5-carboxylic acid ester derivative
EP0315018A2 (en) * 1987-11-04 1989-05-10 Bayer Ag Fluoromethoxyphenyl-dihydropyridines, process for their preparation and their use in drugs
JPH03240773A (en) * 1990-02-16 1991-10-28 Sanyo Kagaku Kenkyusho:Kk Production of nicardipine hydrochloride
EP0657429A1 (en) * 1992-08-31 1995-06-14 Mercian Corporation Optically active 1,4-dihydropyridine compound and process for producing the same
EP0622368A1 (en) * 1993-04-27 1994-11-02 Bayer Ag Quinolyl-dihydropyridine esters for treatment of cardio-circulatory diseases
WO1996006829A1 (en) * 1994-08-29 1996-03-07 Mercian Corporation 1,4-dihydropyridine derivative
EP0779277A1 (en) * 1994-08-29 1997-06-18 Mercian Corporation 1,4-dihydropyridine derivative

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
DATABASE CHEMABS [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; KUKI, MASAKATSU ET AL: "3-Aminocarbonyl-1,4-dihydropyridine-5-carboxylate esters for treatment of circulation disorders", XP002128511, retrieved from STN Database accession no. 111:153644 *
DATABASE CHEMABS [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; TAKEDA, SHIGEKI ET AL: "Preparation of nicardipine hydrochloride", XP002128510, retrieved from STN Database accession no. 116:128681 *
See also references of WO9849144A1 *

Also Published As

Publication number Publication date
US20020111494A1 (en) 2002-08-15
AU7080698A (en) 1998-11-24
JP4332902B2 (en) 2009-09-16
CA2288083A1 (en) 1998-11-05
US6995179B2 (en) 2006-02-07
WO1998049144A1 (en) 1998-11-05
US6350766B1 (en) 2002-02-26
KR20010020267A (en) 2001-03-15
CN1261348A (en) 2000-07-26
EP0985667A1 (en) 2000-03-15
TW446700B (en) 2001-07-21

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